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1. The preconceptional environment affects the implantation process in a murine model of spontaneous abortion

Author

Chaouat, G., Coqué, Nathalie, Hennuy, B., Dubanchet, S., Rodde, Nathalie, Fleurot, Isabelle, Ledée, N., Sandra, Olivier, INSERM U782, Hôpital Antoine Béclère, Mathématiques et Informatique Appliquées (MIA-Paris), Institut National de la Recherche Agronomique (INRA)-AgroParisTech, EMBIC, Lab Tumor Development, Centre Hospitalier Universitaire de Liège, Biologie du Développement et Reproduction (BDR), Institut National de la Recherche Agronomique (INRA), AgroParisTech-Institut National de la Recherche Agronomique (INRA), AP-HP - Hôpital Antoine Béclère [Clamart], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Biologie du développement et reproduction (BDR), and Centre National de la Recherche Scientifique (CNRS)-École nationale vétérinaire d'Alfort (ENVA)-Institut National de la Recherche Agronomique (INRA)

Subjects
[SDV]Life Sciences [q-bio], IMPLANTATION FOETALE
Abstract

absent

Published
2008

2. Cytokine expression at interface : a longitudinal micro array

Author

Chaouat, G., Coqué, Nathalie, Hennuy, B., Dubanchet, S., Fleurot, Isabelle, Rodde, Nathalie, Ledée-Bataille, N., Sandra, Olivier, U782, Institut National de la Santé et de la Recherche Médicale (INSERM), Mathématiques et Informatique Appliquées (MIA-Paris), AgroParisTech-Institut National de la Recherche Agronomique (INRA), EMBIC, Tumor and Developement Laboratory, Université de Liège, Station de physiologie animale, Institut National de la Recherche Agronomique (INRA), Unité 782, UR 0888 Bactéries Lactiques et Pathogènes Opportunistes, Biologie du développement et reproduction (BDR), Centre National de la Recherche Scientifique (CNRS)-École nationale vétérinaire d'Alfort (ENVA)-Institut National de la Recherche Agronomique (INRA), Institut National de la Recherche Agronomique (INRA)-Département Microbiologie et Chaîne Alimentaire (MICA), Institut National de la Recherche Agronomique (INRA)-Bactéries Lactiques et Pathogènes Opportunistes (UBLO), and Biologie du Développement et Reproduction (BDR)

Subjects
reproduction, microarray, cytokineexpression, interface, network, méthode, CYTOKINE, biopuce, [SDV]Life Sciences [q-bio], réseau
Abstract

Main Session 3: Immuno-Endocrine Interactions in Reproduction.; absent

Published
2008
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3. In vivo gene delivery of the murine uterus: what and why?

Author

Rodde, Nathalie, Munaut, C., Prince, Sonia, Olivier, F., Bellemin, A.L., Chaouat, G., Sandra, Olivier, Biologie du développement et reproduction (BDR), Centre National de la Recherche Scientifique (CNRS)-École nationale vétérinaire d'Alfort (ENVA)-Institut National de la Recherche Agronomique (INRA), INSERM U782, AP-HP - Hôpital Antoine Béclère [Clamart], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Université de Liège, and Polyplus-transfection SA

Subjects
[SDV]Life Sciences [q-bio], [INFO]Computer Science [cs], ComputingMilieux_MISCELLANEOUS, MURINE UTERUS
Abstract

International audience

Published
2008

4. Statistical analysis for identifying differentially expressed genes in microarrays data, an overview

Author

Daudin, Jean-Jacques, Aubert, Julie, Mansouri, Nadera, Chaouat, G., Sandra, Olivier, Coqué, Nathalie, Mathématiques et Informatique Appliquées (MIA-Paris), AgroParisTech-Institut National de la Recherche Agronomique (INRA), European Network of Excellence 'EMBryo Implantation Control' (EMBIC), Biologie du développement et reproduction (BDR), Centre National de la Recherche Scientifique (CNRS)-École nationale vétérinaire d'Alfort (ENVA)-Institut National de la Recherche Agronomique (INRA), U 782 Equipe implantation et dialogue cytokinique mère conceptus, Institut National de la Santé et de la Recherche Médicale (INSERM), Biologie du Développement et Reproduction (BDR), Institut National de la Recherche Agronomique (INRA), and Institut National de la Recherche Agronomique (INRA)-AgroParisTech

