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6 results on '"Jean-Pierre Villemot"'

1. Prognostic factors associated with 15-year mortality in patients with hospitalized systolic HF: Results of the observational community-based EPICAL cohort study

Author

Faiez Zannad, Jean-Pierre Villemot, François Alla, Nelly Agrinier, Nathalie Thilly, Serge Briançon, Paul-Michel Mertes, Yves Juillière, CIC 1433 Epidémiologie clinique, Institut National de la Santé et de la Recherche Médicale (INSERM), Maladies chroniques, santé perçue, et processus d'adaptation (APEMAC), Université de Lorraine (UL), Université Paris Descartes - Paris 5 (UPD5), Centre d'Investigation Clinique - Epidemiologie Clinique/essais Cliniques Nancy, Cancéropôle du Grand Est-Institut National de la Santé et de la Recherche Médicale (INSERM), Service de Cardiologie [CHRU Nancy], Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), CIC-Nancy, Institut Lorrain du Coeur et des Vaisseaux Louis Mathieu [Nancy]-Institut National de la Santé et de la Recherche Médicale (INSERM), Nouvel Hôpital Civil, Hospices Civils de Strasbourg, Fédération de Médecine Translationnelle de Strasbourg (FMTS), Université de Strasbourg (UNISTRA), Service de Chirurgie Cardio-vasculaire [CHRU Nancy], EPICAL, Centre d'investigation clinique - Epidémiologie clinique [Nancy] (CIC-EC), Centre d'investigation clinique [Nancy] (CIC), Université de Lorraine (UL)-Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL)-Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université de Lorraine (UL)-Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL)-Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL), and Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL)

Subjects
Male, Survival rate, Time Factors, Kaplan-Meier Estimate, 030204 cardiovascular system & hematology, Severity of Illness Index, Cohort Studies, 0302 clinical medicine, Cause of Death, 030212 general & internal medicine, Prospective Studies, Survivors, Prospective cohort study, ComputingMilieux_MISCELLANEOUS, education.field_of_study, Ejection fraction, Age Factors, Middle Aged, Prognosis, 3. Good health, Hospitalization, Female, France, Cardiology and Cardiovascular Medicine, Cohort study, medicine.medical_specialty, Population, Heart failure, Prognostic factors, Risk Assessment, 03 medical and health sciences, Sex Factors, Predictive Value of Tests, Internal medicine, medicine, Humans, education, Aged, Proportional Hazards Models, Proportional hazards model, business.industry, medicine.disease, Comorbidity, Survival Analysis, Multivariate Analysis, Physical therapy, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, business, Heart Failure, Systolic
Abstract

Aims Little data on very long-term survival and associated prognostic factors in heart failure (HF) are available. The aim was to describe 15-year survival and to identify the baseline prognostic factors associated with mortality in a community-based sample of patients hospitalized for systolic HF. Methods Vital status was collected 15years after inclusion of 352 patients hospitalized for systolic HF born in France from the prospective cohort EPICAL. The prognostic value of baseline socioeconomic, clinical and biological characteristics on 15-year mortality was assessed using Cox models. Results The mean (±SD) age was 63.9 (±10.8)years, 76% of the patients were male, median left ventricular ejection fraction (LVEF) was 23% IR [18–27]. Overall, the mean (±SD) follow-up was 1826 (±111)days. A total of 290 (82.4%) deaths and 22 heart transplantations occurred during the follow-up. The 15-year survival rate was 13.2% (95% CI [9.0–16.3]), i.e. 4.7 times lower than the one observed in the general population. Baseline characteristics associated with 15-year mortality were: age older than 65years (HR=1.48, CI 95% [1.15–1.90]), diabetes mellitus (1.31 [1.00–1.72]), chronic kidney disease (1.73 [1.23–2.43]), serious comorbidity (1.29 [1.02–1.64]), time from first HF diagnosis exceeding 1year at inclusion (1.68 [1.26–2.24]), HF hospitalization during the previous 12months (1.36 [1.04–1.78]), heart rate higher than 110 beats per minute (1.87 [1.26–2.76]), LVEF % (0.88 per quartile increase [0.80–1.98]), and serum sodium below 130mmol/L (3.14 [1.76–5.61]. Conclusions Only 13% of patients hospitalized for HF survived at 15years. The usual mid-term prognostic factors are also predictive of very long-term survival.

