1. Maternal and neonatal outcomes related to Zika virus in pregnant women in Southern Vietnam: An epidemiological and virological prospective analysis
- Author
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Anna Zhukova, Loan Thi Kim Huynh, Thach Van Dang, Hung Thanh Nguyen, Minh Nguyen Quang Ngo, Manh H. Dao, Frédéric Lemoine, Dao Thi Nhu Hoang, Minh Ngoc Nguyen, Tuyet Thi Diem Hoang, Tai Doan Tan Pham, Linh Dang Khanh Vien, Nhu Tuan Nguyen, Arnaud Fontanet, Quyen Ngoc Truc Nguyen, Hai Thanh Pham, Quang Chan Luong, Thai Chau Tran, Thao Thi Thanh Nguyen, Quan Hoang Nguyen, Thang Minh Cao, Quang Duy Pham, Géraldine Piorkowski, Anh Thi Vu, Lien Bich Le, Nhan Nguyen Thanh Le, Hang Thi Thu Pham, Xavier de Lamballerie, Rebecca Grant, Institut Pasteur [Paris] (IP), Sorbonne Université (SU), Institut Pasteur d'Ho Chi Minh Ville, Réseau International des Instituts Pasteur (RIIP), Unité des Virus Emergents (UVE), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Children's Hospital No.1 [Ho Chi Minh City], Hung Vuong Hospital, Tu Du Hospital, Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM), INCEPTION project (PIA/ANR-16-CONV-0005) and a grant received from BNP Paribas Simplidon., We would like to thank David Baud and Leo Pomar from the Lausanne University Hospital, Switzerland for their assistance with the interpretation of the adverse fetal outcomes., ANR-16-CONV-0005,INCEPTION,Institut Convergences pour l'étude de l'Emergence des Pathologies au Travers des Individus et des populatiONs(2016), Zhukova, Anna, Institut Convergences pour l'étude de l'Emergence des Pathologies au Travers des Individus et des populatiONs - - INCEPTION2016 - ANR-16-CONV-0005 - CONV - VALID, and Institut Pasteur [Paris]
- Subjects
medicine.medical_specialty ,Microcephaly ,Serology ,Zika virus ,03 medical and health sciences ,0302 clinical medicine ,Epidemiology ,Internal Medicine ,medicine ,030212 general & internal medicine ,Clade ,030304 developmental biology ,[INFO.INFO-BI] Computer Science [cs]/Bioinformatics [q-bio.QM] ,0303 health sciences ,Pregnancy ,biology ,Obstetrics ,business.industry ,Health Policy ,Medical record ,Public Health, Environmental and Occupational Health ,Obstetrics and Gynecology ,Outbreak ,medicine.disease ,biology.organism_classification ,3. Good health ,Psychiatry and Mental health ,Infectious Diseases ,Pediatrics, Perinatology and Child Health ,Geriatrics and Gerontology ,Public aspects of medicine ,RA1-1270 ,[INFO.INFO-BI]Computer Science [cs]/Bioinformatics [q-bio.QM] ,business ,Research Paper - Abstract
Background In 2016-2017, 68 women in Southern Vietnam had RT-PCR confirmed Zika virus (ZIKV) infection during pregnancy. We report here the outcomes of the pregnancies and the virological analyses related to this outbreak. Methods We collected clinical and epidemiological information from the women who were enrolled in the study. Medical records related to the pregnancy in 2016–2017 were retrieved for those who were not able to be enrolled in the study. Children born to women with ZIKV infection during pregnancy were also enrolled. Serum samples were evaluated for presence of ZIKV antibodies. Phylogenetic analyses were performed on Zika virus genomes sequenced from the 2016–2017 serum samples. Findings Of the 68 pregnancies, 58 were livebirths and 10 were medically terminated. Four of the medical records from cases of fetal demise were able to be retrieved, of which one was consistent with congenital ZIKV infection. Of the 58 women with a livebirth, 21 participated in the follow-up investigation. All but two women had serologic evidence of ZIKV infection. Of the 21 children included in the study (mean age: 30.3 months), 3 had microcephaly at birth. No other clinical abnormalities were reported and no differences in neurodevelopment were observed compared to a control group. Phylogenetic analysis revealed a clade within the ZIKV Asian lineage and branch at the root of samples from the 2013–2014 French Polynesian outbreak. The prM S139N mutation was not observed. Interpretation We have been able to demonstrate a clade within the ZIKV Asian lineage implicated in adverse pregnancy outcomes in Southern Vietnam. Funding INCEPTION project (PIA/ANR-16-CONV-0005) and a grant received from BNP Paribas Simplidon.
- Published
- 2021
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