Subjects
[SDV]Life Sciences [q-bio], education, MICROARRAY TECHNOLOGY, human activities, health care economics and organizations
Abstract

Poster session 7: Statistical analyses of gene expression data; absent

Published
2007

5. Th1/Th2 paradigm in pregnancy: paradigm lost? Cytokines in pregnancy/early abortion: Reexamining the Th1/Th2 paradigm

Author

Chaouat, G., Ledée-Bataille, N., Dubanchet, S., Zourbas, S., Sandra, Olivier, MARTAL, J., Biologie du développement et reproduction (BDR), and Centre National de la Recherche Scientifique (CNRS)-École nationale vétérinaire d'Alfort (ENVA)-Institut National de la Recherche Agronomique (INRA)

Subjects
[SDV]Life Sciences [q-bio], [INFO]Computer Science [cs], IMMUNOLOGIE, ComputingMilieux_MISCELLANEOUS, PLACENTA HUMAIN
Abstract

International audience

Published
2004

6. Reproductive immunology 2003: reassessing the Th1/Th2 paradigm ?

Author

Chaouat, G., Ledée-Bataille, N., Dubanchet, S., Zourbas, S., Sandra, Olivier, MARTAL, J., Biologie du développement et reproduction (BDR), and Centre National de la Recherche Scientifique (CNRS)-École nationale vétérinaire d'Alfort (ENVA)-Institut National de la Recherche Agronomique (INRA)

Subjects
[SDV]Life Sciences [q-bio], RAT, [INFO]Computer Science [cs], IMMUNOLOGIE, CELLULEUSE TUEUSE
Abstract

57 ref.; International audience

Published
2004

7. Cellular immune response to Plasmodium falciparum after pregnancy is related to previous placental infection and parity

Author

Fievet, N., Tami, G., Maubert, B., Moussa, M., Shaw, I. K., Cot, M., Holder, A. A., Chaouat, G., Philippe DELORON, Santé de la mère et de l'enfant en milieu tropical : épidémiologie génétique et périnatale, Université Paris Descartes - Paris 5 (UPD5), Organisation de Coordination pour la Lutte contre les Endémies en Afrique Centrale, Organisation de Coordination pour la lutte contre les Endémies en Afrique Centrale (OCEAC), Cytokines et immunorégulation, Institut National de la Santé et de la Recherche Médicale (INSERM), Division of Parasitology, National Institute for Medical Research, This work was supported by IRD, AUPELF/UREF, INSERM, and EU Contracts TS3CT94 0272 and QLK2-CT-1999-01293. B. M. was the recipient of a fellowship from the French Ministère de l'Education Nationale, de l'Enseignement Supérieur et de la Recherche., Maylin, Françoise, and OCEAC

Subjects
Erythrocytes, Placenta, MESH: Pregnancy, Pregnancy, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, MESH: Animals, Cameroon, Malaria, Falciparum, [SDV.BDD]Life Sciences [q-bio]/Development Biology, Cells, Cultured, MESH: Plasmodium falciparum, Immunity, Cellular, MESH: Cytokines, MESH: Erythrocytes, MESH: Malaria, Falciparum, MESH: Placenta, Parity, MESH: Leukocytes, Mononuclear, [SDV.MHEP.MI] Life Sciences [q-bio]/Human health and pathology/Infectious diseases, Cytokines, MESH: Cell Division, Female, MESH: Antigens, Cell Division, MESH: Cells, Cultured, Adult, lcsh:Arctic medicine. Tropical medicine, Adolescent, lcsh:RC955-962, Plasmodium falciparum, [SDV.MHEP.GEO]Life Sciences [q-bio]/Human health and pathology/Gynecology and obstetrics, lcsh:Infectious and parasitic diseases, MESH: Immunity, Cellular, [SDV.BDD] Life Sciences [q-bio]/Development Biology, parasitic diseases, Animals, Humans, lcsh:RC109-216, Antigens, MESH: Adolescent, MESH: Humans, Research, MESH: Parity, MESH: Adult, MESH: Cameroon, MESH: Pregnancy Compli, [SDV.MHEP.GEO] Life Sciences [q-bio]/Human health and pathology/Gynecology and obstetrics, Pregnancy Complications, Parasitic, Leukocytes, Mononuclear, MESH: Female
Abstract

