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In this paper, an intelligent algorithm for the aerodynamic parameter calibration of wind tunnel experiments of advanced layout aircraft at a high angle of attack is proposed. The proposed algorithm is based on a homologous comparison and tuning algorithm, and it can effectively improve the accuracy of the wind tunnel experiment model. First, based on the analysis of large oscillation wind tunnel experimental data of an advanced layout scaled aircraft, the high angle of attack wind tunnel experimental model composed of static derivative, dynamic derivative, and rotating balance derivative is established. Second, to improve the accuracy of the wind tunnel experimental model effectively, the idea of combing layered calibration and intelligent algorithm for high angle of attack homologous comparison correction is proposed. The proposed method solves the problems of complex structure, a large amount of data, and poor accuracy in homologous comparison of high angle of attack aerodynamic models of advanced layout aircraft. Finally, the homologous comparison interface software is designed based on MATLAB GUI, which integrates the proposed methods and ideas and realizes effective adjustment of aerodynamic parameters of high angle of attack simulation flight wind tunnel test of an advanced layout aircraft. This study provides a reliable engineering and technical means for subsequent high angle of attack flight test verification of the advanced layout aircraft. [ABSTRACT FROM AUTHOR]

Purpose. Coronary artery disease (CAD) is one of the major cardiovascular diseases and the leading cause of death globally. Blood lipid profile is associated with CAD early risk. Therefore, we aim to establish machine learning models utilizing blood lipid profile to predict CAD risk. Methods. In this study, 193 non-CAD controls and 2001 newly-diagnosed CAD patients (1647 CAD patients who received lipid-lowering therapy and 354 who did not) were recruited. Clinical data and the result of routine blood lipids tests were collected. Moreover, low-density lipoprotein cholesterol (LDL-C) subfractions (LDLC-1 to LDLC-7) were classified and quantified using the Lipoprint system. Six predictive models (k-nearest neighbor classifier (KNN), logistic regression (LR), support vector machine (SVM), decision tree (DT), multilayer perceptron (MLP), and extreme gradient boosting (XGBoost)) were established and evaluated by the confusion matrix, area under the receiver operating characteristic (ROC) curve (AUC), recall (sensitivity), accuracy, precision, and F1 score. The selected features were analyzed and ranked. Results. While predicting the CAD development risk of the CAD patients without lipid-lowering therapy in the test set, all models obtained AUC values above 0.94, and the accuracy, precision, recall, and F1 score were above 0.84, 0.85, 0.92, and 0.88, respectively. While predicting the CAD development risk of all CAD patients in the test set, all models obtained AUC values above 0.91, and the accuracy, precision, recall, and F1 score were above 0.87, 0.94, 0.87, and 0.92, respectively. Importantly, small dense LDL-C (sdLDL-C) and LDLC-4 play pivotal roles in predicting CAD risk. Conclusions. In the present study, machine learning tools combining both clinical data and blood lipid profile showed excellent overall predictive power. It suggests that machine learning tools are suitable for predicting the risk of CAD development in the near future. [ABSTRACT FROM AUTHOR]

The reliable and accurate detection of bridges plays an important role in imaging-driven transportation surveillance. It is capable of timely providing the traffic information, leading to safer and more convenient transportation. However, the visual quality of observed images is often inevitably reduced owing to the adverse weather conditions, e.g., haze and low lightness. It is still difficult to adopt the existing powerful deep learning methods to reliably and accurately detect the bridges under different imaging conditions. To achieve satisfactory bridge detection results, we first propose to exploit the data augmentation strategy and physical imaging method to generate the natural-looking experimental dataset, which contains latent high-quality images and their hazy and low-light versions. We then investigate how to further promote the deep learning-based bridge detection methods through the manually generated dataset. It is obvious that the generalization abilities of these deep neural networks are significantly improved using this data augmentation strategy. In this work, we constructed an original dataset consisting of 3500 images of size 900×600, collected under normal imaging condition. Extensive detection experiments will be performed based on the augmented dataset. Experimental results have demonstrated that our automatic bridge detection framework could generate more reliable and accurate results compared with existing detection methods. [ABSTRACT FROM AUTHOR]

Background. Nucleotide excision repair (NER) is pivotal in the development of smoking-related malignancies. Nine core genes (XPA, XPB, XPC, XPD, XPF, XPG, ERCC1, DDB1, and DDB2) are highly involved in the NER process. We combined two phenotypes of NER pathway (NER protein and NER gene mRNA expression) and evaluated their associations with the risks of the head and neck squamous cell carcinomas (HNSCCs) in a Chinese population. Methods. We conducted a case-control study of 337 HNSCC patients and 285 cancer-free controls by measuring the expression levels of nine core NER proteins and NER gene mRNA in cultured peripheral lymphocytes. Results. Compared with the controls, cases had statistically significantly lower protein expression levels of XPA (P < 0.001) and lower mRNA expression levels of XPA and XPB (P = 0.005 and 0.001, respectively). After dividing the subjects by controls' medians of expression levels, we found an association between increased risks of HNSCCs and low XPA protein level ( P trend = 0.031), as well as low mRNA levels of XPA and XPB ( P trend = 0.024 and 0.001, respectively). Subsequently, we correlated the two phenotypes and found associations between the NER mRNA and protein levels. Finally, the sensitivity of the expanded model with protein and mRNA expression levels, in addition to demographic variables, on HNSCCs risk was significantly improved. Conclusions. Combining two phenotypes of NER pathway may be more effective than the model only including one single phenotype for the assessment of risks of HNSCCs. [ABSTRACT FROM AUTHOR]

