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1. Occupational exposure to endotoxins and lung cancer risk results of the ICARE Study

Author

Monica Neri, Gwenn Menvielle, Florence Guida, Danièle Luce, Marie Sanchez, Mireille Matrat, Isabelle Stücker, Florence Molinié, Soumaya Ben Khedher, Sylvie Cénée, Centre de recherche en épidémiologie et santé des populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Université Paris-Sud - Paris 11 (UP11)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM), Imperial College London, Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), La Fondation De France, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris-Sud - Paris 11 (UP11)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Université d'Angers (UA)-Université de Rennes 1 (UR1), and Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )

Subjects
Male, Work, medicine.medical_specialty, Lung Neoplasms, endotoxins, Cumulative Exposure, Adenocarcinoma of Lung, Adenocarcinoma, Logistic regression, Toxicology, 03 medical and health sciences, 0302 clinical medicine, Risk Factors, Internal medicine, Odds Ratio, medicine, Humans, Animal Husbandry, Occupations, Workplace, Lung cancer, Lung, Aged, business.industry, case-control studies, Smoking, Confounding, Public Health, Environmental and Occupational Health, Case-control study, Odds ratio, occupational exposure, Middle Aged, medicine.disease, 030210 environmental & occupational health, Confidence interval, 3. Good health, lung cancer, Logistic Models, 030220 oncology & carcinogenesis, Female, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, France, Occupational exposure, business
Abstract

Purpose We investigated the role of occupational exposure to endotoxin in lung cancer risk in a French population based case-control study. Methods Lifelong work histories of 2926 cases and 3555 controls were collected using standardised questionnaires. Estimation of endotoxin exposure was based on a publication issued by the Institut National de Recherche et de Securite (INRS), which reported measurements in biological aerosols workstations. Several exposure-related variables were created: intensity ( 1000UE/m³), total duration (years), life time cumulative exposure (UE/m³*years) and time since cessation (years). Smoking history was combined into a comprehensive smoking index (CSI) that included mean number of cigarettes/day, duration and time since cessation. Odds ratios (OR) and 95 % confidence intervals (CI) were estimated using unconditional logistic regression models and controlled for main confounding factors including CSI. Results We found an inverse significant association between high endotoxin exposure and lung cancer risk (151 cases/336 controls; OR = 0.64, 95% Cl = 0.5–0.82). The main activity sectors entailing high exposure included dairy, cattle, poultry and pig farms. In contrast, a statistically significant positive association was found for low exposure (OR = 1.33, 95% Cl = 1.08–1.64) (eg. sawmills, wool industry, meat processing). Using restricted splines cubic models, we observed that the association between cumulative endotoxin exposures and lung cancer risk departed significantly from linearity. In addition, the risk decreased with duration and increased with time since cessation, irrespective of the exposure intensity. Analysis by subgroups showed an interaction with tobacco consumption, and light smokers appeared to be more sensitive to endotoxin protective effect. Conclusions Our findings suggest that high exposure to endotoxin confers protection against lung cancer.

Published
2017
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2. A life course approach to explore the biological embedding of socioeconomic position and social mobility through circulating inflammatory markers

Author

Gianluca Campanella, Carlotta Sacerdote, Domenico Palli, Soterios A. Kyrtopoulos, Salvatore Panico, Thierry Lang, Silvia Stringhini, Paolo Vineis, Michelle Kelly-Irving, Marc Chadeau-Hyam, Fatemeh Saberi Hosnijeh, Vittorio Krogh, Raphaële Castagné, Cyrille Delpierre, Roel Vermeulen, Rosario Tumino, Florence Guida, Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées, Epidémiologie et analyses en santé publique : risques, maladies chroniques et handicaps (LEASP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM), CPO Piemonte, Commission of the European Communities, Castagné, Raphaële, Delpierre, Cyrille, Kelly Irving, Michelle, Campanella, Gianluca, Guida, Florence, Krogh, Vittorio, Palli, Domenico, Panico, Salvatore, Sacerdote, Carlotta, Tumino, Rosario, Kyrtopoulos, Soterio, Hosnijeh, Fatemeh Saberi, Lang, Thierry, Vermeulen, Roel, Vineis, Paolo, Stringhini, Silvia, Chadeau Hyam, Marc, LS IRAS EEPI GRA (Gezh.risico-analyse), and dIRAS RA-I&I RA