Background Malaria in pregnancy is characterised by the sequestration of Plasmodium falciparum-infected erythrocytes in placental intervillous spaces. Placental parasites express a specific phenotype, which allows them to cytoadhere to chondroitin sulfate A expressed by syncytiotrophoblasts. Malaria infection during pregnancy allows the acquisition of antibodies against placental parasites, these antibodies are thought to be involved in protection during subsequent pregnancies. Methods To investigate the development of a cellular response to placental parasites during pregnancy, peripheral blood mononuclear cells were collected from women at the time of their confinement. The study was performed in Cameroon where malaria transmission is perennial. In vitro cell proliferation and cytokine production were measured in response to non-malarial activators (concanavalin A and PPD), a recombinant protein from P. falciparum MSP-1, and erythrocytes infected by two P. falciparum lines, RP5 and W2. Like placental parasites, the RP5 line, but not W2, adheres to chondroitin sulfate A and to syncytiotrophoblasts. Results The proliferative response to all antigens was lower for cells obtained at delivery than 3 months later. Most interestingly, the cellular response to the RP5 line of P. falciparum was closely related to parity. The prevalence rate and the levels of response gradually increased with the number of previous pregnancies. No such relationship was observed with W2 line, or MSP-1 antigen. Conclusions This suggests the occurrence of an immune response more specific for the RP5 line in women having had multiple pregnancies, and who are likely to develop immunity to pregnancy-associated parasites. Both humoral and cellular mechanisms may account for the lower susceptibility of multigravidae to malaria.

Published
2002

8. Les interactions immuno-endocrines entre la mère et l'embryon

Author

MARTAL, J., Huynh, L., Zourbas, S., Rogez, C., Charpentier, Nicole, Hermier, P., L'HARIDON, R., Charlier, Madia, Chaouat, G., Germain, Guy, Unité de recherches de Physiologie animale (JOUY PHYSIO A), Institut National de la Recherche Agronomique (INRA), Unité de recherche Virologie et Immunologie Moléculaires (VIM (UR 0892)), Unité de biologie cellulaire et moléculaire, J. Martal (Editeur), and ProdInra, Migration

Subjects
[SDV] Life Sciences [q-bio], [SDV]Life Sciences [q-bio], IMMUNOLOGIE, ComputingMilieux_MISCELLANEOUS
Abstract

National audience

Published
2002

9. A brief review of recent data on some cytokine expressions at the materno-foetal interface which might challenge the classical Th1/Th2 dichotomy

Author

Chaouat, G., Zourbas, S., Ostojic, S., Lappree-Delage, G., Dubanchet, S., Ledée, N., MARTAL, J., Unité biologie du développement et biotechnologie, and École nationale vétérinaire d'Alfort (ENVA)-Institut National de la Recherche Agronomique (INRA)

Subjects
[SDV]Life Sciences [q-bio], IMMUNOLOGIE, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2002

11. Un nouvel interféron embryonnaire à l'activité hormonale

Author

MARTAL, J., Huynh, L., L'HARIDON, R., Camous, Sylvaine, Hermier, P., Charpigny, Gilles, Charlier, Madia, Chaouat, G., ProdInra, Migration, Unité de recherches de Physiologie animale (JOUY PHYSIO A), Institut National de la Recherche Agronomique (INRA), and Unité de recherche Virologie et Immunologie Moléculaires (VIM (UR 0892))

Subjects
[SDV] Life Sciences [q-bio], [SDV]Life Sciences [q-bio], ComputingMilieux_MISCELLANEOUS
Abstract

National audience

Published
1998

12. Recent development and potentialities for reducing embryo mortality in ruminants: the role of IFN-teta and other cytokines in early pregnancy