Circular RNAs (circRNAs) have been demonstrated as potential biomarkers for the diagnosis and treatment of human diseases. Previous studies have unveiled the carcinogenic role of circRNA_102399 (circCNN2) in lung cancer. Through the UALCAN database, it was found that CNN2, the parent gene of circCNN2, was specifically highly expressed in human lung squamous cell carcinoma (LUSC) cells, but the regulatory mechanism of circCNN2 in LUSC is unclear. In this study, circCNN2 expression in LUSC cells was examined via RT-qPCR, and its effects on LUSC progression was verified through functional assays. The subcellular localization of circCNN2 was identified via FISH assay, and the underlying mechanism of circCNN2 on the activation of MAPK signaling pathway was determined through mechanism experiments. Results demonstrated that circCNN2 was upregulated in LUSC cells, and it promoted LUSC cell proliferation and invasion. Besides, circCNN2 acted as a competing endogenous RNA (ceRNA) to sponge miR-184 to upregulate E2F transcription factor 1 (E2F1) expression. Furthermore, it was verified that circCNN2 activated the generic mitogen-activated protein kinases (MAPK) signaling pathway through E2F1 and thus promoting LUSC progression. In a word, this study indicated that circCNN2 activated MAPK signaling pathway through the miR-184/E2F1 axis to promote proliferation and invasion of LUSC cells. [ABSTRACT FROM AUTHOR]

Intelligent design for the animation interaction is very challenging and needs to be resolved on priority basis. If this design is based on smart learning based mechanism, then it will be more appropriate and effective. Therefore, based on the idea of process modeling, the concrete method is based on example modeling and parameterization, and the VC programming environment is the tool. Animated interactions are not counted. The animation parameterization in the sample animation software and its attribute information are calculated, and the principle and realization process of the new animation interaction design are given, as well as the calculation method and steps of each area of animation elements. The same interaction design pattern can be filled in different areas by using parametric methods. In practice, we have increased the diversity of animation interaction design. The method proposed in this paper can quickly and automatically generate a virtual animation design network according to the user's design ideas and can be controlled by the user in real time interactively, providing a good interface and a new way for the user to design animation environment modeling. [ABSTRACT FROM AUTHOR]

Radiation enteritis—clinically manifested as diarrhea, intestinal bleeding, and so on—is frequently caused when the body is exposed to radiation or radiotherapy because the intestine is radiation-sensitive as an abdominal organ. Therefore, strategies to modulate intestinal hemostasis had inspired an important research trend in the process of preventing and treating radiation enteritis. Based on the structural characteristics of montmorillonite (MMT) and the hemostatic drug tranexamic acid (TXA) which was used clinically to treat enteritis, the tranexamic acid-montmorillonite composite material (TXA-MMT) was prepared through intercalation composite technology. According to the analysis of FTIR, XRD, TG-DTG, SEM, and XRF, the prepared TXA-MMT was verified that tranexamic acid could intercalate into layers of montmorillonite. To evaluate the biocompatibility, two experiments were conducted by in vitro hemolysis and in vitro cytotoxicity experiments and results showed that TXA-MMT exhibited good visible biocompatibility. Activated partial thromboplastin time, prothrombin time, and in vitro clotting time were adopted to determine the hemostatic effect of TXA-MMT. Compared with other groups, TXA-MMT revealed a significant decrease in clotting time variations, APTT, and PT. In addition, to investigate the preventive effect of TXA-MMT by the intervention of radiation enteritis mice, inflammatory factors IL-1β, IL-6, and TNF-α and the content of endotoxin in the serum of mice were detected. It demonstrated that TXA-MMT reduced the levels of these factors. Besides, the expression and the pathological changes of the small intestine tissue of mice were relieved. Our findings suggests that TXA-MMT as a promising intercalation composite has a great potential for application in the field of intestinal hemostasis. [ABSTRACT FROM AUTHOR]