Subjects
Adult, Inflammation/blood, Male, medicine.medical_specialty, Socioeconomic position, Epidemiology, [SDV]Life Sciences [q-bio], Granulocyte Colony-Stimulating Factor/blood, Article, 03 medical and health sciences, 0302 clinical medicine, Risk Factors, Granulocyte Colony-Stimulating Factor, Medicine, Humans, Biomarkers/blood, Europe, Female, Middle Aged, Prospective Studies, Social Mobility, 030212 general & internal medicine, Young adult, Prospective cohort study, ComputingMilieux_MISCELLANEOUS, Inflammation, Multidisciplinary, Molecular medicine, business.industry, Social mobility, 3. Good health, European Prospective Investigation into Cancer and Nutrition, 030220 oncology & carcinogenesis, Immunology, Cohort, Life course approach, business, Biomarkers, Demography
Abstract

Lower socioeconomic position (SEP) has consistently been associated with poorer health. To explore potential biological embedding and the consequences of SEP experiences from early life to adulthood, we investigate how SEP indicators at different points across the life course may be related to a combination of 28 inflammation markers. Using blood-derived inflammation profiles measured by a multiplex array in 268 participants from the Italian component of the European Prospective Investigation into Cancer and Nutrition cohort, we evaluate the association between early life, young adulthood and later adulthood SEP with each inflammatory markers separately, or by combining them into an inflammatory score. We identified an increased inflammatory burden in participants whose father had a manual occupation, through increased plasma levels of CSF3 (G-CSF; β = 0.29; P = 0.002) and an increased inflammatory score (β = 1.96; P = 0.029). Social mobility was subsequently modelled by the interaction between father’s occupation and the highest household occupation, revealing a significant difference between “stable Non-manual” profiles over the life course versus “Manual to Non-manual” profiles (β = 2.38, P = 0.023). Low SEP in childhood is associated with modest increase in adult inflammatory burden; however, the analysis of social mobility suggests a stronger effect of an upward social mobility over the life course.

Published
2016
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3. Professional Cleaning Activities and Lung Cancer Risk Among Women Results From the ICARE Study

Author

Matthieu Carton, Alice Atramont, Danièle Luce, Monica Neri, Marie Sanchez, Florence Guida, Mireille Matrat, Isabelle Stücker, Francesca Mattei, Emilie Marrer, Sylvie Cénée, Gwenn Menvielle, Centre de recherche en épidémiologie et santé des populations (CESP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris-Sud - Paris 11 (UP11)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Epidémiologie environnementale des cancers, Université Paris-Sud - Paris 11 (UP11)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Santé et de la Recherche Médicale (INSERM), Cohortes épidémiologiques en population (CONSTANCES), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay-Université de Paris (UP), Institut Pierre Louis d'Epidémiologie et de Santé Publique (iPLESP), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Pierre et Marie Curie - Paris 6 (UPMC), Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Agence Nationale de Securite Sanitaire, de l'alimentation, de l'environnement et du travail (ANSES), Fondation de France, Agence Nationale de la Recherche (ANR), Institut National du Cancer (INCA), Fondation pour la Recherche Medicale (FRM), Institut national de Veille Sanitaire (InVS), Direction Generale de la Sante (DGS), Fondation ARC pour la Recherche sur le Cancer, Direction Generale du Travail rattachee au Ministere du travail, de l'emploi, de la formation professionnelle et du dialogue social (DGT), la Fondation pour la Recherche Medicale et la Fondation ARC pour la Recherche sur le Cancer, Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Université Paris-Sud - Paris 11 (UP11)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay-Université Paris Cité (UPCité), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM), and Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )

Subjects
Male, Gerontology, Lung Neoplasms, Population, men, occupational exposures, Logistic regression, germany, 03 medical and health sciences, 0302 clinical medicine, Risk Factors, Occupational Exposure, Women workers, Odds Ratio, medicine, Humans, 030212 general & internal medicine, Occupations, education, Lung cancer, Aged, [SDV.EE.SANT]Life Sciences [q-bio]/Ecology, environment/Health, education.field_of_study, business.industry, Public Health, Environmental and Occupational Health, Case-control study, Odds ratio, Middle Aged, International Standard Classification of Occupations, medicine.disease, 030210 environmental & occupational health, Confidence interval, 3. Good health, Occupational Diseases, Case-Control Studies, 8. Economic growth, Female, business, france, Demography
Abstract

