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2 results on '"Mélanie Gressette"'

1. Cardiolipin content controls mitochondrial coupling and energetic efficiency in muscle

Author

Serge Luquet, Vladimir Veksler, Céline Henry, Alexandre Prola, Marie Maurer, Alexandra Malgoyre, Hadrien Chauvin, Stéphane Guyot, Jordan Blondelle, Audrey Solgadi, Frédéric Relaix, Frederic Joubert, Fanny Pilot-Storck, Cindy Gallerne, Jean Demarquoy, Geneviève Derumeaux, F. Dumont, Laurent Guillaud, Laurent Tiret, Julien Ternacle, Mélanie Gressette, Arnaud Mourier, Aymeline Vandestienne, Guillaume Courtin, Marie-France Giraud, Nathalie Koulmann, Nahed Khadhraoui, Jérôme Piquereau, Raphaël G. P. Denis, Julien Castel, Thibaut Molinié, Institut Mondor de Recherche Biomédicale (IMRB), Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR10-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Signalisation et physiopathologie cardiovasculaire (CARPAT), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, Unité de Biologie Fonctionnelle et Adaptative (BFA (UMR_8251 / U1133)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Procédés Microbiologiques et Biotechnologiques (PMB), Procédés Alimentaires et Microbiologiques (PAM), Université de Bourgogne (UB)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Université de Bourgogne (UB)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Procédés Alimentaires et Microbiologiques [Dijon] (PAM), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université de Bourgogne (UB)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Université Bourgogne Franche-Comté [COMUE] (UBFC)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement, Institut de biochimie et génétique cellulaires (IBGC), Université Bordeaux Segalen - Bordeaux 2-Centre National de la Recherche Scientifique (CNRS), MICrobiologie de l'ALImentation au Service de la Santé (MICALIS), AgroParisTech-Université Paris-Saclay-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Ingénierie et Plateformes au Service de l'Innovation Thérapeutique (IPSIT), Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Procédés Alimentaires et Microbiologiques [Dijon] (PAM), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université de Bourgogne (UB)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement, Laboratoire de Biologie de l'Exercice pour la Performance et la Santé (LBEPS), Université d'Évry-Val-d'Essonne (UEVE)-Université Paris-Saclay-Institut de Recherche Biomédicale des Armées (IRBA), École du Val de Grâce (EVDG), Service de Santé des Armées, Université Paris-Saclay, Faculté de Pharmacie, 92290 Châtenay-Malabry, France, Plateforme d'Analyse Protéomique de Paris Sud Ouest (PAPPSO), AFM-Téléthon Translamuscle I (#19507) & Translamuscle II (#22946), ANR-12-JSV1-0005,LipidoMyo,Rôle des acides gras à très longue chaîne dans la physiopathologie musculaire(2012), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Université de Bourgogne (UB)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Université Bourgogne Franche-Comté [COMUE] (UBFC)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Université Bourgogne Franche-Comté [COMUE] (UBFC), Université de Bourgogne (UB)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Université Bourgogne Franche-Comté [COMUE] (UBFC), Dijon, Institut Agro, and Université d'Évry-Val-d'Essonne (UEVE)-Université Paris-Saclay-Institut de Recherche Biomédicale des Armées [Brétigny-sur-Orge] (IRBA)

Subjects
muscle, [SDV]Life Sciences [q-bio], Respiratory chain, Diseases and Disorders, Oxidative phosphorylation, [SDV.BC]Life Sciences [q-bio]/Cellular Biology, 030204 cardiovascular system & hematology, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, medicine, Cardiolipin, [SDV.BBM] Life Sciences [q-bio]/Biochemistry, Molecular Biology, [SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology, Inner mitochondrial membrane, [SDV.BC] Life Sciences [q-bio]/Cellular Biology, Research Articles, Fatty acid synthesis, ComputingMilieux_MISCELLANEOUS, 030304 developmental biology, 2. Zero hunger, chemistry.chemical_classification, 0303 health sciences, Multidisciplinary, [SDV.MHEP] Life Sciences [q-bio]/Human health and pathology, ATP synthase, biology, fungi, food and beverages, SciAdv r-articles, Skeletal muscle, Fatty acid, Cell Biology, mitochondrial, Cell biology, medicine.anatomical_structure, chemistry, biology.protein, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology, Research Article
Abstract

Decreasing mitochondrial energy-production efficiency in skeletal muscle can confer protection against diet-induced obesity., Unbalanced energy partitioning participates in the rise of obesity, a major public health concern in many countries. Increasing basal energy expenditure has been proposed as a strategy to fight obesity yet raises efficiency and safety concerns. Here, we show that mice deficient for a muscle-specific enzyme of very-long-chain fatty acid synthesis display increased basal energy expenditure and protection against high-fat diet–induced obesity. Mechanistically, muscle-specific modulation of the very-long-chain fatty acid pathway was associated with a reduced content of the inner mitochondrial membrane phospholipid cardiolipin and a blunted coupling efficiency between the respiratory chain and adenosine 5′-triphosphate (ATP) synthase, which was restored by cardiolipin enrichment. Our study reveals that selective increase of lipid oxidative capacities in skeletal muscle, through the cardiolipin-dependent lowering of mitochondrial ATP production, provides an effective option against obesity at the whole-body level.

