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Your search keyword '"Bei-bei Zhao"' showing total 2 results
Start Over Author "Bei-bei Zhao" Publisher hindawi limited
2 results on '"Bei-bei Zhao"'

1. Integrated Medical Care and the Continuous 4C Nursing Model to Improve Nursing Quality and Clinical Treatment of Patients with Acute Stroke: Based on a Retrospective Case-Control Study.

Author

Jing Zhang, Ling Ling Gu, Yan Xu, Bei Bei Zhao, Dan Li, and ChunLing Xiao

Abstract

Objective. This research paper is based on a retrospective case-control study for exploring the effects of medical nursing integration and the continuous 4C nursing model to improve the clinical treatment and nursing quality of patients with acute stroke. Method. For this purpose, a total of 313 patients with acute stroke, treated in our hospital from February 2020 to April 2021, were enrolled. They were divided into control and study groups with an even number of patients. The control group received integrated medical care number (N = 156), while the study group received integrated medical care and a continuous 4C nursing model (N = 157). In integrated medical care, the general data, self-nursing ability, degree of neurological impairment, Fugl-Meyer Assessment (FMA) score, Barthel index score, and quality of life score were compared between the two groups. Result. The self-nursing concept, self- nursing responsibility, self-nursing skills, health knowledge, and total score of the patients in the study group were higher than those in the control group (P < 0.05). The neurological function scores of the study group were lower than those of the control group at 1, 3, and 6 months after discharge (P < 0.05). The scores of the study group were higher than those of the control group at 1, 3, and 6 months after discharge (P < 0.05). The Barthel index score of the study group was higher than that of the control group at 1, 3, and 6 months after discharge. The scores of physical function, psychological function, social function, and health self- cognition in the study group were lower than those in the control group (P < 0.05). Conclusion. The application of integrated medical care and the continuous 4C nursing model for patients with acute stroke is beneficial to enhance the degree of neurological impairment of stroke patients, improve activities of daily life and motor function, and facilitate patients' quality of life. It is helpful to strengthen the attitude and feeling of cooperation between doctors and nurses, promote cooperation between doctors and nurses, reduce the defects of nursing work, heighten the quality of nursing, and achieve the requirement and goal of effectively promoting high-quality nursing. [ABSTRACT FROM AUTHOR]

Published
2022
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2. TheLegionella pneumophilaeffector WipA disrupts host F‐actin polymerisation by hijacking phosphotyrosine signalling

Author

Dong Shen, Lei He, Zhen-huang Ge, Yun Lin, Bei‐bei Zhao, Yongjun Lu, Shi‐yu He, and Jian‐guo He

Subjects
Proteomics, Virulence Factors, Immunology, Phosphatase, Saccharomyces cerevisiae, macromolecular substances, Endocytosis, Microbiology, Legionella pneumophila, Actin-Related Protein 2-3 Complex, Tight Junctions, Mice, 03 medical and health sciences, Phagocytosis, Tandem Mass Spectrometry, Virology, Animals, Humans, Secretion, Phosphotyrosine, Actin, 030304 developmental biology, 0303 health sciences, biology, 030306 microbiology, Effector, Macrophages, Phosphoproteomics, biology.organism_classification, Actin cytoskeleton, Actins, Cell biology, Actin Cytoskeleton, HEK293 Cells, Host-Pathogen Interactions, Legionnaires' Disease, Protein Tyrosine Phosphatases, Chromatography, Liquid, HeLa Cells, Signal Transduction
Abstract

The major virulence determinant of Legionella pneumophila is the type IVB secretion system (T4BSS), which delivers approximately 330 effector proteins into the host cell to modulate various cellular processes. However, the functions of most effector proteins remain unclear. WipA, an effector, was the first phosphotyrosine phosphatase of Legionella with unknown function. In this study, we found that WipA induced relatively strong growth defects in yeast in a phosphatase activity-dependent manner. Phosphoproteomics data showed that WipA was likely involved into endocytosis, FcγR-mediated phagocytosis, tight junction, and regulation of actin cytoskeleton pathways. Western blotting further confirmed WipA dephosphorylates several proteins associated with actin polymerisation, such as p-N-WASP, p-ARP3, p-ACK1, and p-NCK1. Thus, we hypothesised that WipA targets N-WASP/ARP2/3 complex signalling pathway, leading to disturbance of actin polymerisation. Indeed, we demonstrated that WipA inhibits host F-actin polymerisation by reducing the G-actin to F-actin transition during L. penumophila infection. Furthermore, the intracellular proliferation of wipA/legK2 double mutant was significantly impaired at the late stage of infection, although the absence of WipA does not confer any further effect on actin polymerisation to the legK2 mutant. Collectively, this study provides unique insights into the WipA-mediated regulation of host actin polymerisation and assists us to elucidate the pathogenic mechanisms of L. pnuemophila infection.

Published
2019

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