The survival rate of patients with lung adenocarcinoma (LUAD) is low. This study analyzed the correlation between the expression of long noncoding RNA (lncRNA) and epigenetic alterations along with the investigation of the prognostic value of these outcomes for LUAD. Differentially expressed lncRNAs were identified based on multiomic data and positively related genes using DESeq2 in R, differentially histone-modifying genes specific to LUAD based on histone modification data, gene enhancers from information collected from the FANTOM5 (Function Annotation Of The Mammalian Genome-5) (fantom.gsc.riken.jp/5) human enhancer database, gene promoters using the ChIPseeker and the human lincRNAs Transcripts database in R, and differentially methylated regions (DMRs) using Bumphunter in R. Overall survival was estimated by Kaplan-Meier, comparisons were performed among groups using log-rank tests to derive differences between sample subclasses, and epigenetic lncRNAs (epi-lncRNAs) potentially relevant to LUAD prognosis were identified. A total of seven dysregulated epi-lncRNAs in LUAD were identified by comparing histone modifications and alterations in histone methylation regions on lncRNA promoter and enhancer elements, including H3K4me2, H3K27me3, H3K4me1, H3K9me3, H4K20me1, H3K9ac, H3K79me2, H3K27ac, H3K4me3, and H3K36me3. Furthermore, 69 LUAD-specific dysregulated epi-lncRNAs were identified. Moreover, lncRNAs-based prognostic analysis of LUAD samples was performed and explored that seven of these lncRNAs, including A2M-AS1, AL161431.1, DDX11-AS1, FAM83A-AS1, MHENCR, MNX1-AS1, and NKILA (7-EpiLncRNA), showed the potential to serve as markers for LUAD prognosis. Additionally, patients having a high 7-EpiLncRNA score showed a generally more unfavorable prognosis compared with those which scored lower. Seven lncRNAs were identified as markers of prognosis in patients with LUAD. The outcomes of this research will help us understand epigenetically aberrant regulation of lncRNA expression in LUAD in a better way and have implications for research advances in the regulatory role of lncRNAs in LUAD. [ABSTRACT FROM AUTHOR]

In this paper, 3D particulate scale modelling on the die compaction of DEM generated initial packings of both soft and hard particles was conducted by employing the multiparticle finite element method (MPFEM). The effects of initial packing structures as well as the compaction pressure on the macroscopic and microscopic properties of the whole powder mass and local structures were investigated. In addition, corresponding physical experiments were carried out for model validation. The results show that the compact obtained from the initial dense packing under vibration undergoes yielding stage earlier than that with natural initial packing (without vibration), and the relative density is much higher. Pores that are significantly smaller and with more uniform size and homogenous stress distribution are observed in the former case. Highest stress regions occur in most cases at a grain boundary with large curvature after deformation. Moreover, the high stress in the central part of both soft and hard particles during compaction is significantly reduced after pressure unloading, reaching a new force balance. In this case, the stress is concentrated mainly at the corners of the deformed particles, which creates the risk of cracking during subsequent sintering at either the contact region between particles or the corners. The numerical results are found to be in good agreement with those from physical experiments, confirming the robustness and reliability of the numerical model used in the simulations. [ABSTRACT FROM AUTHOR]

Background. Glycolysis is closely associated with tumor progression, but the roles of lncRNAs in glycolysis have not been comprehensively investigated in lung adenocarcinoma (LUAD). This study is aimed at studying the possible mechanisms of glycolysis-related lncRNAs in tumor development and providing a guidance for targeted therapy. Methods. Unsupervised consensus clustering was used to identify molecular subtypes. Gene enrichment analysis was applied to screen important pathways involved in tumor progression. A series of immune analysis was performed to assess immune infiltration. Critical transcription factors (TFs) interacting with lncRNAs were selected by Pearson correlation analysis. A first-order partial correlation analysis was implemented to identify critical lncRNAs with prognostic significance. Results. Three molecular subtypes (C1, C2, and C3) were identified with distinct overall survival. Three subtypes showed differential immune infiltration, and C3 subtype was the optimal for immunotherapy treatment. Ten lncRNA-TF pairs among four glycolysis-related lncRNAs (FTX, LINC00472, PSMA3-AS1, and SNHG14) and six TFs (FOXP1, SP1, MYC, FOXM1, HIF1A, and FOS) were involved in tumor progression. We identified four critical glycolysis-related lncRNAs significantly associated with prognosis. Conclusions. This study identified three molecular subtypes that could guide personalized therapy. The four-lncRNA prognostic model can serve as an indicator for predicting prognosis or early screening of lung adenocarcinoma patients. The current results improve the understanding of the relation between lncRNAs and glycolysis. [ABSTRACT FROM AUTHOR]

A novel balanced‐to‐unbalanced branch‐line coupler with a large power division ratio (PDR) is proposed in this paper. The proposed coupler consists of six transmission‐line sections, which can be easily synthesized with the prescribed PDR. By changing the electrical lengths of two transmission lines, a large PDR range can be obtained without the use of high‐impedance transmission lines. The closed‐form design equations are provided and discussed. To verify the proposed circuit, a coupler prototype with the PDR of 20 dB and the center frequency of f0 = 1.0 GHz is designed and fabricated. Simulation and measurement results are in good agreement. When the balanced port A is excited, the measured differential‐mode to single‐ended transmission coefficients at f0 for the unbalanced ports D and C are |SsdDA| = −0.28 dB and |SsdCA| = −20.02 dB, respectively, which meet the desired PDR. The measured |SddAA| at f0 is −33.6 dB with a −10‐dB bandwidth of about 12.7% from 0.933 to 1.059 GHz. The |SscDA| and |SscCA| are less than −29.5 dB with a −18‐dB bandwidth of 22.4% from 0.924 to 1.157 GHz. [ABSTRACT FROM AUTHOR]

