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1. Associations between untargeted plasma metabolomic signatures and gut microbiota composition in the Milieu Intérieur population of healthy adults

Author

Partula, Valentin, Deschasaux-Tanguy, Mélanie, Mondot, Stanislas, Victor-Bala, Agnès, Bouchemal, Nadia, Lecuyer, Lucie, Bobin-Dubigeon, Christine, Torres, Marion, Kesse-Guyot, Emmanuelle, Charbit, Bruno, Patin, Etienne, Assmann, Karen, Latino-Martel, Paule, Julia, Chantal, Galan, Pilar, Hercberg, Serge, Quintana-Murci, Lluis, Albert, Matthew, Duffy, Darragh, Lantz, Olivier, Savarin, Philippe, Nawfal Triba, Mohamed, Touvier, Mathilde, The Milieu Interieur, Consortium, Deschasaux-Tanguy, Mélanie, Laboratoires d'excellence - GENETIC & ENVIRONMENTAL CONTROL OF IMMUNE PHENOTYPE VARIANCE: ESTABLISHING A PATH TOWARDS PERSONALIZED MEDICINE - - MILIEU INTERIEUR2010 - ANR-10-LABX-0069 - LABX - VALID, Equipe 3: EREN- Equipe de Recherche en Epidémiologie Nutritionnelle (CRESS - U1153), Université Sorbonne Paris Nord-Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS (U1153 / UMR_A_1125 / UMR_S_1153)), Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Université Paris Diderot, Sorbonne Paris Cité, Paris, France, Université Paris Diderot - Paris 7 (UPD7), MICrobiologie de l'ALImentation au Service de la Santé (MICALIS), AgroParisTech-Université Paris-Saclay-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Chimie, Structures et Propriétés de Biomatériaux et d'Agents Thérapeutiques (CSPBAT), Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université Sorbonne Paris Nord, Institut de Cancérologie de l'Ouest [Angers/Nantes] (UNICANCER/ICO), UNICANCER, Mer, molécules et santé EA 2160 (MMS), Le Mans Université (UM)-Université de Nantes - UFR des Sciences et des Techniques (UN UFR ST), Université de Nantes (UN)-Université de Nantes (UN)-Université de Nantes - UFR des Sciences Pharmaceutiques et Biologiques, Université de Nantes (UN)-Université de Nantes (UN), Centre de Recherche Translationnelle - Center for Translational Science (CRT), Institut Pasteur [Paris] (IP), Génétique Evolutive Humaine - Human Evolutionary Genetics, Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS), Département de Santé Publique [Avicenne], Hôpital Avicenne [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Insitro [San Francisco], CIC1428 IGR-CURIE, Institut Curie [Paris]-Institut National de la Santé et de la Recherche Médicale (INSERM), ANR-10-LABX-0069,MILIEU INTERIEUR,GENETIC & ENVIRONMENTAL CONTROL OF IMMUNE PHENOTYPE VARIANCE: ESTABLISHING A PATH TOWARDS PERSONALIZED MEDICINE(2010), Conservatoire National des Arts et Métiers [CNAM] (CNAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Conservatoire National des Arts et Métiers [CNAM] (CNAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Université de Nantes - UFR des Sciences Pharmaceutiques et Biologiques, Université de Nantes (UN)-Université de Nantes (UN)-Le Mans Université (UM)-Université de Nantes - UFR des Sciences et des Techniques (UN UFR ST), Institut Pasteur [Paris], Institut Pasteur [Paris]-Centre National de la Recherche Scientifique (CNRS), Immunobiologie des Cellules dendritiques, and Institut Pasteur [Paris]-Institut National de la Santé et de la Recherche Médicale (INSERM)

Subjects
0301 basic medicine, Epidemiology, Population, False discovery rate, Medicine (miscellaneous), Faecalibacterium prausnitzii, Gut microbiota, Gut flora, FDR, 03 medical and health sciences, NMR metabolomics, 0302 clinical medicine, Metabolomics, Species level, Negatively associated, epidemiology, Cross-sectional population-based studies, host-gut microbiota relationships, education, Host–gut microbiota relationships, Metabolomic signatures and gut microbiota Gut microbiota, Genetics, education.field_of_study, CPMG, Nutrition and Dietetics, biology, Mass spectrometry, cross-sectional population-based study, biology.organism_classification, [SDV.AEN] Life Sciences [q-bio]/Food and Nutrition, 030104 developmental biology, epidemiology. Study registration: NCT01699893 Carr-Purcell-Meiboom-Gill, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, 030220 oncology & carcinogenesis, Composition (visual arts), [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Species richness, [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition
Abstract

