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1. Roles of Rrp6/EXOSC10-targeted lncRNAs in anti-cancer drug toxicity and cell wall architecture

Author

Stuparević, Igor, Novačić, Ana, Oskomić, Marina, Štrbac, Lucija, Beauvais, Valentin, Primig, Michael, Rahmouni, Rachid, Faculty of Food Technology & Biotechnology [Zagreb], University of Zagreb, Centre de biophysique moléculaire (CBM), Université d'Orléans (UO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC), Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Université d'Orléans (UO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )-Institut National de la Santé et de la Recherche Médicale (INSERM)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Université d'Angers (UA), and Chard-Hutchinson, Xavier

Subjects
[SDV] Life Sciences [q-bio], yeast cell wall, 5-FU, lncRNA, [SDV]Life Sciences [q-bio], ComputingMilieux_MISCELLANEOUS
Abstract

Saccharomyces cerevisiae is a versatile model organism that has been used extensively to study mitotic cell growth and division in the presence of numerous toxic compounds, including chemotherapeutical agents and toxic molecules that affect cell wall formation and maintenance. The widely used anti-cancer drug 5- fluorouracil (5-FU) was initially identified as a DNA replication inhibitor but was later found to also inhibit the conserved 3ʹ-5ʹ exoribonuclease Rrp6/EXOSC10, a catalytic subunit of the nuclear RNA exosome. The protein plays a role in degradation and processing of protein-coding and non-coding transcripts and its absence renders cells hypersensitive to 5-FU. Transcriptome analysis of 5-FU treated yeast cells revealed a negative effect on the expression of the transcriptional activators Swi5 and Ace2 that induce cell cycle regulated genes involved in mitotic cell division. Moreover, we observed that different types of non-coding RNAs (ncRNA) accumulated in 5-FU treated cells, which are typically present at high levels in a strain lacking Rrp6/ EXOSC10. Interestingly, comparison of transcriptome data from wild type and rrp6 mutant strains showed altered expression levels both of genes that encode proteins crucial for cell wall integrity and lncRNAs that either overlap their promoters or that are in a sense/antisense configuration. Consistently, a yeast strain lacking Rrp6 is more sensitive than the wild-type to cell wall stressing compounds. Our data offer interesting leads for the discovery of novel protein-coding and non- coding RNAs that may be involved in 5-FU toxicity and cell wall defects caused by cell wall stressing compounds. These results are potentially important for improving antifungal therapies and 5-FU based chemotherapies. *The authors marked with an asterisk equally contributed to the work.

Published
2021
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2. Transgenerational Inheritance of Environmentally Induced Epigenetic Alterations during Mammalian Development

Author

Legoff, Louis, d'Cruz, Shereen Cynthia, Tevosian, Sergei, Primig, Michael, Smagulova, Fatima, Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), University of Florida [Gainesville] (UF), Université d'Angers (UA)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), and Jonchère, Laurent

Subjects
Genotype, transgenerational inheritance, Quantitative Trait Loci, Inheritance Patterns, Embryonic Development, [SDV.GEN.GA] Life Sciences [q-bio]/Genetics/Animal genetics, Review, [SDV.GEN.GH] Life Sciences [q-bio]/Genetics/Human genetics, Environment, Epigenesis, Genetic, Histones, environmental factors, [SDV.BBM.GTP]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Genomics [q-bio.GN], Animals, Humans, Genetic Association Studies, [SDV.BDD.GAM]Life Sciences [q-bio]/Development Biology/Gametogenesis, Mammals, [SDV.BDD.GAM] Life Sciences [q-bio]/Development Biology/Gametogenesis, epigenetics, histone modifications, Gene Expression Regulation, Developmental, Cellular Reprogramming, Chromatin, [SDV.GEN.GA]Life Sciences [q-bio]/Genetics/Animal genetics, Germ Cells, Phenotype, [SDV.GEN.GH]Life Sciences [q-bio]/Genetics/Human genetics, [SDV.BBM.GTP] Life Sciences [q-bio]/Biochemistry, Molecular Biology/Genomics [q-bio.GN], Gene-Environment Interaction, RNA, Long Noncoding, genome reprograming
Abstract

