Author: "François Gautier" / Publisher: hal ccsd - Searchworks@Jio Institute Digital Library Search Results

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1. Energy harvesting efficiency of unimorph piezoelectric acoustic black hole cantilever shunted by resistive and inductive circuits

Author: Haiqin Li, Olivier Doaré, Cyril Touzé, Adrien Pelat, François Gautier, Touzé, Cyril, Laboratoire d'Acoustique de l'Université du Mans (LAUM), Le Mans Université (UM)-Centre National de la Recherche Scientifique (CNRS), Institut des Sciences de la mécanique et Applications industrielles (IMSIA - UMR 9219), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-École Nationale Supérieure de Techniques Avancées (ENSTA Paris)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-EDF R&D (EDF R&D), and EDF (EDF)-EDF (EDF)
Subjects: [SPI.ACOU]Engineering Sciences [physics]/Acoustics [physics.class-ph], RL circuits, [SPI.ACOU] Engineering Sciences [physics]/Acoustics [physics.class-ph], Piezoelectric energy harvesting, Applied Mathematics, Mechanical Engineering, Modal electro-mechanical coupling factor, [SPI.MECA.VIBR]Engineering Sciences [physics]/Mechanics [physics.med-ph]/Vibrations [physics.class-ph], Condensed Matter Physics, Acoustic Black Hole, [SPI.MECA.STRU]Engineering Sciences [physics]/Mechanics [physics.med-ph]/Structural mechanics [physics.class-ph], Mechanics of Materials, Modeling and Simulation, Electro-mechanical modeling, General Materials Science, [SPI.MECA.VIBR] Engineering Sciences [physics]/Mechanics [physics.med-ph]/Vibrations [physics.class-ph], [SPI.MECA.STRU] Engineering Sciences [physics]/Mechanics [physics.med-ph]/Structural mechanics [physics.class-ph]
Abstract: International audience; A unimorph piezoelectric cantilever equipped with an Acoustic Black Hole (ABH) termination is designed for broadband energy harvesting. The ABH termination, with its tapered region, induces a focusing of the flexural vibrations which can be used to increase the efficiency of an energy harvesting device. A modal-based analytical model is presented, providing an explicit form of the electro-mechanical coupling for each beam eigenmode. Closed-form expressions for the coupled mechanical response and electrical outputs are obtained, allowing one to draw out a complete parametric study to optimize the device. The optimization procedure is conducted following two steps: first, optimal location and dimensions of a single piezoelectric patch are achieved by maximizing the modal electro-mechanical coupling factor (MEMCF) for each structural mode. Thanks to the proposed analytical approach, it is clearly shown that by putting the piezoelectric patch at the maximum of the strain field in the tapered termination, and by adjusting its length in accordance with the focalization created by the ABH effect, the ABH cantilever produces much higher MEMCFs over a wide frequency range and thus outperforms those of a uniform beam. Second, optimization of the shunted circuit is comprehensively performed for a circuit with only resistance, or both resistance and inductance, in series or in parallel. Analytical results show that the key design rule resides in matching the time scale of the circuit with that of the forcing frequency. Addition of the inductance allows enhancing the performance, but on a narrow frequency band. Finally, broadband advantages can be further obtained by considering multiple piezoelectric patches, in which the optimum is obtained when the shunted circuit in each patch is tuned targeting an eigenmode of the ABH beam.
Published: 2022

2. Prospective external validation of a new non‐invasive test for the diagnosis of non‐alcoholic steatohepatitis in patients with type 2 diabetes

Author: Stanislas Pol, Christian Boitard, Nathalie Gault, Jimmy Mullaert, Pauline Manchon, J.M. Castille, Sébastien Czernichow, Thierry Poynard, Jean-François Gautier, Béatrice Parfait, Benoit Terris, Estelle Marcault, Anaïs Vallet-Pichard, Etienne Larger, Valérie Paradis, Cédric Laouénan, F. Drane, Laurent Castera, Valentina Peta, Dominique Valla, Angelique Brzustowski, Olivier Deckmyn, Pierre Bedossa, Nassima Si Mohammed, Mark Ibberson, Dominique Roulot, Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Institute of cardiometabolism and nutrition (ICAN), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Centre de recherche sur l'Inflammation (CRI (UMR_S_1149 / ERL_8252 / U1149)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), AP-HP - Hôpital Bichat - Claude Bernard [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), BioPredictive [Paris], Centre d'investigation Clinique [CHU Bichat] - Épidémiologie clinique (CIC 1425), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM), Chercheur indépendant, Hôpital Cochin [AP-HP], Swiss Institute of Bioinformatics [Lausanne] (SIB), Université de Lausanne (UNIL), Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases (ICAN), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Institut de Cardiométabolisme et Nutrition = Institute of Cardiometabolism and Nutrition [CHU Pitié Salpêtrière] (IHU ICAN), CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Université de Lausanne = University of Lausanne (UNIL), and Gestionnaire, HAL Sorbonne Université 5
Subjects: Liver Cirrhosis, medicine.medical_specialty, Biopsy, Type 2 diabetes, Gastroenterology, 03 medical and health sciences, Liver disease, 0302 clinical medicine, Fibrosis, Non-alcoholic Fatty Liver Disease, Internal medicine, Post-hoc analysis, Non‐invasive Testing for Nash with Type 2 Diabetes, medicine, Humans, Superfast, Pharmacology (medical), Prospective Studies, 030304 developmental biology, 0303 health sciences, Hepatology, business.industry, FibroTest, Type 2 Diabetes Mellitus, Reproducibility of Results, [SDV.MHEP.HEG]Life Sciences [q-bio]/Human health and pathology/Hépatology and Gastroenterology, medicine.disease, [SDV.MHEP.HEG] Life Sciences [q-bio]/Human health and pathology/Hépatology and Gastroenterology, 3. Good health, Diabetes Mellitus, Type 2, Liver, 030211 gastroenterology & hepatology, Steatohepatitis, Steatosis, business
Abstract: Summary Background One of the unmet needs in patients with type 2 diabetes mellitus (T2DM) is the prediction of non‐alcoholic liver disease by non‐invasive blood tests, for each of the three main histological features, fibrosis, non‐alcoholic steatohepatitis (NASH) and steatosis. Aims To validate externally the performances of a recent panel, Nash‐FibroTest, for the assessment of the severity of fibrosis stages, NASH grades and steatosis grades. Methods We prospectively analysed 272 patients with T2DM. Standard definitions of stages and grades were used, and analyses were centralised and blinded. The performances of the FibroTest, NashTest‐2 and SteatoTest‐2 were assessed using the Obuchowski measure (OM), the main outcome recommended as a summary measure of accuracy includeing all pairwise stages and grades comparisons, which is not provided par the extensively used binary area under the ROC curve. Results The diagnostic performance of each component of the panel was significant. OM (SE; significance) of the FibroTest, the NashTest‐2 and the SteatoTest‐2 was 0.862 (0.012; P, From a single blood sample, the Nash FibroTest panel provides non‐invasive diagnosis of the stages of fibrosis and the grades of NASH, including ballooning and lobular inflammation, and steatosis grades in patients with type 2 diabetes mellitus.
Published: 2021
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3. Oral corticoid, aspirin, anticoagulant, colchicine, and furosemide to improve the outcome of hospitalized COVID-19 patients - the COCAA-COLA cohort study

Author: Bruno Mégarbane, Damien Sène, Florine Feron, Jean-Pierre Riveline, A. Lopes, Jean-François Gautier, Claire Vandiedonck, Franck Mauvais-Jarvis, Jean-Philippe Kevorkian, Kladoum Nassarmadji, Stéphane Mouly, Hôpital Lariboisière-Fernand-Widal [APHP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Immunologie humaine, physiopathologie & immunothérapie (HIPI (UMR_S_976 / U976)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), Centre de Recherche des Cordeliers (CRC (UMR_S_1138 / U1138)), École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Université Paris Cité (UPCité), Optimisation thérapeutique en Neuropsychopharmacologie (OPTeN (UMR_S_1144 / U1144)), Tulane University, Service de Réanimation Médicale et Toxicologique [Hôpital Lariboisière], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Lariboisière-Fernand-Widal [APHP], and Mégarbane, Bruno
Subjects: Microbiology (medical), 2019-20 coronavirus outbreak, medicine.medical_specialty, Coronavirus disease 2019 (COVID-19), medicine.drug_class, [SDV.MHEP.PSR]Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tract, Cola (plant), Cohort Studies, chemistry.chemical_compound, [SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, Adrenal Cortex Hormones, Furosemide, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, Internal medicine, medicine, Humans, Colchicine, Letter to the Editor, [SDV.MHEP.ME] Life Sciences [q-bio]/Human health and pathology/Emerging diseases, Aspirin, [SDV.MHEP.ME]Life Sciences [q-bio]/Human health and pathology/Emerging diseases, biology, SARS-CoV-2, business.industry, Anticoagulant, Anticoagulants, COVID-19, biology.organism_classification, [SDV.MHEP.CSC] Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, [SDV.TOX] Life Sciences [q-bio]/Toxicology, Treatment Outcome, Infectious Diseases, chemistry, [SDV.TOX]Life Sciences [q-bio]/Toxicology, [SDV.MHEP.MI] Life Sciences [q-bio]/Human health and pathology/Infectious diseases, [SDV.MHEP.PSR] Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tract, business, Cohort study, medicine.drug
Abstract: International audience
Published: 2021
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4. Sex disparities in COVID-19 outcomes of inpatients with diabetes: insights from the CORONADO study

Author: L Bordier, Pierre Fontaine, Sandrine Lablanche, Abdallah Al-Salameh, Sarra Smati, Amandine Galioot, Adèle Lasbleiz, Olivier Bourron, Matthieu Wargny, Sandrine Coudol, Béatrice Guyomarch, Dominique Seret-Bégué, Sara Barraud, Eric Renard, Céline Gonfroy-Leymarie, Anna Flaus-Furmaniuk, Sybil Charrière, Bertrand Cariou, Emmanuel Cosson, Philippe Thuillier, Franck Mauvais-Jarvis, Jean-François Gautier, Bruno Vergès, Edith Bigot, Bruno Guerci, Bruno Fève, Matthieu Pichelin, Jean-Daniel Lalau, Louis Potier, Muriel Bourgeon, Samy Hadjadj, Gaëtan Prévost, Etienne Larger, Marion Munch, Nicolas Chevalier, Yves Reznik, Sophie Borot, Paul Sibilia, Pierre Gourdy, Bruno Laviolle, Coralie Amadou, Michel Marre, Blandine Tramunt, Institut des Maladies Métaboliques et Cardiovasculaires (I2MC), Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM), Unité de recherche de l'institut du thorax (ITX-lab), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN), Centre hospitalier universitaire de Nantes (CHU Nantes), CHU Amiens-Picardie, Périnatalité et Risques Toxiques - UMR INERIS_I 1 (PERITOX), Institut National de l'Environnement Industriel et des Risques (INERIS)-Université de Picardie Jules Verne (UPJV)-CHU Amiens-Picardie, Centre Hospitalier Sud Francilien, Centre Hospitalier Universitaire de Reims (CHU Reims), Centre de Recherche en Sciences et Technologies de l'Information et de la Communication - EA 3804 (CRESTIC), Université de Reims Champagne-Ardenne (URCA), Hôpital d'Instruction des Armées Begin, Service de Santé des Armées, Service de Diabétologie - Endocrinologie [CHRU Besançon], Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon), AP-HP - Hôpital Antoine Béclère [Clamart], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), AP-HP Hôpital Bicêtre (Le Kremlin-Bicêtre), CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Centre de Recherche des Cordeliers (CRC (UMR_S_1138 / U1138)), École Pratique des Hautes Études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Université Paris Cité (UPCité), Institut de Cardiométabolisme et Nutrition = Institute of Cardiometabolism and Nutrition [CHU Pitié Salpêtrière] (IHU ICAN), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Hôpital Louis Pradel [CHU - HCL], Hospices Civils de Lyon (HCL), Cardiovasculaire, métabolisme, diabétologie et nutrition (CarMeN), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Hospices Civils de Lyon (HCL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Centre Hospitalier Universitaire de Nice (CHU Nice), Hôpital Jean Verdier [AP-HP], Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS (U1153 / UMR_A_1125 / UMR_S_1153)), Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), CHU Saint-Antoine [AP-HP], Centre hospitalier Félix-Guyon [Saint-Denis, La Réunion], Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Hôpital Claude Huriez [Lille], CHU Lille, CHU Bordeaux [Bordeaux], Centre Hospitalier René Dubos [Pontoise], Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), CHU Grenoble, AP-HP - Hôpital Cochin Broca Hôtel Dieu [Paris], Assistance Publique - Hôpitaux de Marseille (APHM), Centre recherche en CardioVasculaire et Nutrition = Center for CardioVascular and Nutrition research (C2VN), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Centre d'Investigation Clinique [Rennes] (CIC), Université de Rennes (UR)-Hôpital Pontchaillou-Institut National de la Santé et de la Recherche Médicale (INSERM), CHU Pontchaillou [Rennes], Hôpital Ambroise Paré [AP-HP], CHU Strasbourg, AP-HP - Hôpital Bichat - Claude Bernard [Paris], Différenciation et communication neuronale et neuroendocrine (DC2N), Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service d'endocrinologie, diabétologie et maladies métaboliques [Rouen], CHU Rouen, Normandie Université (NU)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU), CHU Montpellier, Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Institut de Génomique Fonctionnelle (IGF), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), CHU Caen, Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN), Centre Hospitalier de Gonesse, Centre Hospitalier Universitaire d'Angers (CHU Angers), PRES Université Nantes Angers Le Mans (UNAM), Groupe d'Etude de la Thrombose de Bretagne Occidentale (GETBO), Université de Brest (UBO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Brestois Santé Agro Matière (IBSAM), Université de Brest (UBO)-Université de Brest (UBO), CHU Dijon, Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon), Service de Diabétologie et Endocrinologie, Centre d’Investigation Clinique de Nantes (CIC Nantes), Université de Nantes (UN)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre hospitalier universitaire de Nantes (CHU Nantes), Tulane University, Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM), Service de Diabétologie [CHU Pitié-Salpétrière], École pratique des hautes études (EPHE), CRHU Nancy, Jonchère, Laurent, Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées, unité de recherche de l'institut du thorax UMR1087 UMR6291 (ITX), Université de Picardie Jules Verne (UPJV)-CHU Amiens-Picardie-Institut National de l'Environnement Industriel et des Risques, CH Evry-Corbeil, Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Hôpital Pontchaillou-Institut National de la Santé et de la Recherche Médicale (INSERM), Université de Montpellier (UM)-Université Montpellier 1 (UM1)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Montpellier 2 - Sciences et Techniques (UM2)-Centre National de la Recherche Scientifique (CNRS), Institut Brestois Santé Agro Matière (IBSAM), Université de Brest (UBO)-Université de Brest (UBO)-Université de Brest (UBO), and CHU Toulouse [Toulouse]
Subjects: Male, Endocrinology, Diabetes and Metabolism, [SDV]Life Sciences [q-bio], 030204 cardiovascular system & hematology, Severity of Illness Index, law.invention, 0302 clinical medicine, Endocrinology, Risk Factors, law, Hospital Mortality, Aged, 80 and over, [SDV.MHEP.EM] Life Sciences [q-bio]/Human health and pathology/Endocrinology and metabolism, Sex Characteristics, COPD, Incidence, Incidence (epidemiology), General Medicine, Middle Aged, [SDV.MHEP.EM]Life Sciences [q-bio]/Human health and pathology/Endocrinology and metabolism, Prognosis, Intensive care unit, 3. Good health, Hospitalization, [SDV] Life Sciences [q-bio], Intensive Care Units, Population study, Female, France, Sex characteristics, medicine.medical_specialty, Diabetes Complications, 03 medical and health sciences, Internal medicine, Diabetes mellitus, Severity of illness, Diabetes Mellitus, medicine, Humans, Aged, Retrospective Studies, Inpatients, SARS-CoV-2, business.industry, COVID-19, Retrospective cohort study, medicine.disease, Respiration, Artificial, business, 030217 neurology & neurosurgery
Abstract: Objective Male sex is one of the determinants of severe coronavirus diseas-e-2019 (COVID-19). We aimed to characterize sex differences in severe outcomes in adults with diabetes hospitalized for COVID-19. Methods We performed a sex-stratified analysis of clinical and biological features and outcomes (i.e. invasive mechanical ventilation (IMV), death, intensive care unit (ICU) admission and home discharge at day 7 (D7) or day 28 (D28)) in 2380 patients with diabetes hospitalized for COVID-19 and included in the nationwide CORONADO observational study (NCT04324736). Results The study population was predominantly male (63.5%). After multiple adjustments, female sex was negatively associated with the primary outcome (IMV and/or death, OR: 0.66 (0.49–0.88)), death (OR: 0.49 (0.30–0.79)) and ICU admission (OR: 0.57 (0.43–0.77)) at D7 but only with ICU admission (OR: 0.58 (0.43–0.77)) at D28. Older age and a history of microvascular complications were predictors of death at D28 in both sexes, while chronic obstructive pulmonary disease (COPD) was predictive of death in women only. At admission, C-reactive protein (CRP), aspartate amino transferase (AST) and estimated glomerular filtration rate (eGFR), according to the CKD-EPI formula predicted death in both sexes. Lymphocytopenia was an independent predictor of death in women only, while thrombocytopenia and elevated plasma glucose concentration were predictors of death in men only. Conclusions In patients with diabetes admitted for COVID-19, female sex was associated with lower incidence of early severe outcomes, but did not influence the overall in-hospital mortality, suggesting that diabetes mitigates the female protection from COVID-19 severity. Sex-associated biological determinants may be useful to optimize COVID-19 prevention and management in women and men.
Published: 2021
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5. Optimal absorption of flexural energy in thin plates by critically coupling a locally resonant grating

Author: Jean-Philippe Groby, Adrien Pelat, J. Leng, Vicent Romero-García, Rubén Picó, François Gautier, Laboratoire d'Acoustique de l'Université du Mans (LAUM), Centre National de la Recherche Scientifique (CNRS)-Le Mans Université (UM), Instituto de Investigación para la Gestión Integrada de Zonas Costeras [Universitat Politècnica de València] (IGIC), and Universitat Politècnica de València (UPV)
Subjects: Coupling, [SPI.ACOU]Engineering Sciences [physics]/Acoustics [physics.class-ph], Work (thermodynamics), Materials science, business.industry, General Engineering, General Physics and Astronomy, Metamaterial, 02 engineering and technology, Grating, 021001 nanoscience & nanotechnology, 01 natural sciences, Physics::Fluid Dynamics, Optics, Flexural strength, 0103 physical sciences, Reflection (physics), 010306 general physics, 0210 nano-technology, business, Absorption (electromagnetic radiation), Energy (signal processing), ComputingMilieux_MISCELLANEOUS
Abstract: The optimal absorption of flexural energy by the critical coupling of a locally resonant grating embedded in a thin plate is reported in this work for the reflection and transmission problems. The ...
Published: 2021
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6. Experimental evidence of energy transfer and vibration mitigation in a vibro-impact acoustic black hole

Author: Haiqin Li, François Gautier, Mathieu Secail-Geraud, Cyril Touzé, Adrien Pelat, Laboratoire d'Acoustique de l'Université du Mans (LAUM), Le Mans Université (UM)-Centre National de la Recherche Scientifique (CNRS), Institut des Sciences de la mécanique et Applications industrielles (IMSIA - UMR 9219), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-École Nationale Supérieure de Techniques Avancées (ENSTA Paris)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-EDF R&D (EDF R&D), EDF (EDF)-EDF (EDF), Centre National de la Recherche Scientifique (CNRS)-Le Mans Université (UM), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-École Nationale Supérieure de Techniques Avancées (ENSTA Paris)-Centre National de la Recherche Scientifique (CNRS)-Université Paris-Saclay-EDF R&D (EDF R&D), and Touzé, Cyril
Subjects: Optimal design, Acoustics and Ultrasonics, Acoustics, Edge (geometry), 01 natural sciences, Damping capacity, Vibro-impact nonlinearity, 0103 physical sciences, 010301 acoustics, 010302 applied physics, Physics, [SPI.ACOU]Engineering Sciences [physics]/Acoustics [physics.class-ph], [SPI.ACOU] Engineering Sciences [physics]/Acoustics [physics.class-ph], [SPI.GCIV.DV] Engineering Sciences [physics]/Civil Engineering/Dynamique, vibrations, [SPI.MECA.VIBR]Engineering Sciences [physics]/Mechanics [physics.med-ph]/Vibrations [physics.class-ph], Passive damping, Vibration mitigation, Acoustic Black Hole, Vibration, Maxima and minima, Black hole, Nonlinear system, Energy transfer, [SPI.MECA.STRU]Engineering Sciences [physics]/Mechanics [physics.med-ph]/Structural mechanics [physics.class-ph], [SPI.MECA.VIBR] Engineering Sciences [physics]/Mechanics [physics.med-ph]/Vibrations [physics.class-ph], [SPI.GCIV.DV]Engineering Sciences [physics]/Civil Engineering/Dynamique, vibrations, [SPI.MECA.STRU] Engineering Sciences [physics]/Mechanics [physics.med-ph]/Structural mechanics [physics.class-ph], Beam (structure)
Abstract: International audience; An experimental demonstration of the broadband passive damping capacity of a vibro-impact acoustic black hole (VI-ABH) is reported. A VI-ABH is an adaptation of the classical ABH design consisting of a beam with a tapered edge of decreasing thickness creating an acoustic black hole (ABH), complemented by contact points on which the beam impacts during its vibration. The contact nonlinearity creates a rapid and efficient transfer of vibrational energy from the low-frequency range, where the ABH is known to be ineffective, to the high-frequency range, thus improving the global passive vibration mitigation characteristics. The optimal design of a VI-ABH follows the rule of locating the contact points at local maxima of the low-frequency modes. Experiments clearly demonstrate the gain in performance, both in forced and free vibrations.
Published: 2021

7. Predictors of hospital discharge and mortality in patients with diabetes and COVID-19: updated results from the nationwide CORONADO study

