1. Effect of parathyroidectomy on quality of life and non-specific symptoms in normocalcaemic primary hyperparathyroidism
- Author
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Niki Christou, Antoine Hamy, Claire Blanchard, Carole Guerin, Frederic Sebag, Muriel Mathonnet, P Guillot, Sahar Bannani, Eric Mirallié, C. Caillard, Clinique de Chirurgie Digestive et Endocrinienne [CHU Nantes], Centre hospitalier universitaire de Nantes (CHU Nantes), Service de Chirurgie digestive, endocrinienne et générale [CHU Limoges], CHU Limoges, Laboratoire de Géologie de Lyon - Terre, Planètes, Environnement [Lyon] (LGL-TPE), École normale supérieure - Lyon (ENS Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), Hémodynamique, Interaction Fibrose et Invasivité tumorales Hépatiques (HIFIH), Université d'Angers (UA), Endocrinologie, diabète, maladies métaboliques (CHU Marseille, AP-HM), Assistance Publique - Hôpitaux de Marseille (APHM), Unité de recherche de l'institut du thorax (ITX-lab), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN), Service de Chirurgie Digestive et Endocrinienne [Nantes], Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-École normale supérieure - Lyon (ENS Lyon), and unité de recherche de l'institut du thorax UMR1087 UMR6291 (ITX)
- Subjects
Parathyroidectomy ,Male ,Quality of life ,medicine.medical_specialty ,endocrine system diseases ,medicine.medical_treatment ,[SDV]Life Sciences [q-bio] ,030209 endocrinology & metabolism ,Preoperative care ,03 medical and health sciences ,0302 clinical medicine ,Non specific ,Internal medicine ,Surveys and Questionnaires ,medicine ,80 and over ,Humans ,Prospective Studies ,Prospective cohort study ,Aged ,Aged, 80 and over ,business.industry ,Hyperparathyroidism ,Significant difference ,Middle Aged ,Hyperparathyroidism, Primary ,University hospital ,medicine.disease ,3. Good health ,Treatment Outcome ,030220 oncology & carcinogenesis ,Surgery ,Female ,business ,Primary hyperparathyroidism ,Primary ,Follow-Up Studies - Abstract
Background Normocalcaemic primary hyperparathyroidism (NcPHPT) is a new clinical entity being diagnosed increasingly among patients with mild primary hyperparathyroidism (PHPT). The aim of this study was to evaluate quality of life and non-specific symptoms before and after parathyroidectomy in patients with NcPHPT compared with those with hypercalcaemic mild PHPT (Hc-m-PHPT). Methods This was a prospective multicentre study of patients with mild PHPT from four university hospitals. Patients were evaluated before operation, and 3, 6 and 12 months after surgery for quality of life using the SF-36-v2® questionnaire, as well as for 25 non-specific symptoms. Results Before operation, the only statistically significant difference between the NcPHPT and Hc-m-PHPT groups was in the mean(s.d.) blood calcium level (2·54 versus 2·73 mmol; P < 0·001). At 1 year after surgery, the blood calcium level had improved significantly in both groups, with no significant difference between them. Quality of life improved significantly in each group compared with its preoperative score, with regard to the physical component summary (P = 0·040 and P = 0·016 respectively), whereas the mental component summary improved significantly in the Hc-m-PHPT group only (P = 0·043). Only two non-specific symptoms improved significantly in the NcPHPT group compared with nine in the Hc-m-PHPT group. Conclusion Parathyroidectomy mildly improves quality of life and some non-specific symptoms in patients with NcPHPT.
- Published
- 2018
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