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It is shown that the size and relative positions of two irregular rough particles can be analyzed using interferometric out-of-focus imaging despite the overlapping of their out-of-focus images. Simulations are confirmed by experiments done with ice particles generated in a freezing column.

Équipe 107 : Physique des plasmas chauds; International audience; Firstly, a brief overview will be given on different models that are able to describe the behaviour of wave propagation as a function of specific frequency ranges. Each range corresponds to different heating systems, namely, 20-100 MHz for the ion cyclotron resonant heating, 2-20 GHz for lower-hybrid heating or current drive, and 100-250 GHz for electron cyclotron resonant heating or current drive systems. The specification of every system will be explained in detail, including the typical set of equations and the assumptions needed to describe the properties of these heating or current drive systems, as well as their specific domains of validity. In these descriptions, special attention will be paid to the boundary conditions. A review of specific physical problems associated with the wave heating systems will also be provided. The review will detail the role of simulation in answering questions that arise from experiments on magnetized plasma devices devoted to fusion. A few examples that will be covered are the impact of edge turbulence on wave propagation and its consequences on heating system performance, the effects of fast particles and ponderomotive effects, among others. A study that is more focused on radio-frequency sheath effects will also be discussed. It shows that such simulations require very sophisticated tools to gain a partial understanding of the observations undertaken in dedicated experiments. To conclude this review, an overview will be given about the requirements and progress necessary to obtain relevant predictive simulation tools able to describe the wave heating systems used in fusion devices.

Équipe 107 : Physique des plasmas chauds; International audience; A novel method to simulate ion cyclotron wave coupling in the edge of a tokamak plasma with the finite element technique is presented. It is applied in the commercial software COMSOL Multiphysics. Its main features include the perfectly matched layer (PML) technique to emulate radiating boundary conditions beyond a critical cutoff layer for the fast wave (FW), full-wave propagation across the inhomogeneous cold peripheral plasma and a detailed description of the wave launcher geometry. The PML technique, while widely used in numerical simulations of wave propagation, has scarcely been used for magnetized plasmas, due to specificities of this gyrotropic material. A versatile PML formulation, valid for full dielectric tensors, is summarized and interpreted as wave propagation in an artificial medium. The behavior of this technique has been checked for plane waves on homogeneous plasmas. Wave reflection has been quantified and compared to analytical predictions. An incompatibility issue for adapting the PML for forward (FW) and backward (slow wave (SW)) propagating waves simultaneously has been evidenced. In a tokamak plasma, this critical issue is overcome by taking advantage of the inhomogeneous density profile to reflect the SW before it reaches the PML. The simulated coupling properties of a Tore Supra ion cyclotron resonance heating (ICRH) antenna have been compared to experimental values in a situation of good single-pass absorption. The necessary antenna elements to include in the geometry to recover the coupling properties obtained experimentally are also discussed.

20th International Conference on Plasma-Surface Interactions in Controlled Fusion Devices (PSI), Forschungszentrum Julich, Aachen, GERMANY, MAY 21-25, 2012; International audience; The influence of RF electric fields on retarding field analyzer (RFA) measurements of sheath potential, V-sh is investigated. One-dimensional particle-in-cell simulations show that the RFA is able to measure reliably the rectified dc sheath potential only for ion plasma frequencies omega(pi) similar to the rf wave frequency omega(rf), while for real SOL conditions (omega(pi) > omega(rf)), when the RFA is magnetically connected to an RF antenna, it is strongly underestimated. An alternative method to investigate RF sheaths effects is proposed that uses broadening of the ion distribution function as evidence of the rf electric fields in the sheath. RFA measurements in Tore Supra indicate that the average effects of rf potentials do indeed propagate from the antenna 12 m along magnetic field lines.

International audience; Mutations within the gene encoding for the chloride ion channel cystic fibrosis transmembrane conductance regulator (CFTR) results in cystic fibrosis (CF), the most common lethal autosomal recessive genetic disease that causes a number of long-term health problems, as the bone disease. Osteoporosis and increased vertebral fracture risk associated with CF disease are becoming more important as the life expectancy of patients continues to improve. The etiology of low bone density is multifactorial, most probably a combination of inadequate peak bone mass during puberty and increased bone losses in adults. Body mass index, male sex, advanced pulmonary disease, malnutrition and chronic therapies are established additional risk factors for CF-related bone disease (CFBD). Consistently, recent evidence has confirmed that CFTR plays a major role in the osteoprotegerin (OPG) and COX-2 metabolite prostaglandin E2 (PGE2) production, two key regulators in the bone formation and regeneration. Several others mechanisms were also recognized from animal and cell models contributing to malfunctions of osteoblast (cell that form bone) and indirectly of bone-resorpting osteoclasts. Understanding such mechanisms is crucial for the development of therapies in CFBD. Innovative therapeutic approaches using CFTR modulators such as C18 have recently shown in vitro capacity to enhance PGE2 production and normalized the RANKL-to-OPG ratio in human osteoblasts bearing the mutation F508del-CFTR and therefore potential clinical utility in CFBD. This review focuses on the recently identified pathogenic mechanisms leading to CFBD and potential future therapies for treating CFBD.