Published
2021
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2. The BET Bromodomain Inhibitor I-BET-151 Induces Structural and Functional Alterations of the Heart Mitochondria in Healthy Male Mice and Rats

Author

Christine Péchoux, Natalia Gambaryan, Marc Humbert, Fabrice Antigny, Sharon Mumby, Angèle Boet, Ian M. Adcock, Benoit Ranchoux, Mélanie Gressette, Catherine Rucker-Martin, Mélanie Lambert, Valérie Domergue, David Montani, Anne Garnier, Jérôme Piquereau, Frédéric Perros, Perros, Frédéric, Jeunes Chercheuses et Jeunes Chercheurs - Mécanismes épigénétiques dans l'inflammation et le remodelage vasculaire de l'hypertension pulmonaire - - EMIR2013 - ANR-13-JSV1-0011 - JC - VALID, Idex Paris-Saclay - - IPS2011 - ANR-11-IDEX-0003 - IDEX - VALID, Signalisation et physiopathologie cardiovasculaire (UMRS1180), Institut National de la Santé et de la Recherche Médicale (INSERM), Hypertension arterielle pulmonaire physiopathologie et innovation thérapeutique, Centre Chirurgical Marie Lannelongue (CCML)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université Paris-Saclay, Université Paris-Sud - Paris 11 - Faculté de médecine (UP11 UFR Médecine), Université Paris-Sud - Paris 11 (UP11), Réanimation des cardiopathies congénitales [Le Plessis-Robinson] (Centre chirurgical Marie Lannelongue), Centre Chirurgical Marie Lannelongue (CCML), Génétique Animale et Biologie Intégrative (GABI), Institut National de la Recherche Agronomique (INRA)-AgroParisTech, National Heart and Lung Institute [London] (NHLI), Imperial College London-Royal Brompton and Harefield NHS Foundation Trust, Institut Paris Saclay d’Innovation Thérapeutique (IPSIT), Université Paris-Sud - Paris 11 (UP11)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), This work was supported by research grants from INSERM, National Funding Agency for Research (ANR) (Grant ANR-13-JSV1-0011-01), Laboratoire d’Excellence (LabEx) en Recherche sur le Médicament et l’Innovation Thérapeutique (LERMIT), Assistance Publique Hôpitaux de Paris (Département Hospitalo-Universitaire Thorax Innovation), Legs Poix (Chancellerie des Universités de Paris). F.A. was supported by a post-doctoral grant from Aviesan and by Lefoulon Delalande Institute. INSERM UMR_S 999 research unit, ANR-13-JSV1-0011,EMIR,Mécanismes épigénétiques dans l'inflammation et le remodelage vasculaire de l'hypertension pulmonaire(2013), ANR-11-IDEX-0003,IPS,Idex Paris-Saclay(2011), Centre chirurgical Marie Lannelongue-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre chirurgical Marie Lannelongue, and AgroParisTech-Institut National de la Recherche Agronomique (INRA)

Subjects
Male, 0301 basic medicine, Chemistry, Multidisciplinary, Cardiomyopathy, MELANOMA, Mitochondrion, Mitochondria, Heart, lcsh:Chemistry, Electrocardiography, 0302 clinical medicine, Medicine, Citrate synthase, lcsh:QH301-705.5, Spectroscopy, biology, COMBINING BET, General Medicine, 3. Good health, Computer Science Applications, [SDV.MHEP.CSC] Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, mitochondria, Chemistry, medicine.anatomical_structure, Organ Specificity, 030220 oncology & carcinogenesis, Physical Sciences, HDAC INHIBITORS, Life Sciences & Biomedicine, Biochemistry & Molecular Biology, medicine.medical_specialty, PROTEINS, 0699 Other Biological Sciences, bromodomain and extra-terminal domain, cardiotoxicity, heart, Heterocyclic Compounds, 4 or More Rings, Article, Catalysis, Inorganic Chemistry, 03 medical and health sciences, [SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, bromodomain and extra-terminal domain inhibitor, medicine.artery, Internal medicine, 0399 Other Chemical Sciences, C-MYC, Animals, STRATEGY, Rats, Wistar, Physical and Theoretical Chemistry, Molecular Biology, 0604 Genetics, Cardiotoxicity, Aorta, Science & Technology, Chemical Physics, business.industry, Organic Chemistry, Skeletal muscle, medicine.disease, Bromodomain, Mice, Inbred C57BL, 030104 developmental biology, Endocrinology, lcsh:Biology (General), lcsh:QD1-999, Pulmonary artery, biology.protein, business
Abstract

The bromodomain and extra-terminal domain family inhibitors (BETi) are a promising new class of anticancer agents. Since numerous anticancer drugs have been correlated to cardiomyopathy, and since BETi can affect non-cancerous tissues, we aimed to investigate in healthy animals any ultrastructural BETi-induced alterations of the heart as compared to skeletal muscle. Male Wistar rats were either treated during 3 weeks with I-BET-151 (2 or 10 mg/kg/day) (W3) or treated for 3 weeks then allowed to recover for another 3 weeks (W6) (3-weeks drug washout). Male C57Bl/6J mice were only treated during 5 days (50 mg/kg/day). We demonstrated the occurrence of ultrastructural alterations and progressive destruction of cardiomyocyte mitochondria after I-BET-151 exposure. Those mitochondrial alterations were cardiac muscle-specific, since the skeletal muscles of exposed animals were similar in ultrastructure presentation to the non-exposed animals. I-BET-151 decreased the respiration rate of heart mitochondria in a dose-dependent manner. At the higher dose, it also decreased mitochondrial mass, as evidenced by reduced right ventricular citrate synthase content. I-BET-151 reduced the right and left ventricular fractional shortening. The concomitant decrease in the velocity-time-integral in both the aorta and the pulmonary artery is also suggestive of an impaired heart function. The possible context-dependent cardiac side effects of these drugs have to be appreciated. Future studies should focus on the basic mechanisms of potential cardiovascular toxicities induced by BETi and strategies to minimize these unexpected complications.

Published
2019
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