International audience; Objectives: Lung cancer risk associated with occupational cleaning activities has been investigated in the population-based case-control study ICARE. Methods: Occupational history was collected by standardized interviews. Jobs were first defined according to the International Standard Classification of Occupations (ISCO) codes and then categorized according to activity sectors. Adjusted odds ratios (ORs) were estimated by unconditional logistic regression, separately for women (619 cases and 760 controls) and men (2265 and 2780). Results: Thirty percent of women and 2.3% of men controls ever held a cleaner or care job. Women who worked as housemaids longer than 7 years showed an OR of 1.76 [95% confidence interval (95% CI) 1.09 to 2.87] with respect to controls. Women employed in domestic service sector for a long time had an OR of 2.06 (95% CI 1.15 to 3.66). Conclusion: We confirmed and redefined the association of lung cancer with occupational cleaning, which concerns a considerable proportion of women workers.

Published
2016
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4. Occupational Exposure to Diesel Motor Exhaust and Lung Cancer: A Dose-Response Relationship Hidden by Asbestos Exposure Adjustment? The ICARE Study

Author

Mireille Matrat, Florence Guida, Sylvie Cénée, Joelle Févotte, Matthieu Carton, Diane Cyr, Gwenn Menvielle, Sophie Paget-Bailly, Loredana Radoï, Annie Schmaus, Simona Bara, Michel Velten, Danièle Luce, Isabelle Stücker, null The Icare Study Group, Unité de pathologie professionnelle, CHI Créteil, Institut Mondor de Recherche Biomédicale (IMRB), Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR10-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Centre de recherche en épidémiologie et santé des populations (CESP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris-Sud - Paris 11 (UP11)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Unité Mixte de Recherche Epidémiologique et de Surveillance Transport Travail Environnement (UMRESTTE UMR T9405), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut Français des Sciences et Technologies des Transports, de l'Aménagement et des Réseaux (IFSTTAR), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Institut Pierre Louis d'Epidémiologie et de Santé Publique (iPLESP), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Francim : Réseau français des registres des cancers, CHU Toulouse [Toulouse]-Hôpital Purpan [Toulouse], CHU Toulouse [Toulouse], Registre des cancers de la Manche, CHPC - Site Louis Pasteur, Centre Hospitalier Public du Cotentin (CHPC)-Centre Hospitalier Public du Cotentin (CHPC), Service d'Epidémiologie et de Biostatistique, Centre Paul Strauss : Centre Régional de Lutte contre le Cancer (CRLCC), Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Université Paris-Sud - Paris 11 (UP11)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM), Registre des cancers de la Manche [CHPC - Site Louis Pasteur], Site Louis Pasteur [CHPC], CH Centre Hospitalier Public du Cotentin (CHPC)-CH Centre Hospitalier Public du Cotentin (CHPC), Registre général des cancers du Tarn, Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), and Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )

Subjects
Article Subject, genetic structures, Epidemiology, business.industry, [SDV]Life Sciences [q-bio], lcsh:R, Public Health, Environmental and Occupational Health, Large population, lcsh:Medicine, Cumulative Exposure, medicine.disease_cause, medicine.disease, Asbestos, eye diseases, 3. Good health, Toxicology, Dose–response relationship, Environmental health, Genetics, medicine, Occupational exposure, business, Lung cancer, Carcinogen, Research Article
Abstract

Background. In a French large population-based case-control study we investigated the dose-response relationship between lung cancer and occupational exposure to diesel motor exhaust (DME), taking into account asbestos exposure.Methods. Exposure to DME was assessed by questionnaire. Asbestos was taken into account through a global indicator of exposure to occupational carcinogens or by a specific JEM.Results. We found a crude dose response relationship with most of the indicators of DME exposure, including with the cumulative exposure index. All results were affected by adjustment for asbestos exposure. The dose response relationships between DME and lung cancer were observed among subjects never exposed to asbestos.Conclusions. Exposure to DME and to asbestos is frequently found among the same subjects, which may explain why dose-response relationships in previous studies that adjusted for asbestos exposure were inconsistent.

