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Your search keyword '"MAIONE, FRANCESCO"' showing total 12 results
Start Over Author "MAIONE, FRANCESCO" Publisher hindawi limited
12 results on '"MAIONE, FRANCESCO"'

3. Long-Term Functional Results of a Modified Caudal-to-Cranial Approach in Laparoscopic Segmental Left Colectomy for Diverticular Disease

Author

Manigrasso, Michele, primary, Pesce, Marcella, additional, Milone, Marco, additional, Anoldo, Pietro, additional, D’Amore, Anna, additional, Galasso, Giovanni, additional, Gennarelli, Nicola, additional, Maione, Francesco, additional, Vertaldi, Sara, additional, Sarnelli, Giovanni, additional, and De Palma, Giovanni Domenico, additional

Published
2021
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12. Phosphodiesterase-1 Inhibitory Activity of Two Flavonoids Isolated from Pistacia integerrima J. L. Stewart Galls.

Author

Rauf, Abdur, Saleem, Muhammad, Uddin, Ghias, Siddiqui, Bina S., Khan, Haroon, Raza, Muslim, Hamid, Syeda Zehra, Khan, Ajmal, Maione, Francesco, Mascolo, Nicola, and De Feo, Vincenzo

Subjects
ASTHMA treatment, FLAVONOIDS, ANALYSIS of variance, HERBAL medicine, MEDICINAL plants, AYURVEDIC medicine, METHANOL, SNAKE venom, T-test (Statistics), TRADITIONAL medicine, PLANT extracts, PHOSPHODIESTERASE inhibitors, DATA analysis software, IN vitro studies, THERAPEUTICS
Abstract

Pistacia integerrima is one of twenty species among the genus Pistacia. Long horn-shaped galls that develop on this plant are harvested and used in Ayurveda and Indian traditional medicine to make “karkatshringi”, a herbal medicine used for the treatment of asthma and different disorders of respiratory tract. However, until now, the molecular mechanisms of action of “karkatshringi” and its chemical characterization are partially known. This study deals with the isolation and characterization of the active constituents from the methanolic extract of P. integerrima galls and it was also oriented to evaluate in vitro and in silico their potential enzymatic inhibitory activity against phosphodiesterase-1 (PDE1), a well-known enzyme involved in airway smooth muscle activity and airway inflammation. Our results showed that the methanolic extract of P. integerrima galls and some of its active constituents [naringenin (1) and 3,5,7,4′-tetrahydroxy-flavanone (2)] are able in vitro to inhibit PDE1 activity (59.20 ± 4.95%, 75.90 ± 5.90%, and 65.25 ± 5.25%, resp.) and demonstrate in silico an interesting interaction with this enzymatic site. Taken together, our results add new knowledge of chemical constituents responsible for the biological activity of P. integerrima and contextually legitimate the use of this plant in folk medicine. [ABSTRACT FROM AUTHOR]

Published
2015
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