Published
2017

2. Small Cardiac Hemangioma: A Challenge for Diagnosis and Dilemma for Management

Author

Pierre-Yves Marie, Yihua Liu, Virginie Cahn, Damien Mandry, Nguyen Tran, Jean-Pierre Villemot, Pablo Maureira, Christine Selton-Suty, Thierry Folliguet, Service de Chirurgie Cardio-vasculaire [CHRU Nancy], Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), Service de Cardiologie [CHRU Nancy], Service d'Imagerie Médicale [CHRU Nancy], Défaillance Cardiovasculaire Aiguë et Chronique (DCAC), Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL), Imagerie Adaptative Diagnostique et Interventionnelle (IADI), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL), Ecole de Chirurgie, Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Faculté de Médecine, Service de Pathologie [CHRU Nancy], and Université de Lorraine (UL)-Institut National de la Santé et de la Recherche Médicale (INSERM)

Subjects
Pulmonary and Respiratory Medicine, Coronary angiography, Male, medicine.medical_specialty, Time Factors, Heart Ventricles, Magnetic Resonance Imaging, Cine, 030204 cardiovascular system & hematology, Risk Assessment, Diagnosis, Differential, Heart Neoplasms, 03 medical and health sciences, 0302 clinical medicine, Image Interpretation, Computer-Assisted, medicine, Humans, Neoplasm Invasiveness, Hemangioma, Capillary, Cardiac Surgical Procedures, Cardiac Tumors, Neoplasm Staging, medicine.diagnostic_test, business.industry, Capillary hemangioma, Cardiac hemangioma, Myxoma, Magnetic resonance imaging, Middle Aged, medicine.disease, 3. Good health, Surgery, Tumor Burden, medicine.anatomical_structure, Treatment Outcome, 030228 respiratory system, Ventricle, Echocardiography, Clinical diagnosis, Radiology, Cardiology and Cardiovascular Medicine, business, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology, Follow-Up Studies
Abstract

International audience; A small cardiac tumor in the left ventricle was discovered incidentally in a 53-year-old patient by echocardiography and was further confirmed by magnetic resonance imaging. A clinical diagnosis of "fibroelastoma or myxoma with an atypical location?" was made, and an uneventful surgical resection was carried out in consideration of the potential embolic risk. The histologic analysis revealed a capillary hemangioma. A posteriori, we reviewed the coronary angiography performed 2 years earlier and found a typical "tumor blush" sign. We discuss the diagnostic features of this case and the alternative approaches that could have been chosen, including a conservative approach with close follow-up.

Published
2014

3. Left atrial radiofrequency ablation during mitral valve surgery: a prospective randomized multicentre study (SAFIR)

Author

Brigitte DeBreyne, Thierry Caus, Jean-François Obadia, Philippe Chevalier, Christian Dechillou, Jean-Pierre Villemot, P. Touboul, Philippe Mabot, Serge Barry, Hervé Corbineau, Jean-Claude Deharo, Alain Leizorovicz, Jean-Pierre Carteaux, Pablo Maureira, Service de cardiologie, Hôpital Est -Lyon, Evaluation et modélisation des effets thérapeutiques, Département biostatistiques et modélisation pour la santé et l'environnement [LBBE], Laboratoire de Biométrie et Biologie Evolutive - UMR 5558 (LBBE), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS)-Laboratoire de Biométrie et Biologie Evolutive - UMR 5558 (LBBE), Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS), Service de Chirurgie Cardio-vasculaire [CHRU Nancy], Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), Service de chirurgie thoracique cardiaque et vasculaire [Rennes] = Thoracic and Cardiovascular Surgery [Rennes], CHU Pontchaillou [Rennes], Service de chirurgie cardiaque, Université de la Méditerranée - Aix-Marseille 2-Assistance Publique - Hôpitaux de Marseille (APHM)- Hôpital de la Timone [CHU - APHM] (TIMONE), Service de cardiologie et maladies vasculaires [Rennes] = Cardiac, Thoracic, and Vascular Surgery [Rennes], Service de Cardiologie [CHRU Nancy], Service de chirurgie thoracique cardiaque et vasculaire [Rennes], Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Hôpital Pontchaillou-CHU Pontchaillou [Rennes], and Service de cardiologie et maladies vasculaires [Rennes]