Author: Nicolas Chevalier, Bruno Vergès, Etienne Larger, L Bordier, Delphine Demarsy, Jean-François Thébaut, Dominique Seret-Bégué, Matthieu Wargny, Pierre-Antoine Gourraud, Coralie Amadou, Nathanaëlle Montanier, Myriam Lungo, P. Serusclat, Claude Chaumeil, Audrey Zabulon, Louis Potier, Jean-Baptiste Bonnet, Bertrand Cariou, Matthieu Pichelin, Pierre Gourdy, Anne-Marie Guedj, Nathalie Jeandidier, Jean-Philippe Le Berre, René Robert, Vincent Rigalleau, Ronan Roussel, O. Dupuy, Fritz-Line Velayoudom, Sarra Smati, Jean-François Gautier, Françoise Plat, Samy Hadjadj, Olivier Bourron, Camille Vatier, Patrice Winiszewski, Pierre-Yves Benhamou, Blandine Tramunt, Marie Dumas, Philippe Moulin, Patrice Darmon, Anna Flaus-Furmaniuk, B. Delenne, unité de recherche de l'institut du thorax UMR1087 UMR6291 (ITX), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN), CIC - CHU Bichat, Institut National de la Santé et de la Recherche Médicale (INSERM), Service de Diabétologie - Maladies Métaboliques - Nutrition, CHU Toulouse [Toulouse], Centre Hospitalier Sud Francilien, Laboratory of Fundamental and Applied Bioenergetics = Laboratoire de bioénergétique fondamentale et appliquée (LBFA), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Grenoble Alpes (UGA), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Hôpital d'Instruction des Armées Begin, Service de Santé des Armées, Service de Diabétologie [CHU Pitié-Salpétrière], CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Centre recherche en CardioVasculaire et Nutrition = Center for CardioVascular and Nutrition research (C2VN), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), CHU Toulouse [Toulouse]-Hôpital de Rangueil, CH Evry-Corbeil, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Service de diabétologie [CHU Pitié-Salpétrière], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Unité de recherche de l'institut du thorax (ITX-lab), Service Diabétologie [CHU Toulouse], Pôle Cardiovasculaire et Métabolique [CHU Toulouse], Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)-Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), and Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)
Subjects: Male, Percentile, Home discharge, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, 030204 cardiovascular system & hematology, 0302 clinical medicine, Mechanical ventilation, Risk Factors, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, Hospital Mortality, Aged, 80 and over, Anticoagulant, Diabetes, Middle Aged, [SDV.MHEP.EM]Life Sciences [q-bio]/Human health and pathology/Endocrinology and metabolism, Prognosis, Patient Discharge, 3. Good health, Metformin, Hospitalization, Death, Female, France, Admission plasma glucose, medicine.drug, medicine.medical_specialty, Statin, HbA1c, Coronavirus disease 2019 (COVID-19), medicine.drug_class, 030209 endocrinology & metabolism, Article, Diabetes Complications, 03 medical and health sciences, Diabetes mellitus, Internal medicine, Internal Medicine, medicine, Diabetes Mellitus, Humans, HbA(1c), Aged, Retrospective Studies, business.industry, SARS-CoV-2, COVID-19, Retrospective cohort study, Length of Stay, medicine.disease, Respiration, Artificial, Discharge, business, Follow-Up Studies
Abstract: Aims/hypothesis This is an update of the results from the previous report of the CORONADO (Coronavirus SARS-CoV-2 and Diabetes Outcomes) study, which aims to describe the outcomes and prognostic factors in patients with diabetes hospitalised for coronavirus disease-2019 (COVID-19). Methods The CORONADO initiative is a French nationwide multicentre study of patients with diabetes hospitalised for COVID-19 with a 28-day follow-up. The patients were screened after hospital admission from 10 March to 10 April 2020. We mainly focused on hospital discharge and death within 28 days. Results We included 2796 participants: 63.7% men, mean age 69.7 ± 13.2 years, median BMI (25th–75th percentile) 28.4 (25.0–32.4) kg/m2. Microvascular and macrovascular diabetic complications were found in 44.2% and 38.6% of participants, respectively. Within 28 days, 1404 (50.2%; 95% CI 48.3%, 52.1%) were discharged from hospital with a median duration of hospital stay of 9 (5–14) days, while 577 participants died (20.6%; 95% CI 19.2%, 22.2%). In multivariable models, younger age, routine metformin therapy and longer symptom duration on admission were positively associated with discharge. History of microvascular complications, anticoagulant routine therapy, dyspnoea on admission, and higher aspartate aminotransferase, white cell count and C-reactive protein levels were associated with a reduced chance of discharge. Factors associated with death within 28 days mirrored those associated with discharge, and also included routine treatment by insulin and statin as deleterious factors. Conclusions/interpretation In patients with diabetes hospitalised for COVID-19, we established prognostic factors for hospital discharge and death that could help clinicians in this pandemic period. Trial registration Clinicaltrials.gov identifier: NCT04324736 Graphical abstract
Published: 2021
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8. Response to Letter to the Editor from Woolcott and Castilla-Bancayán: 'Diabetes Increases Severe COVID-19 Outcomes Primarily in Younger Adults'

Author: Etienne Larger, Emmanuel Cosson, Thomas Moreau, Philippe Chanson, Sopio Tatulashvili, Ronan Roussel, Etienne Dancoisne, Muriel Bourgeon, Bruno Fève, Jean-François Gautier, Kankoe Sallah, Agnès Hartemann, Marc Diedisheim, Christiane Ajzenberg, Marie-Laure Raffin-Sanson, Sébastien Czernichow, Louis Potier, Christel Daniel, Feve, Bruno, Hôpital Cochin [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Centre de Recherche des Cordeliers (CRC (UMR_S_1138 / U1138)), École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Université Paris Cité (UPCité), AP-HP - Hôpital Bichat - Claude Bernard [Paris], Centre d'investigation Clinique [CHU Bichat] - Épidémiologie clinique (CIC 1425), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service de Diabétologie et Endocrinologie, Hôpital Avicenne [AP-HP], Equipe 3: EREN- Equipe de Recherche en Epidémiologie Nutritionnelle (CRESS - U1153), Université Sorbonne Paris Nord-Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS (U1153 / UMR_A_1125 / UMR_S_1153)), Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Centre de Recherche Saint-Antoine (CRSA), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases (ICAN), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Institut de Cardiométabolisme et Nutrition = Institute of Cardiometabolism and Nutrition [CHU Pitié Salpêtrière] (IHU ICAN), CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Service d'Endocrinologie, diabétologie et endocrinologie de la reproduction [CHU Saint-Antoine], CHU Saint-Antoine [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Physiologie et physiopathologie endocriniennes (PHYSENDO), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, Hôpital Bicêtre, Equipe 5 : METHODS - Méthodes de l’évaluation thérapeutique des maladies chroniques (CRESS - U1153), Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS (U1153 / UMR_A_1125 / UMR_S_1153)), Hôpital Européen Georges Pompidou [APHP] (HEGP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO), Service d’endocrinologie et nutrition [AP-HP Ambroise-Paré], Hôpital Ambroise Paré [AP-HP], Université de Versailles Saint-Quentin-en-Yvelines - UFR Sciences de la santé Simone Veil (UVSQ Santé), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), AP-HP - Hôpital Antoine Béclère [Clamart], CHU Henri Mondor, Service de Diabétologie [CHU Pitié-Salpétrière], Laboratoire d'Informatique Médicale et Ingénierie des Connaissances en e-Santé (LIMICS), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Université Sorbonne Paris Nord, Modelling brain structure, function and variability based on high-field MRI data (PARIETAL), Service NEUROSPIN (NEUROSPIN), Université Paris-Saclay-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Inria Saclay - Ile de France, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria), Service d'endocrinologie, diabétologie et nutrition [CHU Bichat], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-AP-HP - Hôpital Bichat - Claude Bernard [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Cité (UPCité), École Pratique des Hautes Études (EPHE), and CHU Henri Mondor [Créteil]
Subjects: medicine.medical_specialty, Pediatrics, 2019-20 coronavirus outbreak, Letter to the editor, Coronavirus disease 2019 (COVID-19), Endocrinology, Diabetes and Metabolism, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), [SDV]Life Sciences [q-bio], Clinical Biochemistry, Biochemistry, Endocrinology, Internal medicine, Diabetes mellitus, Correspondence, medicine, Diabetes Mellitus, Humans, Hyperplasia, diabetes, business.industry, SARS-CoV-2, Biochemistry (medical), COVID-19, Letter to the Editor Response, medicine.disease, mortality, [SDV] Life Sciences [q-bio], age, Younger adults, business, AcademicSubjects/MED00250
Abstract: International audience; No abstract available
Published: 2021
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9. Zero reflections by a 1D Acoustic Black Hole termination using thermally controlled damping

Author: Guillaume Raybaud, Morvan Ouisse, François Gautier, Adrien Pelat, Laboratoire d'Acoustique de l'Université du Mans (LAUM), Le Mans Université (UM)-Centre National de la Recherche Scientifique (CNRS), Franche-Comté Électronique Mécanique, Thermique et Optique - Sciences et Technologies (UMR 6174) (FEMTO-ST), Université de Technologie de Belfort-Montbeliard (UTBM)-Ecole Nationale Supérieure de Mécanique et des Microtechniques (ENSMM)-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC)-Centre National de la Recherche Scientifique (CNRS), and femto-st, dma
Subjects: Coupling, Materials science, Acoustics and Ultrasonics, Mechanical Engineering, Stiffness, 02 engineering and technology, Mechanics, [PHYS.MECA]Physics [physics]/Mechanics [physics], Condensed Matter Physics, 01 natural sciences, Black hole, Vibration, Temperature gradient, 020303 mechanical engineering & transports, 0203 mechanical engineering, Mechanics of Materials, 0103 physical sciences, Thermal, medicine, [PHYS.MECA] Physics [physics]/Mechanics [physics], Reflection coefficient, medicine.symptom, 010301 acoustics, Beam (structure)
Abstract: International audience; The design of lightweight and stiff structures with attractive vibration damping properties is a major issue in mechanical engineering. The insertion of Acoustic Black Holes (ABH) in a beam is a technique that consists in locally reducing its thickness at the end and coating it with a visco-elastic film. The reflection coefficient of the resulting system decreases with frequency and displays typical arches which can exactely reach zero when the amount of losses is well adjusted, reaching the critical coupling condition. However, the precise amount of added damping is very difficult to tune by using classical visco-elastic layers. It is here proposed to control it by using a thermal active system acting in a shape memory polymer (SMP). In this manner, the damping and stiffness profiles become tunable via a given thermal gradient which leads to create an enhanced ABH (eABH) that can be tuned in real time, so that the critical coupling can be reached. The objective of the paper is to demonstrate numerically and experimentally the capability of an eABH to achieve exact zero reflections using precise control of temperature gradients.
Published: 2021

10. Stay-at-Home Orders During the COVID-19 Pandemic, an Opportunity to Improve Glucose Control Through Behavioral Changes in Type 1 Diabetes

Author: Louis Potier, Olivier Lantieri, Ronan Roussel, Jean-Pierre Riveline, Etienne Larger, Jean-François Gautier, Rachel Assemien, Daphné Carreira, Boris Hansel, Gestionnaire, Hal Sorbonne Université, CIC - CHU Bichat, Institut National de la Santé et de la Recherche Médicale (INSERM), Centre de Recherche des Cordeliers (CRC (UMR_S_1138 / U1138)), École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Université Paris Cité (UPCité), Service de diabétologie [CHU Cochin], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Cochin [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Hôpital Lariboisière-Fernand-Widal [APHP], and Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Université de Paris (UP)
Subjects: Adult, Blood Glucose, Research design, medicine.medical_specialty, Endocrinology, Diabetes and Metabolism, [SDV]Life Sciences [q-bio], 030209 endocrinology & metabolism, Hypoglycemia, 03 medical and health sciences, 0302 clinical medicine, Diabetes mellitus, Blood Glucose Self-Monitoring, Pandemic, Internal Medicine, medicine, Humans, 030212 general & internal medicine, Glycemic, Advanced and Specialized Nursing, Type 1 diabetes, SARS-CoV-2, business.industry, COVID-19, Middle Aged, medicine.disease, 3. Good health, [SDV] Life Sciences [q-bio], Diabetes Mellitus, Type 1, Communicable Disease Control, Emergency medicine, Observational study, business
Abstract: OBJECTIVE To investigate the impact of coronavirus disease 2019 lockdown on glycemic control and associated factors in people living with type 1 diabetes. RESEARCH DESIGN AND METHODS An observational evaluation from a self-reported questionnaire on behavioral changes and glycemic information from flash glucose monitoring (FGM) during the lockdown in 1,378 individuals living with type 1 diabetes who used a French dedicated nationwide web application (CoviDIAB). RESULTS The main outcome was the change of the mean glucose level 2 months before and 1 month after the lockdown. We found that mean glucose improved from 9.1 ± 1.7 mmol/L to 8.7 ± 1.7 mmol/L (P < 0.001). Factors associated with better glycemic control were a decrease of alcohol consumption (odds ratio [OR] 1.75 [95% CI 1.04–2.94]), an increase in the frequency of FGM scans (OR 1.48 [1.04–2.10]) and in the number of hypoglycemia events (OR 1.67 [1.13–2.46]), and an easier diabetes control perception (OR 1.71 [1.18–2.49]). CONCLUSIONS Our findings suggest that lockdown has a positive impact on glycemic control in people with type 1 diabetes.
Published: 2021
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11. Outcome of SARS-CoV-2 infection linked to MAIT cell activation and cytotoxicity: evidence for an IL-18 dependent mechanism

Author: Renato Costa Monteiro, Christian Boitard, Maria Hurtado-Nedelec, Frédéric Pène, Héloïse Flament, Benjamin Terrier, Samuel Lebourgeois, Jean-François Timsit, Muriel Andrieu, Nadine Ajzenberg, Sandrine Luce, Jean-François Gautier, Jade Ghosn, Yazdan Yazdanpanah, Amine Toubal, Camille Rousseau, Agnès Lehuen, Diane Descamps, Léo Bertrand, Lucie Beaudoin, Karine Bailly, B Visseaux, Matthieu Rouland, Anaïs Vallet-Pichard, Pauline Soulard, Zouriatou Gouda, Centre de recherche sur l'Inflammation (CRI (UMR_S_1149 / ERL_8252 / U1149)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Dysfonctionnements Immunitaires [AP-HP Hôpital Bichat, Paris], AP-HP - Hôpital Bichat - Claude Bernard [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Nord Val de Seine, Institut Cochin (IC UM3 (UMR 8104 / U1016)), Infection, Anti-microbiens, Modélisation, Evolution (IAME (UMR_S_1137 / U1137)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP)-Université Sorbonne Paris Nord, Service de Virologie [CHU Bichat], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-AP-HP - Hôpital Bichat - Claude Bernard [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Service de diabétologie [CHU Cochin], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Cochin [AP-HP], Département d'hépatologie [CHU Cochin], Institut National de la Santé et de la Recherche Médicale (INSERM)-Hôpital Cochin [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Service de diabétologie et d'endocrinologie [CHU Lariboisière], Hôpital Lariboisière-Fernand-Widal [APHP], Laboratoire d'Hématologie [Bichat], Laboratoire de Recherche Vasculaire Translationnelle (LVTS (UMR_S_1148 / U1148)), Medical Intensive Care Unit, AP-HP, Cochin University Hospital, Paris, France., Unité de Soins Intensifs [CHU Cochin], Service de médecine interne et centre de référence des maladies rares [CHU Cochin], Unité de soins intensifs médicaux et infectieux [AP-HP Hôpital Bichat-Claude-Bernard], Lehuen, Agnès, Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Université Sorbonne Paris Nord, Hôpital Cochin [AP-HP], and Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)
Subjects: 0303 health sciences, [SDV.IMM] Life Sciences [q-bio]/Immunology, business.industry, Mechanism (biology), Cell, Phenotype, 3. Good health, 03 medical and health sciences, 0302 clinical medicine, medicine.anatomical_structure, Immune system, 030220 oncology & carcinogenesis, Immunology, Medicine, Cytotoxic T cell, [SDV.IMM]Life Sciences [q-bio]/Immunology, Interleukin 18, business, Cell activation, Cytotoxicity, 030304 developmental biology
Abstract: Immune system dysfunction is paramount in Coronavirus disease 2019 (COVID-19) severity and fatality rate. Mucosal-Associated Invariant T (MAIT) cells are innate-like T cells involved in mucosal immunity and protection against viral infections. Here, we studied the immune cell landscape, with emphasis on MAIT cells, in a cohort of 182 patients including patients at various stages of disease activity. A profound decrease of MAIT cell counts in blood of critically ill patients was observed. These cells showed a strongly activated and cytotoxic phenotype that positively correlated with circulating pro-inflammatory cytokines, notably IL-18. MAIT cell alterations markedly correlated with disease severity and patient mortality. SARS-CoV-2-infected macrophages activated MAIT cells in a cytokine-dependent manner involving an IFNα-dependent early phase and an IL-18-induced later phase. Therefore, altered MAIT cell phenotypes represent valuable biomarkers of disease severity and their therapeutic manipulation might prevent the inflammatory phase involved in COVID-19 aggravation.
Published: 2020
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12. Blood glucose levels and COVID-19. Reply to Sardu C, D’Onofrio N, Balestrieri ML et al [letter] and Lepper PM, Bals R, Jüni P et al [letter]

Author: Amélie Ducet-Boiffard, Muriel Bourgeon-Ghittori, Claude Chaumeil, Louis Potier, Florence Baudoux, Jean François Gautier, Jean-Pierre Riveline, Coralie Amadou, Emmanuel Cosson, Emmanuel Disse, Michael Joubert, Gaëtan Prévost, Pierre Gourdy, Olivier Bourron, Véronique Kerlan, Blandine Tramunt, Sophie Borot, Charles Thivolet, Abdallah Al-Salameh, Matthieu Wargny, Bruno Laviolle, René Robert, Lucien Marchand, Gwénaëlle Arnault, Ariane Sultan, Laurent Meyer, Sandrine Coudol, David Boutoille, Matthieu Pichelin, Pierre Jean Saulnier, Patrice Darmon, Bernard Bauduceau, Bénédicte Gaborit, Ronan Roussel, Bertrand Cariou, Ingrid Allix, Camille Vatier, Samy Hadjadj, Jean François Thébaut, Unité de recherche de l'institut du thorax (ITX-lab), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN), Hôpital Guillaume-et-René-Laennec [Saint-Herblain], Centre hospitalier universitaire de Nantes (CHU Nantes), CHU Amiens-Picardie, Université de Picardie Jules Verne (UPJV), Centre Hospitalier Universitaire d'Angers (CHU Angers), PRES Université Nantes Angers Le Mans (UNAM), Centre Hospitalier Sud Francilien, Centre hospitalier Bretagne Atlantique (Morbihan) (CHBA), Hôpital Claude Huriez [Lille], CHU Lille, Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon), AP-HP - Hôpital Antoine Béclère [Clamart], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), AP-HP Hôpital Bicêtre (Le Kremlin-Bicêtre), CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Centre de Recherche des Cordeliers (CRC (UMR_S_1138 / U1138)), École Pratique des Hautes Études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Université Paris Cité (UPCité), Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases (ICAN), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Institut de Cardiométabolisme et Nutrition = Institute of Cardiometabolism and Nutrition [CHU Pitié Salpêtrière] (IHU ICAN), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-CHU Pitié-Salpêtrière [AP-HP], Service des maladies infectieuses et tropicales [CHU Nantes], Pharmacologie des anti-infectieux (PHAR), Université de Poitiers-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre hospitalier universitaire de Poitiers (CHU Poitiers), Fédération française des diabétiques, Hôpital Avicenne [AP-HP], Centre de Recherche en Nutrition Humaine - Ile de France (CRNH - IDF), Unité de Recherche en Epidémiologie Nutritionnelle (UREN), Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Sorbonne Paris Nord, Service d'endocrinologie, diabète, maladies métaboliques [Hôpital de la Conception - APHM], Aix Marseille Université (AMU), Centre recherche en CardioVasculaire et Nutrition = Center for CardioVascular and Nutrition research (C2VN), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Cardiovasculaire, métabolisme, diabétologie et nutrition (CarMeN), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Hospices Civils de Lyon (HCL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Hôpital Nord [CHU - APHM], Service Endocrinologie - Diabétologie [CHU Caen], Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-CHU Caen, Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Tumorothèque de Caen Basse-Normandie (TCBN), Centre Hospitalier Régional Universitaire de Brest (CHRU Brest), Groupe d'Etude de la Thrombose de Bretagne Occidentale (GETBO), Université de Brest (UBO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Brestois Santé Agro Matière (IBSAM), Université de Brest (UBO)-Université de Brest (UBO), Centre d'Investigation Clinique [Rennes] (CIC), Université de Rennes (UR)-Hôpital Pontchaillou-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre hospitalier Saint Joseph - Saint Luc [Lyon], CHU Strasbourg, Service d'endocrinologie, diabétologie et nutrition [CHU Bichat], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-AP-HP - Hôpital Bichat - Claude Bernard [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Cité (UPCité), CHU Rouen, Normandie Université (NU), Hôpital Lariboisière-Fernand-Widal [APHP], CIC - Poitiers, Université de Poitiers-Centre hospitalier universitaire de Poitiers (CHU Poitiers)-Direction Générale de l'Organisation des Soins (DGOS)-Institut National de la Santé et de la Recherche Médicale (INSERM), CIC Montpellier, Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Hôpital Saint Eloi (CHRU Montpellier), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Institut National de la Santé et de la Recherche Médicale (INSERM), Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] (PhyMedExp), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Institut des Maladies Métaboliques et Cardiovasculaires (I2MC), Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), CHU Saint-Antoine [AP-HP], Centre de Recherche Saint-Antoine (CRSA), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), CORONADO, Société Francophone du Diabète, CORONADO, Fondation francophone Recherche Diabète, CORONADO, Fonds dotation du CHU de Nantes, unité de recherche de l'institut du thorax UMR1087 UMR6291 (ITX), CH Evry-Corbeil, Service de Diabétologie [CHU Pitié-Salpétrière], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Université de Paris (UP), Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Institute of cardiometabolism and nutrition (ICAN), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU), Conservatoire National des Arts et Métiers [CNAM] (CNAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Sorbonne Paris Nord, Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Hospices Civils de Lyon (HCL), Université de Brest (UBO)-Institut Brestois Santé Agro Matière (IBSAM), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Hôpital Pontchaillou-Institut National de la Santé et de la Recherche Médicale (INSERM), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université de Paris (UP), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-CHU Saint-Eloi-Institut National de la Santé et de la Recherche Médicale (INSERM), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM), CHU Toulouse [Toulouse], Service d'Endocrinologie, diabétologie et endocrinologie de la reproduction [CHU Saint-Antoine], Centre de Recherche Saint-Antoine (CR Saint-Antoine), Sorbonne Université (SU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Saint-Antoine [AP-HP], Gestionnaire, Hal Sorbonne Université, Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Service de diabétologie [CHU Pitié-Salpétrière], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Hospices Civils de Lyon (HCL), Institut Brestois Santé Agro Matière (IBSAM), Université de Brest (UBO)-Université de Brest (UBO)-Université de Brest (UBO), Université de Montpellier (UM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées, and Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-CHU Saint-Antoine [AP-HP]
Subjects: 2019-20 coronavirus outbreak, biology, Coronavirus disease 2019 (COVID-19), business.industry, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Endocrinology, Diabetes and Metabolism, [SDV]Life Sciences [q-bio], COVID-19, 030209 endocrinology & metabolism, Human physiology, medicine.disease, biology.organism_classification, Virology, [SDV] Life Sciences [q-bio], 03 medical and health sciences, Pneumonia, 0302 clinical medicine, Pandemic, Internal Medicine, Medicine, 030212 general & internal medicine, business, Coronavirus Infections, Betacoronavirus, ComputingMilieux_MISCELLANEOUS
Abstract: International audience
Published: 2020
Full Text: View/download PDF

