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16 results on '"Ko, Kam Ming"'

1. Evaluation of Beneficial and Adverse Effects of a Diet Supplemented with Schisandrae Fructus Seed Ethanol Extract on Lipid and Glucose Metabolism in Normal and Hypercholesterolemic/Hyperglycemic Mice

Author

Wang, Xiao-Yan, primary, Song, Xue-Lan, additional, Zhang, Yi, additional, Luo, Gan, additional, Tai, Hai-Chuan, additional, Lin, Zhao-Heng, additional, Zhu, Pei-Li, additional, Sun, Nan, additional, Chu, Zhu-Sheng, additional, Yu, Zhi-Ling, additional, Pan, Si-Yuan, additional, Tang, Jin-Fa, additional, and Ko, Kam-Ming, additional

Published
2021
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3. A Cistanches Herba Fraction/β-Sitosterol Causes a Redox-Sensitive Induction of Mitochondrial Uncoupling and Activation of Adenosine Monophosphate-Dependent Protein Kinase/Peroxisome Proliferator-Activated ReceptorγCoactivator-1 in C2C12 Myotubes: A Possible Mechanism Underlying the Weight Reduction Effect

Author

Wong, Hoi Shan, primary, Chen, Jihang, additional, Leong, Pou Kuan, additional, Leung, Hoi Yan, additional, Chan, Wing Man, additional, and Ko, Kam Ming, additional

Published
2015
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6. Supplementation with the Extract of Schisandrae Fructus Pulp, Seed, or Their Combination Influences the Metabolism of Lipids and Glucose in Mice Fed with Normal and Hypercholesterolemic Diet

Author

Wang, Xiao-Yan, Yu, Zhi-Ling, Pan, Si-Yuan, Zhang, Yi, Sun, Nan, Zhu, Pei-Li, Jia, Zhan-Hong, Zhou, Shu-Feng, Ko, Kam Ming, Wang, Xiao-Yan, Yu, Zhi-Ling, Pan, Si-Yuan, Zhang, Yi, Sun, Nan, Zhu, Pei-Li, Jia, Zhan-Hong, Zhou, Shu-Feng, and Ko, Kam Ming

Abstract

Schisandrae Fructus (SF), which possesses five tastes: sweet (fruit skin), sour (pulp), bitter/pungent (seed core), and saltiness (all parts), can produce a wide spectrum of biological activities in the body. Here, we investigated the effects of the ethanolic extract of SF pulp, seed, or their combination (namely, EtSF-P, EtSF-S, or EtSF-P/S, resp.; collectively called EtSF) on the metabolism of lipids and glucose in normal diet- (ND-) and hypercholesterolemic diet- (HCLD-) fed mice. Supplementation with EtSF significantly reduced hepatic triglyceride and cholesterol levels by 18-47% in both ND- and HCLD-fed mice. EtSF supplementation reduced serum triglyceride levels (approximately 29%), whereas EtSF-P and EtSF-S/P elevated serum cholesterol (up to 26 and 44%, resp.) in HCLD-fed mice. Treatment with EtSF decreased hepatic glucose levels (by 9-44%) in both ND- and HCLD-fed mice. Supplementation with EtSF-S or EtSF-S/P (at 1 and 3%) increased biliary or fecal TC contents in HCLD-fed mice. However, supplementation with EtSF-S/P at 9% reduced biliary TC levels in HCLD-fed mice. EtSF-P or EtSF-S/P supplementation reduced serum alanine aminotransferase activity in HCLD-fed mice. The findings suggested that supplementation with EtSF lowered lipid and glucose accumulation in the liver and increased fecal cholesterol contents in mice. Dietary supplementation with EtSF-P or EtSF-S/P attenuated liver damage in HCLD-fed mice.

Published
2014

16. A Cistanches Herba Fraction/β-Sitosterol Causes a Redox-Sensitive Induction of Mitochondrial Uncoupling and Activation of Adenosine Monophosphate-Dependent Protein Kinase/Peroxisome Proliferator-Activated Receptor γ Coactivator-1 in C2C12 Myotubes: A Possible Mechanism Underlying the Weight Reduction Effect

Author

Wong, Hoi Shan, Chen, Jihang, Leong, Pou Kuan, Leung, Hoi Yan, Chan, Wing Man, and Ko, Kam Ming

Subjects
MITOCHONDRIAL physiology, ACTION potentials, ACTIVE oxygen in the body, ANIMAL experimentation, BIOCHEMISTRY, CELL culture, CELL receptors, HERBAL medicine, CHINESE medicine, TRANSCRIPTION factors, WEIGHT loss, WESTERN immunoblotting, PLANT extracts, DATA analysis software, SKELETAL muscle, DESCRIPTIVE statistics, IN vitro studies, PHARMACOKINETICS
Abstract

Previous studies have demonstrated that HCF1, a semipurified fraction of Cistanches Herba, causes weight reduction in normal diet- and high fat diet-fed mice. The weight reduction was associated with the induction of mitochondrial uncoupling and changes in metabolic enzyme activities in mouse skeletal muscle. To further investigate the biochemical mechanism underlying the HCF1-induced weight reduction, the effect of HCF1 and its active component, β-sitosterol (BSS), on C2C12 myotubes was examined. Incubation with HCF1/BSS caused a transient increase in mitochondrial membrane potential (MMP), possibly by fluidizing the mitochondrial inner membrane. The increase in MMP was paralleled to an increase in mitochondrial reactive oxygen species (ROS) production. Mitochondrial ROS, in turn, triggered a redox-sensitive induction of mitochondrial uncoupling by uncoupling protein 3 (UCP3). Biochemical analysis indicated that HCF1 was capable of activating an adenosine monophosphate-dependent protein kinase/peroxisome proliferator-activated receptor γ coactivator-1 pathway and thereby increased the expression of cytochrome c oxidase and UCP3. Animal studies using mitochondrial recoupler also confirmed the role of mitochondrial uncoupling in the HCF1-induced weight reduction. In conclusion, a HCF1/BSS causes the redox-sensitive induction of mitochondrial uncoupling and activation of AMPK/PGC-1 in C2C12 myotubes, with resultant reductions in body weight and adiposity by increased energy consumption. [ABSTRACT FROM AUTHOR]

Published
2015
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