Author

Martal, J., Sylvaine Camous, Huynh, L., Frederic Lantier, Hermier, P., Haridon, R. L., Gilles Charpigny, Madia Charlier, Chaouat, G., Unité de recherches de Physiologie animale (JOUY PHYSIO A), Institut National de la Recherche Agronomique (INRA), Unité de Pathologie Infectieuse et Immunologie [Nouzilly] (PII), Unité de recherche Virologie et Immunologie Moléculaires (VIM (UR 0892)), and ProdInra, Migration

Subjects
[SDV.BDLR]Life Sciences [q-bio]/Reproductive Biology, [SDV.BDLR] Life Sciences [q-bio]/Reproductive Biology, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
1997

13. Cytokines et gestation

Author

Chaouat, G., MARTAL, J., ProdInra, Migration, J.M. Cavaillon (Editeur), Unité de recherches de Physiologie animale (JOUY PHYSIO A), and Institut National de la Recherche Agronomique (INRA)

Subjects
[SDV] Life Sciences [q-bio], [SDV]Life Sciences [q-bio], IMMUNOLOGIE
Abstract

chap. 31

Published
1996

14. IL-10 prevents naturally occuring fetal loss in the CBA x DBA/2 mating combination, and local defect in IL-10 production in this abortion-prone combination is corrected by in vivo injection of IFN-tau

Author

Chaouat, G., Assal Meliani, A., MARTAL, J., Raghupathy, R., Elliot, J., Mosmann, T., Wegmann, T.G., ProdInra, Migration, Unité de recherches de Physiologie animale (JOUY PHYSIO A), and Institut National de la Recherche Agronomique (INRA)

Subjects
[SDV] Life Sciences [q-bio], [SDV]Life Sciences [q-bio], IMMUNOLOGIE
Published
1995

15. Les interférons trophoblastiques et la tolérance immunologique embryonnaire

Author

MARTAL, J., de la Llosa-Hermier, M.P., Huynh, L., Millet, S., L'HARIDON, R., Assal, A., Roignant, N., Chaouat, G., Unité de recherches de Physiologie animale (JOUY PHYSIO A), Institut National de la Recherche Agronomique (INRA), Unité de recherche Virologie et Immunologie Moléculaires (VIM (UR 0892)), and ProdInra, Migration

Subjects
[SDV] Life Sciences [q-bio], TOLERANCE IMMUNOLOGIQUE, [SDV]Life Sciences [q-bio]
Abstract

163 ref.; National audience

Published
1995

16. In vivo immunosuppressive effects of recombinant ovine interferon-tau (Trophoblastin) : r.oTP (r.oIFN-tau) inhibits local GVH reaction in mice (PLN assay), prevents fetal resorptions, and favors embryo survival and implantation in the CBA/JxDBA/2 mice combination

Author

Assal-Meliani, A., Kinsky, R., MARTAL, J., Chaouat, G., ProdInra, Migration, Unité de recherches de Physiologie animale (JOUY PHYSIO A), and Institut National de la Recherche Agronomique (INRA)

Subjects
[SDV] Life Sciences [q-bio], [SDV]Life Sciences [q-bio]
Published
1995

17. Immunoendocrine functions of trophoblast interferons (IFN-tau or TP-1 or trophoblastins) in the maternal recognition of pregnancy

Author

MARTAL, J., Assal, N.E., Assal, A., Zouari, K., Huynh, L., Reinaud, Pierrette, Charpigny, Gilles, Charlier, Madia, Chaouat, G., ProdInra, Migration, S.R. Glasser (Editeur), Unité de recherches de Physiologie animale (JOUY PHYSIO A), and Institut National de la Recherche Agronomique (INRA)

Subjects
[SDV] Life Sciences [q-bio], [SDV]Life Sciences [q-bio], IMMUNOLOGIE, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
1994

18. Recombinant ovine trophoblastin (roTP) inhibits ovine, murine and human lymphocyte proliferation

Author

Assal-Meliani, A., Charpigny, Gilles, Reinaud, Pierrette, Martal, J., Chaouat, G., Unité de recherches de Physiologie animale (JOUY PHYSIO A), Institut National de la Recherche Agronomique (INRA), and ProdInra, Migration

Subjects
[SDV] Life Sciences [q-bio], [SDV]Life Sciences [q-bio], IMMUNOLOGIE, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
1993