13. Phenotypic characteristics and prognosis of inpatients with COVID-19 and diabetes: the CORONADO study

Author: Amélie Ducet-Boiffard, Muriel Bourgeon-Ghittori, Claude Chaumeil, Pierre Jean Saulnier, Sandrine Coudol, Bertrand Cariou, Camille Vatier, Jean François Gautier, David Boutoille, Charles Thivolet, Abdallah Al-Salameh, Pierre Gourdy, Sophie Borot, Michael Joubert, Samy Hadjadj, Bruno Laviolle, Matthieu Wargny, Ingrid Allix, Ariane Sultan, Florence Baudoux, Gaëtan Prévost, René Robert, Coralie Amadou, Laurent Meyer, Jean-Pierre Riveline, Matthieu Pichelin, Patrice Darmon, Blandine Tramunt, Bernard Bauduceau, Jean François Thébaut, Gwénaëlle Arnault, Olivier Bourron, Lucien Marchand, Bénédicte Gaborit, Ronan Roussel, Emmanuel Cosson, Emmanuel Disse, Véronique Kerlan, Louis Potier, Centre hospitalier universitaire de Nantes (CHU Nantes), unité de recherche de l'institut du thorax UMR1087 UMR6291 (ITX), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN), CHU Amiens-Picardie, Centre Hospitalier Universitaire d'Angers (CHU Angers), PRES Université Nantes Angers Le Mans (UNAM), Centre Hospitalier Sud Francilien, CH Evry-Corbeil, Centre hospitalier Bretagne Atlantique (Morbihan) (CHBA), Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Hôpital d'Instruction des Armées Begin, Service de Santé des Armées, Service de Diabétologie - Endocrinologie [CHRU Besançon], Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon), AP-HP - Hôpital Antoine Béclère [Clamart], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Service de Diabétologie [CHU Pitié-Salpétrière], CHU Pitié-Salpêtrière [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Service des maladies infectieuses et tropicales [CHU Nantes], Pharmacologie des anti-infectieux (PHAR), Université de Poitiers-Institut National de la Santé et de la Recherche Médicale (INSERM), Fédération française des diabétiques, Université Sorbonne Paris Cité (USPC), Centre d’Investigation Clinique de Nantes (CIC Nantes), Université de Nantes (UN)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre hospitalier universitaire de Nantes (CHU Nantes), Centre recherche en CardioVasculaire et Nutrition = Center for CardioVascular and Nutrition research (C2VN), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Cardiovasculaire, métabolisme, diabétologie et nutrition (CarMeN), Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Hospices Civils de Lyon (HCL), Centre Hospitalier Départemental - Hôpital de La Roche-sur-Yon, Service d'endocrinologie, nutrition et maladies métaboliques [Hôpital Nord - APHM], Assistance Publique - Hôpitaux de Marseille (APHM)- Hôpital Nord [CHU - APHM], Centre Hospitalier Régional Universitaire de Brest (CHRU Brest), CHU Pontchaillou [Rennes], Centre d'Investigation Clinique [Rennes] (CIC), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Hôpital Pontchaillou-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Les Hôpitaux Universitaires de Strasbourg (HUS), Service d'endocrinologie, diabétologie, nutrition, Différenciation et communication neuronale et neuroendocrine (DC2N), Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre de Recherche des Cordeliers (CRC (UMR_S_1138 / U1138)), École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Université de Paris (UP), Service des urgences [Poitiers], Centre hospitalier universitaire de Poitiers (CHU Poitiers), CIC - Poitiers, Université de Poitiers-Centre hospitalier universitaire de Poitiers (CHU Poitiers)-Direction Générale de l'Organisation des Soins (DGOS)-Institut National de la Santé et de la Recherche Médicale (INSERM), Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] (PhyMedExp), Université de Montpellier (UM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), CHU Saint-Antoine [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Institut des Maladies Métaboliques et Cardiovasculaires (I2MC), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM), CORONADO Initiative Emergency grant, Air Liquide, CORONADO Initiative Emergency Grant, Fondation Francophone pour la Recherche sur le Diabète, CORONADO Initiative Emergency Grant, Sociéte Francophone du Diabète, Unité de recherche de l'institut du thorax (ITX-lab), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Hospices Civils de Lyon (HCL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Centre Hospitalier Départemental - Hôpital de La Roche-sur-Yon (CHD Vendée), Université de Rennes (UR)-Hôpital Pontchaillou-Institut National de la Santé et de la Recherche Médicale (INSERM), Service d'endocrinologie, diabétologie et maladies métaboliques [Rouen], CHU Rouen, Normandie Université (NU)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU), École Pratique des Hautes Études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Université Paris Cité (UPCité), Service des urgences [CHU Poitiers], Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université de Picardie Jules Verne (UPJV), Service de diabétologie - endocrinologie, Centre Hospitalier Régional Universitaire [Besançon] (CHRU Besançon)-Hôpital Jean Minjoz, Hôpital Antoine Béclère, Service de diabétologie [CHU Pitié-Salpétrière], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Pitié-Salpêtrière [AP-HP], Unité de Recherche en Epidémiologie Nutritionnelle (UREN), Conservatoire National des Arts et Métiers [CNAM] (CNAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Sorbonne Paris Nord, Centre de Recherche en Nutrition Humaine - Ile de France (CRNH - IDF), Université de Nantes (UN)-Centre hospitalier universitaire de Nantes (CHU Nantes)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service d'endocrinologie, diabète, maladies métaboliques [Hôpital de la Conception - APHM], Aix Marseille Université (AMU), Centre recherche en CardioVasculaire et Nutrition (C2VN), Aix Marseille Université (AMU)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut National de la Santé et de la Recherche Médicale (INSERM), Hospices Civils de Lyon (HCL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Groupe d'Etude de la Thrombose de Bretagne Occidentale (GETBO), Université de Brest (UBO)-Institut Brestois Santé Agro Matière (IBSAM), Université de Brest (UBO), École pratique des hautes études (EPHE)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Université de Paris (UP), Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Centre Hospitalier Universitaire de Toulouse, Jonchère, Laurent, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées, and Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université de Lyon-Université Claude Bernard Lyon 1 (UCBL)
Subjects: medicine.medical_specialty, HbA1c, medicine.medical_treatment, Endocrinology, Diabetes and Metabolism, 030209 endocrinology & metabolism, Type 2 diabetes, Logistic regression, Article, 03 medical and health sciences, BMI, 0302 clinical medicine, Mechanical ventilation, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, Internal medicine, Diabetes mellitus, medicine, Internal Medicine, 030212 general & internal medicine, [SDV.MHEP.ME] Life Sciences [q-bio]/Human health and pathology/Emerging diseases, [SDV.MHEP.EM] Life Sciences [q-bio]/Human health and pathology/Endocrinology and metabolism, Univariate analysis, [SDV.MHEP.ME]Life Sciences [q-bio]/Human health and pathology/Emerging diseases, business.industry, Tracheal intubation, Diabetes, COVID-19, [SDV.MHEP.EM]Life Sciences [q-bio]/Human health and pathology/Endocrinology and metabolism, medicine.disease, Comorbidity, 3. Good health, Death, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, Hypertension, [SDV.MHEP.MI] Life Sciences [q-bio]/Human health and pathology/Infectious diseases, Observational study, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, business
Abstract: Aims/hypothesis Coronavirus disease-2019 (COVID-19) is a life-threatening infection caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) virus. Diabetes has rapidly emerged as a major comorbidity for COVID-19 severity. However, the phenotypic characteristics of diabetes in COVID-19 patients are unknown. Methods We conducted a nationwide multicentre observational study in people with diabetes hospitalised for COVID-19 in 53 French centres in the period 10–31 March 2020. The primary outcome combined tracheal intubation for mechanical ventilation and/or death within 7 days of admission. Age- and sex-adjusted multivariable logistic regressions were performed to assess the prognostic value of clinical and biological features with the endpoint. ORs are reported for a 1 SD increase after standardisation. Results The current analysis focused on 1317 participants: 64.9% men, mean age 69.8 ± 13.0 years, median BMI 28.4 (25th–75th percentile: 25.0–32.7) kg/m2; with a predominance of type 2 diabetes (88.5%). Microvascular and macrovascular diabetic complications were found in 46.8% and 40.8% of cases, respectively. The primary outcome was encountered in 29.0% (95% CI 26.6, 31.5) of participants, while 10.6% (9.0, 12.4) died and 18.0% (16.0, 20.2) were discharged on day 7. In univariate analysis, characteristics prior to admission significantly associated with the primary outcome were sex, BMI and previous treatment with renin–angiotensin–aldosterone system (RAAS) blockers, but not age, type of diabetes, HbA1c, diabetic complications or glucose-lowering therapies. In multivariable analyses with covariates prior to admission, only BMI remained positively associated with the primary outcome (OR 1.28 [1.10, 1.47]). On admission, dyspnoea (OR 2.10 [1.31, 3.35]), as well as lymphocyte count (OR 0.67 [0.50, 0.88]), C-reactive protein (OR 1.93 [1.43, 2.59]) and AST (OR 2.23 [1.70, 2.93]) levels were independent predictors of the primary outcome. Finally, age (OR 2.48 [1.74, 3.53]), treated obstructive sleep apnoea (OR 2.80 [1.46, 5.38]), and microvascular (OR 2.14 [1.16, 3.94]) and macrovascular complications (OR 2.54 [1.44, 4.50]) were independently associated with the risk of death on day 7. Conclusions/interpretations In people with diabetes hospitalised for COVID-19, BMI, but not long-term glucose control, was positively and independently associated with tracheal intubation and/or death within 7 days. Trial registration clinicaltrials.gov NCT04324736.
Published: 2020
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14. Design of a Multiwaves Vibration Filtering

Author: François Gautier, Vicent Romero-García, Adrien Pelat, Thierry Bourdon, Jules Plisson, Laboratoire d'Acoustique de l'Université du Mans (LAUM), Centre National de la Recherche Scientifique (CNRS)-Le Mans Université (UM), VITESCO Technologies France SAS, Vitesco Technologies, and Romero Garcia, Vicente
Subjects: Vibration, Computer science, Acoustics, 020101 civil engineering, 02 engineering and technology, [PHYS.MECA]Physics [physics]/Mechanics [physics], [PHYS.MECA] Physics [physics]/Mechanics [physics], 021001 nanoscience & nanotechnology, 0210 nano-technology, [PHYS.MECA.ACOU] Physics [physics]/Mechanics [physics]/Acoustics [physics.class-ph], 0201 civil engineering, [PHYS.MECA.ACOU]Physics [physics]/Mechanics [physics]/Acoustics [physics.class-ph]
Abstract: International audience; In vibroacoustics, bandgap effects related to periodic and/or locally resonant architectural materials can lead to new types of structural vibration filters. This communication concerns periodic pipes used in industrial context. Such pipes are seen, as architectural structural waveguides in which bending, torsional, and longitudinal waves can propagate. To control the propagation of these vibrations and reduce their possible noise disturbance, Bragg or resonant band effects can be obtained by architecting the axial variations of the cross-section. As a result, a waveguide can be tuned to create stop bands with bandwidths large enough to make them interesting for industrial applications. For this purpose, dispersion relations are derived and analyzed based on the Floquet method and numerical Finite Element simulations. In many practical cases, all kinds of waves generally coexist due to the inevitable structural couplings. Therefore, the optimization of the geometric and mechanical characteristics of the structural couplings. Therefore, the optimization of the geometric and mechanical characteristics of the structure must be realized to attenuate several ( at least two) types of waves at the same time. The response of optimized architecture pipes of finite size is simulated using the finite element method in order to illustrate the potential filter effect for practical applications.
Published: 2020

15. Experimental evidence of absolute band gaps in phononic crystal pipes

Author: Adrien Pelat, François Gautier, Vicente Romero Garcia, Thierry Bourdon, Jules Plisson, Laboratoire d'Acoustique de l'Université du Mans (LAUM), Centre National de la Recherche Scientifique (CNRS)-Le Mans Université (UM), Vitesco Technologies, and Agence Nationale Recherche Technologie, Vitesco Technology France SAS
Subjects: 010302 applied physics, [PHYS.MECA.VIBR]Physics [physics]/Mechanics [physics]/Vibrations [physics.class-ph], Materials science, Physics and Astronomy (miscellaneous), Band gap, Acoustics, Bandwidth (signal processing), Viscoelasticity, 02 engineering and technology, Optimization algorithms, Lossy compression, 021001 nanoscience & nanotechnology, 01 natural sciences, [PHYS.MECA.ACOU]Physics [physics]/Mechanics [physics]/Acoustics [physics.class-ph], Vibration, Dispersion function, Phononic crystal, Simplex algorithm, Flexural strength, 0103 physical sciences, Wave mechanics, Finite-element analysis, Center frequency, 0210 nano-technology, Experiment design
Abstract: International audience; The vibration filtering properties of a phononic crystal pipe whose unit cell consists of two segments of different material and cross-section are studied numerically and experimentally. Such an architected bi-material pipe leads to an alignment of the dispersion branches in the same frequency ranges for all types of waves (flexural, longitudinal, torsional), leading to an absolute band gap. Each motion is studied by a 1D model in which the propagation of Floquet-Bloch waves in lossy media are considered. The numerical optimization is based on the simplex algorithm and aims to control both the central frequency and the band width of the absolute band gap on a selected target. Experimental characterization of a demonstrator confirms the filtering effects due to partial and absolute band gaps even in the presence of quite high structural damping.
Published: 2020
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16. Metformin use is associated with a reduced risk of mortality in patients with diabetes hospitalised for COVID-19

Author: Anne Dutour, Matthieu Wargny, Michael Joubert, D. Gouet, Thierry Duriez, Rachel Desailloud, Gaëtan Prévost, Pierre Gourdy, Bertrand Cariou, Matthieu Pichelin, Christelle Raffaitin-Cardin, Thomas Goronflot, Frédérique Olivier, Ingrid Julier, Céline Gonfroy, Ingrid Allix, Laurent Meyer, Etienne Larger, Coralie Amadou, Lucien Marchand, Dominique Seret-Bégué, Pierre-Jean Saulnier, Charles Thivolet, Abdallah Al-Salameh, Camille Vatier, Olivier Bourron, Ronan Roussel, Samy Hadjadj, Jean-François Gautier, Nicolas Wiernsperger, Pascale Quiniou, Jean-Daniel Lalau, Michel Marre, CHU Amiens-Picardie, Université de Picardie Jules Verne (UPJV), Périnatalité et Risques Toxiques - UMR INERIS_I 1 (PERITOX), Université de Picardie Jules Verne (UPJV)-CHU Amiens-Picardie-Institut National de l'Environnement Industriel et des Risques, Centre hospitalier universitaire de Nantes (CHU Nantes), unité de recherche de l'institut du thorax UMR1087 UMR6291 (ITX), Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Centre d’Investigation Clinique de Nantes (CIC Nantes), Université de Nantes (UN)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre hospitalier universitaire de Nantes (CHU Nantes), Association REMEDES [Ville-sur-Jarnioux], Centre Hospitalier Universitaire d'Angers (CHU Angers), PRES Université Nantes Angers Le Mans (UNAM), Centre Hospitalier Sud Francilien, CH Evry-Corbeil, Centre de Recherche des Cordeliers (CRC (UMR_S_1138 / U1138)), École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Université de Paris (UP), Centre Hospitalier de Cholet (CHC), Hôpital Lariboisière-Fernand-Widal [APHP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Hôpital Nord [CHU - APHM], Centre Hospitalier René Dubos [Pontoise], Centre Hospitalier de La Rochelle (CHR), CHU Caen, Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN), Centre Hospitalier Alès-Cévennes (CHAC), Hôpital Cochin [AP-HP], Centre Hospitalier Saint Joseph (CH St Joseph), Hôpital Ambroise Paré [AP-HP], Les Hôptaux universitaires de Strasbourg (HUS), CHU Strasbourg, Centre hospitalier de Cahors, Département d'Endocrinologie, Diabète et Maladies Métaboliques [CHU Rouen], CHU Rouen, Normandie Université (NU)-Normandie Université (NU), Université de Rouen Normandie (UNIROUEN), Normandie Université (NU), Centre Hospitalier Régional Universitaire de Brest (CHRU Brest), Centre Hospitalier Libourne, CIC - Poitiers, Université de Poitiers-Centre hospitalier universitaire de Poitiers (CHU Poitiers)-Direction Générale de l'Organisation des Soins (DGOS)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre Hospitalier de Gonesse (CHU Gonesse), Cardiovasculaire, métabolisme, diabétologie et nutrition (CarMeN), Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Hospices Civils de Lyon (HCL), Centre National de Référence des Pathologies Rares de l'Insulino-Sécrétion et de l'Insulino-Sensibilité [CHu Saint-Antoine] (PRISIS), CHU Saint-Antoine [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Institut des Maladies Métaboliques et Cardiovasculaires (I2MC), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut National de l'Environnement Industriel et des Risques (INERIS)-Université de Picardie Jules Verne (UPJV)-CHU Amiens-Picardie, Unité de recherche de l'institut du thorax (ITX-lab), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Université Paris Cité (UPCité), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Hospices Civils de Lyon (HCL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), and CarMeN, laboratoire
Subjects: Male, medicine.medical_specialty, endocrine system diseases, Propensity score, Endocrinology, Diabetes and Metabolism, [SDV]Life Sciences [q-bio], 030209 endocrinology & metabolism, Type 2 diabetes, 030204 cardiovascular system & hematology, Lower risk, 03 medical and health sciences, 0302 clinical medicine, Endocrinology, Mechanical ventilation, Internal medicine, Diabetes mellitus, Internal Medicine, medicine, Clinical endpoint, Humans, Hypoglycemic Agents, Survival analysis, Aged, Aged, 80 and over, business.industry, Mortality rate, General Medicine, Middle Aged, medicine.disease, Respiration, Artificial, Metformin, 3. Good health, [SDV] Life Sciences [q-bio], Hospitalization, Death, Diabetes Mellitus, Type 2, Propensity score matching, Original Article, Female, business, Covid-19, medicine.drug
Abstract: International audience; AIMS: Metformin exerts anti-inflammatory and immunosuppressive effects. We addressed the impact of prior metformin use on prognosis in patients with type 2 diabetes hospitalised for COVID-19. METHODS: CORONADO is a nationwide observational study that included patients with diabetes hospitalised for COVID-19 between March 10 and April 10, 2020 in 68 French centres. The primary outcome combined tracheal intubation and/or death within 7 days of admission. A Kaplan-Meier survival curve was reported for death up to day 28. The association between metformin use and outcomes was then estimated in a logistic regression analysis after applying a propensity score inverse probability of treatment weighting approach. RESULTS: Among the 2449 patients included, 1496 were metformin users and 953 were not. Compared with non-users, metformin users were younger with a lower prevalence of diabetic complications, but had more severe features of COVID-19 on admission. The primary endpoint occurred in 28.0% of metformin users (vs 29.0% in non-users, P = 0.6134) on day 7 and in 32.6% (vs 38.7%, P = 0.0023) on day 28. The mortality rate was lower in metformin users on day 7 (8.2 vs 16.1%, P \textless 0.0001) and on day 28 (16.0 vs 28.6%, P \textless 0.0001). After propensity score weighting was applied, the odds ratios for primary outcome and death (OR [95%CI], metformin users vs non-users) were 0.838 [0.649-1.082] and 0.688 [0.470-1.007] on day 7, then 0.783 [0.615-0.996] and 0.710 [0.537-0.938] on day 28, respectively. CONCLUSION: Metformin use appeared to be associated with a lower risk of death in patients with diabetes hospitalised for COVID-19.
Published: 2020
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17. Cortisol and Aldosterone Responses to Hypoglycemia and Na Depletion in Women With Non-Classic 21-Hydroxylase Deficiency

Author: Laurence Pietri, Jean-François Gautier, H. Bry, Michel Azizi, Anne Blanchard, Julien Thomas, Antonin Lamaziere, Yves Le Bouc, Sylvie Salenave, Sylvie Brailly-Tabard, Sophie Christin-Maitre, Lise Duranteau, Bruno Donadille, Céline Piedvache, Aurélien Lorthioir, Peter Kamenický, Jacques Young, Philippe Chanson, Seray Genc, Marie-Laure Raffin-Sanson, CIC - HEGP (CIC 1418), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Européen Georges Pompidou [APHP] (HEGP), and Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPC)
Subjects: Hydrocortisone, Endocrinology, Diabetes and Metabolism, [SDV]Life Sciences [q-bio], Clinical Biochemistry, Biochemistry, chemistry.chemical_compound, 0302 clinical medicine, Endocrinology, Prospective Studies, Aldosterone, 030219 obstetrics & reproductive medicine, biology, Incidence, 21-Hydroxylase, Middle Aged, Prognosis, Female, France, Pseudogenes, Cortisol secretion, Adult, medicine.medical_specialty, Adolescent, food.diet, 030209 endocrinology & metabolism, Equivalence Trials as Topic, Low sodium diet, Hypoglycemia, 03 medical and health sciences, Young Adult, food, Internal medicine, Renin–angiotensin system, medicine, Adrenal insufficiency, Humans, Adrenal Hyperplasia, Congenital, business.industry, Biochemistry (medical), Insulin tolerance test, Sodium, medicine.disease, chemistry, Case-Control Studies, biology.protein, business, Biomarkers, Follow-Up Studies
Abstract: Background Non-classic 21-hydroxylase deficiency is usually diagnosed in post-pubertal women because of androgen excess. Indication of systematic steroid replacement therapy is controversial because the risk of acute adrenal insufficiency is unknown. In order to specify this risk we evaluated the cortisol and aldosterone secretions in response to appropriate pharmacologic challenges. Methods In this prospective case–control non-inferiority study we investigated 20 women with non-classic 21-hydroxylase deficiency carrying biallelic CYP21A2 mutations and with serum 17-hydroxyprogesterone (17OHP) >10 ng/mL after stimulation with Synacthen® (tetracosactrin) and 20 age- and body mass index-matched healthy women with 17OHP after Synacthen® Findings The peak serum cortisol concentration after insulin hypoglycemia was lower in patients than in controls (mean difference –47 ng/mL, 90% CI, –66, P = 0.0026). A peak serum cortisol above a cutoff value of 170 ng/mL was obtained in all controls but only in 55% of patients (P = 0.0039). Twenty-four hours after sodium depletion, blood pressure, plasma sodium, potassium, and serum aldosterone concentrations were comparable between the two groups, but patients had higher stimulated renin concentrations than controls (P = 0.0044). Interpretation Patients with non-classic 21-hydroxylase deficiency frequently display partial cortisol insufficiency and compensated defect in aldosterone secretion. Their clinical management should systematically include assessment of adrenal functions.
Published: 2020
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18. Interpretation of the Acoustic Black Hole effect based on the concept of critical coupling

