1. Significance of Neutrophil Gelatinase-Associated Lipocalin Level-to-Serum Creatinine Ratio for Assessing Severity of Inflammation in Patients with Renal Dysfunction
- Author
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Noriyoshi Fujii, Tatsuyoshi Fujii, and Jong Weon Choi
- Subjects
Adult ,Male ,medicine.medical_specialty ,Article Subject ,lcsh:Medicine ,Inflammation ,Lipocalin ,Systemic inflammation ,Severity of Illness Index ,behavioral disciplines and activities ,Gastroenterology ,General Biochemistry, Genetics and Molecular Biology ,chemistry.chemical_compound ,Lipocalin-2 ,Proto-Oncogene Proteins ,Internal medicine ,Severity of illness ,medicine ,Humans ,Aged ,Aged, 80 and over ,Creatinine ,General Immunology and Microbiology ,medicine.diagnostic_test ,business.industry ,lcsh:R ,Acute-phase protein ,Area under the curve ,General Medicine ,Middle Aged ,Lipocalins ,Endocrinology ,chemistry ,Erythrocyte sedimentation rate ,Female ,Kidney Diseases ,medicine.symptom ,business ,Biomarkers ,Research Article ,Acute-Phase Proteins - Abstract
The aim of this study was to assess the significance of the neutrophil gelatinase-associated lipocalin/serum creatinine ratio (NGAL/sCr ratio) in patients with renal dysfunction. The percent difference between plasma NGAL level and the NGAL/sCr ratio was 36.7% (95% CI, 18.4–83.7%) in patients with sCr level ≥ 1.2 mg/dL. In a multivariate analysis, high sensitivity C-reactive protein (hsCRP) was significantly associated with the NGAL/sCr ratio and plasma NGAL level (r=0.526andr=0.453, resp.,P<0.001). In a receiver operating characteristics curve, the diagnostic ability of the NGAL/sCr ratio to identify hsCRP > 4.0 mg/dL was superior to that of NGAL [0.783 (95% CI, 0.674–0.892) versus 0.733 (95% CI, 0.615–0.852),P=0.032]. The area under the curve of the NGAL/sCr ratio was larger than that of hsCRP to detect corrected erythrocyte sedimentation rate > 25 mm/h and the neutrophil-to-lymphocyte ratio >4.5 in renal dysfunction. In short, the NGAL/sCr ratio may offer useful information when screening patients with both systemic inflammation and renal dysfunction.
- Published
- 2015