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In 2005, USAID and the U.S. President s Emergency Plan for AIDS Relief (PEPFAR), created the Supply Chain Management System (SCMS) to procure and distribute essential medicines and supplies; provide technical assistance to transform existing supply chains; and collaborated with in-country and global partners to coordinate efforts. The new US Global Health Initiative (GHI) initialized in 2010 sought to build on these efforts through strengthened platforms and systems. PEPFAR's five-year strategy, as contribution to the GHI, focused on transitioning the program from an emergency response to a sustainable, country-owned effort. The case describes the general approach designed by SCMS, the intricacies of its successful implementation in Ethiopia, and the challenges moving forward in that country.

In the year 2000, the Government of the Autonomous Community of Arag n, Spain, made public a project for the development of a large-scale logistics park in the outskirts of the city of Zaragoza. With an area of nearly 13 square kilometers, PLAZA (an acronym for Zaragoza Logistics Platform) would be by far the largest logistics park either built or under development in all of Europe. This case illustrates the motivations behind such an undertaking, the reasoning used in deciding the feasibility of the location of the park, and also the advantages (and disadvantages) related to the project. The case provides sufficient data to prepare an analysis from the point of view of a potential customer, where the cost advantage or disadvantage of locating a facility in Zaragoza (with respect to Rotterdam, a preferred European location) can be quantified, and where the parameters can be changed to determine the main drivers behind such a decision, and how changes in these drivers can affect the customer's analysis. The results are meant to serve as input for PLAZA management to understand which types of customers to target, and how to address the issues that could hinder the park's projected growth.

This case describes the evolution of a liquid petroleum gas (LPG) distributor start-up, incubated by two not-for-profit NGOs to help improve the vaccine cold chain in Northern Mozambique. These NGOs must face the decision whether and how to sell their participation in the start-up. VillageReach and the Mozambican Foundation for Community Development (FDC), both NGOs, got involved in the national immunization program, the Expanded Program on Immunization (EPI), in northern Mozambique. This program's goal was to ensure prompt and universal access to vaccines and other medical supplies. Early on, VillageReach had realized that the program's goals could not be satisfied unless cold storage (and transportation) of the vaccines was guaranteed. Because electricity was scarce and unreliable in the region, VillageReach searched for alternative solutions for supporting cold storage. VillageReach finally decided to use LPG powered refrigerators, and, due to the lack of reliable sources of LPG in the region, FDC and VillageReach went on to fund VidaGas, an LPG distribution company. It soon became evident that an efficient distribution network of LPG could provide benefits to society above and beyond health: at the time, most businesses and households in the region cooked using biomass fuels. Such fuels are a significant health hazard, and also contribute to deforestation in the region. Although VidaGas could be considered a success, it had yet to reach breakeven in its current operations. In addition, new investments would be required to expand operations to neighboring provinces beyond the province used for the pilot, Cabo Delgado. As the Ministry of Health (MoH), FDC and VillageReach are planning to expand the improvements in the national immunization program to these provinces, the presence of a reliable source of LPG would be essential to their goals. At the same time, VillageReach and FDC's resources for further investment are limited.

The case focuses on the challenges of Roche maintaining a supply network for a global influenza pandemic response initiative based on its antiviral drug Tamiflu. The Roche group is a 40 billion CHF company consisting of a pharmaceutical division and a diagnostic division. The company's antiviral drug Tamiflu dominates the market for prevention and treatment of seasonal influenza (flu). Tamiflu, however, could also play an important role in responding to the first wave of a pandemic caused by a particularly harmful strain of the influenza virus A. Tamiflu was designed to be effective against any strain of Type A or B influenza. Thus, there was the potential to establish a preparedness plan based on creating a stockpile of the drug in conjunction with an appropriate plan for distribution to the affected population. The use of Tamiflu in such a crisis would allow the world to respond immediately, rather than having to wait for development of a vaccine which had limitations in its effectiveness and the drug had been endorsed by the WHO as a first line of defense. The case focuses on the challenges of Roche maintaining a supply network for a global pandemic response initiative. Managing supply is particularly challenging for three reasons. First, demand for stockpile quantities is spiky and uncertain, and governments placing orders expect lead times to be short. Second, lead times for increasing capacity are long, as are lead times for drug production and encapsulation. Last, media coverage and press releases made by governments and other stakeholders increase the stakes, as negative media coverage may damage Roche's reputation with consumers, leading to lower sales levels for its products.

Provides a context and exercise for introducing retail inventory management, including cost optimization, service-level criteria, and forecasting in single and multiproduct settings. The owner of a single-location paper and paper products store considers the implications of expansion for inventory management. Considerations include lost sales, retail metrics for multiproduct settings, and shelf space constraints.

Leitax, a young digital camera manufacturer selling its cameras mainly through retailers, experienced poor matching of inventory availability with demand for new and existing products in 2002. Describes the implementation and details of a consensus forecasting approach, a crucial part of a demand and supply planning redesign that was introduced to address the problem. The forecasting approach is a cross-functional one involving the sales, operations, and finance functions. Describes the results of the introduction, including planning challenges the company continued to face.

Provides a context and exercise for introducing retail inventory management, including cost optimization, service-level criteria, and forecasting in single and multiproduct settings. The owner of a single-location paper and paper products store considers the implications of expansion for inventory management. Considerations include lost sales, retail metrics for multiproduct settings, and shelf space constraints. An Excel spreadsheet accompanies and is integral to the case, allowing students to explore these issues. For spreadsheet inquiries, please contact customer service at 1-800-545-7685 or custserv@hbsp.harvard.edu