Author: Jean-Philippe Groby, François Gautier, Adrien Pelat, Vicent Romero-García, Rubén Picó, J. Leng, Laboratoire d'Acoustique de l'Université du Mans (LAUM), Centre National de la Recherche Scientifique (CNRS)-Le Mans Université (UM), Universidad Politecnica de Valencia, Universidad Politécnica de Valencia, and Universitat Politècnica de València (UPV)
Subjects: Timoshenko beam theory, Acoustic Black Hole effect, Acoustics and Ultrasonics, Transfer-matrix method (optics), 09.- Desarrollar infraestructuras resilientes, promover la industrialización inclusiva y sostenible, y fomentar la innovación, 02 engineering and technology, 01 natural sciences, Vibration damper, 0103 physical sciences, Reflection coefficient, 010301 acoustics, Physics, Coupling, [PHYS.MECA.VIBR]Physics [physics]/Mechanics [physics]/Vibrations [physics.class-ph], 06.- Garantizar la disponibilidad y la gestión sostenible del agua y el saneamiento para todos, Mechanical Engineering, Mechanics, 021001 nanoscience & nanotechnology, Condensed Matter Physics, Finite element method, [PHYS.MECA.ACOU]Physics [physics]/Mechanics [physics]/Acoustics [physics.class-ph], Vibration, Critical coupling, Reflection (mathematics), Mechanics of Materials, FISICA APLICADA, 0210 nano-technology, Beam (structure)
Abstract: [EN] An Acoustic Black Hole (ABH) in a one-dimensional (1D) beam is a passive vibration damping device based on a local reduction of the beam thickness attached to a thin layer of attenuating material. This work aims at revisiting the ABH effect by analysing the ABH trapped modes in the complex frequency plane. This analysis relies on an analytical model based on the one-dimensional thin beam theory and the transfer matrix method which assumes that the ABH termination is discretised by constant thickness piecewise elements. The model is validated with numerical simulations by the Finite Element Method. The reflection coefficients of several ABH terminations are studied. The results show that an ABH presents an infinite number of modes associated to an infinite number of poles and zeros of the reflection coefficient, the density and quality factor of which depend on the order of the ABH profile. By considering the ABH termination as an open lossy resonator, its damping efficiency results therefore from a balance between the energy leakage of each mode and its inherent losses, known as the critical coupling condition. In particular, the broadband absorption of the vibration energy is achieved for frequencies higher than that of the mode that is critically coupled. This type of analysis is used to interpret the ABH effect. It provides the losses needed to obtain the critical coupling condition, and is suitable for the optimisation of one-dimensional ABH terminations. (C) 2020 Elsevier Ltd. All rights reserved., This work has been funded by the RFI Le Mans Acoustic (Region Pays de la Loire) within the framework of the Metaplaque project. This article is based on work from COST action DENORMS CA 15125, supported by COST (European Cooperation in Science and Technology). This work was partly supported by the Spanish Ministry of Economy and Innovation (MINECO), by the European Union FEDER through project FIS2015-65998-C2-2, by the project AICO/2016/060 by Conselleria de Educacion, Investigacion, Cultura y Deporte de la Generalitat Valenciana and by the project eTNAA ANR-17-CE08-0035-01 (projet ANR 2017-2010).
Published: 2020
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19. Relationship between obesity and severe COVID ‐19 outcomes in patients with type 2 diabetes: Results from the CORONADO study

Author: Sara Barraud, Anne Dorange, Bertrand Cariou, Louis Potier, Christine Coffin-Boutreux, Natacha Germain, Coralie Amadou, Patrice Winiszewski, Bénédicte Gaborit, Camille Vatier, Blandine Tramunt, Pierre-Jean Saulnier, Stéphanie Laugier-Robiolle, Deborah Ancelle, Etienne Larger, Bénédicte Fremy, Pierre Gourdy, Bruno Vergès, Matthieu Pichelin, Isabelle Moura, Dominique Seret-Bégué, Matthieu Wargny, Olivier Bourron, Arnaud Monier, Samy Hadjadj, Laurent Meyer, Leila Ait Bachir, Cyrielle Caussy, Nadia Sabbah, Jean-François Gautier, Sarra Smati, unité de recherche de l'institut du thorax UMR1087 UMR6291 (ITX), Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Institut des Maladies Métaboliques et Cardiovasculaires (I2MC), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM), CHU Toulouse [Toulouse], Hospices Civils de Lyon (HCL), Cardiovasculaire, métabolisme, diabétologie et nutrition (CarMeN), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Hospices Civils de Lyon (HCL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Assistance Publique-Hôpitaux de Marseille (AP-HM), Centre recherche en CardioVasculaire et Nutrition = Center for CardioVascular and Nutrition research (C2VN), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Centre de Recherche Saint-Antoine (CR Saint-Antoine), Sorbonne Université (SU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Saint-Antoine [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Pathologies biliaires, fibrose et cancer du foie [CHU Saint-Antoine], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Saint-Antoine [AP-HP], Hôpital du Bocage, Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon), Centre Hospitalier Monod, Centre Hospitalier Sud Francilien, CH Evry-Corbeil, Institut hospitalier Franco-Britannique [Levallois-Perret], Sorbonne Université (SU), CHU Pitié-Salpêtrière [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Institut de Cardiométabolisme et Nutrition - Institute of Cardiometabolism and Nutrition, Centre Hospitalier Perigueux, Centre Hospitalier Universitaire de Reims (CHU Reims), Centre Hospitalier Le Mans (CH Le Mans), Centre Hospitalier d'Agen, Hôpital Lariboisière-Fernand-Widal [APHP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Complications vasculaires du diabète (CRC - Inserm U1138), Centre de Recherche des Cordeliers (CRC (UMR_S_1138 / U1138)), École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Université de Paris (UP)-École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Université de Paris (UP), Centre Hospitalier Universitaire de Saint-Etienne (CHU de Saint-Etienne), Service de diabétologie [CHU Cochin], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Cochin [AP-HP], Centre Hospitalier d'Auch (CH Auch), Les Hôpitaux Universitaires de Strasbourg (HUS), Hôpital Louis Pasteur [Chartres], Centre Hospitalier d 'Albi, AP-HP - Hôpital Bichat - Claude Bernard [Paris], Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française], Université de Guyane (UG), Centre Hospitalier de Gonesse (CHU Gonesse), Hôpital Nord Franche-Comté [Hôpital de Trévenans] (HNFC), CIC - Poitiers, Université de Poitiers-Centre hospitalier universitaire de Poitiers (CHU Poitiers)-Direction Générale de l'Organisation des Soins (DGOS)-Institut National de la Santé et de la Recherche Médicale (INSERM), Air Liquide Health Care international AstraZeneca Fondation Francophone pour la Recherche sur le Diabete Hospitalization and Care Organization Division (DHOS) 20-0138Sanofi Societe Francophone du Diabete, Barraud, Sara, Unité de recherche de l'institut du thorax (ITX-lab), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN), Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), Assistance Publique - Hôpitaux de Marseille (APHM), Centre de Recherche Saint-Antoine (CRSA), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), Pathologies biliaires, fibrose et cancer du foie [CRSA], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Institut de Cardiométabolisme et Nutrition = Institute of Cardiometabolism and Nutrition [CHU Pitié Salpêtrière] (IHU ICAN), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Université Paris Cité (UPCité)-École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Université Paris Cité (UPCité), Centre Hospitalier d'Albi, Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM), École Pratique des Hautes Études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Université Paris Cité (UPCité)-École Pratique des Hautes Études (EPHE), and Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] (CHU ST-E)
Subjects: Male, obesity, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, Type 2 diabetes, 030204 cardiovascular system & hematology, Overweight, Body Mass Index, 0302 clinical medicine, Endocrinology, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, Medicine, [SDV.MHEP.EM] Life Sciences [q-bio]/Human health and pathology/Endocrinology and metabolism, 2. Zero hunger, education.field_of_study, Middle Aged, [SDV.MHEP.EM]Life Sciences [q-bio]/Human health and pathology/Endocrinology and metabolism, Patient Discharge, 3. Good health, COVID‐19, elderly, mechanical ventilation, obesity, prognosis, type 2 diabetes, [SDV.MHEP.MI] Life Sciences [q-bio]/Human health and pathology/Infectious diseases, Original Article, Female, type 2 diabetes, medicine.symptom, medicine.medical_specialty, Population, 030209 endocrinology & metabolism, mechanical ventilation, elderly, 03 medical and health sciences, Class I obesity, Internal medicine, Diabetes mellitus, Internal Medicine, Humans, education, Aged, Retrospective Studies, Mechanical ventilation, Inpatients, business.industry, SARS-CoV-2, COVID-19, Original Articles, medicine.disease, Obesity, Respiration, Artificial, Logistic Models, Diabetes Mellitus, Type 2, prognosis, business, Body mass index
Abstract: International audience; Aim: To assess the relationship between body mass index (BMI) classes and early COVID-19 prognosis in inpatients with type 2 diabetes (T2D).Methods: From th e CORONAvirus-SARS-CoV-2 and Diabetes Outcomes(CORONADO) study, we conducted an analysis in patients with T2D categorized by four BMI subgroups according to the World Health Organization classification. Clinical characteristics and COVID-19–related outcomes (i.e. intubation for mechanical ventilation [IMV], death and discharge by day 7 [D7]) were analysed according to BMI status.Results: Among 1965 patients with T2D, 434 (22.1%) normal weight (18.5-24.9 kg/m2, reference group), 726 (36.9%) overweight (25-29.9 kg/m2) and 805 (41.0%) obese subjects were analysed, including 491 (25.0%) with class I obesity (30-34.9 kg/m2) and 314 (16.0%) with class II/III obesity (≥35 kg/m2). In a multivariable-adjusted model, the primary outcome (i.e. IMV and/or death by D7) was significantly associated with overweight (OR 1.65 [1.05-2.59]), class I (OR 1.93 [1.19-3.14]) and class II/III obesity (OR 1.98 [1.11-3.52]). After multivariable adjustment, primary outcome by D7 was significantly associated with obesity in patients aged younger than 75 years, while such an association was no longer found in those aged older than 75 years.Conclusions: Overweight and obesity are associated with poor early prognosis in patients with T2D hospitalized for COVID-19. Importantly, the deleterious impact of obesity on COVID-19 prognosis was no longer observed in the elderly, highlighting the need for specific management in this population.
Published: 2020
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20. A vibro-impact acoustic black hole for passive damping of flexural beam vibrations

Author: Haiqin Li, Cyril Touzé, François Gautier, Xianren Kong, Adrien Pelat, Harbin Institute of Technology (HIT), Institut des Sciences de la mécanique et Applications industrielles (IMSIA - UMR 9219), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-École Nationale Supérieure de Techniques Avancées (ENSTA Paris)-Centre National de la Recherche Scientifique (CNRS)-Université Paris-Saclay-EDF R&D (EDF R&D), EDF (EDF)-EDF (EDF), Laboratoire d'Acoustique de l'Université du Mans (LAUM), Centre National de la Recherche Scientifique (CNRS)-Le Mans Université (UM), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-École Nationale Supérieure de Techniques Avancées (ENSTA Paris)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-EDF R&D (EDF R&D), and Le Mans Université (UM)-Centre National de la Recherche Scientifique (CNRS)
Subjects: Acoustic Black Hole effect, Acoustics and Ultrasonics, 02 engineering and technology, 01 natural sciences, Noise (electronics), Damping, Displacement (vector), 0203 mechanical engineering, 0103 physical sciences, Flexural vibration mitigation, 010301 acoustics, Physics, [SPI.ACOU]Engineering Sciences [physics]/Acoustics [physics.class-ph], Steady state, Mechanical Engineering, [SPI.MECA.VIBR]Engineering Sciences [physics]/Mechanics [physics.med-ph]/Vibrations [physics.class-ph], Mechanics, Condensed Matter Physics, Vibration, Black hole, Nonlinear system, 020303 mechanical engineering & transports, Mechanics of Materials, Energy transfer, [SPI.MECA.STRU]Engineering Sciences [physics]/Mechanics [physics.med-ph]/Structural mechanics [physics.class-ph], [SPI.GCIV.DV]Engineering Sciences [physics]/Civil Engineering/Dynamique, vibrations, Transient (oscillation), Contact nonlinearity, Beam (structure)
Abstract: International audience; Nonlinear flexural vibrations of slender beams holding both an Acoustic Black Hole termination and a contact non-linearity are numerically studied. The Acoustic Black Hole (ABH) effect is a passive vibration mitigation technique, which has shown attractive properties above a given cut-on frequency. In this contribution, a vibro-impact acoustic black hole (VI-ABH) is introduced, the contact nonlinearity being used as a mean to transfer energy from low to high frequencies. A numerical model of a VI-ABH is derived from an Euler-Bernoulli beam. The contact law is handled with a penalization approach, the visco-elastic layer with a Ross-Kerwin-Ungard model and the problem is solved with a modal approach combined with an energy-conserving time integration scheme. Numerical results show that the VI-ABH brings about important modifications, and changes the nature of more traditional black holes, by redistributing all the vibrational energy. It can lead to a strong decrease of the resonance magnitude at low frequencies. Under steady state noise excitation, parametric studies are realised in the cases of a single contact, a grid of contacts and bilateral contacts layouts, in order to find some optimal designs. Transient dynamics is also studied through the analysis of displacement signal envelope and energy decay time. All the numerical results constantly show that the combination the ABH effect and an energy transfer provided by contact nonlinearity leads to very attractive mitigation template including low frequencies.
Published: 2019
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21. Limits of flexural wave absorption by open lossy resonators: reflection and transmission problems

Author: Jean-Philippe Groby, Vicente Romero-García, Adrien Pelat, Rubén Picó, François Gautier, J. Leng, Laboratoire d'Acoustique de l'Université du Mans (LAUM), Centre National de la Recherche Scientifique (CNRS)-Le Mans Université (UM), Instituto de Investigación para la Gestión Integrada de Zonas Costeras [Universitat Politècnica de València] (IGIC), and Universitat Politècnica de València (UPV)
Subjects: Coupling, Physics, Acoustic metamaterials, Locally resonant structures, Scattering, Acoustics, Transfer-matrix method (optics), FOS: Physical sciences, General Physics and Astronomy, Perfect absorption, Applied Physics (physics.app-ph), Physics - Applied Physics, 01 natural sciences, 010305 fluids & plasmas, [PHYS.MECA.ACOU]Physics [physics]/Mechanics [physics]/Acoustics [physics.class-ph], Resonator, FISICA APLICADA, 0103 physical sciences, Reflection (physics), Reflection coefficient, 010306 general physics, Absorption (electromagnetic radiation), Beam (structure)
Abstract: [EN] The limits of flexural wave absorption by open lossy resonators are analytically and numerically reported in this work for both the reflection and transmission problems. An experimental validation for the reflection problem is presented. The reflection and transmission of flexural waves in 1D resonant thin beams are analyzed by means of the transfer matrix method. The hypotheses, on which the analytical model relies, are validated by experimental results. The open lossy resonator, consisting of a finite length beam thinner than the main beam, presents both energy leakage due to the aperture of the resonators to the main beam and inherent losses due to the viscoelastic damping. Wave absorption is found to be limited by the balance between the energy leakage and the inherent losses of the open lossy resonator. The perfect compensation of these two elements is known as the critical coupling condition and can be easily tuned by the geometry of the resonator. On the one hand, the scattering in the reflection problem is represented by the reflection coefficient. A single symmetry of the resonance is used to obtain the critical coupling condition. Therefore the perfect absorption can be obtained in this case. On the other hand, the transmission problem is represented by two eigenvalues of the scattering matrix, representing the symmetric and anti-symmetric parts of the full scattering problem. In the geometry analyzed in this work, only one kind of symmetry can be critically coupled, and therefore, the maximal absorption in the transmission problem is limited to 0.5. The results shown in this work pave the way to the design of resonators for efficient flexural wave absorption., The authors thank Mathieu Secail-Geraud and Julien Nicolas for the development of the experimental set-up. The work has been founded by the RFI Le Mans Acoustic (Region Pays de la Loire) within the framework of the Metaplaque project. This article is based upon work from COST action DENORMS CA 15125, supported by COST (European Cooperation in Science and Technology). The work was partly supported by the Spanish Ministry of Economy and Innovation (MINECO) and European Union FEDER through project FIS2015-65998-C2-2 and by project AICO/2016/060 by Conselleria de Educacion, Investigacion, Cultura y Deporte de la Generalitat Valenciana.
Published: 2019
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22. On the control of the first Bragg band gap in periodic continuously corrugated beam for flexural vibration

Author: François Gautier, Thomas Gallot, Adrien Pelat, Laboratoire d'Acoustique de l'Université du Mans (LAUM), Centre National de la Recherche Scientifique (CNRS)-Le Mans Université (UM), and Universidad de la República [Montevideo] (UCUR)
Subjects: Acoustics and Ultrasonics, Band gap, Noise, vibration, and harshness, 02 engineering and technology, 01 natural sciences, wave coupling, flexural waves, Bragg band gaps, 0203 mechanical engineering, 0103 physical sciences, 010301 acoustics, Physics, Coupling, [PHYS.MECA.VIBR]Physics [physics]/Mechanics [physics]/Vibrations [physics.class-ph], Solid geometry, Mechanical Engineering, Mathematical analysis, Condensed Matter Physics, Finite element method, [PHYS.MECA.ACOU]Physics [physics]/Mechanics [physics]/Acoustics [physics.class-ph], Vibration, 020303 mechanical engineering & transports, Mechanics of Materials, periodic corrugated beam, Plane wave expansion, design tools, Beam (structure)
Abstract: International audience; This work aims to provide better physical understanding of Bragg band gap effects in continuously periodic corrugated beams for flexural waves. The main outcome is the establishement of original algebraic formulas for the band gap width and central frequency. It is shown that the band gap width and central frequency only depend on a thickness contrast parameter. To do so, a so called two-skins geometry is proposed to approximate the usual solid beam cross section, in order to greatly simplify analytical derivations following the Plane Wave Expansion (PWE) method applied to Euler-Bernoulli theory. Theoretical predictions in the two-skins geometry successfully match the results in the practical case of a solid geometry obtained from both experiments on a beam demonstrator and numerical simulations done by classical PWE (1D Euler and Timoshenko theories) or finite element (3D elasticity theory) methods. The complete set of results is benchmarked in details so that the geometrical approximation is validated and the algebraic formulas are usable as design tools of such notch filters. Moreover, flexural and longitudinal motion coupling due to the non-symetrical thickness profile of the demonstrators leads to an additional band gap that is experimentally identified. A numerical study illustrates the resulting double filtering effect. Potential applications of the background provided by this work can concern Noise,Vibration and Harshness (NVH) engineering, for which meta-materials can be very relevant especially when structure lightening is required.
Published: 2019
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23. Collisions in double string plucked instruments: Physical modelling and sound synthesis of the viola caipira

Author: Frédéric Ablitzer, François Gautier, Jose Maria Campos dos Santos, Guilherme Orelli Paiva, Laboratoire d'Acoustique de l'Université du Mans (LAUM), Centre National de la Recherche Scientifique (CNRS)-Le Mans Université (UM), and University of Campinas (UNICAMP)
Subjects: Acoustics and Ultrasonics, 02 engineering and technology, 01 natural sciences, Sympathetic string, String (physics), Theoretical physics, High Energy Physics::Theory, Unison, 0203 mechanical engineering, 0103 physical sciences, Octave, Sound synthesis, Collisions, Viola, 010301 acoustics, Physics, [SPI.ACOU]Engineering Sciences [physics]/Acoustics [physics.class-ph], Mechanical Engineering, Condensed Matter Physics, String musical instruments, Coupling (physics), 020303 mechanical engineering & transports, Modal, Mechanics of Materials, Viola caipira, Guitar, Hybrid model
Abstract: International audience; The viola caipira is a folk guitar widely used in traditional and modern Brazilian music. It consists, in general, of 10 metallic strings arranged in five pairs, tuned in unison or octave, with the thinnest string located in the middle. An experimental study of the viola caipira pluck by means of a high speed camera reveals some specificities of the instrument. It is found that the instrument is characterized by a double pluck excitation since the two strings of a given pair are plucked successively and rapidly. Collisions between strings arranged in the same pair are identified. A hybrid model, based on a modal approach, is carried out for sound synthesis purposes. It includes 10 strings with non-planar motions coupled with the body and collisions between strings. A finite difference scheme is used to compute the coupling forces at each time-step, which permits a set of sound simulations. The effects of string/string collisions on the viola caipira sounds are identified and discussed. It is found that the model reproduces the main vibroacoustic features of the viola caipira, among which the sympathetic string resonances and the string/string collisions observed in the video analysis.
Published: 2019
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24. Nonlinear energy transfer to improve the acoustic black hole effect

Author: Haiqin Li, Vivien DENIS, Adrien Pelat, François Gautier, Cyril Touzé, Institut des Sciences de la mécanique et Applications industrielles (IMSIA - UMR 9219), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-École Nationale Supérieure de Techniques Avancées (ENSTA Paris)-Centre National de la Recherche Scientifique (CNRS)-Université Paris-Saclay-EDF R&D (EDF R&D), EDF (EDF)-EDF (EDF), Laboratoire de Mécanique Gabriel Lamé (LaMé), Université d'Orléans (UO)-Institut National des Sciences Appliquées - Centre Val de Loire (INSA CVL), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université de Tours, Laboratoire d'Acoustique de l'Université du Mans (LAUM), Centre National de la Recherche Scientifique (CNRS)-Le Mans Université (UM), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-École Nationale Supérieure de Techniques Avancées (ENSTA Paris)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-EDF R&D (EDF R&D), Université d'Orléans (UO)-Université de Tours (UT)-Institut National des Sciences Appliquées - Centre Val de Loire (INSA CVL), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA), Le Mans Université (UM)-Centre National de la Recherche Scientifique (CNRS), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université de Tours (UT), and Touzé, Cyril
Subjects: [SPI.ACOU]Engineering Sciences [physics]/Acoustics [physics.class-ph], [SPI.ACOU] Engineering Sciences [physics]/Acoustics [physics.class-ph], [SPI.MECA.VIBR]Engineering Sciences [physics]/Mechanics [physics.med-ph]/Vibrations [physics.class-ph], [SPI.MECA.VIBR] Engineering Sciences [physics]/Mechanics [physics.med-ph]/Vibrations [physics.class-ph], [SPI.MECA]Engineering Sciences [physics]/Mechanics [physics.med-ph], [SPI.MECA] Engineering Sciences [physics]/Mechanics [physics.med-ph]
Abstract: International audience; Acoustic Black Hole effect (ABH) describes a passive vibration mitigation technique used to damp out theflexural vibrations of thin structures such as beams. It relies on a wedge profile where the thickness is gradually decreasing, sothat wave velocities slows down, potentially decaying to zero without reflection. The device generally shows very interestingdamping properties in the mid and high-frequency range, however its efficiency in the low-frequency range still remainslimited. In this contribution, the inclusion of a nonlinearity as a way to improve the low-frequency performance of an ABHis investigated. Indeed, the nonlinearity may be used as a vector to transfer energy from the low to the high frequencyrange, where the damping properties are much more significant. Two different mechanisms are tested, based respectively ongeometric and contact nonlinearity.
Published: 2019

25. Liver adenomatosis in patients with hepatocyte nuclear factor-1 alpha maturity onset diabetes of the young (HNF1A-MODY): Clinical, radiological and pathological characteristics in a French series