Host–microbial co-metabolism products are being increasingly recognised to play important roles in physiological processes. However, studies undertaking a comprehensive approach to consider host–microbial metabolic relationships remain scarce. Metabolomic analysis yielding detailed information regarding metabolites found in a given biological compartment holds promise for such an approach. This work aimed to explore the associations between host plasma metabolomic signatures and gut microbiota composition in healthy adults of the Milieu Intérieur study. For 846 subjects, gut microbiota composition was profiled through sequencing of the 16S rRNA gene in stools. Metabolomic signatures were generated through proton NMR analysis of plasma. The associations between metabolomic variables and α- and β-diversity indexes and relative taxa abundances were tested using multi-adjusted partial Spearman correlations, permutational ANOVA and multivariate associations with linear models, respectively. A multiple testing correction was applied (Benjamini–Hochberg, 10 % false discovery rate). Microbial richness was negatively associated with lipid-related signals and positively associated with amino acids, choline, creatinine, glucose and citrate (−0·133 ≤ Spearman’s ρ ≤ 0·126). Specific associations between metabolomic signals and abundances of taxa were detected (twenty-five at the genus level and nineteen at the species level): notably, numerous associations were observed for creatinine (positively associated with eleven species and negatively associated with Faecalibacterium prausnitzii). This large-scale population-based study highlights metabolites associated with gut microbial features and provides new insights into the understanding of complex host–gut microbiota metabolic relationships. In particular, our results support the implication of a ‘gut–kidney axis’. More studies providing a detailed exploration of these complex interactions and their implications for host health are needed.

Published
2020
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2. Porphyromonas, a potential predictive biomarker of Pseudomonas aeruginosa pulmonary infection in cystic fibrosis

Author

Keravec, Marlène, Mounier, Jérôme, Guilloux, Charles-Antoine, Fangous, Marie-Sarah, Mondot, Stanislas, Vallet, Sophie, Gouriou, Stéphanie, Le Berre, Rozenn, Rault, Gilles, Férec, Claude, Barbier, Georges, Lepage, Patricia, Héry-Arnaud, Geneviève, Université de Bretagne Occidentale, Institut National de la Santé et de la Recherche Médicale (INSERM), MICrobiologie de l'ALImentation au Service de la Santé (MICALIS), Institut National de la Recherche Agronomique (INRA)-AgroParisTech, Université Paris Saclay (COmUE), Centre de Ressources et de Compétences pour la Mucoviscidose Enfants, Partenaires INRAE, French Cystic Fibrosis Association 'Vaincre la Mucoviscidose' RC20170501971, French Cystic Fibrosis Association 'Gregory Lemarchal' RC20170501971, and ProdInra, Migration

Subjects
cystic fibrosis, [SDV] Life Sciences [q-bio], [SDV]Life Sciences [q-bio], microbiota, biomarkers, porphyromonas, pseudomonas aeruginosa
Abstract

Additional material is published online only. To view please visit the journal online (http://dx.doi.org/10.1136/bmjresp-2018-000374).; International audience; Introduction : Pseudomonas aeruginosa pulmonary infections are the primary cause of morbi-mortality in patients with cystic fibrosis (CF). In this cohort study, the objective was to identify candidate biomarkers of P. aeruginosa infection within the airway microbiota. Methods : A 3-year prospective multicentre study (PYOMUCO study) was conducted in Western France and included patients initially P. aeruginosa free for at least 1year. A 16S-targeted metagenomics approach was applied on iterative sputum samples of a first set of patients (n=33). The composition of airway microbiota was compared according to their P. aeruginosa status at the end of the follow-up (colonised vs non-colonised), and biomarkers associated with P. aeruginosa were screened. In a second step, the distribution of a candidate biomarker according to the two groups of patients was verified by qPCR on a second set of patients (n=52) coming from the same cohort and its load quantified throughout the follow-up. Results : Porphyromonas (mainly P. catoniae) was found to be an enriched phylotype in patients uninfected by P. aeruginosa (pDiscussion : Further studies on replication cohorts are needed to validate this potential predictive biomarker, which may be relevant for the follow-up in the early years of patients with CF. The identification of infection candidate biomarkers may offer new strategies for CF prevision medicine.

