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3 results on '"Justina Motiejunaite"'

1. Residual ground glass opacities three months after Covid-19 pneumonia correlate to alteration of respiratory function: The post Covid M3 study

Author

Florence Arnoult, Martin Flamant, Christian Straus, Jésus Gonzalez-Bermejo, Hélène Benzaquen, Justine Frija-Masson, Dominique Penaud, Capucine Morélot-Panzini, Marie-Pierre Debray, Morgane Faure, Antoine Guerder, Victoria Donciu, Camille Taillé, Justina Motiejunaite, Maria Alejandra Galarza-Jimenez, Pierantonio Laveneziana, François-Xavier Lescure, Olivier Lucidarme, Antoine Khalil, Catherine Bancal, Thomas Similowski, Roxane Malrin, Samia Boussouar, Marie-Pia d'Ortho, Alban Redheuil, Emmanuelle Vidal-Petiot, Maladies neurodéveloppementales et neurovasculaires (NeuroDiderot (UMR_S_1141 / U1141)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP), AP-HP - Hôpital Bichat - Claude Bernard [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Physiopathologie et Epidémiologie des Maladies Respiratoires (PHERE (UMR_S_1152 / U1152)), Laboratoire d'Imagerie Biomédicale (LIB), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Institute of cardiometabolism and nutrition (ICAN), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Service de radiologie cardiovasculaire et interventionnelle [CHU Pitié-Salpêtrière], CHU Pitié-Salpêtrière [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Service de Pneumologie et Réanimation Médicale [CHU Pitié-Salpêtrière] (Département ' R3S '), Neurophysiologie Respiratoire Expérimentale et Clinique, Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), Sorbonne Université (SU), Service de Radiologie [CHU Pitié-Salpétrière], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Pitié-Salpêtrière [AP-HP], Centre de recherche sur l'Inflammation (CRI (UMR_S_1149 / ERL_8252 / U1149)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Infection, Anti-microbiens, Modélisation, Evolution (IAME (UMR_S_1137 / U1137)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP)-Université Sorbonne Paris Nord, Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPC), Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases [IHU ICAN], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Institut de Cardiométabolisme et Nutrition = Institute of Cardiometabolism and Nutrition [CHU Pitié Salpêtrière] (IHU ICAN), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Pitié-Salpêtrière [AP-HP], Service de Radiologie cardiovasculaire et interventionnelle [CHU Pitié-Salpêtrière], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Neurophysiologie Respiratoire Expérimentale et Clinique (UMRS 1158), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPC), and Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPC)-Université Sorbonne Paris Nord

Subjects
Pulmonary and Respiratory Medicine, Male, medicine.medical_specialty, ARDS, Vital capacity, Time Factors, Gastroenterology, Severity of Illness Index, [SDV.MHEP.PSR]Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tract, 03 medical and health sciences, FEV1/FVC ratio, 0302 clinical medicine, Chest CT, DLCO, Fibrosis, TLCO, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, Internal medicine, Forced Expiratory Volume, Severity of illness, Medicine, Humans, Respiratory function, 030212 general & internal medicine, Lung, Retrospective Studies, Original Research, [SDV.MHEP.ME]Life Sciences [q-bio]/Human health and pathology/Emerging diseases, business.industry, SARS-CoV-2, COVID-19, Retrospective cohort study, Pneumonia, Middle Aged, respiratory system, medicine.disease, 3. Good health, Respiratory Function Tests, respiratory tract diseases, Invasive ventilation, 030228 respiratory system, Female, Radiography, Thoracic, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, business, Tomography, X-Ray Computed
Abstract

International audience; Introduction: Lung function in survivors of SARS-Co-V2 pneumonia is poorly known, but concern over the possibility of sequelae exists.Methods: Retrospective study on survivors with confirmed infection and pneumonia on chest-CT. Correlations between PFT and residual radiologic anomalies at three months taking into account initial clinical and radiological severity and steroid use during acute phase.Results: 137 patients (69 men, median age 59 (Q1 50; Q3 68), BMI 27.5 kg/m2 (25.1; 31.7)) were assessed. Only 32.9% had normal PFT, 75 had altered DLCO. Median (Q1; Q3) values were: VC 79 (66; 92) % pred, FEV1 81 (68; 89), TLC 78 (67; 85), DLCO 60 (44; 72), and KCO 89 (77; 105). Ground glass opacities (GGO) were present in 103 patients (75%), reticulations in 42 (30%), and fibrosis in 18 (13%). There were significantly lower FEV1 (p = 0.0089), FVC (p = 0.0010), TLC (p < 0.0001) and DLCO (p < 0.0001) for patients with GGO, lower TLC (p = 0.0913) and DLCO (p = 0.0181) between patients with reticulations and lower FVC (p = 0.0618), TLC (p = 0.0742) DLCO (p = 0.002) and KCO (p = 0.0114) between patients with fibrosis. Patients with initial ≥50% lung involvement had significantly lower FEV1 (p = 0.0019), FVC (p = 0.0033), TLC (p = 0.0028) and DLCO (p = 0.0003) compared to patients with ≤10%. There was no difference in PFT and residual CT lesions between patients who received steroids and those who did not.Conclusion: The majority of patients have altered PFT at three months, even in patients with mild initial disease, with significantly lower function in patients with residual CT lesions. Steroids do not seem to modify functional and radiological recovery. Long-term follow-up is needed.

