1. Why interindividual variation in response to consumption of plant food bioactives matters for future personalised nutrition
- Author
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Baukje de Roos, Ana Rodriguez-Mateos, Rikard Landberg, Claudine Manach, Eileen R. Gibney, Francisco A. Tomás-Barberán, Dragan Milenkovic, Tom Van de Wiele, Christine Morand, María Teresa García-Conesa, Unité de Nutrition Humaine (UNH), Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), The Rowett Research Institute, University of Aberdeen, Centro de Edafologia y Biologia aplicada del Segura (CEBAS - CSIC), Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), UCD Institute of Food and Health, University College Dublin (UCD), Department of Biology and Biological Engineering, Food and Nutrition Science, Chalmers University of Technology [Gothenburg, Sweden], Deparment of Nutritional Sciences, School of Life Course Sciences, Faculty of life Sciences and Medicine, King‘s College London, Center for Microbial Ecology and Technology (CMET), Universiteit Gent = Ghent University [Belgium] (UGENT), Faculty of Bioscience Engineering at Ghent University, Cost Action - European Cooperation in Science and Technology FA1403, Unité de Nutrition Humaine - Clermont Auvergne (UNH), Institut National de la Recherche Agronomique (INRA)-Université Clermont Auvergne (UCA), Centro de Edafología y Biología Aplicada del Segura (CEBAS-CSIC), Chalmers University of Technology, King’s College London, and Universiteit Gent = Ghent University (UGENT)
- Subjects
0301 basic medicine ,Male ,Phytochemicals ,Medicine (miscellaneous) ,Biological Availability ,030209 endocrinology & metabolism ,Biology ,Gut flora ,Plant foods ,Interindividual variability ,03 medical and health sciences ,0302 clinical medicine ,Nutrigenomics ,Environmental health ,medicine ,Humans ,Nutritional Physiological Phenomena ,Precision Medicine ,Beneficial effects ,2. Zero hunger ,Cardiometabolic risk ,Consumption (economics) ,030109 nutrition & dietetics ,Nutrition and Dietetics ,Genome, Human ,Research ,Cardiometabolic health ,Food phytochemicals ,medicine.disease ,biology.organism_classification ,Intervention studies ,Obesity ,3. Good health ,Diet ,Gastrointestinal Microbiome ,Variation (linguistics) ,Biological Variation, Population ,Heart Disease Risk Factors ,Metabolome ,Female ,Nutritive Value ,[SDV.AEN]Life Sciences [q-bio]/Food and Nutrition - Abstract
Part of: Nutrition Society Spring Meeting 2019 Conference on ‘Inter-individual differences in the nutrition response: from research to recommendations’; Food phytochemicals are increasingly considered to play a key role in the cardiometabolic health effects of plant foods. However, the heterogeneity in responsiveness to their intake frequently observed in clinical trials can hinder the beneficial effects of these compounds in specific subpopulations. A range of factors, including genetic background, gut microbiota, age, sex and health status, could be involved in these interindividual variations; however, the current knowledge is limited and fragmented. The European network, European Cooperation in Science and Technology (COST)-POSITIVe, has analysed, in a systematic way, existing knowledge with the aim to better understand the factors responsible for the interindividual variation in response to the consumption of the major families of plant food bioactives, regarding their bioavailability and bioefficacy. If differences in bioavailability, likely reflecting differences in human subjects’ genetics or in gut microbiota composition and functionality, are believed to underpin much of the interindividual variability, the key molecular determinants or microbial species remain to be identified. The systematic analysis of published studies conducted to assess the interindividual variation in biomarkers of cardiometabolic risk suggested some factors (such as adiposity and health status) as involved in between-subject variation. However, the contribution of these factors is not demonstrated consistently across the different compounds and biological outcomes and would deserve further investigations. The findings of the network clearly highlight that the human subjects’ intervention studies published so far are not adequate to investigate the relevant determinants of the absorption/metabolism and biological responsiveness. They also emphasise the need for a new generation of intervention studies designed to capture this interindividual variation.
- Published
- 2020