The oxygen lance is a piece of special equipment in the converter steelmaking process for blowing oxygen into the molten steel. After more than 80 years of development, the structure and function of the oxygen lance have undergone many changes. In this paper, based on the theory of hydrodynamics, the jet behavior characteristics of a dual-structure oxygen lance for the converter are determined and optimized by CFD simulations and compared with those of the traditional-structure oxygen lance. The research results show that multiple jets deflect to the central axis of the oxygen lance during movement and the inclination angle of the nozzle holes influences the jet deflection. A decrease in the nozzle hole angle results in an increase in the mutual suction between the streams. With the increasing flow rate through the large holes in the new dual-structure oxygen lance, the dynamic radial pressure increases at the middle of the jet. The jet flow characteristics of the new dual-structure oxygen lance are better than those of the traditional oxygen lance. Its impact on the molten pool includes greater momentum, a larger impact area, and a more uniform and powerful stirring of the molten pool. A nozzle angle of 14° combined with a flow rate ratio of 65% and a nozzle angle of 17° combined with a flow rate ratio of 35% are the optimal parameters for the new dual-structure oxygen lance. [ABSTRACT FROM AUTHOR]

With the development of global urbanization and the construction of regional urbanization, residents around urban cities are increasingly making demands on urban public transportation system. A new kind of modern public transportation vehicle named Multi-Articulated Guided Vehicle based on Virtual Track (MAAV-VT) with the advantages of beautiful, smart energy conservation and environmental protection is proposed in this paper, which aims at optimizing the public transportation system between and within urban areas. Therefore, concentrating on the general design and control strategy, the main contents of this paper are as follows. At first, the design concepts and key technologies of MAAV-VT are introduced. It is the fusion of urban rail transit operation mode and advanced automotive technologies, which have the characteristics of 100% low-floor, medium to high velocity, medium to big capacity, and low construction cost. Then, as the core subsystem, to guarantee the properties of self-guiding and trajectory tracking of the new vehicle, this paper is focused on the control system based on the dynamics and kinematics model of the whole multi-articulated vehicle. The multi-trace-points cooperative trajectory tracking control strategy on the basis of the circulation of feasible path generation method is proposed and the lateral controller is designed for trajectory tracking. The process of feasible path generation is conducted once the tracking error exceeded. A simulation platform is built considering the mechanical properties of each vehicle element and the characteristic of articulated mechanism. Finally, the function of control system is validated. The tracking error of each vehicle elements would be reduced to make sure the whole multi-articulated vehicle moves along the preset virtual track. [ABSTRACT FROM AUTHOR]

Since CaO-Al2O3-based mold fluxes are one of the most important mold flux systems in metallurgic processes, it is important to explore their structure characteristics and viscosity. Molecular dynamics simulation is performed to study the effect of w(CaO)/w(Al2O3) ratio on both the structural and viscosity properties of CaO-Al2O3-based mold fluxes. A systematic analysis of the structure and thermodynamics on CaO-Al2O3-based mold fluxes is carried out, and it is well known that the viscosity of mold fluxes is related to the structure. The results show that the formation of stable structures of Si-O in the mold fluxes was beneficial to reduce the probability of structural interconnection, degree of polymerization, and viscosity of the molten slag. In the cationic structure, the contents of Ca-O-Al and Ca-O-Si are more stable, the interconnection of the Ca-O-Al and Ca-O-Si network weakens, and the viscosity decreases. The tetrahedra [AlO4] and [SiO4] have similar structures, but they exhibit different thermodynamic and physical properties. Viscosity test shows that CaO/Al2O3 = 0.88–2 continuously increased, when the cosolvent content Li2O = 1%–4%, CaO-Al2O3-based mold flux viscosity decreased, the degree of network structure polymerization decreased, and the complex structure depolymerized. Increasing the water content in the cosolvent is beneficial to reduce the viscosity of the crystallizer. [ABSTRACT FROM AUTHOR]