Subjects
Male, Time Factors, Heart disease, Radiofrequency ablation, Heart Valve Diseases, 030204 cardiovascular system & hematology, law.invention, 0302 clinical medicine, [INFO.INFO-TS]Computer Science [cs]/Signal and Image Processing, Recurrence, law, Mitral valve, Clinical endpoint, Sinus rhythm, MESH: Double-Blind Method, Prospective Studies, 030212 general & internal medicine, Stroke, Ultrasonography, MESH: Treatment Outcome, MESH: Aged, MESH: Middle Aged, MESH: Cardiac Surgical Procedures, Atrial fibrillation, General Medicine, Middle Aged, 3. Good health, MESH: Atrial Fibrillation, Treatment Outcome, medicine.anatomical_structure, Catheter Ablation, Cardiology, cardiovascular system, Mitral Valve, Female, [SDV.IB]Life Sciences [q-bio]/Bioengineering, France, Cardiology and Cardiovascular Medicine, [SPI.SIGNAL]Engineering Sciences [physics]/Signal and Image processing, medicine.medical_specialty, MESH: Stroke, 03 medical and health sciences, Double-Blind Method, [SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, Valvulpathie mitrale, Internal medicine, Fibrillation atriale, medicine, Humans, cardiovascular diseases, Cardiac Surgical Procedures, Aged, MESH: Humans, MESH: Catheter Ablation, business.industry, MESH: Time Factors, Ablation par courant de radiofréquence, MESH: Heart Valve Diseases, MESH: Mitral Valve, medicine.disease, MESH: Male, MESH: Prospective Studies, Surgery, MESH: Recurrence, MESH: France, Mitral valve disease, Concomitant, business, MESH: Female
Abstract

International audience; BACKGROUND: Randomized studies evaluating left atrial radiofrequency ablation (RFA) in patients with persistent atrial fibrillation undergoing mitral valve surgery are scarce and monocentric. AIM: To evaluate the efficacy of left atrial RFA concomitant with mitral valve surgery to restore and maintain sinus rhythm. METHODS: The SAFIR is a multicentre, double-blinded, centrally randomized study involving four university hospitals. Between December 2002 and September 2005, 43 patients with mitral valve disease and long-standing, persistent atrial fibrillation (duration>6 months) were included. We compared valvular surgery alone (n=22) or with left atrial RFA (n=21). The main endpoint was sinus rhythm at 12 months without recurrence of arrhythmia during follow-up. Secondary endpoints were surgical adverse events, atrial fibrillation relapses, stroke and echocardiographic measurements after three and 12 months' follow-up. Analyses of the efficacy criteria were performed on an intention-to-treat basis. RESULTS: The primary endpoint occurred significantly more often in the RFA group than in the control group (respectively, 12/21 patients [57%] vs 1/22 patients [4%]; p=0.004). There were more patients with sinus rhythm in the RFA group than in the control group at discharge (72.7% vs 4.8%; p

Published
2009

4. Detection and prediction of acute heart transplant rejection with the myocardial T-2 determination provided by a black-blood magnetic resonance imaging sequence