Author: Christine Bellanne-Chantelot, Charles Thivolet, Pierre-Yves Benhamou, Etienne Larger, Laurence Chiche, Nathalie Jeandidier, Sandrine Laboureau, Luc Fournier, Anne Rod, Jean-Marie Wilhelm, Marc Popelier, Jean-François Gautier, P. Lecomte, Aini Haddouche, Pierre-Jean Guillausseau, Yves Reznik, Lucy Chaillous, René Valéro, Jose Timsit, CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Université Pierre et Marie Curie - Paris 6 (UPMC), Hôpital Européen [Fondation Ambroise Paré - Marseille], Université Paris Diderot - Paris 7 (UPD7), Institut du thorax, Université de Nantes (UN)-IFR26-Institut National de la Santé et de la Recherche Médicale (INSERM), Maladies Métaboliques et Endocrinologie, Université de la Méditerranée - Aix-Marseille 2, Centre recherche en CardioVasculaire et Nutrition = Center for CardioVascular and Nutrition research (C2VN), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Hôpital Cochin [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Service d'endocrinologie [CHU Caen], Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-CHU Caen, Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Tumorothèque de Caen Basse-Normandie (TCBN), Cardiovasculaire, métabolisme, diabétologie et nutrition (CarMeN), Institut National de la Recherche Agronomique (INRA)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Hospices Civils de Lyon (HCL)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre Hospitalier Universitaire [Grenoble] (CHU), Laboratory of Fundamental and Applied Bioenergetics = Laboratoire de bioénergétique fondamentale et appliquée (LBFA), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), Service de Biochimie Métabolique et Centre de Génétique moléculaire et chromosomique [CHU Pitié Salpêtrière], Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-CHU Pitié-Salpêtrière [APHP], Centre recherche en CardioVasculaire et Nutrition (C2VN), CHU Cochin [AP-HP], Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Hospices Civils de Lyon (HCL), Laboratoire de bioénergétique fondamentale et appliquée (LBFA), Université Joseph Fourier - Grenoble 1 (UJF)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Grenoble Alpes (UGA), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Pitié-Salpêtrière [AP-HP], and Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU)
Subjects: Adenoma, Adult, Diagnostic Imaging, Male, endocrine system, medicine.medical_specialty, Adolescent, Endocrinology, Diabetes and Metabolism, [SDV]Life Sciences [q-bio], 030209 endocrinology & metabolism, 030204 cardiovascular system & hematology, Gastroenterology, Maturity onset diabetes of the young, Cohort Studies, 03 medical and health sciences, Liver disease, Young Adult, 0302 clinical medicine, Germline mutation, Diabetes mellitus, Internal medicine, medicine, Humans, Hepatocyte Nuclear Factor 1-alpha, Hnf1a-mody, Child, Family Health, business.industry, Liver Neoplasms, Middle Aged, medicine.disease, 3. Good health, HNF1A, Diabetes Mellitus, Type 2, Mutation, diabetes mellitus, Histopathology, Female, France, business, Rare disease, liver adenomatosis
Abstract: Liver adenomatosis (LA) is a rare disease resulting from biallelic inactivation of the hepatocyte nuclear factor-1 alpha (HNF1A) gene, which induces the proliferation of adenoma cells in liver parenchyma. Liver adenomatosis has only been documented in case reports from patients carrying a HNF1A germline mutation. We have evaluated the frequency of LA among a large cohort of patients with HNF1A-maturity onset diabetes of the young (MODY), previously termed "MODY3," and herein describe its clinical, radiological, and pathological characteristics.In all, 137 HNF1A-MODY subjects from 74 families were screened by liver ultrasonography in 13 centers, and 15 additional cases of LA were later included in the series. Liver adenomatosis was confirmed by liver computed tomography, magnetic resonance imaging (MRI), and/or histopathology.Among 137 carriers of an HNF1A mutation, 9 patients (6.5%) from seven families were diagnosed with LA. Diabetes mellitus was present in 87.5% of patients with LA. In 25% of patients, LA was diagnosed due to intra-abdominal or intratumoral bleeding. Liver biochemistry was near normal in all patients. Liver imaging showed adenomas of various sizes and numbers. On MRI, most nodules had the radiological characteristics of steatotic adenomas. Histopathological confirmation of LA was available in 13 cases, and these adenomas were mostly steatotic. Surgery was initially performed in 37.5% of patients, and liver disease progression was observed in 30%. No disease progression was observed in 14 pregnancies.The frequency of LA in a cohort of screened HNF1A-MODY patients and the high incidence of LA progression and/or hemorrhage warrants systematic screening for liver adenomatosis in HNF1A-MODY families.背景: 肝细胞腺瘤病(liver adenomatosis, LA)是一种由于肝细胞核因子-1α(HNF1A)基因中的双等位基因失活所导致的罕见疾病, 可诱发肝实质中的腺瘤细胞增殖。肝细胞腺瘤病仅见于携带HNF1A种系突变基因患者的病例报告。我们在一个大型HNF1A-青少年发病的成年型糖尿病(MODY, 以前被称为“MODY3”)患者队列中评估了LA的发生率, 并在此对其临床、放射学以及病理学特征进行了描述。方法: 共有137名来自于74个家系的HNF1A-MODY受试者在13个中心接受了肝脏超声检查, 后续还有15名LA患者被纳入这项系列研究。通过肝脏计算机断层扫描、磁共振成像(MRI)和/或组织病理学检查来确诊肝细胞腺瘤病。结果: 在137名HNF1A突变基因携带者中, 来自7个家系的9例(6.5%)患者被诊断为LA。87.5%的LA患者存在糖尿病。25%的患者因出现腹腔内或者肿瘤内出血而被诊断为LA。所有患者的肝脏生化指标均接近正常。肝脏影像学表现为大小不等、数目不等的腺瘤。在MRI上, 大多数结节具有脂肪性腺瘤的影像学特征。13例LA得到组织病理学证实, 并且这些腺瘤以脂肪变性为主。37.5%的患者最初进行了手术, 30%的患者观察到肝脏疾病进展。14例妊娠患者未见疾病进展。结论: 在筛选的HNF1A-MODY患者队列中, 由于LA的高发病率以及LA进展和/或出血的高发生率, 因此很有必要在HNF1A-MODY家系中进行肝细胞腺瘤病的系统筛查。.
Published: 2019
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26. Absorption of flexural waves by 1D resonators in the case of reflection and transmission problems

Author: Leng, Julien, Romero-García, Vicente, Groby, Jean-Philippe, Pelat, Adrien, Pico, Ruben, François, Gautier, Laboratoire d'Acoustique de l'Université du Mans (LAUM), Centre National de la Recherche Scientifique (CNRS)-Le Mans Université (UM), Universitat Politècnica de València (UPV), and Romero Garcia, Vicente
Subjects: [PHYS.MECA]Physics [physics]/Mechanics [physics], [PHYS.MECA] Physics [physics]/Mechanics [physics], [PHYS.MECA.ACOU] Physics [physics]/Mechanics [physics]/Acoustics [physics.class-ph], ComputingMilieux_MISCELLANEOUS, [PHYS.MECA.ACOU]Physics [physics]/Mechanics [physics]/Acoustics [physics.class-ph]
Abstract: International audience
Published: 2018

27. The Roving Wire-Breaking Technique: a low cost mobility measurement procedure for string musical instruments

Author: Frédéric Ablitzer, François Gautier, Jose Maria Campos dos Santos, Guilherme Orelli Paiva, Ecole Nationale Supérieure d'Ingénieurs du Mans (ENSIM), Laboratoire d'Acoustique de l'Université du Mans (LAUM), Centre National de la Recherche Scientifique (CNRS)-Le Mans Université (UM), and University of Campinas [Campinas] (UNICAMP)
Subjects: [SPI.ACOU]Engineering Sciences [physics]/Acoustics [physics.class-ph], Acoustics and Ultrasonics, Computer science, Acoustics, Modal analysis, 020206 networking & telecommunications, 02 engineering and technology, 01 natural sciences, String (physics), law.invention, String musical instruments, Acceleration, Musical acoustics, Modal, law, Step function, 0103 physical sciences, 0202 electrical engineering, electronic engineering, information engineering, Bridge (instrument), Point (geometry), Wire-breaking method, Mobility measurement, 010301 acoustics, Saddle
Abstract: International audience; Bridge mobilities are usually used to characterize the couplings between the strings and the body of plucked or bowed string instruments. Such transfer functions are classically measured using impact hammer technique. An alternative method called wire-breaking method (also known as step relaxation method), introduced initially for the excitation of large structures is investigated in this paper. The method has been adapted to string instruments: it consists in placing a thin copper wire around the string in a position very close to the bridge saddle and pulling aside in the direction of interest until the wire breaks abruptly imparting a step function force to the driving point. When carried out with damped strings, the acceleration of the bridge measured with a miniature sensor provides a good estimation of transfer mobilities. The limits of the technique in terms of repeatability and signal-to-noise ratio are investigated making use of comparisons with results obtained by the classical impact hammer method. It is finally shown that the bridge admittances measured using the “Roving Wire-Breaking Technique” may be used to identify mode shapes components at the bridge using a high resolution modal analysis. Since no force sensor is needed to measure mobility, the technique is low cost and can be used in the instrument maker workshop for instrument modal characterization.
Published: 2018
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28. Occurrence of type 1 and type 2 diabetes in patients treated with immunotherapy (anti-PD-1 and/or anti-CTLA-4) for metastatic melanoma: a retrospective study

Author: Marion Sassier, Matthieu Resche-Rigon, Céleste Lebbé, Pirayeh Eftekhari, Franck Rouby, C. Pages, Jean-François Gautier, Philippe Boudou, Nicole Basset-Seguin, Samia Mourah, Martine Bagot, Laetitia Da Meda, Sylvine Pinel, Marie-Léa Gauci, Barouyr Baroudjian, Tiphaine Vidal-Trecan, Isabelle Madelaine-Chambrin, Institut de Neurosciences des Systèmes (INS), and Institut National de la Santé et de la Recherche Médicale (INSERM)-Aix Marseille Université (AMU)
Subjects: Adult, Male, 0301 basic medicine, Cancer Research, medicine.medical_specialty, medicine.medical_treatment, Programmed Cell Death 1 Receptor, Immunology, Type 2 diabetes, Gastroenterology, 03 medical and health sciences, Insulin resistance, Internal medicine, Diabetes mellitus, medicine, Humans, Immunology and Allergy, CTLA-4 Antigen, Adverse effect, Melanoma, ComputingMilieux_MISCELLANEOUS, Aged, Retrospective Studies, Aged, 80 and over, Type 1 diabetes, business.industry, Incidence, [SCCO.NEUR]Cognitive science/Neuroscience, Antibodies, Monoclonal, Retrospective cohort study, Immunotherapy, Middle Aged, Prognosis, medicine.disease, Diabetes Mellitus, Type 1, 030104 developmental biology, Diabetes Mellitus, Type 2, Oncology, Female, France, business, Follow-Up Studies
Abstract: Anti-PD-1 and anti-CTLA-4 antibodies cause immune-related side effects such as autoimmune type 1 diabetes (T1D). It has also been suggested that by increasing TNF-α, IL-2 and IFN-γ production, anti-PD-1 and/or anti-CTLA-4 treatment could affect pancreatic beta cell function and insulin sensitivity. This study was based on a retrospective observational analysis from 2 July 2014 to 27 June 2016, which evaluated the occurrence of T1D and changes in glycemia and C-reactive protein (CRP) plasma concentrations in patients undergoing anti-PD-1 and/or anti-CTLA-4 treatment for melanoma at the Saint Louis Hospital. All cases of T1D that developed during immunotherapy registered in the French Pharmacovigilance Database (FPVD) were also considered. Among the 132 patients included, 3 cases of T1D occurred. For the remaining subjects, blood glucose was not significantly affected by anti-PD-1 treatment, but CRP levels (mg/l) significantly increased during anti-PD-1 treatment (p = 0.017). However, 1 case of type 2 diabetes (T2D) occurred (associated with a longer therapy duration). Moreover, glycemia of patients pretreated (n = 44) or concomitantly treated (n = 8) with anti-CTLA-4 tended to increase during anti-PD-1 therapy (p = 0.068). From the FPVD, we obtained 14 cases of T1D that occurred during immunotherapy and were primarily characterized by the rapidity and severity of onset. In conclusion, in addition to inducing this rare immune-related diabetes condition, anti-PD-1 treatment appears to increase CRP levels, a potential inflammatory trigger of insulin resistance, but without any short-term impact on blood glucose level.
Published: 2018
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29. Lipid environment induces ER stress, TXNIP expression and inflammation in immune cells of individuals with type 2 diabetes

Author: Catherine Bernard, Aurélie Carlier, Anne-Françoise Batto, Fabienne Foufelle, Olivier Bourron, Nicolas Venteclef, Anaïs Szpigel, Isabelle Hainault, Pascal Ferré, Eric Hajduch, Alain Ktorza, Jean-François Gautier, Centre de Recherche des Cordeliers (CRC (UMR_S 872)), Université Paris Descartes - Paris 5 (UPD5)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Institute of cardiometabolism and nutrition (ICAN), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU), Centre de Recherche des Cordeliers (CRC), Université Paris Diderot - Paris 7 (UPD7)-École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM), Laboratoire de Recherche sur les Cultures Anglophones (LARCA UMR 8225), Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de physiopathologie de la nutrition (LPN), Centre de Recherche des Cordeliers (CRC (UMR_S_1138 / U1138)), École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), Pathologies nutritionnelles et métaboliques : obésité et diabète, Université Pierre et Marie Curie - Paris 6 (UPMC)-IFR58-Institut National de la Santé et de la Recherche Médicale (INSERM), Service de Diabétologie [CHU Pitié-Salpétrière], CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Université Pierre et Marie Curie - Paris 6 (UPMC)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Service de diabétologie [CHU Pitié-Salpétrière], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [APHP]-Sorbonne Université (SU), Université Paris Diderot - Paris 7 (UPD7)-École pratique des hautes études (EPHE)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre National de la Recherche Scientifique (CNRS)-Université Paris Diderot - Paris 7 (UPD7), École pratique des hautes études (EPHE)-Université Paris Diderot - Paris 7 (UPD7)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), and Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-CHU Pitié-Salpêtrière [APHP]
Subjects: 0301 basic medicine, Ceramide, medicine.medical_specialty, Thioredoxin-Interacting Protein, Inflammasomes, THP-1 Cells, Endocrinology, Diabetes and Metabolism, Inflammation, Type 2 diabetes, [SDV.BC]Life Sciences [q-bio]/Cellular Biology, Biology, Fatty Acids, Monounsaturated, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Internal medicine, NLR Family, Pyrin Domain-Containing 3 Protein, Internal Medicine, medicine, Animals, Humans, Rats, Wistar, Cells, Cultured, ComputingMilieux_MISCELLANEOUS, Type 1 diabetes, Dihydroceramide desaturase, Endoplasmic Reticulum Stress, Lipid Metabolism, medicine.disease, Rats, 3. Good health, Oxidative Stress, 030104 developmental biology, Endocrinology, Diabetes Mellitus, Type 2, chemistry, 030220 oncology & carcinogenesis, Leukocytes, Mononuclear, Unfolded Protein Response, Unfolded protein response, medicine.symptom, Carrier Proteins, TXNIP
Abstract: Obesity and type 2 diabetes are concomitant with low-grade inflammation affecting insulin sensitivity and insulin secretion. Recently, the thioredoxin interacting protein (TXNIP) has been implicated in the activation process of the NOD-like receptor family, pyrin domain containing 3 (NLRP3) inflammasome. In this study, we aim to determine whether the expression of TXNIP is altered in the circulating immune cells of individuals with type 2 vs type 1 diabetes and whether this can be related to specific causes and consequences of inflammation. The expression of TXNIP, inflammatory markers, markers of the unfolded protein response (UPR) to endoplasmic reticulum (ER) stress and enzymes involved in sphingolipid metabolism was quantified by quantitative reverse transcription real-time PCR (qRT-PCR) in peripheral blood mononuclear cells (PBMCs) of 13 non-diabetic individuals, 23 individuals with type 1 diabetes and 81 with type 2 diabetes. A lipidomic analysis on the plasma of 13 non-diabetic individuals, 35 individuals with type 1 diabetes and 94 with type 2 diabetes was performed. The effects of ER stress or of specific lipids on TXNIP and inflammatory marker expression were analysed in human monocyte-derived macrophages (HMDMs) and THP-1 cells. The expression of TXNIP and inflammatory and UPR markers was increased in the PBMCs of individuals with type 2 diabetes when compared with non-diabetic individuals or individuals with type 1 diabetes. TXNIP expression was significantly correlated with plasma fasting glucose, plasma triacylglycerol concentrations and specific UPR markers. Induction of ER stress in THP-1 cells or cultured HMDMs led to increased expression of UPR markers, TXNIP, NLRP3 and IL-1β. Conversely, a chemical chaperone reduced the expression of UPR markers and TXNIP in PBMCs of individuals with type 2 diabetes. The lipidomic plasma analysis revealed an increased concentration of saturated dihydroceramide and sphingomyelin in individuals with type 2 diabetes when compared with non-diabetic individuals and individuals with type 1 diabetes. In addition, the expression of specific enzymes of sphingolipid metabolism, dihydroceramide desaturase 1 and sphingomyelin synthase 1, was increased in the PBMCs of individuals with type 2 diabetes. Palmitate or C2 ceramide induced ER stress in macrophages as well as increased expression of TXNIP, NLRP3 and IL-1β. In individuals with type 2 diabetes, circulating immune cells display an inflammatory phenotype that can be linked to ER stress and TXNIP expression. Immune cell ER stress can in turn be linked to the specific exogenous and endogenous lipid environment found in type 2 diabetes.
Published: 2018
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30. Association of environmental markers with childhood type 1 diabetes mellitus revealed by a long questionnaire on early life exposures and lifestyle in a case–control study