Purpose. Head and neck squamous cell carcinoma (HNSCC) is the most common malignant tumors in the world. Genetic variants have an important role in HNSCC progression. Our study is aimed at exploring the relationship between MIR17HG polymorphisms and HNSCC risk in the Chinese Han population. Methods. We recruited 537 HNSCC cases and 533 healthy subjects to detect the correlation of six polymorphisms in MIR17HG with HNSCC susceptibility. The associations were evaluated by computing odds ratios (ORs) and 95% confidence intervals (CIs) using logistic regression analysis. Results. Our study revealed that rs7336610 (OR 1.77, 95 % CI = 1.09 ‐ 2.86 , and p = 0.021) and rs1428 (OR 1.73, 95 % CI = 1.07 ‐ 2.81 , and p = 0.025) are strongly associated with increased susceptibility to HNSCC in men. Besides, rs17735387 played a crucial protective role in stage III/IV HNSCC patients (OR 0.34, 95 % CI = 0.12 ‐ 0.95 , and p = 0.040) compared with stage I/II. Conclusion. Our study firstly indicated that MIR17HG polymorphisms are significantly associated with HNSCC susceptibility, which suggests that MIR17HG has a potential role in the occurrence of HNSCC. [ABSTRACT FROM AUTHOR]

The high content of aluminum in the steel reacts with the CaO-Si2O-based mold fluxes, resulting in deterioration of the mold slag physical and chemical properties, which cannot be applied to the continuous casting molten slag casting process of high-Mn high-Al steel Herein, the thermodynamic and structural properties of low-reactivity CaO-Al2O3-based mold fluxes were investigated. The thermodynamic properties were studied based on the first principles of quantum mechanics. The results show that the formation of stable structures of B-O and O-B-O in the mold fluxes was beneficial to reduce the probability of structural interconnection, degree of polymerization, and viscosity of the molten slag. The increase in the ratio of CaO/Al2O3 = 0.88–2 led to an increase in the O2− concentration. O2− entered the [AlO4] structure to form a stable structure of [AlO6] and [AlO5], wherein [AlO6] was more stable than [AlO5], reducing the degree of polymerization of the network structure. When cosolvent content B2O3 = 2%–10%, a simple layered structure of [BO3] was formed, and the particle migration resistance, break temperature, and viscous activation energy of the mold fluxes were reduced, while the corrected optical basicity of mold fluxes was gradually increased. [ABSTRACT FROM AUTHOR]

This paper presents a numerical investigation on the 2D uniaxial die compaction of TiC-316L stainless steel (abbreviated by 316L) composite powders by the multiparticle finite element method (MPFEM). The effects of TiC-316L particle size ratios, TiC contents, and initial packing structures on the compaction process are systematically characterized and analyzed from macroscale and particulate scale. Numerical results show that different initial packing structures have significant impacts on the densification process of TiC-316L composite powders; a denser initial packing structure with the same composition can improve the compaction densification of TiC-316L composite powders. Smaller size ratio of 316L and TiC particles (R316L/RTiC = 1) will help achieve the green compact with higher relative density as the TiC content and compaction pressure are fixed. Meanwhile, increasing TiC content reduces the relative density of the green compact. In the dynamic compaction process, the void filling is mainly completed by particle rearrangement and plastic deformation of 316L particles. Furthermore, the contacted TiC particles will form the force chains impeding the densification process and cause the serious stress concentration within them. Increasing TiC content and R316L/RTiC can create larger stresses in the compact. The results provide valuable information for the formation of high-quality TiC-316L compacts in PM process. [ABSTRACT FROM AUTHOR]

Background. The relationship between the neutrophil-to-lymphocyte ratio (NLR) and hemorrhagic transformation (HT) in acute ischemic stroke (AIS) treated with intravenous thrombolysis (IVT) remains unclear. This study assessed whether high NLR is associated with HT in this population. Methods. Data were prospectively collected for continuous patients with AIS treated with IVT and retrospectively analyzed. Clinical variables included age, sex, vascular risk factors, National Institutes of Health Stroke Scale (NIHSS) score, onset-to-treatment time, and initial hematologic and neuroimaging findings. HT was confirmed by imaging performed within 3 days after IVT. Symptomatic HT (sHT) was defined as NIHSS score increased by 4 points compared with that on admission according to previously published criteria. The NLR value was based on the blood examination before IVT, and high NLR was defined as ≥75th percentile. Results. The study included 285 patients (201 (70.5%) males, the mean age was 62.3 years (range 29–89)). Seventy-two (25.3%) patients presented with HT, including three (1.1%) with sHT. The median NLR was 2.700 (1.820–4.255, interquartile range). Seventy-one (24.9%) patients had a high NLR (≥4.255) on admission. Univariate analysis indicated that patients with HT had higher NIHSS scores (P < 0.001), systolic blood pressure (SBP), platelet counts, lymphocyte counts, and NLR (P < 0.05), as well as a greater prevalence of high NLR than those without HT (37.5% vs. 20.7% and P = 0.004). Patients with HT were more likely to have hypertension and AF. As lymphocyte counts and high NLR were highly correlated, we used two logistic regression models. In model 1 (with high NLR), NIHSS score on admission (odds ratio (OR) = 1.110, 95% confidence interval (CI) = 1.015–1.044, and P = 0.001), AF (OR = 3.986, 95% CI = 2.095–7.585, and P < 0.001), and high NLR (OR = 2.078, 95% CI = 1.078–4.003, P = 0.029 , sensitivity 0.375, and specificity 0.793) were significant predictors of HT. In model 2 (with lymphocyte counts), NIHSS score on admission (OR = 1.111, 95% CI = 1.050–1.175, and P < 0.001), AF (OR = 3.853, 95% CI = 2.048–7.248, and P < 0.001), and lymphocyte counts (OR = 0.522, 95% CI = 0.333–0.819, and P = 0.005) were significantly associated with HT. Conclusions. High NLR could be a useful marker for predicting HT in AIS patients after IVT. [ABSTRACT FROM AUTHOR]