Published
2019
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3. Alternative stable states in the intestinal ecosystem: proof of concept and a perspective of therapeutic implications

Author

Van De Guchte, Maarten, Burz, Sebastian, Cadiou, Julie, Wu, Jiangbo, Mondot, Stanislas, Blottiere, Hervé M., Dore, Joël, MICrobiologie de l'ALImentation au Service de la Santé (MICALIS), Institut National de la Recherche Agronomique (INRA)-AgroParisTech, MetaGenoPolis, Institut National de la Recherche Agronomique (INRA), Assessing, preserving and restoring man-microbes symbiosis Homo.symbiosus 788191, and Danone Nutricia ResearchEuropean Commission under ERC-2017-AdG n.788191-Homo.symbiosus.

Subjects
Inflammation, [SDV.EE]Life Sciences [q-bio]/Ecology, environment, [SDV.EE.SANT]Life Sciences [q-bio]/Ecology, environment/Health, GI tract, Interaction, Microbiota, Host, [SDV]Life Sciences [q-bio], [SDV.EE.ECO]Life Sciences [q-bio]/Ecology, environment/Ecosystems, Alternative stable states, Therapy, Intestinal ecosystem, Symbiosis, Cure, [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition, ComputingMilieux_MISCELLANEOUS, [SDV.EE.IEO]Life Sciences [q-bio]/Ecology, environment/Symbiosis
Abstract

International audience

Published
2019
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4. Associations entre profils métabolomiques plasmatiques rmn et composition du microbiote intestinal au sein d’une population d’adultes francais en bonne santé

Author

PARTULA, Valentin, Mondot, Stanislas, TORRES, Marion, Kesse-Guyot, Emmanuelle, LECUYER, Lucie, Deschasaux, Mélanie, Assmann, Karen, Latino-Martel, Paule, Buscail, Camille, Julia, Chantal, Galan, Pilar, Hercberg, Serge, Victor-Bala, A, Bouchemal, Nadia, Triba, M, Savarin, Philippe, Rouilly, Vincent, Thomas, S, Quintana-Murci, Lluis, Albert, M, Lantz, Olivier, Duffy, Darragh, Touvier, Mathilde, Consortium Milieu Intérieur, ., Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS (U1153 / UMR_A_1125 / UMR_S_1153)), Université Paris Diderot - Paris 7 (UPD7)-Université Sorbonne Paris Cité (USPC)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Recherche Agronomique (INRA), MICrobiologie de l'ALImentation au Service de la Santé (MICALIS), Institut National de la Recherche Agronomique (INRA)-AgroParisTech, Chimie, Structures et Propriétés de Biomatériaux et d'Agents Thérapeutiques (CSPBAT), Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université Paris 13 (UP13)-Institut Galilée-Université Sorbonne Paris Cité (USPC), Institut Pasteur [Paris], Department of Cancer Immunology, Genentech, Inc. [San Francisco], Institut Curie [Paris], Institut National de la Recherche Agronomique (INRA)-Université Paris Diderot - Paris 7 (UPD7)-Université Paris Descartes - Paris 5 (UPD5)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université Paris 13 (UP13)-Institut Galilée-Université Sorbonne Paris Cité (USPC)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), and Institut Pasteur [Paris] (IP)

Subjects
0303 health sciences, 03 medical and health sciences, 0302 clinical medicine, Nutrition and Dietetics, profils metabolomiques, microbiote intestinal, 030309 nutrition & dietetics, Endocrinology, Diabetes and Metabolism, [SDV]Life Sciences [q-bio], Internal Medicine, 030209 endocrinology & metabolism
Abstract