Published
2015
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5. Coffee consumption and risk of lung cancer: the ICARE study

Author

Annie Schmaus, Isabelle Stücker, Danièle Luce, Marie Sanchez, Harinakshi Sanikini, Gwenn Menvielle, Michel Velten, Loredana Radoï, Diane Cyr, Matthieu Carton, Francesca Mattei, Florence Guida, Sylvie Cénée, Centre de recherche en épidémiologie et santé des populations (CESP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris-Sud - Paris 11 (UP11)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Institut Pierre Louis d'Epidémiologie et de Santé Publique (iPLESP), Sorbonne Université (SU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Recherches épidémiologiques et statistiques sur l'environnement et la santé., Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Santé et de la Recherche Médicale (INSERM), Santé publique et épidémiologie des déterminants professionnels et sociaux de la santé, Epidémiologie, sciences sociales, santé publique (IFR 69), Université Paris 1 Panthéon-Sorbonne (UP1)-Université Paris-Sud - Paris 11 (UP11)-École des hautes études en sciences sociales (EHESS)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Paris 1 Panthéon-Sorbonne (UP1)-Université Paris-Sud - Paris 11 (UP11)-École des hautes études en sciences sociales (EHESS)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Institut Paoli-Calmettes, Fédération nationale des Centres de lutte contre le Cancer (FNCLCC), Equipe RPPC, CETAF, Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Université Paris-Sud - Paris 11 (UP11)-Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), Université Panthéon-Sorbonne (UP1)-Université Paris-Sud - Paris 11 (UP11)-École des hautes études en sciences sociales (EHESS)-Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Panthéon-Sorbonne (UP1)-Université Paris-Sud - Paris 11 (UP11)-École des hautes études en sciences sociales (EHESS)-Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Université Paris-Sud - Paris 11 (UP11)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM), Université Paris 1 Panthéon-Sorbonne (UP1)-Université Paris-Sud - Paris 11 (UP11)-École des hautes études en sciences sociales (EHESS)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Paris 1 Panthéon-Sorbonne (UP1)-Université Paris-Sud - Paris 11 (UP11)-École des hautes études en sciences sociales (EHESS)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut National de la Santé et de la Recherche Médicale (INSERM), and Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )

Subjects
Male, Risk, medicine.medical_specialty, Lung Neoplasms, Epidemiology, Population, Coffee consumption, Coffee, 03 medical and health sciences, 0302 clinical medicine, Environmental health, medicine, Humans, 030212 general & internal medicine, education, Lung cancer, ComputingMilieux_MISCELLANEOUS, 2. Zero hunger, education.field_of_study, business.industry, Public health, Confounding, Case-control study, Feeding Behavior, medicine.disease, 3. Good health, Case-Control Studies, Population Surveillance, 030220 oncology & carcinogenesis, Population study, Female, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, France, business
Abstract

Coffee is one of the most widely consumed beverages and a major dietary exposure in the world. In 2007, the World Cancer Research Fund (WCRF) and the American Institute of Cancer Research (AICR) concluded in its report that for the association between lung cancer with dietary exposures such as coffee intake, the data were either of too low quality, or too inconsistent or the number of studies were too few to allow conclusions to be reached [1]. A meta-analysis (2010) of 13 studies reported significant positive association between coffee consumption and lung cancer risk [2]. However, there may still be residual confounding due to smoking. We sought to examine the association between coffee consumption and lung cancer risk in a large French population-based case–control study, the ICARE study (Investigation of occupational and environmental causes of respiratory cancers). The large sample size of this study allowed us to assess the association by gender, smoking status and histological types of lung cancer. The study design, study population and data collection methods of ICARE study have been described in detail elsewhere [3]. In brief, ICARE study is a large multi-centre

Published
2015
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6. Lung cancer risk among bakers, pastry cooks and confectionary makers: the SYNERGY study