International audience; Genetic studies traditionally focus on DNA as the molecule that passes information on from parents to their offspring. Changes in the DNA code alter heritable information and can more or less severely affect the progeny's phenotype. While the idea that information can be inherited between generations independently of the DNA's nucleotide sequence is not new, the outcome of recent studies provides a mechanistic foundation for the concept. In this review, we attempt to summarize our current knowledge about the transgenerational inheritance of environmentally induced epigenetic changes. We focus primarily on studies using mice but refer to other species to illustrate salient points. Some studies support the notion that there is a somatic component within the phenomenon of epigenetic inheritance. However, here, we will mostly focus on gamete-based processes and the primary molecular mechanisms that are thought to contribute to epigenetic inheritance: DNA methylation, histone modifications, and non-coding RNAs. Most of the rodent studies published in the literature suggest that transgenerational epigenetic inheritance through gametes can be modulated by environmental factors. Modification and redistribution of chromatin proteins in gametes is one of the major routes for transmitting epigenetic information from parents to the offspring. Our recent studies provide additional specific cues for this concept and help better understand environmental exposure influences fitness and fidelity in the germline. In summary, environmental cues can induce parental alterations and affect the phenotypes of offspring through gametic epigenetic inheritance. Consequently, epigenetic factors and their heritability should be considered during disease risk assessment.

Published
2019
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3. Corrigendum: The conserved histone deacetylase Rpd3 and the DNA binding regulator Ume6 repress BOI1's meiotic transcript isoform during vegetative growth in Saccharomyces cerevisiae (vol 96, pg 861, 2015)

Author

Liu, Yuchen, Stuparevic, Igor, Xie, Bingning, Becker, Emmanuelle, Law, Michael J., Primig, Michael, Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), and Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )

Subjects
[SDV]Life Sciences [q-bio]
Abstract

International audience; This article corrects: The conserved histone deacetylase Rpd3 and the DNA binding regulator Ume6 repress BOI1's meiotic transcript isoform during vegetative growth in Saccharomyces cerevisiae. Vol. 96, Issue 4, 861–874, Article first published online: 21 MAR 2015

Published
2016
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4. The conserved histone deacetylase Rpd3 and the DNA binding regulator Ume6 repress BOI1's meiotic transcript isoform during vegetative growth in Saccharomyces cerevisiae

Author

Liu, Yuchen, Stuparevic, Igor, Xie, Bingning, Becker, Emmanuelle, Law, Michael J, Primig, Michael, Institut de recherche en santé, environnement et travail (Irset), Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )-Institut National de la Santé et de la Recherche Médicale (INSERM)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Université d'Angers (UA), R07216NS, Institut national de la santé et de la recherche médicale, Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Université d'Angers (UA)-Université de Rennes 1 (UR1), and Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )

Subjects
GENOME, EXPRESSION, BUDDING YEAST, ACETYLATION, PROTEINS, [SDV]Life Sciences [q-bio], PROGRAM, CELL-CYCLE, SPORE GERMINATION, MEIOSIS, SPORULATION
Abstract

International audience; BOI1 and BOI2 are paralogs important for the actin cytoskeleton andpolar growth. BOI1 encodes a meiotic transcript isoform with an extended5-untranslated region predicted to impair protein translation. It is,however, unknown how the isoform is repressed during mitosis, and ifBoi1 is present during sporulation. By interpreting microarray data fromMATa cells, MATa/ cells, a starving MAT/ control, and a meiosis-impairedrrp6 mutant, we classified BOI1's extended isoform as earlymeiosis-specific. These results were confirmed by RNA-Sequencing, andextended by a 5-RACE assay and Northern blotting, showing that meioticcells induce the long isoform while the mitotic isoform remainsdetectable during meiosis. We provide evidence via motif predictions, anin vivo binding assay and genetic experiments that the Rpd3/Sin3/Ume6histone deacetylase complex, which represses meiotic genes duringmitosis, also prevents the induction of BOI1's 5-extended isoform inmitosis by direct binding of Ume6 to its URS1 target. Finally, we findthat Boi1 protein levels decline when cells switch from fermentation torespiration and sporulation. The histone deacetylase Rpd3 is conserved,and eukaryotic genes frequently encode transcripts with variable 5-UTRs.Our findings are therefore relevant for regulatory mechanisms involvedin the control of transcript isoforms in multi-cellular organisms.

