1. Correlates of the ratio of acceleration time to ejection time in patients with aortic stenosis: An echocardiographic and computed tomography study
- Author
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Laurent Macron, Manuel Toledano, A. Altes, A. Truffier, Cédric Renard, Sylvestre Maréchaux, Yohann Bohbot, Pierre Graux, Gagandeep Chadha, Raphaëlle-Ashley Guerbaai, Julien Dreyfus, Pierre Vladimir Ennezat, Christophe Tribouilloy, David Attias, M. Sochala, Centre cardiologique du Nord (CCN), CHU Amiens-Picardie, University of Basel (Unibas), Mécanismes physiopathologiques et conséquences des calcifications vasculaires - UR UPJV 7517 (MP3CV), and Université de Picardie Jules Verne (UPJV)-CHU Amiens-Picardie
- Subjects
Male ,medicine.medical_specialty ,Time Factors ,[SDV]Life Sciences [q-bio] ,Acceleration ,Hemodynamics ,Computed tomography ,Acceleration time ,030204 cardiovascular system & hematology ,Severity of Illness Index ,Ventricular Function, Left ,03 medical and health sciences ,0302 clinical medicine ,Predictive Value of Tests ,Internal medicine ,medicine ,Humans ,In patient ,030212 general & internal medicine ,Registries ,ComputingMilieux_MISCELLANEOUS ,Aged ,Retrospective Studies ,Aged, 80 and over ,Univariate analysis ,Ejection fraction ,medicine.diagnostic_test ,business.industry ,Calcinosis ,Stroke Volume ,General Medicine ,Aortic Valve Stenosis ,medicine.disease ,Prognosis ,Echocardiography, Doppler ,Stenosis ,Blood pressure ,Aortic valve stenosis ,Aortic Valve ,Cardiology ,Female ,France ,Ejection time ,Cardiology and Cardiovascular Medicine ,business ,Tomography, X-Ray Computed - Abstract
An increased acceleration time to ejection time (AT/ET) ratio is associated with increased mortality in patients with aortic stenosis (AS).To identify the factors associated with an increased AT/ET ratio.The relationships between the AT/ET ratio and clinical and Doppler echocardiographic variables of interest in the setting of AS were analysed retrospectively in 1107 patients with AS and preserved left ventricular (LV) ejection fraction (LVEF). The computed tomography aortic valve calcium (CT-AVC) score was studied in a subgroup of 342 patients.In the univariate analysis, the AT/ET ratio was found to correlate with peak aortic jet velocity (r=0.57; P0.0001), mean pressure gradient (r=0.60; P0.0001), aortic valve area (r=-0.50; P0.0001) and CT-AVC score (r=0.24; P0.0001). The AT/ET ratio had good accuracy in predicting a peak aortic jet velocity≥4 m/s, a mean pressure gradient≥40mmHg and an aortic valve area≤1.0cmThe AT/ET ratio is related to echocardiographic and CT-AVC indices of AS severity. However, multiple intricate factors beyond the haemodynamic and anatomical severity of AS influence the AT/ET ratio, including LV geometry, function and systolic blood pressure. These findings should be considered when assessing the AT/ET ratio in patients with AS and preserved LVEF.
- Published
- 2019
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