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1. Association between B Cell Growth Factors and Primary Sjögren’s Syndrome-Related Autoantibodies in Patients with Non-Hodgkin’s Lymphoma

Author

Zhenhua Xian, Dehua Fu, Shuang Liu, Yang Yao, and Chun Gao

Subjects
Immunologic diseases. Allergy, RC581-607
Abstract

Despite the overall success of using R-CHOP for the care for non-Hodgkin’s lymphoma patients, it is clear that the disease is quite complex and new insight is needed to further stratify the patient for a better personized treatment. In current study, based on previous studies from animal model, new panels combining well-established cytokine (BAFF) and autoantibodies (anti-SSA/Ro) with newly identified cytokine (IL14) and autoantibodies (TSA) were used to evaluate the association between B cell growth factor and Sjögren’s related autoantibodies in NHL patients. The result clearly indicates that there was a unique difference between BAFF and IL14 in association with autoantibodies. While serum BAFF was negatively associated with the presence of both traditional anti-SSA/Ro and novel TSA antibodies in GI lymphoma patient, IL14 was positively associated with the presence of both traditional anti-SSA/Ro and novel TSA antibodies in non-GI lymphoma patient. Long-term follow-ups on these patients and evaluation of their response to the R-CHOP treatment and recurrence rate will be very interesting. Our result provides a solid evidence to support using novel diagnostic panel to better stratify the NHL patients.

Published
2019
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2. Association between B Cell Growth Factors and Primary Sjögren’s Syndrome-Related Autoantibodies in Patients with Non-Hodgkin’s Lymphoma

Author

Shuang Liu, Zhenhua Xian, Chun Gao, Dehua Fu, and Yang Yao

Subjects
Oncology, Adult, Male, lcsh:Immunologic diseases. Allergy, medicine.medical_specialty, Article Subject, medicine.medical_treatment, Immunology, Vesicular Transport Proteins, Disease, 03 medical and health sciences, Young Adult, 0302 clinical medicine, immune system diseases, Internal medicine, hemic and lymphatic diseases, B-Cell Activating Factor, Immunology and Allergy, Medicine, Humans, B-cell activating factor, B cell, 030304 developmental biology, Autoantibodies, 0303 health sciences, B-Lymphocytes, biology, business.industry, Lymphoma, Non-Hodgkin, Autoantibody, General Medicine, Middle Aged, medicine.disease, Lymphoma, Non-Hodgkin's lymphoma, Cytokine, medicine.anatomical_structure, Sjogren's Syndrome, Antibodies, Antinuclear, biology.protein, Female, Interleukin-4, Antibody, business, lcsh:RC581-607, 030215 immunology, Research Article
Abstract

Despite the overall success of using R-CHOP for the care for non-Hodgkin’s lymphoma patients, it is clear that the disease is quite complex and new insight is needed to further stratify the patient for a better personized treatment. In current study, based on previous studies from animal model, new panels combining well-established cytokine (BAFF) and autoantibodies (anti-SSA/Ro) with newly identified cytokine (IL14) and autoantibodies (TSA) were used to evaluate the association between B cell growth factor and Sjögren’s related autoantibodies in NHL patients. The result clearly indicates that there was a unique difference between BAFF and IL14 in association with autoantibodies. While serum BAFF was negatively associated with the presence of both traditional anti-SSA/Ro and novel TSA antibodies in GI lymphoma patient, IL14 was positively associated with the presence of both traditional anti-SSA/Ro and novel TSA antibodies in non-GI lymphoma patient. Long-term follow-ups on these patients and evaluation of their response to the R-CHOP treatment and recurrence rate will be very interesting. Our result provides a solid evidence to support using novel diagnostic panel to better stratify the NHL patients.

Published
2019

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