Author: Jacques Cohen, Isabelle Guilhem, Gilbert Simonin, Françoise Labay, Brigitte Mignot, Chantal Stuckens, Anne-Marie Bertrand, Ariane Zelinsky-Gurung, Dominique Thevenieau, Corinne Fourmy Chatel, Régis Coutant, Vincent Gajdos, S. Le Fur, Marie-Emmanuelle Combes-Moukhovsky, Candace Ben Signor, Djamel Bendifallah, Florence Joubert, Anne Fargeot-Espaliat, Joachim Bassil, Agnès Tamboura, François Kurtz, Norbert Laisney, Agnès Guillou, Lucy Chaillous, Laetitia Pantalone, Sophie Valtat, Marie Laloi-Michelin, Chantal Stheneur, Emmanuelle Dubosclard, Anne Paoli, Véronique Kerlan, Yves Reznic, Sylvaine Clavel, Claudie Kerouedan, Philippe Talon, Armelle Pambou, Iva Gueorguieva, Daniel Dervaux, Hélène Bony-Trifunovic, Régis Piquemal, Pierre Gourdy, Brigitte Zymmermann, Hervé Dubourg, Rachel Desailloud, Stéphanie Jellimann, Pierre-Henri Ducluzeau, Bernard Le Luyer, Guy-André Loeuille, Jamil Khoury, Catherine Atlan, Elisabeth Baechler, Felix Balazard, Berthe Razafimahefa, Pierre Lecomte, Randa Salet, Marina Raoulx, Marie-Laure Pignol, Jean-François Gautier, Christine Vervel, Anne Lienhardt-Roussie, Françoise Popelard, P. Bougnères, Sylviane Fournier, Myriam Pepin-Donat, Mélanie Priou-Guesdon, Marc Nicolino, Sabine Baron, Vincent Rigalleau, Pierre-Yves Benhamou, Edwige Yollin, Marie-Claire Wielickzo, Jacques Weill, Pascal Barat, Déborah Ancelle, Jean-Pierre Brossier, Fabienne Dallavale, Laure Oilleau, Catherine Radet, Sylvie Nadalon, Chantal Metz, Etienne Larger, Céline Lukas, Sophie Caudrelier, Isabelle Guemas, Dominique Paris Bockel, Pierre Bougnères, Arnaud Monier, Estelle Marcoux, Alfred Penformis, Abdelkader Benmahammed, Daniel Terral, Philippe Jan, Marc De Kerdanet, Alain-Jacques Valleron, Catherine Boniface, Denis Dufillot, Frédérique Olivier, Jean-Pierre Cappoen, Anne Gourdin et Catherine Dumont, Guilhem Parlier, Bénédicte Guérin, Marie-Noëlle Bortoluzzi, Odile Richard, Service d'Endocrinologie (AMIENS - Endocrino), CHU Amiens-Picardie, Service Endocrinologie-Diabétologie, Centre Hospitalier Universitaire d'Angers (CHU Angers), PRES Université Nantes Angers Le Mans (UNAM)-PRES Université Nantes Angers Le Mans (UNAM), Endocrinologie pédiatrique[CHU Angers], Université d'Angers (UA)-Centre Hospitalier Universitaire d'Angers (CHU Angers), Centre Hospitalier d’Arras, Université Grenoble Alpes - UFR Médecine (UGA UFRM), Université Grenoble Alpes (UGA), Centre Gabriel Naudé, École pratique des hautes études (EPHE)-École nationale supérieure des sciences de l'information et des bibliothèques (ENSSIB), Université de Lyon-Université de Lyon, Service de pédiatrie [CHRU Besançon], Centre Hospitalier Régional Universitaire [Besançon] (CHRU Besançon), Pédiatrie-diabétologie, Hôpital Jeanne de Flandre [Lille], UMR1286 Nutrition et Biologie Intégrative, Institut National de la Recherche Agronomique (INRA), Hôpital Haut-Lévêque [CHU Bordeaux], CHU Bordeaux [Bordeaux], Consultation Marfan, Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Hôpital Bichat, Service d'Endocrinologie (CHRU - Endocrino), Centre Hospitalier Régional Universitaire de Brest (CHRU Brest), Groupe d'Etude de la Thrombose de Bretagne Occidentale (GETBO), Université de Brest (UBO)-Institut Brestois Santé Agro Matière (IBSAM), Université de Brest (UBO), Pédiatrie Neonatalogie, Centre Hospitalier Général, Brive-la-Gaillarde, Brive-la-Gaillarde, France, Institute for Marine and Antarctic Studies [Horbat] (IMAS), University of Tasmania (UTAS), Eli Lilly UK, Centre de recherche en épidémiologie et santé des populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Université Paris-Sud - Paris 11 (UP11)-Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM), Hôtel-Dieu, CHU Dijon, Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon), Service de Pédiatrie, Centre hospitalier Jean Monnet, Service d'Hépato-Gastroentérologie [CHU Pitié-Salpêtrière], Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-CHU Pitié-Salpêtrière [APHP], CH Laval, CH Le Havre, Thérapie génique, Génomique et Epigénomique (U 1169), Université Paris-Saclay-Institut National de la Santé et de la Recherche Médicale (INSERM)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Sud - Paris 11 (UP11), Service d'endocrinologie pédiatrique [CHU Lille], Hôpital Jeanne de Flandre [Lille]-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Service de Médecine interne A et polyclinique médicale [CHU Limoges], CHU Limoges, Service de Pédiatrie médicale [CHU Limoges], Laboratoire Identité Culturelle, Textes et Théâtralité (ICTT), Avignon Université (AU), Service d'endocrinologie pédiatrique [CHU Lyon-Hospices Civils de Lyon], Hospices Civils de Lyon (HCL), Institut d'Informatique et de Mathématiques Appliquées de Grenoble (IMAG), Université Joseph Fourier - Grenoble 1 (UJF)-Institut National Polytechnique de Grenoble (INPG)-Centre National de la Recherche Scientifique (CNRS), Centre d'Etudes des Mondes Africains (CEMAf), Université Panthéon-Sorbonne (UP1)-Université de Provence - Aix-Marseille 1-École pratique des hautes études (EPHE)-Centre National de la Recherche Scientifique (CNRS), Clinique d'Endocrinologie, Maladies Métaboliques et Nutrition, Hôpital Laennec, Service d'Endocrinologie Pédiatrique [CHU Nantes], Centre hospitalier universitaire de Nantes (CHU Nantes), Department of diabetes, Chu (saint-Louis)/inserm, Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre Hospitalier Universitaire [Rennes], Hôpital Pontchaillou-CHU Pontchaillou [Rennes], Biochimie et Physiologie Moléculaire des Plantes (BPMP), Université de Montpellier (UM)-Centre international d'études supérieures en sciences agronomiques (Montpellier SupAgro)-Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro)-Institut National de la Recherche Agronomique (INRA)-Centre National de la Recherche Scientifique (CNRS), Service de Diabétologie - Maladies Métaboliques - Nutrition, CHU Toulouse [Toulouse]-Hôpital de Rangueil, CHU Toulouse [Toulouse], Geothalg, Université de Liège, Groupe Hospitalier Artois-Ternois Centre Hospitalier d’Arras, Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), École nationale supérieure des sciences de l'information et des bibliothèques (ENSSIB), Université de Lyon-Université de Lyon-École Pratique des Hautes Études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL), Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon), Nutrition et Neurobiologie intégrée (NutriNeuro), Université Bordeaux Segalen - Bordeaux 2-Institut National de la Recherche Agronomique (INRA)-Université Sciences et Technologies - Bordeaux 1 (UB)-Institut Polytechnique de Bordeaux-Ecole nationale supérieure de chimie, biologie et physique, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Bichat, Université de Brest (UBO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Brestois Santé Agro Matière (IBSAM), Université de Brest (UBO)-Université de Brest (UBO), Institute for Marine and Antarctic Studies [Hobart] (IMAS), University of Tasmania [Hobart, Australia] (UTAS), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Université Paris-Sud - Paris 11 (UP11)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] (CHU ST-E), CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Centre Hospitalier de Laval (CH Laval), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, Université Paris 1 Panthéon-Sorbonne (UP1)-Université de Provence - Aix-Marseille 1-École Pratique des Hautes Études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Service Diabétologie [CHU Toulouse], Pôle Cardiovasculaire et Métabolique [CHU Toulouse], Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)-Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), PRES Université Nantes Angers Le Mans (UNAM)-PRES Université Nantes Angers Le Mans (UNAM)-Université d'Angers (UA), Université de Lyon-Université de Lyon-École pratique des hautes études (EPHE), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris-Sud - Paris 11 (UP11)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Service d'Hépato-Gastro-Entérologie [CHU Pitié-Salpêtrière], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille)-Hôpital Jeanne de Flandre [Lille], Université Paris 1 Panthéon-Sorbonne (UP1)-Université de Provence - Aix-Marseille 1-École pratique des hautes études (EPHE), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Centre international d'études supérieures en sciences agronomiques (Montpellier SupAgro)-Institut National de la Recherche Agronomique (INRA)-Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro), Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Institut National de la Recherche Agronomique (INRA)-Centre international d'études supérieures en sciences agronomiques (Montpellier SupAgro)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro), Université Pierre et Marie Curie - Paris 6 (UPMC), Service d'endocrinologie pédiatrique [CHU Bicêtre], Université Paris-Sud - Paris 11 (UP11)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), This study was sponsored by an ongoing institutional grant from NovoNordiskFrance, a specific Inserm support lasting from 2008 to 2014, the ProgrammeHospitalier de Recherche Clinique (PHRC ISIS-DIAB and ISIS-VIRUS), the AgenceNationale de la Recherche (ANR ENVIROGENEPIG), the Association pour laRecherche sur le Diabète (ARD)., The Isis diab collaborative group which is composed of the following physicians: Dominique Thevenieau, Corinne Fourmy Chatel, Rachel Desailloud, Hélène Bony-Trifunovic, Pierre-Henri Ducluzeau, Régis Coutant, Sophie Caudrelier, Armelle Pambou, Emmanuelle Dubosclard, Florence Joubert, Philippe Jan, Estelle Marcoux, Anne-Marie Bertrand, Dr Brigitte Mignot, Alfred Penformis, Chantal Stuckens, Régis Piquemal, Pascal Barat, Vincent Rigalleau, Chantal Stheneur, Sylviane Fournier, Véronique Kerlan, Chantal Metz, Anne Fargeot-Espaliat, Yves Reznic, Frédérique Olivier, Iva Gueorguieva, Arnaud Monier, Catherine Radet, Vincent Gajdos, Daniel Terral, Christine Vervel, Djamel Bendifallah, Candace Ben Signor, Daniel Dervaux, Abdelkader Benmahammed, Guy-André Loeuille, Françoise Popelard, Agnès Guillou, Pierre-Yves Benhamou, Jamil Khoury, Jean-Pierre Brossier, Joachim Bassil, Sylvaine Clavel, Bernard Le Luyer, Pierre Bougnères, Françoise Labay, Isabelle Guemas, Jacques Weill, Jean-Pierre Cappoen, Sylvie Nadalon, Anne Lienhardt-Roussie, Anne Paoli, Claudie Kerouedan, Edwige Yollin, Marc Nicolino, Gilbert Simonin, Jacques Cohen, Catherine Atlan, Agnès Tamboura, Hervé Dubourg, Marie-Laure Pignol, Philippe Talon, Stéphanie Jellimann, Lucy Chaillous, Sabine Baron, Marie-Noëlle Bortoluzzi, Elisabeth Baechler, Randa Salet, Ariane Zelinsky-Gurung, Fabienne Dallavale, Etienne Larger, Marie Laloi-Michelin, Jean-François Gautier, Bénédicte Guérin, Dr Laure Oilleau, Laetitia Pantalone, Céline Lukas, Isabelle Guilhem, Marc De Kerdanet, Marie-Claire Wielickzo, Mélanie Priou-Guesdon, Odile Richard, François Kurtz, Norbert Laisney, Déborah Ancelle, Guilhem Parlier, Catherine Boniface, Dominique Paris Bockel, Denis Dufillot, Berthe Razafimahefa,Pierre Gourdy, Pierre Lecomte, Myriam Pepin-Donat, Marie-Emmanuelle Combes-Moukhovsky, Brigitte Zymmermann, Marina Raoulx, Anne Gourdin et Catherine Dumont., ANR-10-BLAN-1113,HYPOCRYPT-ENVIROGENEPIG,Facteurs Environnementaux, Génétiques et Epigénétiques prédisposant à l'hypospadias et la cryptorchidie communs(2010), BMC, BMC, and BLANC - Facteurs Environnementaux, Génétiques et Epigénétiques prédisposant à l'hypospadias et la cryptorchidie communs - - HYPOCRYPT-ENVIROGENEPIG2010 - ANR-10-BLAN-1113 - BLANC - VALID
Subjects: Pediatrics, medicine.medical_specialty, endocrine system diseases, Epidemiology, [SDV]Life Sciences [q-bio], 030209 endocrinology & metabolism, Correlation and dependence, Environment, 03 medical and health sciences, 0302 clinical medicine, Environmental health, Medicine, 030212 general & internal medicine, ComputingMilieux_MISCELLANEOUS, 030304 developmental biology, 0303 health sciences, Type 1 diabetes, business.industry, Public health, lcsh:Public aspects of medicine, Incidence (epidemiology), Case-control study, Public Health, Environmental and Occupational Health, nutritional and metabolic diseases, lcsh:RA1-1270, [SDV.MHEP.EM]Life Sciences [q-bio]/Human health and pathology/Endocrinology and metabolism, medicine.disease, Bee stings, Data-driven, 3. Good health, [SDV] Life Sciences [q-bio], Cohort, Propensity score matching, Biostatistics, business, Case–control, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology, Research Article, Environmental epidemiology
Abstract: BackgroundThe incidence of childhood type 1 diabetes (T1D) incidence is rising in many countries, supposedly because of changing environmental factors, which are yet largely unknown.PurposeTo unravel environmental markers associated with T1D. Methods: Cases were children with T1D from the French Isis-Diab cohort. Controls were schoolmates or friends of the patients. Parents were asked to fill a 845-item questionnaire investigating the child’s environment before diagnosis. The analysis took into account the matching between cases and controls. A second analysis used propensity score methods.ResultsWe found a negative association of several lifestyle variables, gastroenteritis episodes, dental hygiene, hazelnut cocoa spread consumption, wasp and bee stings with T1D, consumption of vegetables from a farm and death of a pet by old age.ConclusionsThe found statistical association of new environmental markers with T1D calls for replication in other cohorts and investigation of new environmental areas.
Published: 2016
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31. dUTPase ( DUT ) Is Mutated in a Novel Monogenic Syndrome With Diabetes and Bone Marrow Failure

Author: Lorella Marselli, Sophie Romero, Cécile Julier, Baz Baz, Jean-François Gautier, Anne Philippi, Céline Besse, Sarah Ivanoff, Reinaldo Sousa Dos Santos, Piero Marchetti, Marc Nicolino, Decio L. Eizirik, Gérard Socié, Julien Masliah-Planchon, Delphine Bacq, Mathilde Daures, Laura Marroquí, Jean Soulier, Valérie Senée, Université libre de Bruxelles (ULB), UMR958 Protozoaires Entéricoles des Volailles, INRA/ENVL, Islet Cell Laboratory, University of Pisa - Università di Pisa, Centre National de Génotypage (CNG), Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Hôpital Lariboisière, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Lariboisière-Fernand-Widal [APHP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Diderot - Paris 7 (UPD7), Pathologie cellulaire : aspects moléculaires et viraux / Pathologie et Virologie Moléculaire, Institut Universitaire d'Hématologie (IUH), Université Paris Diderot - Paris 7 (UPD7)-Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Groupe Hospitalier Saint Louis - Lariboisière - Fernand Widal [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Centre National de la Recherche Scientifique (CNRS), Service d'endocrinologie pédiatrique [CHU Lyon-Hospices Civils de Lyon], Hospices Civils de Lyon (HCL), Hôpital Saint-Louis, Département d'Informatique [Bruxelles] (ULB), Faculté des Sciences [Bruxelles] (ULB), Université libre de Bruxelles (ULB)-Université libre de Bruxelles (ULB), Université Libre de Bruxelles [Bruxelles] (ULB), Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Hôpital Lariboisière-Université Paris Diderot - Paris 7 (UPD7), Université Paris Diderot - Paris 7 (UPD7)-Université Paris Diderot - Paris 7 (UPD7)-Groupe Hospitalier Saint Louis - Lariboisière - Fernand Widal [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université Paris Diderot - Paris 7 (UPD7)-Assistance publique - Hôpitaux de Paris (AP-HP) (APHP), Computer Science Department [Bruxelles] (ULB), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM), and Université Paris Diderot - Paris 7 (UPD7)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)
Subjects: 0301 basic medicine, Genetics, Mutation, Endocrinology, Diabetes and Metabolism, [SDV]Life Sciences [q-bio], Bone marrow failure, Consanguinity, Bone Marrow Aplasia, Biology, medicine.disease, medicine.disease_cause, 3. Good health, 03 medical and health sciences, Diabetes mellitus genetics, 030104 developmental biology, Internal Medicine, medicine, Missense mutation, Exome, Gene, ComputingMilieux_MISCELLANEOUS
Abstract: We describe a new syndrome characterized by early-onset diabetes associated with bone marrow failure, affecting mostly the erythrocytic lineage. Using whole-exome sequencing in a remotely consanguineous patient from a family with two affected siblings, we identified a single homozygous missense mutation (chr15.hg19:g.48,626,619A>G) located in the dUTPase (DUT) gene (National Center for Biotechnology Information Gene ID 1854), affecting both the mitochondrial (DUT-M p.Y142C) and the nuclear (DUT-N p.Y54C) isoforms. We found the same homozygous mutation in an unrelated consanguineous patient with diabetes and bone marrow aplasia from a family with two affected siblings, whereas none of the >60,000 subjects from the Exome Aggregation Consortium (ExAC) was homozygous for this mutation. This replicated observation probability was highly significant, thus confirming the role of this DUT mutation in this syndrome. DUT is a key enzyme for maintaining DNA integrity by preventing misincorporation of uracil into DNA, which results in DNA toxicity and cell death. We showed that DUT silencing in human and rat pancreatic β-cells results in apoptosis via the intrinsic cell death pathway. Our findings support the importance of tight control of DNA metabolism for β-cell integrity and warrant close metabolic monitoring of patients treated by drugs affecting dUTP balance.
Published: 2017
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32. Improvement of the acoustic black hole effect by using energy transfer due to geometric nonlinearity

Author: François Gautier, Vivien Denis, Adrien Pelat, Cyril Touzé, Laboratoire d'Acoustique de l'Université du Mans (LAUM), Le Mans Université (UM)-Centre National de la Recherche Scientifique (CNRS), Institut des Sciences de la mécanique et Applications industrielles (IMSIA - UMR 9219), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-École Nationale Supérieure de Techniques Avancées (ENSTA Paris)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-EDF R&D (EDF R&D), EDF (EDF)-EDF (EDF), Centre National de la Recherche Scientifique (CNRS)-Le Mans Université (UM), and Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-École Nationale Supérieure de Techniques Avancées (ENSTA Paris)-Centre National de la Recherche Scientifique (CNRS)-Université Paris-Saclay-EDF R&D (EDF R&D)
Subjects: Wave turbulence, 02 engineering and technology, Low frequency, 01 natural sciences, Power law, Damping, Displacement (vector), Optics, 0203 mechanical engineering, Geometric nonlinearity, 0103 physical sciences, [NLIN]Nonlinear Sciences [physics], 010301 acoustics, Added mass, Physics, Modal coupling, Flexural vibration, [SPI.ACOU]Engineering Sciences [physics]/Acoustics [physics.class-ph], Acoustic black hole, business.industry, Applied Mathematics, Mechanical Engineering, [SPI.MECA.VIBR]Engineering Sciences [physics]/Mechanics [physics.med-ph]/Vibrations [physics.class-ph], Mechanics, Vibration, Nonlinear system, 020303 mechanical engineering & transports, Mechanics of Materials, business, Beam (structure)
Abstract: International audience; Acoustic Black Hole effect (ABH) is a passive vibration damping technique without added mass based on flexural waves properties in thin structures with variable thickness. A common implementation is a plate edge where the thickness is locally reduced with a power law profile and covered with a viscoelastic layer. The plate displacement in the small thickness region is large and easily exceeds the plate thickness. This is the origin of geometric nonlinearity which can generate couplings between linear eigenmodes of the structure and induce energy transfer between low and high frequency regimes. This phenomenon may be used to increase the efficiency of the ABH treatment in the low frequency regime where it is usually inefficient. An experimental investigation evidenced that usual ABH implementation gives rise to measurable geometric nonlinearity and typical nonlinear phenomena. In particular, strongly nonlinear regime and wave turbulence are reported. The nonlinear ABH beam is then modeled as a von Kármán plate with variable thickness. The model is solved numerically by using a modal method combined with an energy-conserving time integration scheme. The effects of both the thickness profile and the damping layer are then investigated in order to improve the damping properties of an ABH beam. It is found that a compromise between the two effects can lead to an important gain of efficiency in the low frequency range.
Published: 2017
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33. Loss of the co-repressor GPS2 sensitizes macrophage activation upon metabolic stress induced by obesity and type 2 diabetes

Author: Rongrong Fan, Toby Lawrence, Judith Aron-Wisnewsky, Fabienne Foufelle, Zhiqiang Huang, Patricia Ancel, Anastasios E. Damdimopoulos, Antoine Soprani, Isabelle Hainault, Ning Liang, Saioa Goñi, Raphaelle Ballaire, Jean-François Gautier, Amine Toubal, Karima Drareni, Fawaz Alzaid, Eckardt Treuter, Nicolas Venteclef, Centre d'Immunologie de Marseille - Luminy (CIML), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Swedish Research Council (Vetenskapsradet), Swedish Cancer Society (Cancerfonden), Swedish Diabetes Foundation (Diabetesfonden), Novo Nordisk Foundation (Novo Nordisk Fonden), Center for Biosciences (CIMED) at Karolinska Institutet, French National Agency of Research (CONRAD), French National Agency of Research [ANR CE12 2014], French National Agency of Research (FATMAC), Region Ile de France (CORDDIM), Paris city (EMERGENCE), French Foundation for Medical Research [Equipe FRM DEQ20140329504], French government [ANR-10-IAH, ICAN MetaMACS], Assistance Publique des Hopitaux de Paris (APHP), Programs of Clinical Investigation (CRC Fibrota) [AOO759-32], PHRC Glucostress [P081122], 'Ministere de la Recherche et de l'Enseignement superieur', China Scholarship Council (CRC), Karolinska Institutet (KID), and Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU)
Subjects: 0301 basic medicine, Male, adipose-tissue macrophages, Adipose tissue, Gene Expression, Mice, Obese, Type 2 diabetes, Mice, RNA, Small Interfering, ppar-gamma, Epigenomics, Bone Marrow Transplantation, Mice, Knockout, Reverse Transcriptase Polymerase Chain Reaction, Intracellular Signaling Peptides and Proteins, General Medicine, Middle Aged, Flow Cytometry, Immunohistochemistry, GPS2, Adipose Tissue, [SDV.IMM]Life Sciences [q-bio]/Immunology, Female, medicine.symptom, Adult, medicine.medical_specialty, Blotting, Western, kappa-b, Inflammation, Biology, Diet, High-Fat, Real-Time Polymerase Chain Reaction, General Biochemistry, Genetics and Molecular Biology, insulin-resistance, 03 medical and health sciences, Insulin resistance, Stress, Physiological, Diabetes mellitus, Internal medicine, medicine, Animals, Humans, Obesity, gene, nuclear receptor corepressor, alternative activation, polarization, Macrophages, medicine.disease, signaling pathways, Transplantation, 030104 developmental biology, Endocrinology, RAW 264.7 Cells, Diabetes Mellitus, Type 2, inflammation, Insulin Resistance
Abstract: International audience; Humans with obesity differ in their susceptibility to developing insulin resistance and type 2 diabetes (T2D). This variation may relate to the extent of adipose tissue (AT) inflammation that develops as their obesity progresses. The state of macrophage activation has a central role in determining the degree of AT inflammation and thus its dysfunction, and these states are driven by epigenomic alterations linked to gene expression. The underlying mechanisms that regulate these alterations, however, are poorly defined. Here we demonstrate that a co-repressor complex containing G protein pathway suppressor 2 (GPS2) crucially controls the macrophage epigenome during activation by metabolic stress. The study of AT from humans with and without obesity revealed correlations between reduced GPS2 expression in macrophages, elevated systemic and AT inflammation, and diabetic status. The causality of this relationship was confirmed by using macrophage-specific Gps2-knockout (KO) mice, in which inappropriate co-repressor complex function caused enhancer activation, pro-inflammatory gene expression and hypersensitivity toward metabolic-stress signals. By contrast, transplantation of GPS2-overexpressing bone marrow into two mouse models of obesity (ob/ob and diet-induced obesity) reduced inflammation and improved insulin sensitivity. Thus, our data reveal a potentially reversible disease mechanism that links co-repressor-dependent epigenomic alterations in macrophages to AT inflammation and the development of T2D.
Published: 2016
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34. Association of serum leptin and adiponectin with anthropomorphic indices of obesity, blood lipids and insulin resistance in a Sub-Saharan African population

Author: Clarisse Noël Ayina Ayina, Michel K. Mengnjo, Jean François Gautier, Jean Claude Mbanya, Jean Jacques Noubiap, Laurent Serge Etoundi Ngoa, Eugene Sobngwi, Philippe Boudou, Dpt of Animal Science [Douala], Université de Douala, Groote Schuur and Red Cross Children's Hospital, University of Cape Town, Medical diagnostic center, Yaoundé, Department of Animal Science [Yaoudé], National Advanced School of Engineering (University of Yaounde I), Service de Biologie Hormonale [CHU Saint-Louis], Groupe Hospitalier Saint Louis - Lariboisière - Fernand Widal [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Centre de Recherche des Cordeliers (CRC), Université Pierre et Marie Curie - Paris 6 (UPMC)-École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service de diabétologie et d'endocrinologie [CHU Lariboisière], Hôpital Lariboisière-Fernand-Widal [APHP], University of Yaoundé [Cameroun], National Obesity Center [Yaoundé], Hôpital Central de Yaoundé [Yaoundé], Université Pierre et Marie Curie - Paris 6 (UPMC)-École Pratique des Hautes Études (EPHE), Department of Medicine, Faculty of Health Sciences, National Advanced School of Engineering ( University of Yaounde I ), Centre de Recherche des Cordeliers ( CRC ), Université Paris Diderot - Paris 7 ( UPD7 ) -École pratique des hautes études ( EPHE ) -Université Pierre et Marie Curie - Paris 6 ( UPMC ) -Université Paris Descartes - Paris 5 ( UPD5 ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), Hôpital Lariboisière, and HAL-UPMC, Gestionnaire
Subjects: 0301 basic medicine, Male, Serum, Blood Glucose, Leptin, Endocrinology, Diabetes and Metabolism, Fat Body, Clinical Biochemistry, Blood lipids, Blood Pressure, Body Mass Index, Plasma, 0302 clinical medicine, Waist–hip ratio, Endocrinology, Prevalence, Medicine, Insulin, Homeostasis, Cameroon, Adiposity, 2. Zero hunger, education.field_of_study, [SDV.MHEP] Life Sciences [q-bio]/Human health and pathology, Fasting, Middle Aged, Insulin sensitivity, Lipids, 3. Good health, Blood, Cholesterol, Obesity, Abdominal, Regression Analysis, Female, Adiponectin, Waist Circumference, medicine.medical_specialty, Population, Adipokine, 030209 endocrinology & metabolism, Medical Biochemistry, 03 medical and health sciences, Insulin resistance, Adipokines, Internal medicine, [ SDV.MHEP ] Life Sciences [q-bio]/Human health and pathology, Humans, Obesity, education, Triglycerides, Lipidology, Biochemistry, medical, Homo sapiens, business.industry, Waist-Hip Ratio, Research, Biochemistry (medical), nutritional and metabolic diseases, Cholesterol, LDL, medicine.disease, 030104 developmental biology, Cross-Sectional Studies, business, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology, Obesity indices
Abstract: International audience; BackgroundThere is little data on the metabolic effects of adipokines in sub-Saharan African populations. This study aimed to explore the potential relationship of leptin and adiponectin, with obesity, plasma lipids and insulin resistance in a Cameroonian population.MethodsWe enrolled 167 men and 309 women aged ≥18 years from the general population in Cameroon. Data were collected on waist circumference (WC), body mass index (BMI), waist-to-hip ratio (WHR), body fat (BF%), fasting blood glucose, plasma lipids, adiponectin, leptin, insulin and homeostasis model for assessment of insulin resistance (HOMA-IR). Pearson’s correlation and multiple stepwise linear regression analyses were used to determine correlates of leptin and adiponectin serum levels.ResultsThe prevalence of obesity was higher in women compared to men (p
Published: 2016
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35. Regulatory T Cell Immunotherapy for Type 1 Diabetes: A Step Closer to Success?

