1. CT imaging findings in patients with advanced hepatocellular carcinoma treated with sorafenib: Alternative response criteria (Choi, European Association for the Study of the Liver, and modified Response Evaluation Criteria in Solid Tumor (mRECIST)) versus RECIST 1.1
- Author
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M. Gavanier, C. Sellal, Jean-Pierre Bronowicki, Valérie Laurent, Michel Claudon, Ahmet Ayav, Xavier Orry, Département de Radiologie adultes [CHRU Nancy], Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Université de Lorraine (UL), Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), Imagerie Adaptative Diagnostique et Interventionnelle (IADI), and Université de Lorraine (UL)-Institut National de la Santé et de la Recherche Médicale (INSERM)
- Subjects
Sorafenib ,Adult ,Male ,Niacinamide ,medicine.medical_specialty ,Carcinoma, Hepatocellular ,Hepatocellular carcinoma ,[SDV]Life Sciences [q-bio] ,Antineoplastic Agents ,mRECIST ,RECIST 1.1 ,03 medical and health sciences ,0302 clinical medicine ,Tumoral response assessment ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,Choi ,Survival analysis ,Response Evaluation Criteria in Solid Tumors ,Aged ,Proportional Hazards Models ,Retrospective Studies ,Proportional hazards model ,business.industry ,Phenylurea Compounds ,Hazard ratio ,Liver Neoplasms ,Anti-angiogenic therapy ,Retrospective cohort study ,General Medicine ,Middle Aged ,medicine.disease ,Survival Analysis ,Confidence interval ,3. Good health ,Treatment Outcome ,Liver ,030220 oncology & carcinogenesis ,030211 gastroenterology & hepatology ,Female ,Radiology ,business ,Tomography, X-Ray Computed ,medicine.drug - Abstract
International audience; Purpose: The first aim was to compare Response Evaluation Criteria in Solid Tumor (RECIST) 1.1, modified Response Evaluation Criteria in Solid Tumor (mRECIST), Choi and European Association for the Study of the Liver (EASL) evaluations to assess the response to sorafenib for hepatocellular carcinoma (HCC). The second aim was to describe the evolution of HCC and to identify whether some imaging features are predictive of the absence of response. Materials and methods: This retrospective study included 60 patients with advanced HCC treated with sorafenib. Patients must have undergone a scan prior to treatment to identify the number of lesions, size, enhancement and endoportal invasions, and repeat scans thereafter. Computed tomography (CT) scans were analyzed using RECIST 1.1, mRECIST, Choi and EASL criteria. Overall survival was analyzed. Results: The median overall survival was 10.5 months. On the first CT reevaluation, the sorafenib response rates were 20%, 5%, 7% and 3% according to Choi, EASL, mRECIST and RECIST 1.1. The responders based on Choi exhibited significantly better overall survival compared with non-responders (20.4 months; hazard ratio (HR) 0.042, 95% confidence interval (CI): 0.186-0.94, p = 0.035). A modification of imaging findings was observed in 48.3% of patients, and necrosis was present in 44.1% of patients. Conclusion: This study found a significant difference between Choi versus RECIST 1.1, mRECIST and EASL when evaluating the response to sorafenib in HCC patients.
- Published
- 2016