Discipline Epidemiologie. Introduction et but de l’etude Le co-metabolisme hote-microbiote est a l’origine d’un tres grand nombre de molecules integrees au sein d’axes metaboliques complexes. De nombreuses etudes se sont attachees a la caracterisation fonctionnelle specifique de certaines de ces molecules (AGCC, BCAA, TMAO, etc.), mais les etudes envisageant plus globalement les relations metaboliques entre l’hote et son microbiote intestinal restent rares. A ce titre, l’etude globale des metabolites endogenes et exogenes presents dans le plasma par metabolomique non ciblee semble prometteuse. L’objectif de cette etude etait de caracteriser les associations entre profils metabolomiques plasmatiques et composition du microbiote intestinal dans une population d’adultes en bonne sante. Materiel et methodes La composition du microbiote intestinal a ete determinee dans les selles (sequencage du gene ARNr16S, les matrices de Jaccard et Bray-Curtis ont ete determinees) et les profils metabolomiques ont ete generes en utilisant les sequences RMN CPMG et NOESY sur des echantillons de plasma, chez 846 individus de la population Milieu Interieur. La co-structure globale des donnees 16S et RMN a ete evaluee par co-inertie. Les associations entre variables metabolomiques d’une part et matrices de β-diversite ou abondance des taxons d’autre part ont ete calculees par PERMANOVA ou MaAsLin ajustes sur le sexe, l’âge, l’IMC, le statut tabagique et l’activite physique (PERMANOVA egalement ajustees sur la profondeur de sequencage). Une correction de Benjamini-Hochberg (FDR-10 %) a ete appliquee. Resultats et Analyse statistique La co-inertie globale des donnees microbiote et metabolomique etait limitee (RV ≤ 0,05). En revanche, des associations specifiques ont ete detectees. Les matrices de Jaccard et de Bray-Curtis etaient significativement et respectivement associees a 51 et 3 variables CPMG, dont certaines ont d’ores et deja ete identifiees (pyruvate, tyrosine, choline, glucose, etc.). Des associations entre le pyruvate et 3 genres bacteriens (positives avec Catabacter et Acholeplasma, negative avec Faecalibacterium) ont ete mises en evidence. L’analyse des associations entre variables metabolomiques NOESY et donnees microbiote 16S, et l’identification des metabolites discriminants sont en cours. Conclusion Ces resultats preliminaires permettent de mettre en evidence des associations entre le profil metabolomique RMN determine sur le plasma de l’hote et la composition du microbiote intestinal. Toutefois, cette etude ne permet pas de conclure sur une potentielle relation causale, et d’autres etudes sont necessaires.

Published
2018
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5. A porphyromonas-Pseudomonas aeruginosa 'pas de deux' in the airways microbiota of cystic fibrosis patients

Author

Guilloux, C., Schutz, S., Mondot, Stanislas, Herv-Arnaud, G., Université de Bretagne Occidentale, MICrobiologie de l'ALImentation au Service de la Santé (MICALIS), Institut National de la Recherche Agronomique (INRA)-AgroParisTech, Université Paris Saclay (COmUE), French CF association, and Vaincre la Mucoviscidose

Subjects
[SDV]Life Sciences [q-bio], ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2018
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6. Associations entre les consommations alimentaires et la composition du microbiote intestinal au sein d’une population d’adultes français en bonne santé

Author

PARTULA, Valentin, Mondot, Stanislas, Torres, M., Kesse-Guyot, Emmanuelle, Deschasaux, Mélanie, Latino-Martel, Paule, Galan Hercberg, Maria Del Pilar, Hercberg, Serge, Quintana-Murci, Lluis, Albert, M., Duffy, D., Touvier, Mathilde, Consortium Milieu Intérieur, ., Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS (U1153 / UMR_A_1125 / UMR_S_1153)), Institut National de la Recherche Agronomique (INRA)-Université Paris Diderot - Paris 7 (UPD7)-Université Paris Descartes - Paris 5 (UPD5)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM), MICrobiologie de l'ALImentation au Service de la Santé (MICALIS), Institut National de la Recherche Agronomique (INRA)-AgroParisTech, Université Paris Nord (Paris 13), Génétique Evolutive Humaine - Human Evolutionary Genetics, Institut Pasteur [Paris]-Centre National de la Recherche Scientifique (CNRS), Immunité Innée - Innate Immunity, Institut Pasteur [Paris]-Institut National de la Santé et de la Recherche Médicale (INSERM), and Societe Francaise de Nutrition Enterale et Parenterale (SFNEP). et Societe Francaise de Nutrition (SFN), FRA.

Subjects
[SDV]Life Sciences [q-bio], consommations alimentaires, ComputingMilieux_MISCELLANEOUS, population d'adultes français en bonne santé, composition du microbiote intestinale
Abstract

National audience

Published
2017

7. The human gut microbiome and its dysfunctions through the meta-omics prism

Author

Mondot, Stanislas, Lepage, Patricia, MICrobiologie de l'ALImentation au Service de la Santé (MICALIS), and Institut National de la Recherche Agronomique (INRA)-AgroParisTech

Subjects
metagenomics, inflammation, networks, [SDV]Life Sciences [q-bio], digestive, oral, and skin physiology, microbiota, digestive system, intestine
Abstract

