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Your search keyword '"Hasan Herken"' showing total 3 results
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3 results on '"Hasan Herken"'

1. Serum IL-1β, sIL-2R, IL-6, IL-8 and TNF-α in schizophrenic patients, relation with symptomatology and responsiveness to risperidone treatment

Author

Ayşe Binnur Erbağci, Hasan Herken, Oya Köylüoglu, Necat Yilmaz, and Mehmet Tarakçioglu

Subjects
Pathology, RB1-214
Abstract

Activation of the inflammatory response system and varied levels of cytokines in acute schizophrenia have been suggested by recent studies. Psychopharmacologic agents can differentially effect cytokine production, which suggests that therapeutic function of neuroleptics may involve immunomodulation.

Published
2001
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2. Serum IL-1β , sIL-2R, IL-6, IL-8 and TNF-α in schizophrenic patients, relation with symptomatology and responsiveness to risperidone treatment

Author

Hasan Herken, Ayse Binnur Erbagci, Oya Koyluoglu, Mehmet Tarakcioglu, and Necat Yilmaz

Subjects
Adult, Male, medicine.medical_specialty, Adolescent, Exacerbation, medicine.medical_treatment, Immunology, Adjuvants, Immunologic, Internal medicine, Brief Psychiatric Rating Scale, medicine, lcsh:Pathology, Humans, Interleukin 6, Aged, Risperidone, biology, Interleukin-6, Tumor Necrosis Factor-alpha, business.industry, Interleukin-8, Case-control study, Interleukin, Receptors, Interleukin-2, Cell Biology, Middle Aged, medicine.disease, Endocrinology, Cytokine, Schizophrenia, Case-Control Studies, biology.protein, Female, business, Research Article, Antipsychotic Agents, Interleukin-1, medicine.drug, lcsh:RB1-214
Abstract

Activation of the inflammatory response system and varied levels of cytokines in acute schizophrenia have been suggested by recent studies. Psychopharmacologic agents can differentially effect cytokine production, which suggests that therapeutic function of neuroleptics may involve immunomodulation.The present study was carried out to examine: (i) serum concentrations of interleukin (IL)-1β , soluble interleukin-2 receptor (sIL-2R), IL-6, IL-8 and tumour necrosis factor (TNF)- α in schizophrenic patients; (ii) their relation with psychopathological assessment; and (iii) the relation of the initial cytokine levels with responsiveness to risperidone therapy.Thirty-four drug-free schizophrenic patients with acute exacerbation and 23 age- and gender-matched healthy controls were recruited for this study. Psychopathological assessments at admission and throughout risperidone treatment for 60 days were recorded. Serum cytokine concentrations were determined with chemilumunescence assays.According to our results, serum IL-1β , sIL-2R, IL-6, IL-8 and TNF-α concentrations adjusted for age, gender, body mass index and smoking were no different in patients with schizophrenia and controls and among subtypes of schizophrenia. However, the initial TNF-α concentrations had a significant effect on Brief Psychiatric Rating Scale and Scale Assessment of Positive Symptoms scores. The initial cytokine concentrations of the patients responsive to risperidone were not significantly different from those of non-responsive patients.The present study demonstrates that plasma levels of IL-1β , sIL-2R, IL-6, IL-8 and TNF-α adjusted for confounding factors are not altered in drug-free schizophrenic patients at acute exacerbation. We suggest that, if cytokine production is altered in schizophrenia, these alterations may not be detectable in systemic circulation. According to our results, the therapeutic effect of risperidone is not related to basal levels of the aforementioned cytokines. However, serum TNF-α may contribute to symptomatology in schizophrenia.

Published
2001

3. Lack of Association of catechol-O-Methyltransferase Gene Polymorphism in Obsessive–Compulsive Disorder.

Author

M. Emin Erdal, Şenel Tot, Kemal Yazıcı, Aylin Yazıcı, Hasan Herken, Pervin Erdem, Ebru Derici, and Handan Çamdeviren

Subjects
GENETIC polymorphisms, OBSESSIVE-compulsive disorder, COMPULSIVE behavior, MENTAL illness, NEUROSES
Abstract

The COMT gene has been implicated to be involved in the pathogenesis of obsessive–compulsive disorder (OCD) and various other psychiatric disorders. COMT enzyme activity is governed by a common genetic polymorphism at codon 158 that results in substantial 3- to 4-fold variation in enzymatic activity [a high-activity COMT variant (H) and a low activity variant (L)]. This study evaluates the association between OCD and the COMT gene polymorphism. Fifty-nine OCD patients that were diagnosed according to DSM-IV criteria and 114 healthy control subjects were included in the study. PCR technique was used for molecular analysis. The genotypic pattern of distribution of the COMT gene (H/H, H/L, and L/L genotypes) was not different between the OCD patients and controls. There were no significant differences among the patients with positive family history for OCD, those with negative family history for OCD, and the controls with respect to allele frequencies of the COMT gene polymorphisms. Patients that were homozygous or heterozygous for the L allele had significantly higher insight scores (i.e., poorer insight) on Y-BOCS compared to those homozygous for the H allele. We did not find an association between OCD, family history for OCD, and the COMT gene polymorphism. This study suggests that the COMT gene polymorphism is not directly associated with OCD in our patient group. Depression and Anxiety 18:41–45, 2003. © 2003 Wiley-Liss, Inc. [ABSTRACT FROM AUTHOR]

Published
2003
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