In this paper, factors influencing the inclusion removal in high-manganese and high-aluminum steel in RH refining process were studied by numerical simulations, production practice, and metallographic experiments. A mathematical model for inclusion removal was established, and the phenomenon of inclusions mixing in RH up-leg region was verified due to fluid circulation. Removal efficiency of RH circulation time 120 s is much better than 600 s, and it was the lowest efficiency after 600 s. After 600 s circulation time, it shall not apply in production practice. The mass concentration of inclusions in practical steel was 11.64% probability error than values obtained by numerical simulation, because the numerical simulation did not consider the problem of inclusions adsorbing to the walls of refractory materials and corrosion of refractories. This work lays the foundation for the optimization and upgrading of process technology and establishes big data for full automation of RH out of furnace refining. [ABSTRACT FROM AUTHOR]

Two-dimensional direction-of-arrival (DOA) estimation in coprime planar array involves problems that the complexity of spectral peak search is huge and the noncircular feature of signals is not considered. Considering that unitary estimating signal parameters via rotational invariance techniques (Unitary-ESPRIT) is a low complexity subspace algorithm, an approach to estimate DOA fast for multiple signals is proposed in this paper. We first apply Unitary-ESPRIT to solve one possible value of each signal. Given the relationship between the ambiguous values and real values, we then have all possible values belonging to each subarray. Through finding the common values of two subarrays, we finally obtain the highly precise true DOAs. Moreover, when the signals are noncircular, we present an improved method using noncircular Unitary-ESPRIT, which is favorable in terms of accuracy and degree of freedom. Simulation results demonstrate the effectiveness of our proposed methods. [ABSTRACT FROM AUTHOR]

A novel lectin (ABL) was purified from the dried fruiting bodies of Agaricus bitorquis. An efficient 3-step purification protocol involved two consecutive steps of ion exchange chromatography on Q-Sepharose and SP-Sepharose and gel filtration by FPLC on Superdex 75. ABL is a monomeric protein with the molecular mass of 27.6 kDa, which is different from other lectins from genus Agaricus. Its N-terminal amino acid sequence is EYTISIRVYQTNPKGFNRPV which is unique and sharing considerably high similarity of other mushroom lectins. The hemagglutinating activity of the lectin was inhibited by inulin. Based on hemagglutination tests, ABL prefers rabbit, human type A, and AB erythrocytes to human type B and O erythrocytes. The lectin inhibits the activity of HIV-1 reverse transcriptase and the proliferation of leukemia cell (L1210) with an IC50 value of 4.69 and 4.97 μM, respectively. Furthermore, ABL demonstrates the highest mitogenic activity with a response of 24177.7 ± 940.6 [3H-methyl] thymidine counts per minute (CPM) at a concentration of 0.91 μM. [ABSTRACT FROM AUTHOR]

A 56‐day experiment was carried out to investigate the effects of dietary vitamin C and vitamin E on the growth, antioxidant status and digestive enzyme activities of discus fish (Symphysodon haraldi; initial body weight: 7.96 ± 0.61 g and body length: 5.45 ± 0.65 cm). Animals were fed with 13 different diets including one control diet and 12 treatment diets containing four levels of vitamin C (magnesium‐L‐ascorbyl‐2‐phosphate; 40, 80, 120 and 160 mg/kg) crossed with three levels of vitamin E (DL‐α‐tocopheryl acetate; 40, 80 and 120 mg/kg). The results showed that the fish fed diets containing additional vitamin C (40 mg/kg) and vitamin E (80 mg/kg) showed higher specific growth rate, length growth rate, total antioxidant capacity and protease activity but had lower feed conversion ratio and total superoxide dismutase activity than those fed the control diet. Collectively, these findings suggest that the inclusion of additional 40 mg/kg of vitamin C and 80 mg/kg of vitamin E in the basal diet could have beneficial effect on the growth, antioxidant defence and digestion of S. haraldi. [ABSTRACT FROM AUTHOR]