The microorganisms inhabiting the human gut are abundant (1014 cells) and diverse (approximately 500 species per individual). It is nowacknowledged that the microbiota has coevolved with its host to achieve a symbiotic relationship, leading to physiological homeostasis. The gut microbiota ensures vital functions, such as food digestibility, maturation of the host immune system, and protection against pathogens. Over the last few decades, the gut microbiota has also been associated with numerous diseases, such as inflammatory bowel disease, irritable bowel syndrome, obesity, and metabolic diseases. In most of these pathologies, a microbial dysbiosis has been found, indicating shifts in the taxonomic composition of the gut microbiota and changes in its functionality. Our understanding of the influence of the gut microbiota on human health is still growing. Working with microorganisms residing in the gut is challenging since most of them are anaerobic and a vast majority (approximately 75%) are uncultivable to date. Recently, a wide range of new approaches (meta-omics) has been developed to bypass the uncultivability and reveal the intricate mechanisms that sustain gut microbial homeostasis. After a brief description of these approaches (metagenomics, metatranscriptomics, metaproteomics, and metabolomics), this review will discuss the importance of considering the gut microbiome as a structured ecosystem and the use of meta-omics to decipher dysfunctions of the gut microbiome in diseases.

Published
2016
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8. Habitudes alimentaires et composition du microbiote intestinal dans une population d'adultes français en bonne santé : étude préliminaire

Author

TORRES, Marion, Mondot, Stanislas, Kesse-Guyot, Emmanuelle, Szabo de Edelenyi, Fabien, Lantz, Olivier, Latino-Martel, Paule, Galan, Maria del Pilar, Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS (U1153 / UMR_A_1125 / UMR_S_1153)), Institut National de la Recherche Agronomique (INRA)-Université Paris Diderot - Paris 7 (UPD7)-Université Paris Descartes - Paris 5 (UPD5)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut Pasteur [Paris], and Institut Curie [Paris]

Subjects
microbiote, [SDV]Life Sciences [q-bio], épidémiologie, ComputingMilieux_MISCELLANEOUS, Nutrition
Abstract

National audience

Published
2015

9. Eating habits and intestinal microbiota composition of healthy french people: preliminary study

Author

Torres, Jean Marion, Mondot, Stanislas, Kesse-Guyot, Emmanuelle, Szabo de Edelenyi, Fabien, Lantz, Olivier, Latino-Martel, Paule, Galan, Pilar, Institut National de la Recherche Agronomique (INRA), MICrobiologie de l'ALImentation au Service de la Santé (MICALIS), Institut National de la Recherche Agronomique (INRA)-AgroParisTech, Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS (U1153 / UMR_A_1125 / UMR_S_1153)), Institut National de la Recherche Agronomique (INRA)-Université Paris Diderot - Paris 7 (UPD7)-Université Paris Descartes - Paris 5 (UPD5)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM), and Institut Pasteur [Paris]

Subjects
fluids and secretions, [SDV]Life Sciences [q-bio], digestive, oral, and skin physiology
Abstract

National audience; By the past, studies have shown that diet modulate intestinal microbiota. Our objective was to compare intestinal microbiota composition of healthy subjects, according to food groups’ consumption. Our study includes 134 individuals from the Milieu Intérieur Healthy Donor Cohort, mean age 40.4y; 57.5% women. Eating habits were assessed using a food frequency questionnaire. Composition of the faecal microbiota was established by 16S rRNA gene sequencing. OTU abundance was log10 transformed and OTUs were grouped by phylum and genus. We compared taxa abundance according to eating habits of subjects (ANOVA tests –age and gender adjusted). Compared to individuals that consume more frequently the food group concerned, those who eat less often fish had more Eubacterium spp., Ruminococcus spp., Streptococcus spp. and Actinobacteria. Those who eat less often cheese had less Coprococcus spp., Faecalibacterium spp., Prevotella spp., and Bacteroidetes, and more of Actinobacteria and Verrucomicrobia. Those who eat less often deep-fried foods had less Coprobacillus spp., Turicibacter spp. and Tenericutes. This preliminary study highlights associations between eating habits and microbiota composition. Investigation of associations between gut microbiota composition and diet patterns rather than specific food compounds could be useful to identify microbiota/nutrition signatures related to health

Published
2015

10. Characterization of a microbiota of intestinal origin in white adipose tissue and stroma vascular fraction from healthy and patients according to their BMI

