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Your search keyword '"Ali, Hapipah Mohd"' showing total 6 results
Start Over Author "Ali, Hapipah Mohd" Publisher hindawi limited
6 results on '"Ali, Hapipah Mohd"'

2. A Schiff Base-Derived Copper (II) Complex Is a Potent Inducer of Apoptosis in Colon Cancer Cells by Activating the Intrinsic Pathway

Author

Hajrezaie, Maryam, primary, Paydar, Mohammadjavad, additional, Zorofchian Moghadamtousi, Soheil, additional, Hassandarvish, Pouya, additional, Gwaram, Nura Suleiman, additional, Zahedifard, Maryam, additional, Rouhollahi, Elham, additional, Karimian, Hamed, additional, Looi, Chung Yeng, additional, Ali, Hapipah Mohd, additional, Abdul Majid, Nazia, additional, and Abdulla, Mahmood Ameen, additional

Published
2014
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5. Inclusion Complex of Zerumbone with Hydroxypropyl-β-Cyclodextrin Induces Apoptosis in Liver Hepatocellular HepG2 Cells via Caspase 8/BID Cleavage Switch and Modulating Bcl2/Bax Ratio

Author

Muhammad Nadzri, Nabilah, primary, Abdul, Ahmad Bustamam, additional, Sukari, Mohd Aspollah, additional, Abdelwahab, Siddig Ibrahim, additional, Eid, Eltayeb E. M., additional, Mohan, Syam, additional, Kamalidehghan, Behnam, additional, Anasamy, Theebaa, additional, Ng, Kuan Beng, additional, Syam, Suvitha, additional, Arbab, Ismail Adam, additional, Rahman, Heshu Sulaiman, additional, and Ali, Hapipah Mohd, additional

Published
2013
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6. Inclusion Complex of Zerumbone with Hydroxypropyl-β-Cyclodextrin Induces Apoptosis in Liver Hepatocellular HepG2 Cells via Caspase 8/BID Cleavage Switch and Modulating Bcl2/Bax Ratio.

Author

Nadzri, Nabilah Muhammad, Abdul, Ahmad Bustamam, Sukari, Mohd Aspollah, Abdelwahab, Siddig Ibrahim, Eid, Eltayeb E. M., Mohan, Syam, Kamalidehghan, Behnam, Anasamy, Theebaa, Ng, Kuan Beng, Syam, Suvitha, Arbab, Ismail Adam, Rahman, Heshu Sulaiman, and Ali, Hapipah Mohd

Subjects
APOPTOSIS, BIOLOGICAL assay, CELL lines, HEPATOCELLULAR carcinoma, LIVER, MEDICINAL plants, MITOCHONDRIA, RESEARCH funding, T-test (Statistics), TOXICITY testing, PHYTOCHEMICALS, IN vitro studies
Abstract

Zerumbone (ZER) isolated from Zingiber zerumbet was previously encapsulated with hydroxypropyl-β-cyclodextrin (HPβCD) to enhance ZER's solubility in water, thus making it highly tolerable in the human body. The anticancer effects of this new ZER-HPβCD inclusion complex via apoptosis cell death were assessed in this study for the first time in liver hepatocellular cells, HepG2. Apoptosis was ascertained by morphological study, nuclear stain, and sub-Gl cell population accumulation with G2/M arrest. Further investigations showed the release of cytochrome c and loss of mitochondrial membrane potential, proving mitochondrial dysfunction upon the ZER-HPβCD treatment as well as modulating proapoptotic and anti-apototic Bcl-2 family members. A significant increase in caspase 3/7, caspase 9, and caspase 8 was detected with the depletion of BID cleaved by caspase 8. Collectively, these results prove that a highly soluble inclusion complex of ZER-HPβCD could be a promising anticancer agent for the treatment of hepatocellular carcinoma in humans. [ABSTRACT FROM AUTHOR]

Published
2013
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