Published
2021
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2. Treatment and outcome of adult patients with acute asthma in emergency departments in Australasia, South East Asia and Europe: Are guidelines followed? AANZDEM/EuroDEM study

Author

Cinzia Barletta, Gerben Keijzers, Sharon Klim, Peter A. Jones, Colin A. Graham, Simon Craig, Franck Verschuren, Anna Holdgate, Said Laribi, Oene van Meer, Luis Garcia-Castrillo, Adela Golea, Justina Motiejunaite, Win Sen Kuan, Richard Body, Mehmet Akif Karamercan, Jean Capsec, Anne-Maree Kelly, Veli-Pekka Harjola, Michael Christ, Biomarqueurs CArdioNeuroVASCulaires (BioCANVAS), Université Paris 13 (UP13)-Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM), iThemba Laboratory for Accelerator Based Science, Emergency Department (FV - ED), Saint Luc University Hospital, and UCL - SSS/IREC/MEDA - Pôle de médecine aiguë

Subjects
Adult, Male, medicine.medical_specialty, emergency department, Adolescent, medicine.medical_treatment, [SDV]Life Sciences [q-bio], Guidelines as Topic, dyspnoea, Cohort Studies, 03 medical and health sciences, 0302 clinical medicine, Oxygen therapy, medicine, Humans, 030212 general & internal medicine, Prospective Studies, Prospective cohort study, Asia, Southeastern, ComputingMilieux_MISCELLANEOUS, Asthma, Aged, Aged, 80 and over, Australasia, business.industry, 030208 emergency & critical care medicine, Interrupted Time Series Analysis, Emergency department, Guideline, asthma, Middle Aged, medicine.disease, Comorbidity, 3. Good health, Bronchodilator Agents, Europe, Outcome and Process Assessment, Health Care, Treatment Outcome, Cohort, Emergency medicine, Emergency Medicine, outcome, Female, business, Emergency Service, Hospital, management, Cohort study
Abstract

© 2019 Australasian College for Emergency MedicineObjective: Asthma exacerbations are common presentations to ED. Key guideline recommendations for management include administration of inhaled bronchodilators, systemic corticosteroids and titrated oxygen therapy. Our aim was to compare management and outcomes between patients treated for asthma in Europe (EUR) and South East Asia/Australasia (SEA) and compliance with international guidelines. Methods: In each region, prospective, interrupted time series studies were performed including adult (age >18 years) patients presenting to ED with the main complaint of dyspnoea during three 72 h periods. This was a planned sub-study that included those with an ED primary diagnosis of asthma. Data was collected on demographics, clinical features, treatment in ED, diagnosis, disposition and in-hospital outcome. The results of interest were differences in treatment and outcome between EUR and SEA cohorts. Results: Five hundred and eighty-four patients were identified from 112 EDs (66 EUR and 46 SEA). The cohorts had similar demographics and co-morbidity patterns, with 89% of the cohort having a previous diagnosis of asthma. There were no significant differences in treatment between EUR and SEA patients – inhaled beta-agonists were administered in 86% of cases, systemic corticosteroids in 66%, oxygen therapy in 44% and antibiotics in 20%. Two thirds of patients were discharged home from the ED. Conclusion: The data suggests that compliance with guideline-recommended therapy in both regions, particularly corticosteroid administration, is sub-optimal. It also suggests over-use of antibiotics.

Published
2019
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3. East Asia may have a better 1-year survival following an acute heart failure episode compared with Europe: results from an international observational cohort

Author

Alain Cohen-Solal, Alexandre Mebazaa, Said Laribi, Christian Mueller, Eiichi Akiyama, Kazuo Kimura, Katsuya Kajimoto, Jiri Parenica, Jindrich Spinar, Naoki Sato, Dong-Ju Choi, Aldo P. Maggioni, Johan Lassus, Justina Motiejunaite, Jian Zhang, Lucas Van Aelst, Etienne Gayat, Mattia Arrigo, Jelena Čelutkienė, Jin Joo Park, Shiro Ishihara, Òscar Miró, Kouichi Tamura, Yuhui Zhang, Biomarqueurs CArdioNeuroVASCulaires (BioCANVAS), Université Paris 13 (UP13)-Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM), University of Helsinki, Groupe Hospitalier Saint Louis - Lariboisière - Fernand Widal [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Institut fuer Theoretische Physik (Institut fuer Theoretische Physik), Universität Heidelberg [Heidelberg], University Hospital Brno, Seoul National University [Seoul] (SNU), Nippon Medical School [Tokyo, Japan], Beijing Academy of Agriculture and Forestry Sciences, Université Paris Diderot - Paris 7 (UPD7), Département d'Anesthésie Réanimation SMUR [Paris], and Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Groupe Hospitalier Saint Louis - Lariboisière - Fernand Widal [Paris]

Subjects
Male, medicine.medical_specialty, [SDV]Life Sciences [q-bio], Population, MEDLINE, 030204 cardiovascular system & hematology, Affect (psychology), 03 medical and health sciences, 0302 clinical medicine, medicine, Humans, Multicenter Studies as Topic, Generalizability theory, 030212 general & internal medicine, Disease management (health), Intensive care medicine, education, ComputingMilieux_MISCELLANEOUS, Aged, Aged, 80 and over, Heart Failure, education.field_of_study, Asia, Eastern, business.industry, Disease Management, Middle Aged, Prognosis, medicine.disease, 3. Good health, Europe, Survival Rate, Observational Studies as Topic, Heart failure, Acute Disease, Cohort, Female, Observational study, Cardiology and Cardiovascular Medicine, business
Abstract

Acute heart failure (AHF) is a major health problem worldwide and trials to assess novel therapies are increasingly global, as a means to reduce costs, expedite timelines, provide broad applicability, and satisfy regulatory authorities.The significant geographic differences in patient characteristics, outcomes, and treatment effect may affect trial results and raise important questions about generalizability of the results to a broader population.

Published
2018
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