Published
2015
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5. Combining RNA and Protein Profiling Data with Network Interactions Identifies Genes associated with Spermatogenesis in Mouse and Human

Author

Petit, Fabrice, Kervarrec, Christine, Jamin, Soazik, Smagulova, Fatima, Hao, Chunxiang, Becker, Emmanuelle, Jégou, Bernard, Chalmel, Frédéric, Primig, Michael, Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Université d'Angers (UA)-Université de Rennes 1 (UR1), and Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )

Subjects
Male, Gene Expression Profiling, [SDV]Life Sciences [q-bio], Molecular Sequence Data, Protein Array Analysis, Mice, Fertility, Species Specificity, Testis, Animals, Humans, Gene Regulatory Networks, Amino Acid Sequence, RNA, Messenger, Spermatogenesis, Genome-Wide Association Study, Transcription Factors
Abstract

International audience; Genome-wide RNA profiling studies have identified hundreds of transcripts that are highly expressed in mammalian male germ cells, including many that are undetectable in somatic control tissues. Among them, genes important for spermatogenesis are significantly enriched. Information about mRNAs and their cognate proteins facilitates the identification of novel conserved target genes for functional studies in the mouse. By inspecting genome-wide RNA profiling data, we manually selected 81 genes for which RNA is detected almost exclusively in the human male germline and, in most cases, in rodent testicular germ cells. We observed corresponding mRNA/protein patterns in 43 cases using immunohistochemical data from the Human Protein Atlas and large-scale human protein profiling data obtained via mass spectroscopy. Protein network information enabled us to establish an interaction map of 38 proteins that points to potentially important testicular roles for some of them. We further characterized six candidate genes at the protein level in the mouse. We conclude that conserved genes induced in testis tend to show similar mRNA/protein expression patterns across species. Specifically, our results suggest roles during embryogenesis and adult spermatogenesis for Foxr1 and Sox30 and during spermiogenesis and fertility for Fam71b, 1700019N19Rik, Hmgb4, and Zfp597.

Published
2015
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6. The epigenetic processes of meiosis in male mice are broadly affected by the widely used herbicide atrazine

Author

Gely-Pernot, Aurore, Hao, Chunxiang, Becker, Emmanuelle, Stuparevic, Igor, Kervarrec, Christine, Chalmel, Frédéric, Primig, Michael, Jégou, Bernard, Smagulova, Fatima, Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), University of Zagreb, École des Hautes Études en Santé Publique [EHESP] (EHESP), 11 IRSET Chaire d'excellence, Université Européenne de Bretagne (FR), China Scholarship Council (CN), R13139NS, Atip-Avenir 2013, Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), and Jonchère, Laurent

Subjects
Male, Chromatin Immunoprecipitation, Cell Survival, Double-strand breaks, Receptors, Cytoplasmic and Nuclear, Apoptosis, Epigenesis, Genetic, GTP Phosphohydrolases, Histones, Mice, ChIP-Seq, Testis, Genetics, Animals, Position-Specific Scoring Matrices, DNA Breaks, Double-Stranded, Testosterone, Nucleotide Motifs, Gonadal Steroid Hormones, Binding Sites, [SDV.TOX.ECO] Life Sciences [q-bio]/Toxicology/Ecotoxicology, Sperm Count, Herbicides, Gene Expression Profiling, Computational Biology, High-Throughput Nucleotide Sequencing, H3K4me3, Mitochondria, Meiosis, meiosis, double-strand breaks, gene-chip, atrazine, Atrazine, [SDV.TOX.ECO]Life Sciences [q-bio]/Toxicology/Ecotoxicology, Gene-Chip, Research Article, Genome-Wide Association Study, Protein Binding, Biotechnology
Abstract

Background Environmental factors such as pesticides can cause phenotypic changes in various organisms, including mammals. We studied the effects of the widely used herbicide atrazine (ATZ) on meiosis, a key step of gametogenesis, in male mice. Methods Gene expression pattern was analysed by Gene–Chip array. Genome-wide mapping of H3K4me3 marks distribution was done by ChIP-sequencing of testis tissue using Illumina technologies. RT-qPCR was used to validate differentially expressed genes or differential peaks. Results We demonstrate that exposure to ATZ reduces testosterone levels and the number of spermatozoa in the epididymis and delays meiosis. Using Gene-Chip and ChIP-Seq analysis of H3K4me3 marks, we found that a broad range of cellular functions, including GTPase activity, mitochondrial function and steroid-hormone metabolism, are affected by ATZ. Furthermore, treated mice display enriched histone H3K4me3 marks in regions of strong recombination (double-strand break sites), within very large genes and reduced marks in the pseudoautosomal region of X chromosome. Conclusions Our data demonstrate that atrazine exposure interferes with normal meiosis, which affects spermatozoa production. Electronic supplementary material The online version of this article (doi:10.1186/s12864-015-2095-y) contains supplementary material, which is available to authorized users.

