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2 results on '"Riccardo Di Corato"'

1. Forced- and Self-Rotation of Magnetic Nanorods Assembly at the Cell Membrane: A Biomagnetic Torsion Pendulum

Author

Thierry Meylheuc, Claire Wilhelm, Teresa Pellegrino, François Mazuel, Samuel Mathieu, Myriam Reffay, Riccardo Di Corato, Jean-Claude Bacri, CNRS UMR 7057 - Laboratoire Matières et Systèmes Complexes (MSC) (MSC), Centre National de la Recherche Scientifique (CNRS), MICrobiologie de l'ALImentation au Service de la Santé (MICALIS), Institut National de la Recherche Agronomique (INRA)-AgroParisTech, Istituto Italiano di Tecnologia (IIT), and European Union [648779]

Subjects
assembly, Materials science, Rotation, Polymers, [PHYS.PHYS.PHYS-BIO-PH]Physics [physics]/Physics [physics]/Biological Physics [physics.bio-ph], Torsion, Mechanical, FOS: Physical sciences, 02 engineering and technology, Condensed Matter - Soft Condensed Matter, 010402 general chemistry, 01 natural sciences, Polymerization, Quantitative Biology::Cell Behavior, Physical Phenomena, Biomaterials, Cell membrane, medicine, Humans, General Materials Science, Physics - Biological Physics, Magnetite Nanoparticles, Anisotropy, magnetic nanorods, Rotating magnetic field, Nanotubes, Condensed matter physics, Cell Membrane, rotating magnetic field, General Chemistry, 021001 nanoscience & nanotechnology, 0104 chemical sciences, Magnetic field, Magnetic Fields, medicine.anatomical_structure, Membrane, Biological Physics (physics.bio-ph), membranes, Torsion pendulum clock, PC-3 Cells, Soft Condensed Matter (cond-mat.soft), Nanorod, 0210 nano-technology, Biotechnology
Abstract

International audience; In order to give insights into how anisotropic nano-objects interact with living cell membranes, and possibly self-assemble, we designed magnetic nanorods with average size around 100 nm x 1µm by assembling iron oxide nanocubes within a polymeric matrix under a magnetic field. We then explored the nano-bio interface at the cell membrane under the influence of a rotating magnetic field. We observed a complex structuration of the nanorods intertwined with the membranes. Unexpectedly, after a magnetic rotating stimulation, the resulting macrorods were able to rotate freely for multiple rotations, revealing the creation of a bio-magnetic torsion pendulum.

Published
2017

2. High-Resolution Cellular MRI: Gadolinium and Iron Oxide Nanoparticles for in-Depth Dual-Cell Imaging of Engineered Tissue Constructs

Author

Nathalie Luciani, Pierre Levitz, Riccardo Di Corato, Catherine Le Visage, Didier Letourneur, Claire Wilhelm, François Lux, Florence Gazeau, Olivier Tillement, Delphine Fayol, Matière et Systèmes Complexes (MSC (UMR_7057)), Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Hémostase, bio-ingénierie et remodelage cardiovasculaires (LBPC), Université Paris 13 (UP13)-Université Paris Diderot - Paris 7 (UPD7)-Institut Galilée-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Laboratoire de physique de la matière condensée (LPMC), École polytechnique (X)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physico-Chimie des Matériaux Luminescents (LPCML), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS), Matière et Systèmes Complexes ( MSC ), Université Paris Diderot - Paris 7 ( UPD7 ) -Centre National de la Recherche Scientifique ( CNRS ), Hémostase, bio-ingénierie et remodelage cardiovasculaires ( LBPC ), Université Paris Diderot - Paris 7 ( UPD7 ) -Université Paris 13 ( UP13 ) -Université Sorbonne Paris Cité ( USPC ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Institut Galilée, Laboratoire de physique de la matière condensée ( LPMC ), École polytechnique ( X ) -Centre National de la Recherche Scientifique ( CNRS ), Laboratoire de Physico-Chimie des Matériaux Luminescents ( LPCML ), Université Claude Bernard Lyon 1 ( UCBL ), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique ( CNRS ), Centre National de la Recherche Scientifique (CNRS)-Université Paris Diderot - Paris 7 (UPD7), Université Paris Diderot - Paris 7 (UPD7)-Université Paris 13 (UP13)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Galilée, Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon, and Institut Lumière Matière [Villeurbanne] (ILM)

Subjects
Cell type, Materials science, Gadolinium, General Physics and Astronomy, chemistry.chemical_element, Contrast Media, Nanotechnology, 02 engineering and technology, Regenerative medicine, Sensitivity and Specificity, 030218 nuclear medicine & medical imaging, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Imaging, Three-Dimensional, Tissue engineering, medicine, Nanobiotechnology, Humans, General Materials Science, Magnetite Nanoparticles, Cells, Cultured, [PHYS]Physics [physics], medicine.diagnostic_test, Tissue Engineering, General Engineering, Endothelial Cells, Reproducibility of Results, Magnetic resonance imaging, Mesenchymal Stem Cells, 021001 nanoscience & nanotechnology, Image Enhancement, Magnetic Resonance Imaging, 3. Good health, chemistry, Cell Tracking, Blood Vessels, Stem cell, 0210 nano-technology, Iron oxide nanoparticles, Biomedical engineering
Abstract

International audience; Recent advances in cell therapy and tissue engineering opened new windows for regenerative medicine, but still necessitate innovative noninvasive imaging technologies. We demonstrate that high-resolution magnetic resonance imaging (MRI) allows combining cellular-scale resolution with the ability to detect two cell types simultaneously at any tissue depth. Two contrast agents, based on iron oxide and gadolinium oxide rigid nanoplatforms, were used to "tattoo" endothelial cells and stem cells, respectively, with no impact on cell functions, including their capacity for differentiation. The labeled cells' contrast properties were optimized for simultaneous MRI detection: endothelial cells and stem cells seeded together in a polysaccharide-based scaffold material for tissue engineering appeared respectively in black and white and could be tracked, at the cellular level, both in vitro and in vivo. In addition, endothelial cells labeled with iron oxide nanoparticles could be remotely manipulated by applying a magnetic field, allowing the creation of vessel substitutes with in-depth detection of individual cellular components.

Published
2013

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