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A kurtosis optimization method is proposed to improve the blind separated signal qualities based on the extend-infomax algorithm. The kurtosis of the hypothetical source signal was optimized based on the probability density function of sub-Gaussian signals. Obtained parameters after kurtosis optimization were then utilized to validate the effectiveness of the algorithm, which showed that the running time of the algorithm was significantly reduced, and the qualities of the separated signals were enhanced. Methods. Using kurtosis as a control variable, a one-way analysis of variance (ANOVA) was carried out on the algorithm’s performance metrics, the number of iterations, and the signal-to-noise ratio of the separated signal. Results. The results showed that there were significant differences in the above metrics under different kurtosis levels. The curves of average metric values indicate that, with the increase in kurtosis of the hypothetical source signal, the performance of the algorithm was improved.