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Your search keyword '"Cappellano, Giuseppe"' showing total 5 results
Start Over Author "Cappellano, Giuseppe" Publisher hindawi limited
5 results on '"Cappellano, Giuseppe"'

1. Worse Disease Prognosis Is Associated to an Increase of Platelet-Derived Extracellular Vesicles in Hospitalized SARS-CoV-2 Patients

Author

Raineri, Davide, primary, Venegoni, Chiara, additional, Calella, Maria Grazia, additional, Vaschetto, Rosanna, additional, Scotti, Lorenza, additional, Canciani, Elena, additional, Manfredi, Marcello, additional, Gavelli, Francesco, additional, Castello, Luigi, additional, Chiocchetti, Annalisa, additional, and Cappellano, Giuseppe, additional

Published
2022
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2. Thrombin Cleavage of Osteopontin Modulates Its Activities in Human CellsIn Vitroand Mouse Experimental Autoimmune EncephalomyelitisIn Vivo

Author

Boggio, Elena, primary, Dianzani, Chiara, additional, Gigliotti, Casimiro Luca, additional, Soluri, Maria Felicia, additional, Clemente, Nausicaa, additional, Cappellano, Giuseppe, additional, Toth, Erika, additional, Raineri, Davide, additional, Ferrara, Benedetta, additional, Comi, Cristoforo, additional, Dianzani, Umberto, additional, and Chiocchetti, Annalisa, additional

Published
2016
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4. Thrombin Cleavage of Osteopontin Modulates Its Activities in Human Cells In Vitro and Mouse Experimental Autoimmune Encephalomyelitis In Vivo.

Author

Boggio, Elena, Dianzani, Chiara, Gigliotti, Casimiro Luca, Soluri, Maria Felicia, Clemente, Nausicaa, Cappellano, Giuseppe, Toth, Erika, Raineri, Davide, Ferrara, Benedetta, Comi, Cristoforo, Dianzani, Umberto, and Chiocchetti, Annalisa

Subjects
TREATMENT of encephalomyelitis, OSTEOPONTIN, THROMBIN, CYTOKINES, DISEASE relapse, POST-translational modification, LABORATORY mice, THERAPEUTICS
Abstract

Osteopontin is a proinflammatory cytokine and plays a pathogenetic role in multiple sclerosis and its animal model, experimental autoimmune encephalomyelitis (EAE), by recruiting autoreactive T cells into the central nervous system. Osteopontin functions are modulated by thrombin cleavage generating N- and C-terminal fragment, whose individual roles are only partly known. Published data are difficult to compare since they have been obtained with heterogeneous approaches. Interestingly, thrombin cleavage of osteopontin unmasks a cryptic domain of interaction with α 4 β 1 integrin that is the main adhesion molecule involved in lymphocyte transmigration to the brain and is the target for natalizumab, the most potent drug preventing relapses. We produced recombinant osteopontin and its N- and C-terminal fragments in an eukaryotic system in order to allow their posttranslational modifications. We investigated, in vitro, their effect on human cells and in vivo in EAE. We found that the osteopontin cleavage plays a key role in the function of this cytokine and that the two fragments exert distinct effects both in vitro and in vivo. These findings suggest that drugs targeting each fragment may be used to fine-tune the pathological effects of osteopontin in several diseases. [ABSTRACT FROM AUTHOR]

Published
2016
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5. The Impact of Osteopontin Gene Variations on Multiple Sclerosis Development and Progression

Author

Comi, Cristoforo, primary, Cappellano, Giuseppe, additional, Chiocchetti, Annalisa, additional, Orilieri, Elisabetta, additional, Buttini, Sara, additional, Ghezzi, Laura, additional, Galimberti, Daniela, additional, Guerini, Franca, additional, Barizzone, Nadia, additional, Perla, Franco, additional, Leone, Maurizio, additional, D’Alfonso, Sandra, additional, Caputo, Domenico, additional, Scarpini, Elio, additional, Cantello, Roberto, additional, and Dianzani, Umberto, additional

Published
2012
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