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2 results on '"Dao-fang Ding"'

1. Effectiveness, Medication Patterns, and Adverse Events of Traditional Chinese Herbal Patches for Osteoarthritis: A Systematic Review

Author

Song-Pu Wei, Jian Pang, Yuxin Zheng, Yuelong Cao, Dao-fang Ding, Ningyang Gao, Hong-Sheng Zhan, Tie-li Duan, Ting Liu, and Xuezong Wang

Subjects
medicine.medical_specialty, Traditional medicine, business.industry, Review Article, lcsh:Other systems of medicine, lcsh:RZ201-999, Confidence interval, law.invention, Clinical trial, Diclofenac, Complementary and alternative medicine, Randomized controlled trial, law, Internal medicine, Pill, Relative risk, medicine, Observational study, business, Adverse effect, medicine.drug
Abstract

Objective. The aim of this study is to systematically evaluate the evidence whether traditional Chinese herbal patches (TCHPs) for osteoarthritis (OA) are effective and safe and analyze their medication patterns.Methods. A systematic literature search was performed using all the possible Medical Subject Headings (MeSH) and keywords from January 1979 to July 2013. Both randomized controlled trials (RCTs) and observational studies were included. Estimated effects were analyzed using mean difference (MD) or relative risk (RR) with 95% confidence intervals (CI) and meta-analysis.Results. 86 kinds of TCHPs were identified. RCTs and controlled clinical trials (CCTs) which were mostly of low quality favored TCHPs for local pain and dysfunction relief. TCHPs, compared with diclofenac ointment, had significant effects on global effectiveness rate (RR = 0.50; 95% CI (0.29, 0.87)). Components of formulae were mainly based on the compounds “Xiao Huo Luo Dan” (Minor collateral-freeing pill) and “Du Huo Ji Sheng Tang” (Angelicae PubescentisandLoranthidecoction). Ten kinds of adverse events (AEs), mainly consisting of itching and/or local skin rashes, were identified after 3-4 weeks of follow-up.Conclusions. TCHPs have certain evidence in improving global effectiveness rate for OA; however, more rigorous studies are warranted to support their use.

Published
2014

2. Protective Effect of Ligustrazine on Lumbar Intervertebral Disc Degeneration of Rats Induced by Prolonged Upright Posture.

Author

Qian-Qian Liang, Dao-Fang Ding, Zhi-Jie Xi, Yan Chen, Chen-Guang Li, Shu-Fen Liu, Sheng Lu, Yong-Jian Zhao, Qi Shi, and Yong-Jun Wang

Subjects
*RNA analysis, *CHINESE medicine, *ANALYSIS of variance, *ANIMAL experimentation, *LUMBAR pain, *HERBAL medicine, *IMMUNOHISTOCHEMISTRY, *INTERVERTEBRAL disk, *INTERVERTEBRAL disk displacement, *POLYMERASE chain reaction, *POSTURE, *PROBABILITY theory, *RATS, *RESEARCH funding, *PLANT roots, *TREATMENT effectiveness, *DESCRIPTIVE statistics
Abstract

Most chronic low back pain is the result of degeneration of the lumbar intervertebral disc. Ligustrazine, an alkaloid from Chuanxiong, reportedly is able to relieve pain, suppress inflammation, and treat osteoarthritis and it has the protective effect on cartilage and chondrocytes. Therefore, we asked whether ligustrazine could reduce intervertebral disc degeneration. To determine the effect of ligustrazine on disc degeneration, we applied a rat model. The intervertebral disc degeneration of the rats was induced by prolonged upright posture. We found that pretreatment with ligustrazine for 1 month recovered the structural distortion of the degenerative disc; inhibited the expression of type X collagen, matrix metalloproteinase (MMP)-13, and MMP3; upregulated type II collagen; and decreased IL-1β, cyclooxygenase (COX)-2, and inducible nitric oxide synthase (iNOS) expression. In conclusion, ligustrazine is a promising agent for treating lumbar intervertebral disc degeneration disease. [ABSTRACT FROM AUTHOR]

Published
2014
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