Published
2015
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7. Proteome analysis and genome-wide regulatory motif prediction identify novel potentially sex-hormone regulated proteins in rat efferent ducts

Author

Trépos-Pouplard, Mélanie, Lardenois, Aurélie, Staub, Christophe, Guitton, Nathalie, Dorval-Coiffec, Isabelle, Pineau, Charles, Primig, Michael, Jégou, Bernard, Trépos, Mélanie, Groupe d'Etude de la Reproduction Chez l'Homme et les Mammiferes (GERHM), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES), IMV Technologies, Plate-forme protéomique [Rennes], Plateforme Génomique Santé Biogenouest®, Biogenouest Proteomics Core Facility, Ministère de l’Enseignement, de la Recherche et de la Technologie, Inserm Avenir grant No R07216NS, Conseil Régional de Bretagne, European Project: 212844,EC:FP7:ENV,FP7-ENV-2007-1,DEER(2008), Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM), Forgeron, Christine, and Developmental effects of environment on reproductive health - DEER - - EC:FP7:ENV2008-05-01 - 2012-04-30 - 212844 - VALID

Subjects
Epididymis, Male, oestrogen response elements, Rete Testis, Proteome, Tumor Protein, Translationally-Controlled 1, Estrogens, [SDV.BDLR]Life Sciences [q-bio]/Reproductive Biology, androgen, Response Elements, Rats, Rats, Sprague-Dawley, androgene response elements, Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization, Androgens, efferent ducts, Animals, Electrophoresis, Gel, Two-Dimensional, rat, oestrogen, [SDV.BDLR] Life Sciences [q-bio]/Reproductive Biology, Genome-Wide Association Study
Abstract

International audience; The efferent ducts are a series of tubules that conduct sperm from the rete testis to the epididymis. They absorb most fluid and proteins originating from the rete testis during concentration of spermatozoa prior to their entry into the epididymis. Proteome analysis of micro-dissected efferent duct samples from adult rats was combined with genome-wide computational prediction of conserved hormone response elements to identify factors likely regulated by oestrogens and androgens. We identified 165 proteins and found subsets of the promoters controlling their corresponding genes to contain androgen- and oestrogen response elements (ARE/EREs) at similar frequencies. Moreover, EREs were significantly enriched among the loci identified compared with their genome-wide occurrence. The expression and localization of Anxa6, Ckb, Krt19, Park7, Pdzk1 and Tpt1 in the efferent ducts and other related hormone controlled tissues was further validated at the RNA or protein level. This study identifies many novel proteins predicted to play roles in sperm maturation and male fertility and provides significant computational evidence that the efferent ducts express genes transcriptionally controlled by sex hormones.

Published
2010
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8. Génomique expressionnelle et fonctionnelle de la spermatogenèse chez la truite - Spermgen

Author

Le Gac, Florence, Lareyre, Jean-Jacques, Houlgatte, Rémi, Primig, Michael, Chalmel, Frédéric, Joly, Jean-Stéphane, Sohm, Frédéric, Station commune de Recherches en Ichtyophysiologie, Biodiversité et Environnement (SCRIBE), Institut National de la Recherche Agronomique (INRA), Cardiopathies et mort subite [ERL 3147], Université de Nantes (UN)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Groupe d'Etude de la Reproduction Chez l'Homme et les Mammiferes (GERHM), Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM), USC CNRS jeune équipe Développement, Evolution et Plasticité du Système Nerveux (DEPSN), Plateforme d'ingénierie génétique des animaux modèles (AMAGEN), Institut National de la Recherche Agronomique (INRA)-Centre National de la Recherche Scientifique (CNRS), Programme Genanimal 2006 - ANR SPERMGEN, Institut National de la Santé et de la Recherche Médicale (INSERM), Financement : ANR, Superviseur : Florence Le Gac, Partenaires : Institut National de la Santé et de la Recherche Médicale (INSERM), Plateforme d'ingénierie génétique des animaux modèles (AMAGEN), Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Nantes (UN), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Rennes 1 (UR1), and Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)

Subjects
[SDV]Life Sciences [q-bio], [INFO]Computer Science [cs]
Published
2010

9. The non-coding expression program of yeast meiosis

Author

Primig, Michael, Brébion, Alice, Biozentrum, Swiss Institute of Bioinformatics [Lausanne] (SIB), Université de Lausanne (UNIL)-Université de Lausanne (UNIL), Groupe d'Etude de la Reproduction Chez l'Homme et les Mammiferes (GERHM), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES), Université de Lausanne = University of Lausanne (UNIL)-Université de Lausanne = University of Lausanne (UNIL), and Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM)

Subjects
[SDV] Life Sciences [q-bio], [SDV]Life Sciences [q-bio], ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2009