Author: Jean-François Gautier, Jagadeesh Bayry, Centre de Recherche des Cordeliers (CRC), Université Paris Diderot - Paris 7 (UPD7)-École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université Pierre et Marie Curie - Paris 6 - UFR de Médecine Pierre et Marie Curie (UPMC), Université Pierre et Marie Curie - Paris 6 (UPMC), Université Sorbonne Paris Cité (USPC), Institut National de la Santé et de la Recherche Médicale (INSERM), Centre de Recherche des Cordeliers (CRC (UMR_S_1138 / U1138)), École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), Université Pierre et Marie Curie - Paris 6 (UPMC)-École Pratique des Hautes Études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM), École Pratique des Hautes Études (EPHE), Bayry, Jagadeesh, and Université Pierre et Marie Curie - Paris 6 (UPMC)-École pratique des hautes études (EPHE)
Subjects: 0301 basic medicine, Regulatory T cell, Physiology, medicine.medical_treatment, MEDLINE, chemical and pharmacologic phenomena, T-Lymphocytes, Regulatory, [SDV.IMM.II]Life Sciences [q-bio]/Immunology/Innate immunity, Article, 03 medical and health sciences, Diabetes mellitus, medicine, Humans, [SDV.IMM.ALL]Life Sciences [q-bio]/Immunology/Allergology, [SDV.IMM.II] Life Sciences [q-bio]/Immunology/Innate immunity, Molecular Biology, ComputingMilieux_MISCELLANEOUS, Type 1 diabetes, biology, Adult patients, business.industry, hemic and immune systems, Immunotherapy, Cell Biology, medicine.disease, 3. Good health, 030104 developmental biology, medicine.anatomical_structure, Diabetes Mellitus, Type 1, Polyclonal antibodies, Immunology, biology.protein, business, [SDV.IMM.ALL] Life Sciences [q-bio]/Immunology/Allergology
Abstract: Type 1 diabetes (T1D) is an autoimmune disease that occurs in genetically susceptible individuals. Regulatory T cells (Tregs) have been shown to be defective in the autoimmune disease setting. Thus, efforts to repair or replace Tregs in T1D may reverse autoimmunity and protect the remaining insulin-producing β cells. On the basis of this premise, a robust technique has been developed to isolate and expand Tregs from patients with T1D. The expanded Tregs retained their T cell receptor diversity and demonstrated enhanced functional activity. We report on a phase 1 trial to assess safety of Treg adoptive immunotherapy in T1D. Fourteen adult subjects with T1D, in four dosing cohorts, received ex vivo–expanded autologous CD4+CD127lo/−CD25+ polyclonal Tregs (0.05 × 108 to 26 × 108 cells). A subset of the adoptively transferred Tregs was long-lived, with up to 25% of the peak level remaining in the circulation at 1 year after transfer. Immune studies showed transient increases in Tregs in recipients and retained a broad Treg FOXP3+CD4+CD25hiCD127lo phenotype long-term. There were no infusion reactions or cell therapy–related high-grade adverse events. C-peptide levels persisted out to 2+ years after transfer in several individuals. These results support the development of a phase 2 trial to test efficacy of the Treg therapy.
Published: 2016
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36. Amortissement de vibrations de poutres par effet Trou Noir : caractérisation expérimentale et modèles numériques

Author: Vivien DENIS, Adrien Pelat, François Gautier, Cyril Touzé, Laboratoire d'Acoustique de l'Université du Mans (LAUM), Centre National de la Recherche Scientifique (CNRS)-Le Mans Université (UM), Institut des Sciences de la mécanique et Applications industrielles (IMSIA - UMR 9219), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-École Nationale Supérieure de Techniques Avancées (ENSTA Paris)-Centre National de la Recherche Scientifique (CNRS)-Université Paris-Saclay-EDF R&D (EDF R&D), EDF (EDF)-EDF (EDF), Le Mans Université (UM)-Centre National de la Recherche Scientifique (CNRS), and Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-École Nationale Supérieure de Techniques Avancées (ENSTA Paris)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-EDF R&D (EDF R&D)
Subjects: [SPI.ACOU]Engineering Sciences [physics]/Acoustics [physics.class-ph], [SPI.MECA.VIBR]Engineering Sciences [physics]/Mechanics [physics.med-ph]/Vibrations [physics.class-ph], [SPI.MECA.MSMECA]Engineering Sciences [physics]/Mechanics [physics.med-ph]/Materials and structures in mechanics [physics.class-ph], [NLIN]Nonlinear Sciences [physics]
Abstract: National audience; L'effet Trou Noir Acoustique (TN) est une technique passive d'amortissement de vibrations sans ajout de masse fondée sur les propriétés des ondes de flexion dans des structures minces d'épaisseur variable. La mise en oeuvre habituelle consiste en une plaque avec une extrémité profilée selon une loi exponentielle, recouverte d'un film viscoélastique. L'inhomogénéité de la structure conduit à une baisse de la célérité et une augmentation de l'amplitude des ondes de flexion, ce qui a pour conséquence une dissipation d'énergie efficace quand un film amortissant est placé dans la zone de faible épaisseur. Lorsqu'un tel profil est placé à l'extrémité d'une poutre, des caractérisations expérimentales sont possibles à l'aide du coefficient de réflexion ou du recouvrement modal. Des modèles numériques d'une telle structure existent et peuvent aider à comprendre le rôle de la variation d'épaisseur, les effets d'imperfections de fabrication ou encore les effets non-linéaires dus aux faibles épaisseurs.
Published: 2016

37. Glucocorticoids Inhibit Basal and Hormone-Induced Serotonin Synthesis in Pancreatic Beta Cells

Author: Jean-Marie Launay, Moina Hasni Ebou, Ghislaine Guillemain, B. Blondeau, Pascal Ferré, Bernadette Breant, Jean-Pierre Riveline, François Tronche, Jacques Callebert, Jean-François Gautier, Amrit Singh-Estivalet, Centre de Recherche des Cordeliers ( CRC ), Université Paris Diderot - Paris 7 ( UPD7 ) -École pratique des hautes études ( EPHE ) -Université Pierre et Marie Curie - Paris 6 ( UPMC ) -Université Paris Descartes - Paris 5 ( UPD5 ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), Service de Biochimie et de Biologie Moléculaire, Assistance publique - Hôpitaux de Paris (AP-HP)-Hôpital Lariboisière-Université Paris Diderot - Paris 7 ( UPD7 ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), Physiopathologie des Maladies du Système Nerveux Central, Université Pierre et Marie Curie - Paris 6 ( UPMC ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Centre National de la Recherche Scientifique ( CNRS ), Centre Hospitalier Lariboisière, Université Paris Diderot - Paris 7 ( UPD7 ), Centre de Recherche des Cordeliers (CRC), Université Pierre et Marie Curie - Paris 6 (UPMC)-École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Lariboisière-Fernand-Widal [APHP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Pierre et Marie Curie - Paris 6 (UPMC), Université Paris Diderot - Paris 7 (UPD7), HAL UPMC, Gestionnaire, Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), and Université Pierre et Marie Curie - Paris 6 (UPMC)-École Pratique des Hautes Études (EPHE)
Subjects: 0301 basic medicine, Physiology, Peptide Hormones, lcsh:Medicine, Gene Expression, Tryptophan Hydroxylase, Biochemistry, chemistry.chemical_compound, Mice, 0302 clinical medicine, Glucocorticoid receptor, Endocrinology, Aromatic Amino Acids, Glucagon-Like Peptide 1, Insulin-Secreting Cells, Insulin Secretion, Medicine and Health Sciences, Amino Acids, Neurotransmitter, lcsh:Science, Multidisciplinary, TPH1, geography.geographical_feature_category, [SDV.MHEP] Life Sciences [q-bio]/Human health and pathology, TPH2, Organic Compounds, Monosaccharides, Tryptophan, Neurochemistry, Neurotransmitters, Islet, 3. Good health, Chemistry, Physical Sciences, Beta cell, Anatomy, hormones, hormone substitutes, and hormone antagonists, Research Article, medicine.medical_specialty, Biogenic Amines, Serotonin, endocrine system, Carbohydrates, 030209 endocrinology & metabolism, Endocrine System, Biology, Cell Line, 03 medical and health sciences, Exocrine Glands, Extraction techniques, Internal medicine, [ SDV.MHEP ] Life Sciences [q-bio]/Human health and pathology, medicine, Genetics, Animals, Glucocorticoids, Pancreas, geography, Endocrine Physiology, Venoms, lcsh:R, Organic Chemistry, Chemical Compounds, Correction, Biology and Life Sciences, Proteins, Tryptophan hydroxylase, Hormones, RNA extraction, Prolactin, Research and analysis methods, 030104 developmental biology, Glucose, chemistry, Exenatide, lcsh:Q, Peptides, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology, Neuroscience
Abstract: International audience; Diabetes is a major complication of chronic Glucocorticoids (GCs) treatment. GCs induce insulin resistance and also inhibit insulin secretion from pancreatic beta cells. Yet, a full understanding of this negative regulation remains to be deciphered. In the present study, we investigated whether GCs could inhibit serotonin synthesis in beta cell since this neurotransmitter has been shown to be involved in the regulation of insulin secretion. To this aim, serotonin synthesis was evaluated in vitro after treatment with GCs of either islets from CD1 mice or MIN6 cells, a beta-cell line. We also explored the effect of GCs on the stimulation of serotonin synthesis by several hormones such as prolactin and GLP 1. We finally studied this regulation in islet in two in vivo models: mice treated with GCs and with liraglutide, a GLP1 analog, and mice deleted for the glucocorticoid receptor in the pancreas. We showed in isolated islets and MIN6 cells that GCs decreased expression and activity of the two key enzymes of serotonin synthesis, Tryptophan Hydroxylase 1 (Tph1) and 2 (Tph2), leading to reduced serotonin contents. GCs also blocked the induction of serotonin synthesis by prolactin or by a previously unknown serotonin activator, the GLP-1 analog exendin-4. In vivo, activation of the Glucagon-like-Peptide-1 receptor with liraglutide during 4 weeks increased islet serotonin contents and GCs treatment prevented this increase. Finally, islets from mice deleted for the GR in the pancreas displayed an increased expression of Tph1 and Tph2 and a strong increased serotonin content per islet. In conclusion, our results demonstrate an original inhibition of serotonin synthesis by GCs, both in basal condition and after stimulation by prolactin or activators of the GLP-1 receptor. This regulation may contribute to the deleterious effects of GCs on beta cells.
Published: 2016
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38. Scattering effects induced by imperfections on an acoustic black hole placed at a structural waveguide termination

Author: François Gautier, Vivien Denis, Adrien Pelat, Laboratoire d'Acoustique de l'Université du Mans (LAUM), and Le Mans Université (UM)-Centre National de la Recherche Scientifique (CNRS)
Subjects: Materials science, Acoustics and Ultrasonics, flexural vibration, Vibration control, 02 engineering and technology, 01 natural sciences, Optics, 0203 mechanical engineering, Flexural strength, 0103 physical sciences, Tearing, Waveguide (acoustics), imperfections, Reflection coefficient, 010301 acoustics, [PHYS.MECA.VIBR]Physics [physics]/Mechanics [physics]/Vibrations [physics.class-ph], reflection coefficient, damping, Scattering, business.industry, Mechanical Engineering, scattering, Mechanics, Dissipation, Condensed Matter Physics, inhomogeneous structural waveguide, 020303 mechanical engineering & transports, Amplitude, Mechanics of Materials, acoustic black hole, wave method, business
Abstract: International audience; The so-called " acoustic black hole " effect (ABH) is a passive vibration control technique based on the flexural waves properties in thin structure of varying thickness. A usual implementation consists in using a plate with tapered extremity with a power-law profile, covered with a thin damping layer. The inhomogeneity of the structure leads to a decrease of flexural wave speed and an increase of their amplitude, therefore resulting in an efficient energy dissipation if damping layer is placed where the thickness is minimal. The manufacture of an efficient extremity is difficult because of the small thickness, and often generates imperfections and tearing. Moreover , previous works suggest multiple that flexural modes are propagating across the width of the ABH tip. A model of an ABH multimodal waveguide taking into account an imperfect termination is developed. It shows that an elementary imperfection can affect the reflection coefficient of the extremity and reduce it. Scattering and propagation properties of the extremity are also studied. An incident mode excites several modes that are localised in the tapered region and local resonances explain the drops in the reflection coefficient. Experimental evidence of the influence of the imperfection on the reflection coefficient is provided. A key result of the paper is that manufacturing imperfections are not detrimental to the ABH effect.
Published: 2016
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39. Death, end-stage renal disease and renal function decline in patients with diabetic nephropathy in French cohorts of type 1 and type 2 diabetes

Author: Pierre Gourdy, Pierre-Jean Saulnier, Jean-François Gautier, Frédéric Fumeron, Elise Gand, Kammel Mohammedi, Ahmed-Amine Kasmi, Michel Marre, Diabhycar study groups, Bertrand Cariou, Samy Hadjadj, Eva Feigerlova, Guillaume Charpentier, Ronan Roussel, CIC - Poitiers, Université de Poitiers-Centre hospitalier universitaire de Poitiers (CHU Poitiers)-Direction Générale de l'Organisation des Soins (DGOS)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre hospitalier universitaire de Poitiers (CHU Poitiers), Ischémie Reperfusion en Transplantation d’Organes Mécanismes et Innovations Thérapeutiques ( IRTOMIT), Université de Poitiers-Institut National de la Santé et de la Recherche Médicale (INSERM), unité de recherche de l'institut du thorax UMR1087 UMR6291 (ITX), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN), Déterminants génétiques du diabète de type 2 et de ses complications vasculaires ((U 695)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Diderot - Paris 7 (UPD7), Service de diabétologie, Centre Hospitalier Sud Francilien, CH Evry-Corbeil-CH Evry-Corbeil, Hôpital Lariboisière, Université Paris Diderot - Paris 7 (UPD7)-Hôpital Lariboisière-Fernand-Widal [APHP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Service de Diabétologie - Maladies Métaboliques - Nutrition, CHU Toulouse [Toulouse]-Hôpital de Rangueil, CHU Toulouse [Toulouse], Unité de recherche de l'institut du thorax (ITX-lab), Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Lariboisière-Fernand-Widal [APHP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Diderot - Paris 7 (UPD7), Service Diabétologie [CHU Toulouse], Pôle Cardiovasculaire et Métabolique [CHU Toulouse], Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)-Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), and Steichen, Clara
Subjects: 0301 basic medicine, Male, Endocrinology, Diabetes and Metabolism, [SDV]Life Sciences [q-bio], Type 2 diabetes, Kaplan-Meier Estimate, Kidney Function Tests, Diabetic nephropathy, Cohort Studies, chemistry.chemical_compound, 0302 clinical medicine, Risk Factors, Diabetic Nephropathies, ComputingMilieux_MISCELLANEOUS, Proteinuria, [SDV.MHEP] Life Sciences [q-bio]/Human health and pathology, Incidence, Middle Aged, [SDV] Life Sciences [q-bio], Female, France, medicine.symptom, Glomerular Filtration Rate, Adult, medicine.medical_specialty, Renal function, 030209 endocrinology & metabolism, End stage renal disease, 03 medical and health sciences, Internal medicine, Diabetes mellitus, Internal Medicine, medicine, Humans, Aged, Type 1 diabetes, Creatinine, business.industry, medicine.disease, 030104 developmental biology, Endocrinology, Diabetes Mellitus, Type 1, chemistry, Diabetes Mellitus, Type 2, Multivariate Analysis, Linear Models, Kidney Failure, Chronic, business, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract: Microvascular complications are a common feature of diabetes but additional research is needed regarding diabetic nephropathy endpoints in type 1 and type 2 diabetes. We compared 277 type 1 diabetes patients with 942 type 2 diabetes patients, with clinical proteinuria and no end-stage renal disease (ESRD) at baseline, prospectively followed for death, ESRD and decline in estimated glomerular filtration rate (eGFR, all available measures). The incidence rate of death was 67.0 (95% CI 59.2, 74.8) vs 24.6 (95% CI, 19.0, 30.2) per 1,000 patient-years, in type 2 diabetes and type 1 diabetes, respectively. Unadjusted risk for death was greater for type 2 diabetes patients (HR 3.423; 95% CI, 2.501, 4.683; p
Published: 2016
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40. Kidney Dysfunction in Adult Offspring Exposed In Utero to Type 1 Diabetes Is Associated with Alterations in Genome-Wide DNA Methylation

Author: Ronan Roussel, F. Travert, Jean-Pierre Riveline, Michel Marre, Naima Bellili-Muñoz, Jean-François Gautier, Pascal Ferré, B. Blondeau, François Rouzet, Lila Sabrina Fetita, E. Larger, Raphaël Porcher, Philippe Boudou, Simeon-Pierre Choukem, Eric Ravussin, Samy Hadjadj, Charbel Abi Khalil, Chu (saint-Louis)/inserm, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Centre de Recherche des Cordeliers (CRC), Université Pierre et Marie Curie - Paris 6 (UPMC)-École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM), Department of diabetes and endocrinology, Hôpital Lariboisière-APHP, Department of biostatistics and medical computing, Groupe Hospitalier Saint Louis - Lariboisière - Fernand Widal [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Department of diabetes, AP-HP - Hôpital Bichat - Claude Bernard [Paris], Centre Hospitalier Sud Francilien, CH Evry-Corbeil-CH Evry-Corbeil, Department of endocrinology and diabetes, Centre hospitalier universitaire de Poitiers (CHU Poitiers), Hôtel-Dieu, Unit of transfer in molecular oncology and hormonology, Hopital Saint-Louis [AP-HP] (AP-HP), INSERM U695, Université Paris Diderot - Paris 7 (UPD7), Penington Biomedical research center, Los Angeles, Nuclear Medicine Department [Hôpital Bichat - Claude Bernard], Université Pierre et Marie Curie - Paris 6 (UPMC)-École Pratique des Hautes Études (EPHE), Université Paris Diderot - Paris 7 ( UPD7 ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), Centre de Recherche des Cordeliers ( CRC ), Université Paris Diderot - Paris 7 ( UPD7 ) -École pratique des hautes études ( EPHE ) -Université Pierre et Marie Curie - Paris 6 ( UPMC ) -Université Paris Descartes - Paris 5 ( UPD5 ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), Centre hospitalier universitaire de Poitiers ( CHU Poitiers ), AP-HP Groupe Hospitalier Saint-Louis, Université Paris Diderot - Paris 7 ( UPD7 ), Department of nuclear medicine, and HAL UPMC, Gestionnaire
Subjects: Male, lcsh:Medicine, Kidney, Fathers, 0302 clinical medicine, Pregnancy, Leukocytes, Amino Acids, lcsh:Science, 0303 health sciences, [SDV.MHEP] Life Sciences [q-bio]/Human health and pathology, Multidisciplinary, Genome, Methylation, Middle Aged, 3. Good health, medicine.anatomical_structure, CpG site, Prenatal Exposure Delayed Effects, DNA methylation, Female, Research Article, Glomerular Filtration Rate, Adult, Quality Control, medicine.medical_specialty, Offspring, Mothers, 030209 endocrinology & metabolism, Biology, DNA methyltransferase, 03 medical and health sciences, [ SDV.MHEP ] Life Sciences [q-bio]/Human health and pathology, Internal medicine, medicine, Humans, Epigenetics, 030304 developmental biology, Genome, Human, lcsh:R, DNA, DNA Methylation, Endocrinology, Diabetes Mellitus, Type 1, Regional Blood Flow, Hyperglycemia, lcsh:Q, CpG Islands, Genomic imprinting, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract: Background Fetal exposure to hyperglycemia impacts negatively kidney development and function. Objective Our objective was to determine whether fetal exposure to moderate hyperglycemia is associated with epigenetic alterations in DNA methylation in peripheral blood cells and whether those alterations are related to impaired kidney function in adult offspring. Design Twenty nine adult, non-diabetic offspring of mothers with type 1 diabetes (T1D) (case group) were matched with 28 offspring of T1D fathers (control group) for the study of their leukocyte genome-wide DNA methylation profile (27,578 CpG sites, Human Methylation 27 BeadChip, Illumina Infinium). In a subset of 19 cases and 18 controls, we assessed renal vascular development by measuring Glomerular Filtration Rate (GFR) and Effective Renal Plasma Flow (ERPF) at baseline and during vasodilatation produced by amino acid infusion. Results Globally, DNA was under-methylated in cases vs. controls. Among the 87 CpG sites differently methylated, 74 sites were less methylated and 13 sites more methylated in cases vs. controls. None of these CpG sites were located on a gene known to be directly involved in kidney development and/or function. However, the gene encoding DNA methyltransferase 1 (DNMT1)—a key enzyme involved in gene expression during early development–was under-methylated in cases. The average methylation of the 74 under-methylated sites differently correlated with GFR in cases and controls. Conclusion Alterations in methylation profile imprinted by the hyperglycemic milieu of T1D mothers during fetal development may impact kidney function in adult offspring. The involved pathways seem to be a nonspecific imprinting process rather than specific to kidney development or function.
Published: 2015
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41. High-speed digital in-line holography as multipoint vibrometry to analyze vibrations of structures

Author: François Gautier, Julien Poittevin, Charles Pezerat, Pascal Picart, Laboratoire d'Acoustique de l'Université du Mans (LAUM), Centre National de la Recherche Scientifique (CNRS)-Le Mans Université (UM), Ecole Nationale Supérieure d'Ingénieurs du Mans (ENSIM), and SPIE
Subjects: Diffraction, Physics, [SPI.ACOU]Engineering Sciences [physics]/Acoustics [physics.class-ph], Field (physics), business.industry, Holography, Physics::Optics, Laser, law.invention, Vibration, Optics, Interference (communication), law, [SPI.OPTI]Engineering Sciences [physics]/Optics / Photonic, Time domain, business, [SPI.SIGNAL]Engineering Sciences [physics]/Signal and Image processing, Digital holography
Abstract: International audience; Structural vibrations can be measured with optical digital holography. Such a method provides measurements with a very high spatial resolution and is a nonintrusive technique. This method is based on the interference between a reference laser beam and the field diffracted by the studied object. Using a high speed camera, it can also be implemented in the time domain to investigate non-stationary problems.In this paper, we present a recent investigation which shows that the high-speed digital holography is comparable with classical laser vibrometry. Furthermore, an experimental investigation of the vibratory field inside the Acoustic Black Hole is discussed. The principle of digital holography is explained and it is used here to provide a full field measurement of the velocity field at the extremity of the structure.
Published: 2015
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42. Osteoprotegerin in relation to insulin resistance and blood lipids in sub-Saharan African women with and without abdominal obesity

