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Your search keyword '"Peng, Yong"' showing total 34 results
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34 results on '"Peng, Yong"'

4. Metabolic Modulation and Potential Biomarkers of the Prognosis Identification for Severe Aortic Stenosis after TAVR by a Metabolomics Study

Author

Liao, Yanbiao, primary, Liu, Chang, additional, Xiong, Tianyuan, additional, Zhao, Mingyue, additional, Zheng, Wen, additional, Feng, Yuan, additional, Li, Yijian, additional, Ou, Yuanweixiang, additional, Zhao, Zhengang, additional, Peng, Yong, additional, Wei, Jiafu, additional, Li, Qiao, additional, Meng, Wei, additional, Liu, Xiaojing, additional, and Chen, Mao, additional

Published
2020
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12. Strategies and Advancements in Harnessing the Immune System for Gastric Cancer Immunotherapy

Author

Mei Shi Yeo, Vinod Vijay Subhash, Woei Loon Tan, and Wei Peng Yong

Subjects
lcsh:Immunologic diseases. Allergy, Oncology, medicine.medical_specialty, medicine.medical_treatment, Immunology, Review Article, Tumor initiation, Cancer Vaccines, Immune System Phenomena, Immune system, Cancer immunotherapy, Monitoring, Immunologic, Stomach Neoplasms, Internal medicine, Tumor Microenvironment, medicine, Humans, Immunology and Allergy, Clinical Trials as Topic, Tumor microenvironment, biology, business.industry, Cancer, General Medicine, Immunotherapy, medicine.disease, Clinical trial, biology.protein, Antibody, lcsh:RC581-607, business, Immunologic Memory
Abstract

In cancer biology, cells and molecules that form the fundamental components of the tumor microenvironment play a major role in tumor initiation, and progression as well as responses to therapy. Therapeutic approaches that would enable and harness the immune system to target tumor cells mark the future of anticancer therapy as it could induce an immunological memory specific to the tumor type and further enhance tumor regression and relapse-free survival in cancer patients. Gastric cancer is one of the leading causes of cancer-related mortalities that has a modest survival benefit from existing treatment options. The advent of immunotherapy presents us with new approaches in gastric cancer treatment where adaptive cell therapies, cancer vaccines, and antibody therapies have all been used with promising outcomes. In this paper, we review the current advances and prospects in the gastric cancer immunotherapy. Special focus is laid on new strategies and clinical trials that attempt to enhance the efficacy of various immunotherapeutic modalities in gastric cancer.

Published
2015

18. Mechanism of Selective Inhibition of Yohimbine and Its Derivatives in Adrenoceptorα2 Subtypes

Author

Liu Hai-Bo, Peng Yong, Xu Jun, Xiao Pei-gen, and Huang Lu-qi

Subjects
lcsh:Chemistry, lcsh:QD1-999, Article Subject, Adrenergic receptor, Chemistry, Docking (molecular), Stereochemistry, medicine, General Chemistry, Selective inhibition, Receptor, Yohimbine, medicine.drug
Abstract

Some natural alkaloids from medicinal plants, such as yohimbine and its derivatives, have been reported with adrenoceptor (AR)α2 subtypes inhibiting activity. In trying to address the possible mechanism of the action, a set of homology models of ARα2 was built based on MOE. After that, docking and molecular dynamics methods were used to investigate the binding modes of yohimbine and its 2 derivatives in the active pocket of adrenoceptorα2 subtype A, B, and C. The key interactions between the 3 ligands and the 3 receptors were mapped. Binding mode analysis presents a strong identity in the key residues in each subtype. Only a few differences play the key role in modulating selectivity of yohimbine and its derivatives. These results can guide the design of new selective ARα2 inhibitors.

Published
2013

22. Cortex phellodendriExtract Relaxes Airway Smooth Muscle

Author

Jiang, Qiu-Ju, primary, Chen, Weiwei, additional, Dan, Hong, additional, Tan, Li, additional, Zhu, He, additional, Yang, Guangzhong, additional, Shen, Jinhua, additional, Peng, Yong-Bo, additional, Zhao, Ping, additional, Xue, Lu, additional, Yu, Meng-Fei, additional, Ma, Liqun, additional, Si, Xiao-Tang, additional, Wang, Zhuo, additional, Dai, Jiapei, additional, Qin, Gangjian, additional, Zou, Chunbin, additional, and Liu, Qing-Hua, additional

Published
2016
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26. A Low-Overhead Cooperative Retransmission Scheme for IR-UWB Networks