Author

Serino, M., Luche, E., Klopp, P., Chabo, C., Bouchez, Olivier, Klopp, Christophe, Mariette, Jérôme, Lluch, Jérôme, Iacovoni, J., Mondot, Stanislas, Lepage, Patricia, Dore, Joel, Bouloumie, A., Valet, P., Burcelin, R., Institut de médecine moléculaire de Rangueil (I2MR), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-IFR150-Institut National de la Santé et de la Recherche Médicale (INSERM), Laboratoire de Génétique Cellulaire (LGC), Ecole Nationale Vétérinaire de Toulouse (ENVT), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Recherche Agronomique (INRA), Unité de Biométrie et Intelligence Artificielle (UBIA), Institut National de la Recherche Agronomique (INRA), MICrobiologie de l'ALImentation au Service de la Santé (MICALIS), Institut National de la Recherche Agronomique (INRA)-AgroParisTech, Institut National de la Recherche Agronomique (INRA)-Ecole Nationale Vétérinaire de Toulouse (ENVT), and Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées

Subjects
[SDV.SA]Life Sciences [q-bio]/Agricultural sciences, obesity, microbiota, gut
Abstract

absent

Published
2011

11. La concentration sanguine d'ADN bactérien prédit la survenue du diabète en population générale

Author

Amar, J., Chabo, C., Lange, C., Serino, M., Iacovoni, J., Mondot, Stanislas, Lepage, Patricia, Mariette, J., Lantieri, O., Perez, L., Marre, Michel, Klopp, P., Courtney, Michael, Charles, M. A., Balkau, B., Burcelin, R., U558, Institut National de la Santé et de la Recherche Médicale (INSERM), Institut de médecine moléculaire de Rangueil (I2MR), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-IFR150-Institut National de la Santé et de la Recherche Médicale (INSERM), U1018, MICrobiologie de l'ALImentation au Service de la Santé (MICALIS), Institut National de la Recherche Agronomique (INRA)-AgroParisTech, Genotoul Platform, Institut National de la Recherche Agronomique (INRA), Déterminants génétiques du diabète de type 2 et de ses complications vasculaires ((U 695)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Diderot - Paris 7 (UPD7), Génopole Toulouse Midi-Pyrénées [Auzeville] (GENOTOUL), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Ecole Nationale Vétérinaire de Toulouse (ENVT), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Ecole Nationale Vétérinaire de Toulouse (ENVT), Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM), and Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM)

Subjects
[SDV.SA]Life Sciences [q-bio]/Agricultural sciences
Abstract

absent

Published
2011

12. Comparative assessment of human and farm animal faecal microbiota using real-time quantitative PCR

Author

Furet, Jean-pierre, Firmesse, Olivier, Gourmelon, Michele, Bridonneau, Chantal, Tap, Julien, Mondot, Stanislas, Dore, Joel, Corthier, Gerard, Unité de recherche d'Écologie et Physiologie du Système Digestif (UEPSD), Institut National de la Recherche Agronomique (INRA), and Institut Français de Recherche pour l'Exploitation de la Mer (IFREMER)

Subjects
Clostridium, DNA, Bacterial, [SDV]Life Sciences [q-bio], Sequence Analysis, DNA, Polymerase Chain Reaction, Sensitivity and Specificity, Feces, fluids and secretions, Animals, Domestic, RNA, Ribosomal, 16S, quantitative PCR, Animals, Bacteroides, Humans, human, Bifidobacterium, faecal microbiota, farm animals
Abstract

International audience; Pollution of the environment by human and animal faecal pollution affects the safety of shellfish, drinking water and recreational beaches. To pinpoint the origin of contaminations, it is essential to define the differences between human microbiota and that of farm animals. A strategy based on real-time quantitative PCR (qPCR) assays was therefore developed and applied to compare the composition of intestinal microbiota of these two groups. Primers were designed to quantify the 16S rRNA gene from dominant and subdominant bacterial groups. TaqMan probes were defined for the qPCR technique used for dominant microbiota. Human faecal microbiota was compared with that of farm animals using faecal samples collected from rabbits, goats, horses, pigs, sheep and cows. Three dominant bacterial groups (Bacteroides/Prevotella, Clostridium coccoides and Bifidobacterium) of the human microbiota showed differential population levels in animal species. The Clostridium leptum group showed the lowest differences among human and farm animal species. Human subdominant bacterial groups were highly variable in animal species. Partial least squares regression indicated that the human microbiota could be distinguished from all farm animals studied. This culture-independent comparative assessment of the faecal microbiota between humans and farm animals will prove useful in identifying biomarkers of human and animal faecal contaminations that can be applied to microbial source tracking methods.

Published
2009
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