4 results on '"VITAMIN C"'
Search Results
2. Peelu (Salvadora oleoides Decne.): An Unexplored Medicinal Fruit with Minerals, Antioxidants, and Phytochemicals.
- Author
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Razzaq, Kashif, Sadiq, Muhammad Muzzammal, Ashraf, Hashir, Naz, Ambreen, Hussain, Abid, Maqbool, Amir, Altaf, Muhammad Tanveer, Ullah, Sami, Akhtar, Gulzar, Faried, Hafiz Nazar, Amin, Muhammad, Rajwana, Ishtiaq Ahmad, Khan, Ahmad Sattar, Alfarraj, Saleh, Ansari, Mohammad Javed, and Saleem, Ammara
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FUNCTIONAL foods , *EXPERIMENTAL design , *BIOCHEMISTRY , *MEDICINAL plants , *PLANT anatomy , *ANTIOXIDANTS , *VITAMIN C , *PHYTOCHEMICALS , *PLANTS , *CAROTENOIDS , *FRUIT , *MICRONUTRIENTS , *MINERALS - Abstract
The Peelu (Salvadora oleoides Decne.) fruit is well known for its nutritional and medicinal values. The current study analyzed the chemical composition of Salvadora oleoides fruit. Fresh Peelu fruits were harvested, and physicochemical properties, proximate composition, macro- and micronutrients, and phytochemical properties were determined. Moreover, ethanol and methanol fruit extract was analyzed for physicochemical properties. The Peelu fruit seemed to be a potential source of essential macro- ((nitrogen (N), phosphorus (P), potassium (K), calcium (Ca), and magnesium (Mg)) and micronutrients (zinc (Zn), manganese (Mn), iron (Fe), and copper (Cu)). The fruit had significant biochemical properties (total soluble solids (TSS), total acidity (TA), and TSS : TA ratio) with appreciable moisture, crude fiber, and ash contents. The fruit extracts demonstrated significantly higher antioxidants and phenolics, ascorbic acid contents, and carotenoids. Phytochemical screening of fruit revealed the presence of coumarins, flavonoids, phlobatannins, tannins, and terpenoids. Physicochemical and sensory evaluation of extracts indicated its potential for further in vivo study trials. The Peelu fruit was found to be a good source of mineral nutrients, proximate contents, vitamins (ascorbic acid and carotenoid), phytochemicals (total phenolic sand antioxidant contents), and pharmaceutically important metabolites that can be used as functional drink. [ABSTRACT FROM AUTHOR]
- Published
- 2022
- Full Text
- View/download PDF
3. Antioxidant and Anticholinesterase Properties of the Aqueous Extract of Balanites aegyptiaca L. Delile Fruit Pulp on Monosodium Glutamate-Induced Excitotoxicity in Swiss Mice.
- Author
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Parfait, Bouvourné, Galba Jean, Beppe, Roger, Ponka, Hervé Hervé, Ngatanko Abaissou, Balbine, Kamleu Kwingwa, Guillaume, Camdi Woumitna, Simon Desire, Guedang Nyayi, Linda, Damo Kamda Jorelle, Léa Blondelle, Kenko Djoumessie, and Germain, Sotoing Taiwe
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NITRIC oxide analysis , *NEUROTOXICOLOGY , *BIOMARKERS , *ACETYLCHOLINESTERASE , *MEMORY , *ANIMAL behavior , *HYPERKINESIA , *SYNDROMES , *MONOSODIUM glutamate , *HIPPOCAMPUS (Brain) , *ANIMAL experimentation , *CHOLINESTERASE inhibitors , *ANTIOXIDANTS , *VITAMIN C , *OXIDATIVE stress , *FRUIT , *DESCRIPTIVE statistics , *PLANT extracts , *MICE - Abstract
Balanites aegyptiaca L. Delile (B. aegyptiaca) is used in traditional medicine for the treatment of memory impairment. This work aims to evaluate the antioxidant and anticholinesterase potential of BA fruit pulp extract on excitotoxicity induced by monosodium glutamate (MSG). MSG was administered 30 minutes after treatment with B. aegyptiaca aqueous fruit pulp extract (50, 125, 250, and 500 mg/kg) and vitamin C (100 mg/kg) for 30 days. The negative control group received only MSG, while the control group was given distilled water daily. Behavioral tests parameters (using the novel object recognition, Y-maze, and Barnes maze tests), oxidative stress biomarkers (malondialdehyde, superoxide dismutase, and catalase), nitric oxide, and acetylcholinesterase activity and