Author: Jean François Gautier, Mickael Essouma, Eugene Sobngwi, Laurent Serge Etoundi Ngoa, Clarisse Noël Ayina Ayina, Jean Jacques Noubiap, Philippe Boudou, Department of animal science, Université de Douala, Department of internal medicine and specialties, Université de Yaoundé I, Laboratory for molecular medicine and metabolism, National Obesity Center [Yaoundé], Hôpital Central de Yaoundé [Yaoundé], Department of medicine, Groote Schuur and Red Cross Children's Hospital, Medical diagnostic center, Yaoundé, Department of hormaonal biology, Groupe Hospitalier Saint Louis - Lariboisière - Fernand Widal [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Department of diabetes and endocrinology, Centre de Recherche des Cordeliers (CRC), Université Pierre et Marie Curie - Paris 6 (UPMC)-École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM), Department of Medicine, Faculty of Health Sciences, Administateur, HAL Sorbonne Université, Université Pierre et Marie Curie - Paris 6 (UPMC)-École Pratique des Hautes Études (EPHE), Université de Yaoundé I [Yaoundé], Centre de Recherche des Cordeliers ( CRC ), and Université Paris Diderot - Paris 7 ( UPD7 ) -École pratique des hautes études ( EPHE ) -Université Pierre et Marie Curie - Paris 6 ( UPMC ) -Université Paris Descartes - Paris 5 ( UPD5 ) -Institut National de la Santé et de la Recherche Médicale ( INSERM )
Subjects: Blood Glucose, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, Fat Body, Blood lipids, Blood Pressure, Receptors, Tumor Necrosis Factor, Body Mass Index, Insulin, Homeostasis, Abdominal obesity, 2. Zero hunger, Immunoassay, [SDV.MHEP] Life Sciences [q-bio]/Human health and pathology, medicine.diagnostic_test, Diabetes, Fasting, Lipids, Blood, Cholesterol, Obesity, Abdominal, Regression Analysis, medicine.symptom, Waist Circumference, Lipoproteins, HDL, Risk, musculoskeletal diseases, medicine.medical_specialty, Waist, Short Report, Insulin resistance, Metabolic Diseases, [ SDV.MHEP ] Life Sciences [q-bio]/Human health and pathology, Internal medicine, Diabetes mellitus, Internal Medicine, medicine, Obesity, Bone Resorption, Homo sapiens, business.industry, Cholesterol, HDL, Sub-Saharan Africans, Osteoprotegerin, Cholesterol, LDL, medicine.disease, Endocrinology, Cross-Sectional Studies, business, Lipid profile, Body mass index, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract: International audience; Background : Osteoprotegerin (OPG), a soluble member of the tumor necrosis factor receptor superfamily that inhibits bone resorption, has been suggested as a potential marker of cardiovascular risk. This study aimed to assess the relationship between insulin resistance, lipid profile and OPG levels in obese and non-obese sub-Saharan African women.Methods :Sixty obese (44) and non-obese (16) volunteer women aged 18 to 40 years were recruited in this cross-sectional study. Their clinical (age, height, weight, waist circumference, systolic and diastolic blood pressures) and biochemical parameters (fasting blood glucose, total cholesterol, high density lipoprotein-cholesterol (HDL-C)) were measured using standard methods. Insulin levels were measured using an electrochemiluminescence immunoassay, while OPG levels were measured using the ELISA technique. Low density lipoprotein-cholesterol (LDL-C), body mass index (BMI) and Homeostasis Model Assessment of Insulin Resistance (HOMA-IR) were calculated using standard methods. Abdominal obesity was defined as a waist circumference ≥ 80 cm.Results : OPG levels were higher in obese than in normal subjects, though the difference was not significant (p = 0.9). BMI, waist circumference, percent body fat and systolic blood pressure were significantly higher in obese than in non-obese subjects (p
Published: 2015
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43. Artificial cochlea and acoustic black hole travelling waves observation: Model and experimental results

Author: Simon Foucaud, Yves Gourinat, François Gautier, Guilhem Michon, Adrien Pelat, Institut Clément Ader (ICA), Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Centre National de la Recherche Scientifique (CNRS)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-IMT École nationale supérieure des Mines d'Albi-Carmaux (IMT Mines Albi), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-Institut Supérieur de l'Aéronautique et de l'Espace (ISAE-SUPAERO), Laboratoire d'Acoustique de l'Université du Mans (LAUM), Centre National de la Recherche Scientifique (CNRS)-Le Mans Université (UM), Institut Supérieur de l'Aéronautique et de l'Espace (ISAE-SUPAERO)-Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), Institut National des Sciences Appliquées (INSA)-Université de Toulouse (UT)-Institut National des Sciences Appliquées (INSA)-Université de Toulouse (UT)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Centre National de la Recherche Scientifique (CNRS)-IMT École nationale supérieure des Mines d'Albi-Carmaux (IMT Mines Albi), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT), Le Mans Université (UM)-Centre National de la Recherche Scientifique (CNRS), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-IMT École nationale supérieure des Mines d'Albi-Carmaux (IMT Mines Albi)-Institut Supérieur de l'Aéronautique et de l'Espace (ISAE-SUPAERO), Institut Supérieur de l'Aéronautique et de l'Espace - ISAE-SUPAERO (FRANCE), and Université du Maine (FRANCE)
Subjects: [PHYS.MECA.VIBR]Physics [physics]/Mechanics [physics]/Vibrations [physics.class-ph], Physics, [SPI.ACOU]Engineering Sciences [physics]/Acoustics [physics.class-ph], Acoustics and Ultrasonics, Mechanical Engineering, Acoustics, Condensed Matter Physics, Vibration, Viscoelasticity, Acoustique, [PHYS.MECA.ACOU]Physics [physics]/Mechanics [physics]/Acoustics [physics.class-ph], Cochlea, Black hole, Standing wave, Physics::Fluid Dynamics, Flexural strength, Mechanics of Materials, Waveguide (acoustics), Thin film, Acoustic, ComputingMilieux_MISCELLANEOUS, Excitation
Abstract: International audience; An inhomogeneous fluid structure waveguide reproducing passive behaviour of the inner ear is modelled with the help of the Wentzel–Kramers–Brillouin method. A physical setup is designed and built. Experimental results are compared with a good correlation to theoretical ones. The experimental setup is a varying width plate immersed in fluid and terminated with an acoustic black hole. The varying width plate provides a spatial repartition of the vibration depending on the excitation frequency. The acoustic black hole is made by decreasing the plate׳s thickness with a quadratic profile and by covering this region with a thin film of viscoelastic material. Such a termination attenuates the flexural wave reflection at the end of the waveguide, turning standing waves into travelling waves.
Published: 2014
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44. Estimation of mechanical properties of panels based on modal density and mean mobility measurements

Author: Bertrand David, François Gautier, Benjamin Elie, Laboratoire d'Acoustique de l'Université du Mans (LAUM), Centre National de la Recherche Scientifique (CNRS)-Le Mans Université (UM), Laboratoire Traitement et Communication de l'Information (LTCI), and Institut Mines-Télécom [Paris] (IMT)-Télécom Paris
Subjects: Loss factor, Computation, Modal testing, Aerospace Engineering, Modulus, 02 engineering and technology, 01 natural sciences, Subspace method, 0103 physical sciences, 0202 electrical engineering, electronic engineering, information engineering, Mid-frequency, Mode density, 010301 acoustics, Modal identification, Civil and Structural Engineering, Mathematics, [PHYS.MECA.VIBR]Physics [physics]/Mechanics [physics]/Vibrations [physics.class-ph], Estimation of signal parameters via rotational invariance techniques, business.industry, Mechanical Engineering, Modal analysis using FEM, Mathematical analysis, 020206 networking & telecommunications, Structural engineering, Stringed instrument making, Wood, Computer Science Applications, Modal, Control and Systems Engineering, Signal Processing, business, [SPI.SIGNAL]Engineering Sciences [physics]/Signal and Image processing, Subspace topology
Abstract: The mechanical characteristics of wood panels used by instrument makers are related to numerous factors, including the nature of the wood or characteristic of the wood sample (direction of fibers, micro-structure nature). This leads to variations in the Young's modulus, the mass density, and the damping coefficients. Existing methods for estimating these parameters are not suitable for instrument makers, mainly because of the need of expensive experimental setups, or complicated protocols, which are not adapted to a daily practice in a workshop. In this paper, a method for estimating the Young's modulus, the mass density, and the modal loss factors of flat panels, requiring a few measurement points and an affordable experimental setup, is presented. It is based on the estimation of two characteristic quantities: the modal density and the mean mobility. The modal density is computed from the values of the modal frequencies estimated by the subspace method ESPRIT (Estimation of Signal Parameters via Rotational Invariance Techniques), associated with the signal enumeration technique ESTER (ESTima-tion of ERror). This modal identification technique is proved to be robust in the low-and the mid-frequency domains, i.e. when the modal overlap factor does not exceed 1. The estimation of the modal parameters also enables the computation of the modal loss factor in the low-and the mid-frequency domains. An experimental fit with the theoretical expressions for the modal density and the mean mobility enables an accurate estimation of the Young's modulus and the mass density of flat panels. A numerical and an experimental study show that the method is robust, and that it requires solely a few measurement points.
Published: 2013
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45. Fetal PGC-1 alpha Overexpression Programs Adult Pancreatic beta-Cell Dysfunction

Author: Jean-Pierre Riveline, Pascal Ferré, Ping Zhang, Bérengère Valtat, Nicolas Venteclef, Jean-François Gautier, B. Blondeau, Mathieu Armanet, A. Besseiche, Bernadette Breant, Amrit Singh-Estivalet, Daniel P. Kelly, François Tronche, Expression des Gènes et comportement adaptatifs = Molecular Genetics, Neurophysiology and Behavior (NPS-15), Neurosciences Paris Seine (NPS), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut de Biologie Paris Seine (IBPS), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut de Biologie Paris Seine (IBPS), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Ministere de l'Enseignement Superieur et de la Recherche, Fondation pour la Recherche Medicale, INSERM, CNRS, European Union [FP5 Nutrix QLK1-CT-2000-00083, FP6 Earnest Food-CT-2005-007036], Agence Nationale de la Recherche [A05245DS], Societe Francophone du Diabete, Institut Benjamin Delessert, Neuroscience Paris Seine (NPS), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut de Biologie Paris Seine (IBPS), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Institut de Biologie Paris Seine (IBPS), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Institut de Biologie Paris Seine (IBPS), and Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Pierre et Marie Curie - Paris 6 (UPMC)
Subjects: Blood Glucose, medicine.medical_specialty, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, Cell, 030209 endocrinology & metabolism, Biology, Mice, 03 medical and health sciences, 0302 clinical medicine, Pregnancy, Insulin-Secreting Cells, Internal medicine, Internal Medicine, medicine, Animals, Insulin, RNA, Messenger, Receptor, Psychological repression, Transcription factor, Cells, Cultured, Original Research, 030304 developmental biology, Homeodomain Proteins, Regulation of gene expression, 0303 health sciences, Fetus, 16. Peace & justice, Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha, Glucose, medicine.anatomical_structure, Endocrinology, Gene Expression Regulation, Islet Studies, Trans-Activators, PDX1, Female, [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], Food Deprivation, Transcription Factors
Abstract: International audience; Adult beta-cell dysfunction, a hallmark of type 2 diabetes, can be programmed by adverse fetal environment. We have shown that fetal glucocorticoids (GCs) participate in this programming through inhibition of beta-cell development. Here we have investigated the molecular mechanisms underlying this regulation. We showed that GCs stimulate the expression of peroxisome proliferator-activated receptor-gamma coactivator-1 alpha (PGC-1 alpha), a coregulator of the GCs receptor (GR), and that the overexpression of PGC-1 alpha represses genes important for beta-cell development and function. More precisely, PGC-1 alpha inhibited the expression of the key beta-cell transcription factor pancreatic duodenal homeobox 1 (Pdx1). This repression required the GR and was mediated through binding of a GR/PGC-1 alpha complex to the Pdx1 promoter. To explore PGC-1 alpha function, we generated mice with inducible beta-cell PGC-1 alpha overexpression. Mice overexpressing PGC-1 alpha exhibited at adult age impaired glucose tolerance associated with reduced insulin secretion, decreased beta-cell mass, and beta-cell hypotrophy. Interestingly, PGC-1 alpha expression in fetal life only was sufficient to impair adult beta-cell function whereas beta-cell PGC-1 alpha overexpression from adult age had no consequence on beta-cell function. Altogether, our results demonstrate that the GR and PGC-1 alpha participate in the fetal programming of adult beta-cell function through inhibition of Pdx1 expression. Diabetes 62:1206-1216, 2013
Published: 2013
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46. Analysis of bridge mobility of violins

Author: Elie, Benjamin, François, Gautier, Bertrand, David, Elie, Benjamin, Laboratoire d'Acoustique de l'Université du Mans (LAUM), Le Mans Université (UM)-Centre National de la Recherche Scientifique (CNRS), Télécom ParisTech - TSI, Laboratoire Traitement et Communication de l'Information (LTCI), and Télécom ParisTech-Institut Mines-Télécom [Paris] (IMT)-Centre National de la Recherche Scientifique (CNRS)-Télécom ParisTech-Institut Mines-Télécom [Paris] (IMT)-Centre National de la Recherche Scientifique (CNRS)
Subjects: [SPI.ACOU]Engineering Sciences [physics]/Acoustics [physics.class-ph], Violins, [SPI.ACOU] Engineering Sciences [physics]/Acoustics [physics.class-ph], Formant, Bridge mobility, Bridge Hill, [PHYS.MECA.ACOU] Physics [physics]/Mechanics [physics]/Acoustics [physics.class-ph], [PHYS.MECA.ACOU]Physics [physics]/Mechanics [physics]/Acoustics [physics.class-ph]
Abstract: International audience; This paper focuses on the bridge mobility of violins. The mobility, or mechanical admittance, quantifies the efficiency of the instrument body to vibrate when a force is applied to the structure. The computation of the mean mobility, after the Skudrzyk's mean-value theorem, enables a global characterization of the bridge mobility. The choices made by the luthier, when he builds, restores, or adjusts an instrument, modify the mobility and the mean mobility: this is the signature of the instrument. This study shows that the bridge mobility measurement may be helpful for luthiers to objectively characterize an instrument. Two experimental applications on the violin are presented in the paper: the first one studies the characterization of the same violin in several configurations, corresponding to different positions of the soundpost. The second application studies the effect of a violin mute on both the bridge mobility and the spectral characteristics of the produced sound. This study is a part of the PAFI project, which aims to develop a set of tools dedicated to instrument makers.
Published: 2013

47. Macro parameters describing the mechanical behavior of classical guitars

Author: Benjamin Elie, Bertrand David, François Gautier, Laboratoire d'Acoustique de l'Université du Mans (LAUM), Centre National de la Recherche Scientifique (CNRS)-Le Mans Université (UM), Signal, Statistique et Apprentissage (S2A), Laboratoire Traitement et Communication de l'Information (LTCI), Institut Mines-Télécom [Paris] (IMT)-Télécom Paris-Institut Mines-Télécom [Paris] (IMT)-Télécom Paris, Département Traitement du Signal et des Images (TSI), Télécom ParisTech-Centre National de la Recherche Scientifique (CNRS), and HAL, TelecomParis
Subjects: Sound Spectrography, Acoustics and Ultrasonics, Computation, Rigidity (psychology), Vibration, 01 natural sciences, 03 medical and health sciences, 0302 clinical medicine, Optics, Arts and Humanities (miscellaneous), 0103 physical sciences, Characteristic admittance, C++ string handling, Computer Simulation, Invariant (mathematics), 030223 otorhinolaryngology, 010301 acoustics, ComputingMilieux_MISCELLANEOUS, [SPI.SIGNAL] Engineering Sciences [physics]/Signal and Image processing, Mathematics, business.industry, Mathematical analysis, Numerical Analysis, Computer-Assisted, Signal Processing, Computer-Assisted, Acoustics, Models, Theoretical, [PHYS.MECA.ACOU]Physics [physics]/Mechanics [physics]/Acoustics [physics.class-ph], Range (mathematics), Sound, [PHYS.MECA.ACOU] Physics [physics]/Mechanics [physics]/Acoustics [physics.class-ph], business, [SPI.SIGNAL]Engineering Sciences [physics]/Signal and Image processing, Algorithms, Music, Subspace topology
Abstract: Since the 1960s and 1970s, researchers have proposed simplified models using only a few parameters to describe the vibro-acoustical behavior of string instruments in the low-frequency range. This paper presents a method for deriving and estimating a few important parameters or features describing the mechanical behavior of classical guitars over a broader frequency range. These features are selected under the constraint that the measurements may readily be made in the workshop of an instrument maker. The computations of these features use estimates of the modal parameters over a large frequency range, made with the high-resolution subspace ESPRIT algorithm (Estimation of Signal Parameters via Rotational Invariant Techniques) and the signal enumeration technique ESTER (ESTimation of ERror). The methods are applied to experiments on real metal and wood plates and numerical simulations of them. The results on guitars show a nearly constant mode density in the mid- and high-frequency ranges, as it is found for a flat panel. Four features are chosen as characteristic parameters of this equivalent plate: Mass, rigidity, characteristic admittance, and the mobility deviation. Application to a set of 12 guitars indicates that these features are good candidates to discriminate different classes of classical guitars.
Published: 2012

48. Simulation of vibrations of a 2D acoustic black hole placed in an infinite plate using the Finite Difference Time Domain method

Author: Vivien DENIS, Adrien Pelat, François Gautier, System, HAL, and Société Française d'Acoustique
Subjects: [SPI.ACOU] Engineering Sciences [physics]/Acoustics [physics.class-ph], damping, acoustic black hole, vibration, simulation
Abstract: The acoustic black hole effect is resulting from properties of propagation of flexural wave in beams and plates having non homogeneous thicknesses: if the thickness decreases locally, flexural waves slow down and the amplitude of the displacement field increases, leading to efficient energy dissipation if an absorbing layer is placed where the thickness is minimum. A pit of power law profile placed inside an elastic plate plays the role of a vibration damper and is called 2-dimensional acoustic black hole. Theoretical model of the phenomenon has been developed in the case of beams (1- dimensional configuration) and for linear medium. However, experimental testing on 2D configuration tends to show some unexpected damping effects that are possibly related to local nonlinear phenomena. A numerical model in the time domain based on the finite difference method is proposed to investigate the interaction between an incident wave emitted by a point source and a 2D acoustic black hole placed on an infinite plate. The local nonlinearities are taken into account using Von Karman theory of plate. Perfectly Matched Layer (PML) is used to represent the infinite plate. Numerical simulations permit to quantify the influence of the local non linear effects on the plate damping.
Published: 2012

49. Therapeutic use of recombinant methionyl human leptin

Author: Corinne Vigouroux, Jean-François Gautier, Camille Vatier, Vigouroux, Corinne, Centre de Recherche Saint-Antoine (UMRS893), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre de Recherche des Cordeliers (CRC (UMR_S 872)), Université Pierre et Marie Curie - Paris 6 (UPMC)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Service de diabétologie et d'endocrinologie, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Groupe Hospitalier Saint Louis - Lariboisière - Fernand Widal [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Service de biochimie et hormonologie [CHU Tenon], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Tenon [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU), CHU Tenon [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Centre de Recherche Saint-Antoine ( CR Saint-Antoine ), Université Pierre et Marie Curie - Paris 6 ( UPMC ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), Centre de Recherche des Cordeliers ( CRC (UMR_S 872) ), Université Pierre et Marie Curie - Paris 6 ( UPMC ) -Université Paris Descartes - Paris 5 ( UPD5 ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Centre National de la Recherche Scientifique ( CNRS ), Assistance publique - Hôpitaux de Paris (AP-HP)-Groupe Hospitalier Saint Louis - Lariboisière - Fernand Widal [Paris], Assistance publique - Hôpitaux de Paris (AP-HP)-CHU Tenon [APHP], Université Paris Descartes - Paris 5 (UPD5)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), and Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)
Subjects: Leptin, medicine.medical_specialty, MESH: Diabetes Mellitus, MESH: Mutation, 030209 endocrinology & metabolism, Biology, medicine.disease_cause, Biochemistry, 03 medical and health sciences, 0302 clinical medicine, Immune system, Insulin resistance, Weight loss, Internal medicine, medicine, Diabetes Mellitus, Animals, Humans, MESH: Obesity, Secretion, MESH: Animals, Obesity, 030304 developmental biology, 2. Zero hunger, [SDV.MHEP.EM] Life Sciences [q-bio]/Human health and pathology/Endocrinology and metabolism, 0303 health sciences, Mutation, Leptin Deficiency, MESH: Humans, MESH : Humans, digestive, oral, and skin physiology, General Medicine, MESH: Leptin, [ SDV.MHEP.EM ] Life Sciences [q-bio]/Human health and pathology/Endocrinology and metabolism, [SDV.MHEP.EM]Life Sciences [q-bio]/Human health and pathology/Endocrinology and metabolism, medicine.disease, 3. Good health, MESH : Diabetes Mellitus, Endocrinology, MESH : Leptin, MESH : Obesity, MESH : Animals, medicine.symptom, MESH : Mutation, Recombinant methionyl human leptin
Abstract: International audience; Recombinant methionyl human leptin (r-metHuLeptin) was first used as a replacement therapy in patients bearing inactivating mutations in the leptin gene. In this indication, it was shown since 1999 to be very efficient in inducing a dramatic weight loss in rare children and adults with severe obesity due to the lack of leptin. These first clinical trials clearly showed that r-metHuLeptin acted centrally to reduce food intake, inducing loss of fat mass, and to correct metabolic alterations, immune and neuroendocrine defects. A few years later, r-metHuLeptin was also shown to reverse the metabolic complications associated with lipodystrophic syndromes, due to primary defects in fat storage, which induce leptin deficiency. The beneficial effects, which could be mediated by central and/or peripheral mechanisms, are thought to mainly involve the lowering effects of leptin on ectopic lipid storage, in particular in liver and muscles, reducing insulin resistance. Interestingly, r-metHuLeptin therapy also reversed the hypothalamic-pituitary-gonadal axis dysfunctions associated with hypothalamic amenorrhea. However, if r-metHuLeptin treatment has been shown to be dramatically efficient in leptin-deficient states, its very limited effect in inducing weight loss in common obese patients revealed that, in patients with adequate leptin secretion, mechanisms of leptin resistance and leptin tolerance prevent r-metHuLeptin from inducing any additional effects. This review will present the current data about the effects of r-metHuLeptin therapy in humans, and discuss the recent perspectives of this therapy in new indications.
Published: 2012
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50. Assessment of the impact of the Eyjafjallajokull's eruption on surface air quality in France

Author: Augustin Colette, Nicolas Alsac, Bertrand Bessagnet, Hugues Biaudet, Laura Chiappini, Olivier Favez, Emeric FREJAFON, François Gautier, Fabrice Godefroy, Martial Haeffelin, Eva Leoz, Laure Malherbe, Frédérik Meleux, Laurent Menut, Yohann Morille, Arnaud Papin, Christophe Pietras, Martine Ramel, Laurence Rouil, Institut National de l'Environnement Industriel et des Risques (INERIS), Laboratoire de Météorologie Dynamique (UMR 8539) (LMD), Département des Géosciences - ENS Paris, École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-École des Ponts ParisTech (ENPC)-École polytechnique (X)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut national des sciences de l'Univers (INSU - CNRS)-École polytechnique (X)-École des Ponts ParisTech (ENPC)-Centre National de la Recherche Scientifique (CNRS)-Département des Géosciences - ENS Paris, École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL), and Civs, Gestionnaire
Subjects: [SDE] Environmental Sciences, [SDE]Environmental Sciences
Published: 2010

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