Author

Chen-Khong Tham, Peng-Yong Kong, and Ghasem Naddafzadeh Shirazi

Subjects
Scheme (programming language), Engineering, lcsh:Computer engineering. Computer hardware, Exploit, Retransmission, lcsh:TK7800-8360, lcsh:TK7885-7895, Data_CODINGANDINFORMATIONTHEORY, lcsh:Technology, Genetics, Overhead (computing), Fading, computer.programming_language, business.industry, Network packet, lcsh:T, ComputerSystemsOrganization_COMPUTER-COMMUNICATIONNETWORKS, lcsh:Electronics, Ranging, Diversity gain, Animal Science and Zoology, lcsh:Electrical engineering. Electronics. Nuclear engineering, business, computer, lcsh:TK1-9971, Computer network
Abstract

The UWB unique properties such as fine ranging and immunity to small scale fading are utilized in order to exploit the multiuser diversity in UWB networks. The optimal cooperation strategies in the absence of control packet overhead are analyzed in the proactive and reactive settings. It is shown that the proposed method achieves a considerable diversity gain while minimizing the overhead of control packet exchange that is required for coordination among the relays.

Published
2008

32. Strategies and Advancements in Harnessing the Immune System for Gastric Cancer Immunotherapy.

Author

Vinod Vijay Subhash, Mei Shi Yeo, Woei Loon Tan, Wei Peng Yong, Subhash, Vinod Vijay, Yeo, Mei Shi, Tan, Woei Loon, and Yong, Wei Peng

Subjects
IMMUNE system physiology, CELL physiology, CLINICAL trials, IMMUNITY, IMMUNOTHERAPY, CANCER vaccines, STOMACH tumors, TUMOR treatment
Abstract

In cancer biology, cells and molecules that form the fundamental components of the tumor microenvironment play a major role in tumor initiation, and progression as well as responses to therapy. Therapeutic approaches that would enable and harness the immune system to target tumor cells mark the future of anticancer therapy as it could induce an immunological memory specific to the tumor type and further enhance tumor regression and relapse-free survival in cancer patients. Gastric cancer is one of the leading causes of cancer-related mortalities that has a modest survival benefit from existing treatment options. The advent of immunotherapy presents us with new approaches in gastric cancer treatment where adaptive cell therapies, cancer vaccines, and antibody therapies have all been used with promising outcomes. In this paper, we review the current advances and prospects in the gastric cancer immunotherapy. Special focus is laid on new strategies and clinical trials that attempt to enhance the efficacy of various immunotherapeutic modalities in gastric cancer. [ABSTRACT FROM AUTHOR]

Published
2015
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33. Mechanism of Selective Inhibition of Yohimbine and Its Derivatives in Adrenoceptor α2 Subtypes.

Author

Liu Hai-Bo, Peng Yong, Huang Lu-qi, Xu Jun, and Xiao Pei-Gen

Subjects
*YOHIMBINE, *ADRENERGIC receptors, *DRUG derivatives, *ALKALOIDS, *MEDICINAL plants, *MOLECULAR docking, *CHEMICAL reactions
Abstract

Some natural alkaloids from medicinal plants, such as yohimbine and its derivatives, have been reported with adrenoceptor (AR) α2 subtypes inhibiting activity. In trying to address the possible mechanism of the action, a set of homology models of AR α2 was built based on MOE. After that, docking and molecular dynamics methods were used to investigate the binding modes of yohimbine and its 2 derivatives in the active pocket of adrenoceptor al subtype A, B, and C. The key interactions between the 3 ligands and the 3 receptors were mapped. Binding mode analysis presents a strong identity in the key residues in each subtype. Only a few differences play the key role in modulating selectivity of yohimbine and its derivatives. These results can guide the design of new selective AR α2 inhibitors. [ABSTRACT FROM AUTHOR]

Published
2013
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34. A Low-Overhead Cooperative Retransmission Scheme for IR-UWB Networks.

Author

Shirazi, Ghasem Naddafzadeh, Peng-Yong Kong, and Chen-Khong Tham

Subjects
ULTRA-wideband antennas, DATA transmission systems, TELECOMMUNICATION systems, ELECTRONIC data interchange, CUSTOMER lifetime value, CUSTOMER loyalty, COMMUNICATIONS industries, COMMUNICATION, DIGITAL communications
Abstract

The UWB unique properties such as fine ranging and immunity to small scale fading are utilized in order to exploit the multiuser diversity in UWB networks. The optimal cooperation strategies in the absence of control packet overhead are analyzed in the proactive and reactive settings. It is shown that the proposed method achieves a considerable diversity gain while minimizing the overhead of control packet exchange that is required for coordination among the relays. [ABSTRACT FROM AUTHOR]

Published
2008
Full Text
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