1. Body Mass Index (BMI) and Its Influence on the Cardiovascular and Operative Risk Profile in Coronary Artery Bypass Grafting Patients: Impact of Inflammation and Leptin
- Author
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Alina Hanf, K. Buschmann, Christian F. Vahl, Ryan Chaban, Julius Wrobel, Andreas Daiber, Ahmed Ghazy, Katrin Schäfer, R. Rösch, and Andres Beiras-Fernandez
- Subjects
Leptin ,Male ,Aging ,medicine.medical_specialty ,Article Subject ,Adipokine ,Adipose tissue ,030209 endocrinology & metabolism ,Coronary Artery Disease ,030204 cardiovascular system & hematology ,Biochemistry ,Body Mass Index ,Coronary artery disease ,03 medical and health sciences ,0302 clinical medicine ,Diabetes mellitus ,Internal medicine ,medicine ,Humans ,Myocardial infarction ,Coronary Artery Bypass ,Aged ,Inflammation ,QH573-671 ,business.industry ,Cell Biology ,General Medicine ,Middle Aged ,medicine.disease ,medicine.anatomical_structure ,Cardiology ,business ,Cytology ,Body mass index ,Artery ,Research Article - Abstract
Background. Obesity is related to coronary artery disease (CAD) and worse outcomes in coronary artery bypass graft (CABG) patients. Adipose tissue itself is an endocrine organ that secretes many humoral mediators, such as adipokines, which can induce or reduce inflammation and oxidative stress. Objectives. We investigate the relationship between the body mass index (BMI), inflammation, and oxidative stress by measuring serum levels of leptin, interleukin-6, and 3-nitrotyrosine in CABG patients and correlate their levels to the cardiovascular and operative risk profiles. Methods and Results. 45 men (2, who were diagnosed with CAD and scheduled for elective CABG, were included after applying the following exclusion criteria: prior myocardial infarction, reoperation, female gender, and smoking. Patients’ blood samples were taken preoperatively. Several markers were measured. We found significant correlations between leptin and BMI p<0.0001 as well as between leptin and 3-nitrotyrosine p=0.006. Interleukin-6 was correlated with C-reactive protein p<0.0001 and with the incidence of insulin-dependent diabetes mellitus p=0.036, arterial hypertension p=0.044, reduced left ventricular function p=0.003, and severe coronary calcification p=0.015. It was also associated with significantly longer extracorporeal bypass time p=0.009. Postoperative deep sternal wound infections could be predicted by a higher BMI p=0.003 and leptin level p=0.001. Conclusions. There seems to be a correlation between inflammatory processes and cardiovascular morbidity in our cohort. Further, the incidence of deep sternal wound infections is related to a higher BMI and leptin serum level.
- Published
- 2020