Author

N. Hassan, Jean Pierre Villemot, Gilles Karcher, Kiril Tzvetanov, Jean Pierre Carteaux, Paul Walker, Pierre Y. Marie, Sophie Mattei, Nicolas Danchin, Olivier Claudon, J.M. Escanye, Michael Angioi, Alain Bertrand, Service de Médecine Nucléaire [Nancy], Centre Hospitalier Régional Universitaire de Nancy ( CHRU Nancy ), Risque cardiovasculaire, rigidité-fibrose et hypercoagulabilité ( RCV ), Université Henri Poincaré - Nancy 1 ( UHP ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), Service de Cardiologie [CHRU Nancy], Service d'Hématologie [CHRU Nancy], laboratoire de methodologie RMN, Université Henri Poincaré - Nancy 1 ( UHP ) -Centre National de la Recherche Scientifique ( CNRS ), Service de Chirurgie Cardiaque [CHRU Nancy], Imagerie Adaptative Diagnostique et Interventionnelle ( IADI ), Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Université de Lorraine ( UL ), Service de cardiologie [Rouen], CHU Rouen-Université de Rouen Normandie ( UNIROUEN ), Normandie Université ( NU ) -Normandie Université ( NU ), Laboratoire Electronique, Informatique et Image ( Le2i ), Université de Bourgogne ( UB ) -AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Centre National de la Recherche Scientifique ( CNRS ), Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), Risque cardiovasculaire, rigidité-fibrose et hypercoagulabilité (RCV), Université Henri Poincaré - Nancy 1 (UHP)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université Henri Poincaré - Nancy 1 (UHP)-Centre National de la Recherche Scientifique (CNRS), Imagerie Adaptative Diagnostique et Interventionnelle (IADI), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL), Service de cardiologie [CHU Rouen], CHU Rouen, Normandie Université (NU)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU), Laboratoire Electronique, Informatique et Image [UMR6306] (Le2i), Université de Bourgogne (UB)-Centre National de la Recherche Scientifique (CNRS)-École Nationale Supérieure d'Arts et Métiers (ENSAM), Arts et Métiers Sciences et Technologies, HESAM Université (HESAM)-HESAM Université (HESAM)-Arts et Métiers Sciences et Technologies, HESAM Université (HESAM)-HESAM Université (HESAM)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement, Université de Rouen Normandie (UNIROUEN), and Normandie Université (NU)-Normandie Université (NU)-CHU Rouen

Subjects
Adult, Graft Rejection, Male, Adolescent, medicine.medical_treatment, Black blood, 030204 cardiovascular system & hematology, 030218 nuclear medicine & medical imaging, 03 medical and health sciences, 0302 clinical medicine, Biopsy, medicine, [INFO.INFO-IM]Computer Science [cs]/Medical Imaging, Humans, Lung transplantation, Aged, Heart transplantation, medicine.diagnostic_test, [ INFO.INFO-IM ] Computer Science [cs]/Medical Imaging, business.industry, Magnetic resonance imaging, Middle Aged, Magnetic Resonance Imaging, Echocardiography, Doppler, Transplantation, Heart transplant rejection, Heart Transplantation, Female, Cardiology and Cardiovascular Medicine, Nuclear medicine, business, Complication
Abstract

