1. Novel Insights into the Molecular Features and Regulatory Mechanisms of Mitochondrial Dynamic Disorder in the Pathogenesis of Cardiovascular Disease
- Author
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Yaoyuan Zhang, Zhongqing Chen, Fengfan Xia, Lulan Li, Xiaojie Peng, Ying Tan, Haihong Fang, Wenqian Liu, and Zhenhua Zeng
- Subjects
0301 basic medicine ,Aging ,Mitochondrial Diseases ,Disease ,Review Article ,030204 cardiovascular system & hematology ,Mitochondrion ,Biochemistry ,Mitochondrial Dynamics ,Models, Biological ,Pathogenesis ,03 medical and health sciences ,0302 clinical medicine ,Diabetic cardiomyopathy ,medicine ,MFN1 ,Animals ,Humans ,QH573-671 ,business.industry ,Cell Biology ,General Medicine ,medicine.disease ,Fusion protein ,030104 developmental biology ,Cardiovascular Diseases ,Optic Atrophy 1 ,Mitochondrial fission ,Cytology ,business ,Neuroscience - Abstract
Mitochondria maintain mitochondrial homeostasis through continuous fusion and fission, that is, mitochondrial dynamics, which is precisely mediated by mitochondrial fission and fusion proteins, including dynamin-related protein 1 (Drp1), mitofusin 1 and 2 (Mfn1/2), and optic atrophy 1 (OPA1). When the mitochondrial fission and fusion of cardiomyocytes are out of balance, they will cause their own morphology and function disorders, which damage the structure and function of the heart, are involved in the occurrence and progression of cardiovascular disease such as ischemia-reperfusion injury (IRI), septic cardiomyopathy, and diabetic cardiomyopathy. In this paper, we focus on the latest findings regarding the molecular features and regulatory mechanisms of mitochondrial dynamic disorder in cardiovascular pathologies. Finally, we will address how these findings can be applied to improve the treatment of cardiovascular disease.
- Published
- 2021