10. Towards total transcript profiling of meiosis and gametogenesis

Author

Primig, Michael, Biozentrum, Swiss Institute of Bioinformatics [Lausanne] (SIB), Université de Lausanne (UNIL)-Université de Lausanne (UNIL), Groupe d'Etude de la Reproduction Chez l'Homme et les Mammiferes (GERHM), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES), Brébion, Alice, Université de Lausanne = University of Lausanne (UNIL)-Université de Lausanne = University of Lausanne (UNIL), and Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM)

Subjects
[SDV.BC]Life Sciences [q-bio]/Cellular Biology, [SDV.BC] Life Sciences [q-bio]/Cellular Biology, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2008

11. SPERMGEN - Gene expression profiling and functional analysis in trout spermatogenesis: gene expression profiles and regulation cross species comparative studies, functional analysis in transgenic fish

Author

Le Gac, Florence, Houlgatte, R., Jégou, B., Joly, Jean-Stephane, Primig, Michael, ProdInra, Migration, Station commune de Recherches en Ichtyophysiologie, Biodiversité et Environnement (SCRIBE), Institut National de la Recherche Agronomique (INRA), Institut Fédératif de Recherche - Génétique Fonctionnelle Agronomie et Santé (IFR 140 GFAS), Institut National de la Santé et de la Recherche Médicale (INSERM), Groupe d'Etude de la Reproduction Chez l'Homme et les Mammiferes (GERHM), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES), USC CNRS jeune équipe Développement, Evolution et Plasticité du Système Nerveux (DEPSN), Swiss Institute of Bioinformatics [Lausanne] (SIB), Université de Lausanne (UNIL), Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM), and Université de Lausanne = University of Lausanne (UNIL)

Subjects
[SDV] Life Sciences [q-bio], [SDV]Life Sciences [q-bio], POISSON TRANSGENIQUE, [INFO]Computer Science [cs], [INFO] Computer Science [cs], ComputingMilieux_MISCELLANEOUS, GENOMIQUE, SALMONIDE
Abstract

National audience

Published
2007

12. Expression profiling of the human male germline reveals novel potential cancer/testis genes

Author

Chalmel, Frédéric, Rolland, Antoine, Niederhauser-Wiederkehr, Christa, Demougin, Philippe, Chung, S., Pineau, Charles, Wolgemuth, Debra J, Jégou, Bernard, Primig, Michael, Groupe d'Etude de la Reproduction Chez l'Homme et les Mammiferes (GERHM), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut National de la Santé et de la Recherche Médicale (INSERM), Biozentrum, Swiss Institute of Bioinformatics [Lausanne] (SIB), Université de Lausanne (UNIL)-Université de Lausanne (UNIL), Swiss Institute of Bioinformatics - Basel, University of Basel (Unibas)-Swiss Institute of Bioinformatics [Lausanne] (SIB), Biozentrum [Basel, Suisse], University of Basel (Unibas), Columbia University Medical Center (CUMC), Columbia University [New York], Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université de Lausanne = University of Lausanne (UNIL)-Université de Lausanne = University of Lausanne (UNIL), Brébion, Alice, Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Rennes 1 (UR1), and Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)

Subjects
[SDV.MHEP.EM] Life Sciences [q-bio]/Human health and pathology/Endocrinology and metabolism, [SDV.MHEP.EM]Life Sciences [q-bio]/Human health and pathology/Endocrinology and metabolism
Published
2006

13. The Core Meiotic Transcriptome in Mammals

Author

Rolland, Antoine, Chalmel, Frédéric, Niederhauser-Wiederkehr, Christa, Demougin, Philippe, Chung, S., Pineau, Charles, Wolgemuth, Debra J, Jégou, Bernard, Primig, Michael, Groupe d'Etude de la Reproduction Chez l'Homme et les Mammiferes (GERHM), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES), Biozentrum, Swiss Institute of Bioinformatics [Lausanne] (SIB), Université de Lausanne (UNIL)-Université de Lausanne (UNIL), Swiss Institute of Bioinformatics - Basel, Université de Lausanne (UNIL)-Université de Lausanne (UNIL)-University of Basel (Unibas), Biozentrum [Basel, Suisse], University of Basel (Unibas), Columbia University Medical Center (CUMC), Columbia University [New York], Brébion, Alice, University of Basel (Unibas)-Swiss Institute of Bioinformatics [Lausanne] (SIB), Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM), and Université de Lausanne = University of Lausanne (UNIL)-Université de Lausanne = University of Lausanne (UNIL)

Subjects
[SDV.MHEP.EM] Life Sciences [q-bio]/Human health and pathology/Endocrinology and metabolism, [SDV.MHEP.EM]Life Sciences [q-bio]/Human health and pathology/Endocrinology and metabolism
Published
2006

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