1. Quantum dots encapsulated with curcumin inhibit the growth of colon cancer, breast cancer and bacterial cells
- Author
-
Woroud Haroun, Abdeslam-Hassen Meniai, Iman Almansour, Firdos Alam Khan, Khulood M. Al-Khater, Sarah Mousa Asiri, Widyan Alamoudi, Wahida Louaer, Abdelhamid Elaissari, Narimane Lammari, Sultan Akhtar, Adeeb Shezad Muhammad Siar, Imam Abdulrahman bin Faisal University, Laboratoire d'automatique, de génie des procédés et de génie pharmaceutique (LAGEPP), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-École Supérieure Chimie Physique Électronique de Lyon-Centre National de la Recherche Scientifique (CNRS), and University of Constantine
- Subjects
Curcumin ,Colorectal cancer ,Biomedical Engineering ,Medicine (miscellaneous) ,Nanoparticle ,Breast Neoplasms ,Bioengineering ,02 engineering and technology ,Development ,Bacterial growth ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Breast cancer ,Quantum Dots ,Spectroscopy, Fourier Transform Infrared ,medicine ,Humans ,[CHIM]Chemical Sciences ,General Materials Science ,Viability assay ,ComputingMilieux_MISCELLANEOUS ,Antibacterial agent ,Bacteria ,Chemistry ,021001 nanoscience & nanotechnology ,medicine.disease ,HEK293 Cells ,[SDU]Sciences of the Universe [physics] ,030220 oncology & carcinogenesis ,Colonic Neoplasms ,Drug delivery ,MCF-7 Cells ,Cancer research ,Nanoparticles ,0210 nano-technology - Abstract
Aim: To synthesize and examine the impact of free Eudragit® RS 100 nanoparticles (LN01), Quantum dots curcumin-loaded Eudragit RS 100 nanoparticles (LN04), and un-encapsulated curcumin nanoparticles (LN06) on cancerous and bacterial cells. Materials & methods: The LN01, LN04, LN06 were synthesized and characterized by Fourier transform infrared, ζ potential, UV–Vis spectroscopy, transmission electron microscopy and scanning electron microscopy and their biological activities were evaluated. Results: LN04 profoundly inhibited the growth of colon (HCT-116) cancerous cells (10.64% cell viability) and breast cancer (MCF-7) cells (10.32% cell viability) with compared to LN01 and LN06. Normal cells (HEK-293) did not show any inhibition after treatments. In addition, LN04 show better inhibitory action on bacterial growth compared with LN01 and LN06. Conclusion: We suggest that LN04 selectively target cancerous and bacterial cells and therefore possess potential anticancer and antibacterial capabilities.
- Published
- 2020
- Full Text
- View/download PDF