1. Approach to Pregnancy Affected by Kell Alloimmunization.
- Author
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Aykut, Serdar, Demir, Suleyman Cansun, Evruke, Ismaıl Cuneyt, Sucu, Mete, Uzay, Fatma Islek, Avan, Mesut, Bayer, Ozge Keles, Yalcin, Emre, and Piccaluga, Pier Paolo
- Subjects
ERYTHROBLASTOSIS fetalis ,BLOOD group antigens ,MISCARRIAGE ,PREGNANT women ,BLOOD groups ,HYDROPS fetalis - Abstract
Hemolytic disease of the fetus and newborn (HDFN) is the development of anemia, hyperbilirubinemia, and finally hydrops fetalis in the fetus when antibodies to antigens on the surface of erythrocytes are transferred from the placenta to the fetus. The most common cause is D‐HDFN. K (KEL1) from the Kell blood group system is the most potent immunogenic antigen after D among all blood group antigens. K‐HDFN occurs in 0.1–0.3% of pregnant women. It accounts for 10% of cases of antibody‐mediated severe fetal anemia. We present a successful management of Kell alloimmunization in a pregnant woman who had 3 times pregnancy loss with hydrops fetalis due to K‐HDFN and who was proven to have K‐HDFN in the postnatal period in her last pregnancy. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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