1. Research Progress on the Pathological Mechanisms of Podocytes in Diabetic Nephropathy
- Author
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Xinmiao Wang, Lin Han, Xiaolin Tong, Xin-Yi Fang, Yu Wei, Linhua Zhao, Lili Zhang, Yu-Jiao Zheng, Zhige Wen, and Qing Wang
- Subjects
0301 basic medicine ,Endocrinology, Diabetes and Metabolism ,Apoptosis ,Review Article ,Diseases of the endocrine glands. Clinical endocrinology ,Muscle hypertrophy ,Podocyte ,Diabetic nephropathy ,03 medical and health sciences ,0302 clinical medicine ,Endocrinology ,Diabetes mellitus ,medicine ,Autophagy ,Animals ,Humans ,Diabetic Nephropathies ,skin and connective tissue diseases ,Pathological ,business.industry ,Podocytes ,Research ,Transdifferentiation ,RC648-665 ,medicine.disease ,030104 developmental biology ,medicine.anatomical_structure ,030220 oncology & carcinogenesis ,Cell Transdifferentiation ,Cancer research ,Disease Progression ,sense organs ,Signal transduction ,business ,Signal Transduction - Abstract
Diabetic nephropathy (DN) is not only an important microvascular complication of diabetes but also the main cause of end-stage renal disease. Studies have shown that the occurrence and development of DN are closely related to morphological and functional changes in podocytes. A series of morphological changes after podocyte injury in DN mainly include podocyte hypertrophy, podocyte epithelial-mesenchymal transdifferentiation, podocyte detachment, and podocyte apoptosis; functional changes mainly involve podocyte autophagy. More and more studies have shown that multiple signaling pathways play important roles in the progression of podocyte injury in DN. Here, we review research progress on the pathological mechanism of morphological and functional changes in podocytes associated with DN, to provide a new target for delaying the occurrence and development of this disorder.
- Published
- 2020