1. Sulfonic Acid-Containing Flavonoids from the Roots of Phyllanthus acidus
- Author
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Mehdi A. Beniddir, Pierre Le Pogam, Warinthorn Chavasiri, Thammarat Aree, Jean-François Gallard, Dinh Hung Mac, Van-Kieu Nguyen, Xuan-Hao Bui, Huu-Hung Nguyen, Kim-Phi-Phung Nguyen, Thuc-Huy Duong, Joël Boustie, Ho Chi Minh city University of Technology and Education, Chulalongkorn University [Bangkok], Molécules bioactives, conception, isolement et synthèse (MBCIS), Université Paris-Sud - Paris 11 (UP11)-Centre National de la Recherche Scientifique (CNRS), Institut de Chimie des Substances Naturelles (ICSN), Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC), Nguyen Tat Thanh University [Vietnam] (NTTU), Institut des Sciences Chimiques de Rennes (ISCR), Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Ecole Nationale Supérieure de Chimie de Rennes (ENSCR)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Université de Rennes (UNIV-RENNES)-Institut National des Sciences Appliquées (INSA), Chulalongkorn University, Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Université de Rennes (UR)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), and Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Ecole Nationale Supérieure de Chimie de Rennes (ENSCR)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)
- Subjects
Phyllanthus ,Magnetic Resonance Spectroscopy ,Chemical structure ,Pharmaceutical Science ,Sulfonic acid ,01 natural sciences ,Plant Roots ,Analytical Chemistry ,chemistry.chemical_compound ,X-Ray Diffraction ,Drug Discovery ,Organic chemistry ,[CHIM]Chemical Sciences ,Pharmacology ,chemistry.chemical_classification ,Flavonoids ,biology ,010405 organic chemistry ,Plant Extracts ,Organic Chemistry ,Nuclear magnetic resonance spectroscopy ,Isoflavones ,biology.organism_classification ,0104 chemical sciences ,010404 medicinal & biomolecular chemistry ,Complementary and alternative medicine ,chemistry ,Molecular Medicine ,Sulfonic Acids ,Two-dimensional nuclear magnetic resonance spectroscopy - Abstract
International audience; Six new sulfonic acid-containing flavonoids, acidoflavanone (1), acidoauronol (2), 5- O-methylacidoauronol (3), acidoaurone (4), acidoisoflavone (5), and acidoflavonol (6), were isolated from the EtOH extract of the roots of Phyllanthus acidus. Their structures were unambiguously established by interpretation of their HRESIMS and 1D and 2D NMR data, single-crystal X-ray diffraction analysis, and comparison to the literature data. These new structures represent the first examples of sulfonic acid-containing flavanones, auronols, aurones, and isoflavones.
- Published
- 2018