1. A Comparative Analysis of PID, Lead, Lag, Lead-Lag, and Cascaded Lead Controllers for a Drug Infusion System
- Author
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Sana Shuja, Ali Khaqan, Sobia Shakeel, Qadeer Ul-Hasan, Raja Ali Riaz, Shahzad A. Malik, Abeera Saleem, and Zuwwar Khan Jadoon
- Subjects
0209 industrial biotechnology ,Engineering ,lcsh:Medical technology ,Article Subject ,Biomedical Engineering ,PID controller ,Health Informatics ,02 engineering and technology ,Feedback ,020901 industrial engineering & automation ,Control theory ,0202 electrical engineering, electronic engineering, information engineering ,medicine ,Humans ,MATLAB ,Lead (electronics) ,Propofol ,Infusion Pumps ,computer.programming_language ,lcsh:R5-920 ,business.industry ,Total intravenous anesthesia ,020208 electrical & electronic engineering ,Drug infusion ,Control engineering ,Models, Theoretical ,lcsh:R855-855.5 ,Anesthesia, Intravenous ,Surgery ,Lead–lag compensator ,business ,lcsh:Medicine (General) ,computer ,Anesthetics, Intravenous ,Biotechnology ,medicine.drug ,Research Article - Abstract
Goal. The aim of this paper is to conduct a comprehensive comparative analysis between five different controllers for a drug infusion system in total intravenous anesthesia (TIVA) administration. Methods. The proposed method models a dilution chamber with first order exponential decay characteristics to represent the pharmacokinetic decay of a drug. The dilution chamber is integrated with five different control techniques with a simulation-based comparative analysis performed between them. The design process is conducted using MATLAB SISOTOOL. Results. The findings show that each controller has its own merits and demerits. The results generated using MATLAB signify and confirm the effectiveness of PI and cascaded lead controllers, with cascaded lead controller as the best control technique to automate and control the propofol delivery. Conclusion. In this paper, different control techniques for measurement-based feedback-controlled propofol delivery is confirmed with promising results. Significance. The comparative analysis showed that this drug infusion platform, merged with the proper control technique, will perform eminently in the field of total intravenous anesthesia.
- Published
- 2017