Author

Maria Teresa Landi, Per Gustavsson, John R. McLaughlin, Hans Erich Wichmann, Tabea Treppmann, David Zaridze, Florence Guida, Kurt Straif, Roel Vermeulen, Nils Plato, Eleonora Fabianova, Lap Ah Tse, Marie-Élise Parent, Vladimir Janout, Peter Rudnai, Vladimir Bencko, Neil E. Caporaso, Ann Olsson, Neil Pearce, Adonina Tardón, Paolo Boffetta, Isabelle Stücker, Lorenzo Richiardi, Dario Consonni, Rodica Stanescu Dumitru, Andrea 't Mannetje, Thomas Behrens, Neonila Szeszenia-Dabrowska, Karl-Heinz Jöckel, Franco Merletti, Ignatius Tak-sun Yu, Bas Bueno-de-Mesquita, Dario Mirabelli, Simone Benhamou, Jolanta Lissowska, Hermann Pohlabeln, Hans Kromhout, Susan Peters, Lenka Foretova, John K. Field, Joachim Schüz, Irene Brüske, Lorenzo Simonato, Thomas Brüning, Wolfgang Ahrens, Beate Pesch, Benjamin Kendzia, Jack Siemiatycki, Paul A. Demers, Institute for Prevention and Occupational Medicine of the German Social Accident Insurance (IPA), Centre International de Recherche contre le Cancer - International Agency for Research on Cancer (CIRC - IARC), Organisation Mondiale de la Santé / World Health Organization Office (OMS / WHO), The Institute of Environmental Medicine [Stockholm] (IMM), Karolinska Institutet [Stockholm], Institute for Medical Informatics, Biometry and Epidemiology, University Hospital of Essen, Leibniz Institute for Prevention Research and Epidemiology - BIPS, Leibniz Association, Institute for Statistics, University of Bremen, Institute of Epidemiology I, German Research Center for Environmental Health-Helmholtz-Zentrum München (HZM), Cancer Epidemiology Unit, Université de Turin, Department of Environmental Medicine and Public Health, Universita degli Studi di Padova, Institute of Carcinogenesis, Russian Academy of Medical Sciences, The Nofer Institute of Occupational Medicine, National Institute of Environmental Health, Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Regional Authority of Public Health [Slovaquia] (RAPH), Ministry of Health of the Slovak Republic [Slovaquia], Molecular Epidemiology of Cancer Unit, CIBER de Epidemiología y Salud Pública (CIBERESP), Roy Castle Lung Cancer Research Programme, University of Liverpool, National Institute of Public Health [Romania] (INSP), Institute of Hygiene and Epidemiology, Charles University [Prague] (CU)-1st Faculty of Medicine, Department of Cancer Epidemiology and Genetics, Masaryk Memorial Cancer Institute (RECAMO), Faculty of Medicine, Palacky University Olomouc, Centre de Recherche du Centre Hospitalier de l’Université de Montréal (CR CHUM), Centre Hospitalier de l'Université de Montréal (CHUM), Université de Montréal (UdeM)-Université de Montréal (UdeM), Institut Armand Frappier (INRS-IAF), Réseau International des Instituts Pasteur (RIIP)-Institut National de la Recherche Scientifique [Québec] (INRS), Cancer Care Ontario, Occupational Cancer Research Centre, National Cancer Institute [Bethesda] (NCI-NIH), National Institutes of Health [Bethesda] (NIH), Division of Environmental Epidemiology, Utrecht University [Utrecht]-Institute of Risk Assessment Sciences, Western Australian Institute for Medical Research, The University of Western Australia (UWA), Variabilité Génétique et Maladies Humaines, Institut Universitaire d'Hématologie (IUH), Université Paris Diderot - Paris 7 (UPD7)-Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre de recherche en épidémiologie et santé des populations (CESP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris-Sud - Paris 11 (UP11)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), University Paris-Sud, Unit of Epidemiology, Fondazione IRCCS Ca' Granda - Ospedale Maggiore Policlinico, National Institute for Public Health and the Environment [Bilthoven] (RIVM), Centre for Public Health Research, Faculty of Epidemiology and Population Health [London], London School of Hygiene and Tropical Medicine (LSHTM), Division of Occupational and Environmental Health, JC School of Public Health and Primary Care, The Chinese University of Hong Kong [Hong Kong]-The Chinese University of Hong Kong [Hong Kong], The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai [New York] (MSSM), International Prevention Research Institute (IPRI), This study was supported by the German Social Accident Insurance, grant FP 271. Grant sponsors of the individual studies were the Canadian Institutes of Health Research and Guzzo-SRC Chair in Environment and Cancer, the Fondation de France, the German Federal Ministry of Education, Science, Research, and Technology and the Ministry of Labour and Social Affairs, the EC's INCO-COPERNICUS Program, the Polish State Committee for Science Research, the Roy Castle Foundation, the NIH/NCI/DCEG Intramural Research Program, Lombardy Region, INAIL and the European Union Nuclear Fission Safety Program, the Italian Association for Cancer Research, Region Piedmont, the Compagnia di San Paolo, the Europe Against Cancer Program, the Swedish Council for Work Life Research and the Swedish EPA, the University of Oviedo, the European Regional Development Fund and the State Budget of the Czech Republic (RECAMO, CZ.1.05/2.1.00/03.0101), CIBERESP and FISS-PI060604., Behrens, T., Kendzia, B., Treppmann, T., Olsson, A., Jöckel, K.-H., Gustavsson, P., Pohlabeln, H., Ahrens, W., Brüske, I., Wichmann, H.-E., Merletti, F., Mirabelli, D., Richiardi, L., Simonato, L., Zaridze, D., Szeszenia-Dabrowska, N., Rudnai, P., Lissowska, J., Fabianova, E., Tardón, A., Field, J., Dumitru, R.S., Bencko, V., Foretova, L., Janout, V., Siemiatycki, J., Parent, M.-E., McLaughlin, J., Demers, P., Landi, M.T., Caporaso, N., Kromhout, H., Vermeulen, R., Peters, S., Benhamou, S., Stücker, I., Guida, F., Consonni, D., Bueno-de-Mesquita, B., Mannetje, A.'., Pearce, N., Tse, L.A., Yu, I.T.-S., Plato, N., Boffetta, P., Straif, K., Schüz, J., Pesch, B., and Brüning, T.

