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1. Spectral and spatial shaping of a laser-produced ion beam for radiation-biology experiments

Author

A. Cirrone, Elsa Bayart, Victor Malka, Frederic Pouzoulet, V. Letellier, Valentina Scuderi, Alessandro Flacco, B. Vauzour, L. Pommarel, Francesco Romano, F. Goudjil, Francesco Schillaci, Catherine Nauraye, Eric Deutsch, Frédérique Mégnin-Chanet, O. Delmas, Laboratoire d'optique appliquée (LOA), École Nationale Supérieure de Techniques Avancées (ENSTA Paris)-École polytechnique (X)-Centre National de la Recherche Scientifique (CNRS), DAM Île-de-France (DAM/DIF), Direction des Applications Militaires (DAM), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Biophysique moléculaire, Institut Curie [Paris]-Institut National de la Santé et de la Recherche Médicale (INSERM), Radiothérapie moléculaire (UMR 1030), Université Paris-Sud - Paris 11 (UP11)-Institut Gustave Roussy (IGR)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut Curie [Paris], Centre de prothonthérapie d'Orsay Institut Curie, Istituto Nazionale di Fisica Nucleare, Sezione di Catania (INFN), Università degli studi di Catania [Catania], MATIS CNR-INFM Dipartimento di Metodologie Fisiche e Chimiche (DMFCI) (MATIS), Università degli studi di Catania [Catania]- Istituto Nazionale di Fisica Nucleare (INFN), Sources compactes de Particules pour Lasers & Applications (SPL), École Nationale Supérieure de Techniques Avancées (ENSTA Paris)-École polytechnique (X)-Centre National de la Recherche Scientifique (CNRS)-École Nationale Supérieure de Techniques Avancées (ENSTA Paris)-École polytechnique (X)-Centre National de la Recherche Scientifique (CNRS), OSEO Project No. I0901001W-SAPHIR, European Project: 339128,EC:FP7:ERC,ERC-2013-ADG,X-FIVE(2014), European Project: 654148,H2020,H2020-INFRAIA-2014-2015,LASERLAB-EUROPE(2015), and Università degli studi di Catania = University of Catania (Unict)

Subjects
Nuclear and High Energy Physics, Physics and Astronomy (miscellaneous), Ion beam, Physics::Instrumentation and Detectors, CELL IRRADIATION EXPERIMENTS, Physics::Medical Physics, Electron, 01 natural sciences, THERAPY, law.invention, Optics, Nuclear magnetic resonance, law, ACCELERATED PROTONS, 0103 physical sciences, Dosimetry, lcsh:Nuclear and particle physics. Atomic energy. Radioactivity, Irradiation, 010306 general physics, ComputingMilieux_MISCELLANEOUS, [PHYS]Physics [physics], [PHYS.PHYS.PHYS-OPTICS]Physics [physics]/Physics [physics]/Optics [physics.optics], [PHYS.PHYS]Physics [physics]/Physics [physics], 010308 nuclear & particles physics, business.industry, Surfaces and Interfaces, Laser, ELECTRONS, Beamline, Magnet, Physics::Accelerator Physics, lcsh:QC770-798, business, [CHIM.RADIO]Chemical Sciences/Radiochemistry, Beam (structure), SYSTEM, RADIOTHERAPY
Abstract

International audience; The study of radiation biology on laser-based accelerators is most interesting due to the unique irradiation conditions they can produce, in terms of peak current and duration of the irradiation. In this paper we present the implementation of a beam transport system to transport and shape the proton beam generated by laser-target interaction for in vitro irradiation of biological samples. A set of four permanent magnet quadrupoles is used to transport and focus the beam, efficiently shaping the spectrum and providing a large and relatively uniform irradiation surface. Real time, absolutely calibrated, dosimetry is installed on the beam line, to enable shot-to-shot control of dose deposition in the irradiated volume. Preliminary results of cell sample irradiation are presented to validate the robustness of the full system.

Published
2017
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2. Genomic Diversity and Evolution of the Lyssaviruses

Author

Edward C. Holmes, Laurent Dacheux, Hervé Bourhy, Olivier Delmas, Chiraz Talbi, Florence Larrous, Christiane Bouchier, Dynamique des Lyssavirus et Adaptation à l'Hôte (DyLAH), Institut Pasteur [Paris] (IP), Pennsylvania State University (Penn State), Penn State System, Génomique (Plate-Forme) - Genomics Platform, O. Delmas was supported by the European commission through the 'VIZIER' Integrated project (LSHG-CT-2004-511966). This work was also funded by the VIZIER program, and by the grant of Genomic Platform Ile de France 'Analyse de la Diversité Génétique des Rhabdoviridae' 2005–2006, and in part by NIH grant number GM080533-01., and European Project: 28804,VIZIER

Subjects
Genome evolution, Genotype, Sequence analysis, [SDV]Life Sciences [q-bio], Molecular Sequence Data, Public Health and Epidemiology/Infectious Diseases, lcsh:Medicine, Genomics, Genome, Viral, Biology, Genome, Virology/Emerging Viral Diseases, Evolution, Molecular, 03 medical and health sciences, Mice, Open Reading Frames, Phylogenetics, Sequence Homology, Nucleic Acid, Infectious Diseases/Viral Infections, Animals, Humans, lcsh:Science, Phylogeny, 030304 developmental biology, Genomic organization, Neurological Disorders/Infectious Diseases of the Nervous System, Whole genome sequencing, Genetics, 0303 health sciences, Base Composition, Multidisciplinary, Phylogenetic tree, Base Sequence, Infectious Diseases/Infectious Diseases of the Nervous System, 030306 microbiology, lcsh:R, Genetic Variation, Virology/Virus Evolution and Symbiosis, Evolutionary Biology/Microbial Evolution and Genomics, Lyssavirus, lcsh:Q, Research Article
Abstract

International audience; Lyssaviruses are RNA viruses with single-strand, negative-sense genomes responsible for rabies-like diseases in mammals. To date, genomic and evolutionary studies have most often utilized partial genome sequences, particularly of the nucleoprotein and glycoprotein genes, with little consideration of genome-scale evolution. Herein, we report the first genomic and evolutionary analysis using complete genome sequences of all recognised lyssavirus genotypes, including 14 new complete genomes of field isolates from 6 genotypes and one genotype that is completely sequenced for the first time. In doing so we significantly increase the extent of genome sequence data available for these important viruses. Our analysis of these genome sequence data reveals that all lyssaviruses have the same genomic organization. A phylogenetic analysis reveals strong geographical structuring, with the greatest genetic diversity in Africa, and an independent origin for the two known genotypes that infect European bats. We also suggest that multiple genotypes may exist within the diversity of viruses currently classified as 'Lagos Bat'. In sum, we show that rigorous phylogenetic techniques based on full length genome sequence provide the best discriminatory power for genotype classification within the lyssaviruses.

Published
2008
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