This paper proposes a novel supply chain joint-financing pattern for SMEs with limited funds and financing difficulties. The proposed pattern was designed for green investment under cap-and-trade systems and to promote low-carbon economies characterized by bilateral capital restricted supply chains. The basic conditions for supply chain coordination of low-carbon buy-back contracts are derived through a basic model with no funding support. The joint-financing decisions model is analyzed according to the decision-making behavior of all parties and coordination among components of the supply chain system. The risk to which the bank is subjected under low-carbon transactions is also discussed. The proposed model not only reduces the carbon emissions of unit products, but also expands the scale of production. There are negative correlations between unit emissions reduction with the sharing coefficient of reduction costs, the loan rate, and the wholesale price. To minimize environmental effects while maximizing societal benefits, the government is recommended to ensure a reasonable trade-off between green-innovation subsidies and penalties. [ABSTRACT FROM AUTHOR]

Stretch-induced relaxation has not been clearly identified in gastrointestinal tract. The present study is to explore the role of large conductance calcium-activated potassium channels (BKCa) in stretch-induced relaxation of colon. The expression and currents of BKCa were detected and the basal muscle tone and contraction amplitude of colonic smooth muscle strips were measured. The expression of BKCa in colon is higher than other GI segments (P < 0.05). The density of BKCa currents was very high in colonic smooth muscle cells (SMCs). BKCa in rat colonic SMCs were sensitive to stretch. The relaxation response of colonic SM strips to stretch was attenuated by charybdotoxin (ChTX), a nonspecific BKCa blocker (P < 0.05). After blocking enteric nervous activities by tetrodotoxin (TTX), the stretch-induced relaxation did not change (P > 0.05). Still, ChTX and iberiotoxin (IbTX, a specific BKCa blocker) attenuated the relaxation of the colonic muscle strips enduring stretch (P < 0.05). These results suggest stretch-activation of BKCa in SMCs was involved in the stretch-induced relaxation of colon. Our study highlights the role of mechanosensitive ion channels in SMCs in colon motility regulation and their physiological and pathophysiological significance is worth further study. [ABSTRACT FROM AUTHOR]

Establishing high-speed and reliable underwater acoustic networks among multiunmanned underwater vehicles (UUVs) is basic to realize cooperative and intelligent control among different UUVs. Nevertheless, different from terrestrial network, the propagation speed of the underwater acoustic network is 1500 m/s, which makes the design of the underwater acoustic network MAC protocols a big challenge. In accordance with multichannel MAC protocols, data packets and control packets are transferred through different channels, which lowers the adverse effect of acoustic network and gradually becomes the popular issues of underwater acoustic networks MAC protocol research. In this paper, we proposed a control packet collision avoidance algorithm utilizing time-frequency masking to deal with the control packets collision in the control channel. This algorithm is based on the scarcity of the noncoherent underwater acoustic communication signals, which regards collision avoiding as separation of the mixtures of communication signals from different nodes. We first measure the W-Disjoint Orthogonality of the MFSK signals and the simulation result demonstrates that there exists time-frequency mask which can separate the source signals from the mixture of the communication signals. Then we present a pairwise hydrophones separation system based on deep networks and the location information of the nodes. Consequently, the time-frequency mask can be estimated. [ABSTRACT FROM AUTHOR]

Renewable energy is critical for improving energy structure and reducing environment pollution. But its strong fluctuation and randomness have a serious effect on the stability of the microgrid without the coordination of the energy storage batteries. The main factors that influence the development of the energy storage system are the lack of valid operation and maintenance management as well as the cost control. By analyzing the typical characteristics of the energy storage batteries in their life cycle, the geometric process-based model including the deteriorating system and the improving system is firstly built for describing the operation process, the preventive maintenance process, and the corrective maintenance process. In addition, this paper proposes an optimized management strategy, which aims to minimize the long-run average cost of the energy storage batteries by defining the time interval of the detection and preventive maintenance process as well as the optimal corrective maintenance times, subjected to the state of health and the reliability conditions. The simulation is taken under the built model by applying the proposed energy storage batteries’ optimized management strategy, which verifies the effectiveness and applicability of the management strategy, denoting its obvious practicality on the current application. [ABSTRACT FROM AUTHOR]

More and more network cameras are now working over distributed networks, offering the capability of remote intelligent video surveillance. In this paper, we bring forward an original particle filter tracking algorithm named labelled particle filter which describes each image patch with a binary label. Based on the imaging theory of thermography, moving objects, such as pedestrians and automobiles, usually have higher intensities compared with the background in a gray-level pseudocolor mode. Thus an image patch can be classified into two categories according to its intensity distribution, and we can use a one-bit binary label, positive or negative, to describe the attribute of image patch. Therefore, the candidate target template is established only if the label of candidate target matches the label of reference target, and the computational complexity is reduced consequently. Experiments are conducted to show that the proposed algorithm can handle real-time object tracking with less time cost while maintaining high tracking accuracy. [ABSTRACT FROM AUTHOR]

