1. High-Grade Transformation (Dedifferentiation) of Acinic Cell Carcinoma of the Parotid Gland: Report of an Unusual Variant
- Author
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Nabil N. Al Zaher, Faiza Alotaibi, Sarah S. Al-Otaibi, M. A. Dababo, and Yaseer N. Al Zaher
- Subjects
medicine.medical_specialty ,Facial swelling ,Pathology ,Salivary gland ,business.industry ,Clinical course ,Case Report ,General Medicine ,medicine.disease ,lcsh:Otorhinolaryngology ,lcsh:RF1-547 ,Parotid gland ,Acinic cell carcinoma ,03 medical and health sciences ,Transformation (genetics) ,0302 clinical medicine ,medicine.anatomical_structure ,030220 oncology & carcinogenesis ,medicine ,Histopathology ,030223 otorhinolaryngology ,business - Abstract
Acinic cell carcinoma with high-grade transformation of the salivary gland is an unusual variant with less than fifty cases being reported in the literature. It is characterized by a low- and high-grade component juxtaposed with one another and tends to take on a more aggressive clinical course than its low-grade counterpart, suggesting a poor clinical outcome. We, hereby, report a case of acinic cell carcinoma in a 48-year-old woman with a 6-month history of a right parotid facial swelling rapidly increasing in size. The tumor was initially resected; however, residual focal tissue subsequently revealed areas typical of low-grade acinic cell carcinoma as well as high-grade transformation/dedifferentiation via histopathology.
- Published
- 2017