1. The anti-staphylococcal lipolanthines are ribosomally synthesized lipopeptides
- Author
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Jozsef Aszodi, Natalia A. Jungmann, Guillaume Lesquame, Sophie Tirat, Roderich D. Süssmuth, Vincent Wiebach, Andi Mainz, Mary‐Ann J. Siegert, Dominique Le Beller, Assia Dreux-Zigha, Technical University of Berlin / Technische Universität Berlin (TU), Institut Charles Viollette (ICV) - EA 7394 (ICV), Université d'Artois (UA)-Institut National de la Recherche Agronomique (INRA)-Université du Littoral Côte d'Opale (ULCO)-Institut Supérieur d'Agriculture-Université de Lille, Deutsche Forschungsgemeinschaft [SU 239/25-1], Technical University Berlin, and Université du Littoral Côte d'Opale (ULCO)-Université de Lille-Institut National de la Recherche Agronomique (INRA)-Université d'Artois (UA)-Institut Supérieur d'Agriculture
- Subjects
Methicillin-Resistant Staphylococcus aureus ,0301 basic medicine ,[SDV]Life Sciences [q-bio] ,Microbial Sensitivity Tests ,Microbacterium arborescens ,01 natural sciences ,Lipopeptides ,03 medical and health sciences ,chemistry.chemical_compound ,Biosynthesis ,Gene cluster ,Moiety ,Molecular Biology ,chemistry.chemical_classification ,010405 organic chemistry ,Fatty acid ,Cell Biology ,Antimicrobial ,In vitro ,Anti-Bacterial Agents ,3. Good health ,0104 chemical sciences ,030104 developmental biology ,chemistry ,Biochemistry ,Genome mining ,Ribosomes - Abstract
International audience; The potent antibacterial lanthipeptide microvionin, isolated from a culture of Microbacterium arborescens, exhibits a new triamino-dicarboxylic acid moiety, termed avionin, and an unprecedented N-terminal guanidino fatty acid. We identified the corresponding biosynthetic gene cluster and reconstituted central steps of avionin biosynthesis in vitro. Genome mining and isolation of nocavionin from Nocardia terpenica revealed a widespread distribution of this lanthipeptide class, termed lipolanthines, which may be useful as future antimicrobial drugs.
- Published
- 2018
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