International audience; Abstract: OBJECTIVES This study aimed to determine whether the myocardial T-2 relaxation time, determined using a black-blood magnetic resonance imaging (MRI) sequence, could predict acute heart transplant rejection. BACKGROUND The use of black-blood MRI sequences allows suppression of the confusing influence of blood signal when myocardial T-2 is calculated to detect myocardial edema. METHODS A total of 123 investigations, including cardiac MRI and myocardial biopsy, were performed 8 +/- 11 months after heart transplantation. Myocardial T-2 was determined using an original inversion-recovery/spin-echo sequence. RESULTS A higher than normal T-2 (greater than or equal to 56 ms) allowed an accurate detection of the moderate acute rejections evidenced at baseline biopsy (greater than or equal to International Society for Heart and Lung Transplantation grade 2): sensitivity, 89% and specificity, 70% (p < 0.0001). T-2 was increased in grade 2 (n = 11) compared with grade 0 (n = 49, p < 0.05), grade 1A (n = 34, p < 0.05) and grade 1B (n = 21, p < 0.05); T-2 was further increased in grade 3 (n = 8) compared with grade 2 (p < 0.05). In addition, in patients without rejection equal to or greater than grade 2 at baseline, a T-2 higher than normal (56 ms) was correlated with the subsequent occurrence of equal or greater than grade 2 rejection within the next three months: sensitivity 63% (12/19) and specificity 78% (64/82) (p = 0.001). CONCLUSIONS Myocardial T-2 determined using a black-blood MRI sequence, is sufficiently sensitive to identify most; of the moderate acute rejections documented with biopsy at the same time, but is also a predictor of the subsequent occurrence of such biopsy-defined rejections.

Published
2001

5. Study of myocardial adenosine metabolism using microdialysis?$eapplication to the model of brain dead pig and during cardioprotection under cardiopulmonary by-pass in man

Author

Halejcio-Delophont, Patricia, Université Henri Poincaré - Nancy 1 (UHP), Université Henri Poincaré - Nancy 1, Jean-Pierre Villemot, and UL, Thèses

Subjects
Cardiovasculaire, [SDV.MHEP] Life Sciences [q-bio]/Human health and pathology, Myocarde, Microdialyse cérébrale, Microdialyse, Adénosine, Cardioprotection, Mort cérébrale, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract

Not available, Non disponible

Published
1998

6. Etude chez le porc des conséquences de la mort cérébrale et de l'infarctus expérimental sur les communications intercellulaires myocardiques : noradrénaline, neuropeptide Y, angiotensine II et endothéline-1 : médiateurs vasoconstricteurs

Author

El-Abbassi, Khalid, UL, Thèses, Université Henri Poincaré - Nancy 1 (UHP), Université Henri Poincaré - Nancy 1, and Jean-Pierre Villemot

Subjects
Suidae, Porc, Angiotensine II, [SDV.MHEP] Life Sciences [q-bio]/Human health and pathology, Endothélines, Facteurs EDCF, [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], Infarctus du myocarde, Neuropeptide Y, [SDV.NEU] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology, Norépinéphrine, Mort cérébrale
Abstract

Non disponible / Not available, L'analyse des communications intercellulaires et de leurs rôles dans l'intégration neuroendocrine du tissu cardiaque est examinée dans deux modèles physiopathologiques, la mort cérébrale et l'infarctus expérimental du myocarde chez le porc. Le développement d'une application originale de la technique de microdialyse du liquide interstitiel à l'étude du myocarde permet le monitorage de la libération de noradrénaline (NA) et de trois peptides vasoconstricteurs, le Neuropeptide Y, (NPY) l'Angiotensine II (Ang II) et l'Endothéline (ET-I). Après la mort cérébrale, l'existence d'une libration massive de NA et prolongée du NPY, explique la survenue de lésions myocardiques précoces selon un mécanisme toxique direct et/ou d'une vasoconstriction coronaire. Une production myocardique d'Ang II et une libération préférentielle d'ET-I vers le pôle tissulaire sont également démontrés. Ce dernier peptide ne semble pas être responsable de l'ischémie myocardique globale observée chez les animaux en état de mort cérébrale. L'analyse des conséquences d'une ischémie myocardique focalisée sur la neurotransmission sympathique met en évidence une libération modérée de NPY utilisé comme témoin d'exocytose. Dans le territoire ischémique, une libération intense de Na selon un mécanisme non exocytosique par le biais d'un fonctionnement inversé du système de recapture de la NA est mise en évidence. Enfin, la mise à disposition d'un outil simple permettant l'analyse de la composition du liquide interstitiel constitue une avancée déterminante dans le domaine de l'étude du métabolisme cellulaire ou de la pharmacologie cardio-vasculaire.

Published
1997

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