hippocampal architecture were evaluated. Results obtained revealed that different doses of B. aegyptiaca significantly reversed the deleterious effect of MSG on memory. This was displayed by a significant (p < 0.05) increment in the percentage of spontaneous alternation in the Y-maze test and a significant (p < 0.001) increase in discrimination index in novel object recognition observed with 500 mg/kg extract dose. Moreover, the extract (250 and 500 mg/kg doses) significantly (p < 0.001) increased direct search strategy and significantly decreased (p < 0.01) the time taken to find the target hole in the Barnes maze. A modulation of hyperactivity was observed after administration of all extract doses compared to the negative control group in the open arena. Furthermore, the highest dose of the extract caused a significant (p < 0.001) improvement in antioxidant enzymes activity, associated with a significant (p < 0.001) decrement in nitric oxide and malondialdehyde concentrations and a significant (p < 0.01) decrease in acetylcholinesterase activity. Treatment with the extract also restored normal hippocampal cell architecture. B. aegyptiaca fruit pulp extract could thus confer neuroprotection through its antioxidant and anticholinesterase potential. [ABSTRACT FROM AUTHOR]
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- 2022
- Full Text
- View/download PDF
4. Kiwifruit Alleviates Learning and Memory Deficits Induced by Pb through Antioxidation and Inhibition of Microglia Activation In Vitro and In Vivo
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Dong Xing, Wei-Zhen Xue, Yiwen Chen, Yongsheng Liu, Hui-Li Wang, Yi Xu, Qian-Qian Yang, and Rong-Xin Zou
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0301 basic medicine ,Aging ,Dendritic spine ,Antioxidant ,Article Subject ,medicine.medical_treatment ,Actinidia ,Ascorbic Acid ,Pharmacology ,Real-Time Polymerase Chain Reaction ,Biochemistry ,PC12 Cells ,Antioxidants ,Rats, Sprague-Dawley ,03 medical and health sciences ,0302 clinical medicine ,In vivo ,Memory ,Lactation ,medicine ,Animals ,lcsh:QH573-671 ,Memory Disorders ,Microglia ,biology ,Vitamin C ,Chemistry ,lcsh:Cytology ,Cell Biology ,General Medicine ,biology.organism_classification ,In vitro ,Rats ,030104 developmental biology ,medicine.anatomical_structure ,Lead ,Fruit ,030217 neurology & neurosurgery ,Research Article - Abstract
Lead (Pb) exposure, in particular during early postnatal life, increases susceptibility to cognitive dysfunction and neurodegenerative outcomes. The detrimental effect of Pb exposure is basically due to an increasing ROS production which overcomes the antioxidant systems and finally leads to cognitive dysfunction. Kiwifruit is rich in the antioxidants like vitamin C and polyphenols. This study aims to investigate the effects and mechanism of kiwifruit to alleviate learning and memory deficits induced by Pb exposure. Sprague-Dawley (SD) rat pups acquired Pb indirectly through their mothers during lactation period and after postnatal day 21 (PND21) directly acquired Pb by themselves. Five kinds of kiwifruits were collected in this study and the amounts of vitamin C and polyphenols in them were measured and the antioxidation effects were determined. Among them, Qinmei kiwifruit (Qm) showed the strongest antioxidation effects in vitro. In vivo, Qm significantly repaired Pb-induced learning and memory deficits and dendritic spine loss. In addition, Pb compromised the enzymatic activity and transcriptional levels of SOD and GSH-Px and decreased the microglial activation, which, to some extent, could be reversed by Qm kiwifruit administration. The results suggest that kiwifruit could alleviate Pb-induced cognitive deficits possibly through antioxidative stress and microglia inactivation. Consequently, kiwifruit could be potentially regarded as the functional food favorable in the prevention and treatment of Pb intoxication.
- Published
- 2017
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