Nowadays more and more network thermal imaging cameras are working over distributed networks, offering the capability of online remote intelligent video surveillance. In this paper, we propose an original intrusion detection and cooperative tracking approach applied for PTZ (Pan/Tilt/Zoom) network thermal imagers. It consists of three modules. The key module is the real-time FOV (Field of View) matching module, which is realized in a parallel way. The intrusion detection module first eliminates the offset between current frame and prior frame through FOV matching and then handles intrusion detection by motion detection in the preset surveillance zone. The cooperative tracking module shifts the priority of tracking by imager pose estimation, which is also based on FOV matching, avoiding transferring the local features from one imager to another. Experiments are conducted to demonstrate that the proposed approach is of high accuracy for intrusion detection and cooperative tracking and keeps the frame rate over 20 fps. [ABSTRACT FROM AUTHOR]

Background. Safflower Yellow Injection has been reported as a treatment for acute cerebral infarction in recent studies in China. However, there is a lack of availability of the evidence for the efficacy and safety of Safflower Yellow Injection for the treatment of acute ischemic stroke. So we investigated the effects of Safflower Yellow Injection for the treatment of acute cerebral infarction. Method. All subjects were randomly divided into Safflower Yellow Injection group given Safflower Yellow Injection (80 mg) and control group given placebo (0 mg) injection by intravenous drop once daily for 14 days. National Institute of Health Stroke Scale (NIHSS); hemorheological detection; coagulation function; and serum inflammatory markers, tumor necrosis factor-alpha (TNF-α), interleukin-1β (IL-1β), and interleukin-6 (IL-6), were used to investigate the effects before and 14 days after the treatment. Results. The scores of NIHSS were decreased on day 7 and day 14 after treatment. The hemorheological index of RBC deformation and RBC aggregation were significantly improved, prothrombin time (PT) increased, and fibrinogen (FIB) and TNF-α, IL-1β, and IL-6 were decreased in patients treated with Safflower Yellow injection on day 14 after treatment (P<0.05). Conclusion. Data suggests that Safflower Yellow Injection therapy may be beneficial for acute cerebral infarction. [ABSTRACT FROM AUTHOR]

Ganoderma, also known as Lingzhi or Reishi, has been used for medicinal purposes in Asian countries for centuries. It is a medicinal fungus with a variety of biological properties including immunomodulatory and antitumor activities. In this study, we investigated the molecular mechanisms by which Ganoderma tsugae (GT), one of the most common species of Ganoderma, inhibits the proliferation of HER2-overexpressing cancer cells. Here, we show that a quality assured extract of GT (GTE) inhibited the growth of HER2-overexpressing cancer cells in vitro and in vivo and enhanced the growth-inhibitory effect of antitumor drugs (e.g., taxol and cisplatin) in these cells. We also demonstrate that GTE induced cell cycle arrest by interfering with the HER2/PI3K/Akt signaling pathway. Furthermore, GTE curtailed the expression of the HER2 protein by modulating the transcriptional activity of the HER2 gene and the stability/degradation of the HER2 protein. In conclusion, this study suggests that GTE may be a useful adjuvant therapeutic agent in the treatment of cancer cells that highly express HER2. [ABSTRACT FROM AUTHOR]

Ganoderma tsugae (GT) is a traditional Chinese medicine that exhibits significant antitumor activities against many types of cancer. This study investigated the molecular mechanism by which GT suppresses the growth of doxorubicin-resistant lung adenocarcinoma H23/0.3 cells. Our results reveal that GT inhibits the viability ofH23/0.3 cells in vitro and in vivo and sensitizes the growth suppression effect of doxorubicin on H23/0.3 cells. The data also show that GT induces S phase arrest by interfering with the protein expression of cyclin A, cyclin E, CDK2, and CDC25A. Furthermore, GT induces cellular apoptosis via induction of a mitochondria/caspase pathway. In addition, we also demonstrate that the suppression of cell proliferation by GT is through downregulation of the PI3K/Akt signaling pathway. In conclusion, this study suggests that GT may be a useful adjuvant therapeutic agent in the treatment of lung cancer. [ABSTRACT FROM AUTHOR]

Pullulan was hydrolyzed by pullulanase producted by Bacillus megaterium. The ABTS+, OH, and DPPH scavenging activities of hydrolysates were 37.73, 21.67, and 17.03%, respectively, when its concentration reached 30 mg/ml, significantly higher than pullulan (p < 0.05). Edible coatings based on pullulan hydrolysates were used to preserve Nile tilapia (Oreochromis niloticus) fillets under ice storage. The results showed that 2 and 3% hydrolysates were most effective in decreasing physicochemical changes including 2‐thiobarbituric acid (TBA), total volatile basic nitrogen, electrical conductivity, pH, water loss, and discoloration, inhibiting bacterial growth; and increasing the sensory quality of fish fillets compared with control samples (p < 0.05), and no significant differences were observed between them (p > 0.05). Practical applications: Edible coating based on polysaccharide is an ideal method of fish fillets preservation. Results indicated that pullulan hydrolysates has good ability on extending shelf life of fish fillets. This study could provide a efficient method on the quality control of Nile tilapia fillets. [ABSTRACT FROM AUTHOR]