1. BRCA mutation in breast cancer patients: Prognostic impact and implications on clinical management.
- Author
-
Loi, Mauro, Desideri, Isacco, Olmetto, Emanuela, Francolini, Giulio, Greto, Daniela, Bonomo, Pierluigi, Simontacchi, Gabriele, Di Brina, Lucia, Meattini, Icro, and Livi, Lorenzo
- Subjects
BREAST cancer prognosis ,BREAST tumors ,BREAST tumor treatment ,ESTROGEN receptors ,CANCER patients ,COMBINED modality therapy ,HEALTH status indicators ,GENETIC mutation ,PROGESTERONE receptors ,TUMOR markers ,BRCA genes ,TREATMENT effectiveness ,TUMOR grading ,THERAPEUTICS ,GENETICS - Abstract
BRCA1/2 mutations are involved in breast cancer (BC) susceptibility but their influence on outcome is unclear. We reviewed BC patients tested for BRCA to determine biological features and influence on outcome. BRCA‐1 was correlated to younger age (P = 0.035), nodal involvement (P = 0.030), higher tumor grade (P = 0.0022) and Ki‐67 (P = 0.014), ER/PgR negative status (P = 0.00042 and 0.0091, respectively), and use of adjuvant chemotherapy (P = 0.000038); BRCA was neither predictive for chemotherapy administration nor resulted in impaired outcome or occurrence of secondary BC. BRCA status did not influence outcome despite higher biological aggressiveness and younger age at presentation. [ABSTRACT FROM AUTHOR]
- Published
- 2018
- Full Text
- View/download PDF