Subjects
Male, xposure to occupational lung carcinogens, Lung Neoplasms, [SDV]Life Sciences [q-bio], Medizin, MESH: Logistic Models, Logistic regression, MESH: Occupational Exposure, baker, 0302 clinical medicine, Risk Factors, MESH: Risk Factors, Odds Ratio, Food Industry, smoking behaviour, baking-related occupation, Control subjects, 030210 environmental & occupational health, MESH: Case-Control Studies, MESH: Food Industry, Occupational Diseases, 030220 oncology & carcinogenesis, Smoking status, Female, MESH: Occupational Diseases, medicine.medical_specialty, Article, 03 medical and health sciences, Occupational Exposure, medicine, Humans, Occupations, Lung cancer, MESH: Occupations, MESH: Humans, business.industry, Public Health, Environmental and Occupational Health, Case-control study, Odds ratio, medicine.disease, MESH: Male, MESH: Odds Ratio, Surgery, MESH: Lung Neoplasms, lung cancer, Increased risk, Logistic Models, Case-Control Studies, business, MESH: Female, Demography
Abstract

Introduction Some studies have suggested increased lung cancer risks among bakers, however the results overall were inconsistent. The authors studied lung cancer risks among bakers and baking-related occupations in the SYNERGY pooled case–control database from 16 countries. Methods Occupation in a baking-related job was identified from the subjects’ job histories. ORs adjusted for log(age), study centre, smoking behaviour and ever employment in a job with known exposure to occupational lung carcinogens were calculated by unconditional logistic regression. Findings were stratified by sex, histological subtype of lung cancer and smoking status. Results 19 366 cases (15 606 men) and 23 670 control subjects (18 528 men) were included. 473 cases (415 men, 58 women) and 501 controls (437 men, 64 women) had ever worked in baking or a related job. We did not observe an increased risk for men in baking (OR 1.01; 95% CI 0.86 to 1.18). No linear trends were observed for duration of employment. Some results suggested increased lung cancer risks for women, for example, for working as a baker for >30 years and in never-smokers, but after exclusion of one study these increased risks disappeared. Discussion The findings from this study do not suggest increased lung cancer risks in baking-related professions.

Published
2013
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