1. Platelet Serotonin Levels Are Associated with Plasma Soluble Leptin Receptor Concentrations in Normoglycemic Women
- Author
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Malin Fex, José Suazo, Pablo Olmos, J. Alfredo Martínez, Luis Rodrigo Cataldo, Jose E. Galgani, Carolina Bravo, and José Luis Santos
- Subjects
Blood Glucose ,Leptin ,0301 basic medicine ,Endocrinology, Diabetes and Metabolism ,Fatty Acids, Nonesterified ,lcsh:Diseases of the endocrine glands. Clinical endocrinology ,Body Mass Index ,0302 clinical medicine ,Endocrinology ,Insulin ,Glucose homeostasis ,Platelet ,Chile ,Chemokine CCL2 ,Glucose tolerance test ,Anthropometry ,medicine.diagnostic_test ,Lipids ,Receptors, Leptin ,Female ,Adiponectin ,hormones, hormone substitutes, and hormone antagonists ,Research Article ,Adult ,Blood Platelets ,Serotonin ,medicine.medical_specialty ,Article Subject ,Adipokine ,030209 endocrinology & metabolism ,Young Adult ,03 medical and health sciences ,Insulin resistance ,Adipokines ,Internal medicine ,medicine ,Humans ,lcsh:RC648-665 ,Leptin receptor ,Tumor Necrosis Factor-alpha ,business.industry ,Glucose Tolerance Test ,Lipid Metabolism ,medicine.disease ,Cross-Sectional Studies ,030104 developmental biology ,Insulin Resistance ,business ,Hormone - Abstract
Most peripheral serotonin (5-hydroxytryptamine (5HT)) is synthetized in the gut with platelets being its main circulating reservoir. 5HT is acting as a hormone in key organs to regulate glucose and lipid metabolism. However, the relation between platelet 5HT levels and traits related to glucose homeostasis and lipid metabolism in humans remains poorly explored. The objectives of this study were (a) to assess the association between platelet 5HT levels and plasma concentration of nonesterified fatty acids (NEFAs) and some adipokines including leptin and its soluble leptin receptor (sOb-R), (b) to assess the association between platelet 5HT levels and anthropometric traits and indexes of insulin secretion/sensitivity derived from oral glucose tolerance test (OGTT), and (c) to evaluate changes in platelet 5HT levels in response to OGTT. In a cross-sectional study, 59 normoglycemic women underwent a standard 2-hour OGTT. Plasma leptin, sOb-R, total and high molecular weight adiponectin, TNFα, and MCP1 were determined by immunoassays. Platelet 5HT levels and NEFAs were measured before and after OGTT. The free leptin index was calculated from leptin and sOb-R measurements. Insulin sensitivity indexes derived from OGTT (HOMA-S and Matsuda ISICOMP) and plasma NEFAs (Adipose-IR, Revised QUICKI) were also calculated. Our data show that among metabolic traits, platelet 5HT levels were associated with plasma sOb-R (r=0.39,p=0.003, correctedp=0.018). Platelet 5HT levels were reduced in response to OGTT (779±237vs.731±217 ng/109platelets,p=0.005). In conclusion, platelet 5HT levels are positively associated with plasma sOb-R concentrations and reduced in response to glucose intake possibly indicating a role of peripheral 5HT in leptin-mediated appetite regulation.
- Published
- 2019
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