19. Characterization, antiluteolytic and immunosuppressive effects of ovine trophoblastin (oTP, alpha-interferon of class 'III')

Author

Martal, J., Assal, A., Assal, E., Charlier, Madia, Charpigny, Gilles, Guillomot, Michel, Chaouat, G., ProdInra, Migration, G. Chaouat (Editeur), J. Mowbray (Editeur), Unité de recherches de Physiologie animale (JOUY PHYSIO A), and Institut National de la Recherche Agronomique (INRA)

Subjects
[SDV] Life Sciences [q-bio], [SDV]Life Sciences [q-bio], ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
1991

21. The mannose binding lectin pathway and early complement activation in (murine) abortion

Author

Nathalie Lédée, Olivier Sandra, Roberta Bulla, Gérard Chaouat, Marie Petitbarat, Sylvie Dubanchet, Francesco Tedesco, Institut National de la Santé et de la Recherche Médicale (INSERM), Université Paris-Sud - Paris 11 (UP11), Hôpital Antoine Béclère, Assistance Publique - Hôpitaux de Paris (AP-HP), Università degli studi di Trieste, Biologie du développement et reproduction (BDR), Centre National de la Recherche Scientifique (CNRS)-École nationale vétérinaire d'Alfort (ENVA)-Institut National de la Recherche Agronomique (INRA), Petitbarat, M, Dubanchet, S, Bulla, Roberta, Sandra, O, Ledee, N, Tedesco, F, and Chaouat, G.

Subjects
[SDV]Life Sciences [q-bio], Immunology, 03 medical and health sciences, 0302 clinical medicine, C-type lectin, Immunology and Allergy, [INFO]Computer Science [cs], mouse, ComputingMilieux_MISCELLANEOUS, Mannan-binding lectin, 030219 obstetrics & reproductive medicine, mannose binding lectin, biology, Chemistry, GENETIQUE ANIMALE, CD69, Obstetrics and Gynecology, BIOLOGIE, mannose binding lectin, abortion, mouse, abortion, 3. Good health, Complement system, Reproductive Medicine, Biochemistry, Concanavalin A, Lectin pathway, biology.protein, Ficolin, MASP1, 030215 immunology
Abstract

Introduction: Girardi and Salmon highlighted the role of complement in early gestation failures in mice. We wanted to identify the pathway of its early activation in the murine natural immune resorbtion model she used. Methods: We monitored the protein and mRNAs expression of MBL-A and C, C3, at different days of gestation, in the uteri of either an “abortive murine combination” DBA/2-mated CBA/J females or a non abortive control mating and established MBL KO congenics on CBA/J background. Results: BALB/c-mated CBA/J females. We also comparatively quantified their expression by RT-PCR. The immunohistochemistry experiments revealed the presence of these (3) proteins and a differential expression of MBL-A between CBA/J × BALB/c and CBA/J × DBA/2 pregnancies while MBL-C was undetectable. However our results of RT-PCR revealed a very low or null local expression of MBL-A and C RNAs and no change in C3 RNA expression in the two combinations. We suggest that MBL-A, and C3 are produced elsewhere but activated locally. To verify the role of MBL, we established at INRA animal facility from breeders from Charles River Iffac Credo France on CBA/J background MBL-A, MBL-C, and MBL-A + C double congenics KO strain starting from MBL KO mice provided by Drs. Jensenius and Thiel Denmark. Albeit the results are still preliminary, at the 5th generation (96.88% of the genome of the KO is already CBA/J), our first results reveal a significant decrease of resorption (using chi-squared test with correction for small samples) in MBL-A KO CBA/J × DBA/2 compared with CBA/J × DBA/2 mating (4.3%, e.g. the incompressible rate of pregnancy loss due to chromosomal anomalies induced foetal demises in mice) versus 12.2% (the usual abortion rate seen in conventional but very clean breeding conditions as is the case at INRA). Depending on breeding and backcrosses, data at the 6th or 7th generation, and with more mice, will eventually be presented. Published data about MBL in human will also be discussed. Conclusions: These results reconcile the “danger” signals and the classical abortive cytokinic pathways, and have profound implications both in murine models and human clinics, which will also be discussed.

Published
2010
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