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Your search keyword '"Chih-Ping Hsu"' showing total 2 results
Start Over Author "Chih-Ping Hsu" Publisher hindawi limited
2 results on '"Chih-Ping Hsu"'

1. Induction of Apoptosis and Cell Cycle Arrest in Human Colorectal Carcinoma by Litchi Seed Extract

Author

Yuan-Chiang Chung, Yu-Ting Tsia, Chiu-Chen Huang, Jyh-Ching Chou, Yi-Hsien Lin, Jhih-Rou Su, Chih-Ping Hsu, and Chih-Cheng Lin

Subjects
Cell cycle checkpoint, Article Subject, Colorectal cancer, Health, Toxicology and Mutagenesis, lcsh:Biotechnology, lcsh:Medicine, Antineoplastic Agents, Apoptosis, Biology, Litchi, Cell Line, Tumor, lcsh:TP248.13-248.65, Genetics, medicine, Humans, Molecular Biology, Cyclin, Dose-Response Relationship, Drug, Plant Extracts, Cell growth, lcsh:R, Cancer, food and beverages, Cell Cycle Checkpoints, General Medicine, Cell cycle, medicine.disease, Treatment Outcome, Cell culture, Seeds, Immunology, Cancer research, Molecular Medicine, Colorectal Neoplasms, Research Article, Biotechnology
Abstract

The Litchi (Litchi chinensis) fruit products possess rich amounts of flavanoids and proanthocyanidins. Its pericarp has been shown to inhibit breast and liver cancer cell growth. However, the anticolorectal cancer effect of Litchi seed extract has not yet been reported. In this study, the effects of polyphenol-rich Litchi seed ethanol extract (LCSP) on the proliferation, cell cycle, and apoptosis of two colorectal cancer cell lines Colo320DM and SW480 were examined. The results demonstrated that LCSP significantly induced apoptotic cell death in a dose-dependent manner and arrested cell cycle in G2/M in colorectal carcinoma cells. LCSP also suppressed cyclins and elevated the Bax : Bcl-2 ratio and caspase 3 activity. This study providesin vitroevidence that LCSP serves as a potential chemopreventive agent for colorectal cancer.

Published
2012

2. The Inhibitory Effect of Ellagic Acid on Cell Growth of Ovarian Carcinoma Cells.

Author

Yuan-Chiang Chung, Li-Cheng Lu, Ming-Hsiu Tsai, Yu-Jen Chen, Yi-Ying Chen, Shih-Ping Yao, and Chih-Ping Hsu

Subjects
*ANTINEOPLASTIC agents, *APOPTOSIS, *BENZOPYRANS, *CELL culture, *FLOW cytometry, *OVARIAN tumors, *RESEARCH funding, *T-test (Statistics), *PLANT extracts, *DATA analysis software, *IN vitro studies
Abstract

Ellagic acid (EA) is able to inhibit the growth of several cancer cells; however, its effect on human ovarian carcinoma cells has not yet been investigated. Ovarian carcinoma ES-2 and PA-1 cells were treated with EA (10-100 ΜM) and assessed for viability, cell cycle, apoptosis, anoikis, autophagy, and chemosensitivity to doxorubicin and their molecular mechanisms. EA inhibited cell proliferation in a dose- and time-dependent manner by arresting both cell lines at the Gl phase of the cell cycle, which were from elevating p53 and Cip1/p21 and decreasing cyclin D1 and E levels. EA also induced caspase-3-mediated apoptosis by increasing the Bax: Bcl-2 ratio and restored anoikis in both cell lines. The enhancement of apoptosis and/or inhibition of autophagy in these cells by EA assisted the chemotherapy efficacy. The results indicated that EA is a potential novel chemoprevention and treatment assistant agent for human ovarian carcinoma. [ABSTRACT FROM AUTHOR]

Published
2013
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