1. Staphylococcus aureus Toxins: An Update on Their Pathogenic Properties and Potential Treatments
- Author
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Albert Sotto, Virginie Molle, Nour Ahmad-Mansour, Jean-Philippe Lavigne, Paul Loubet, Catherine Dunyach-Remy, Cassandra Pouget, LPHI - Laboratory of Pathogen Host Interactions (LPHI), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Centre Hospitalier Universitaire de Nîmes (CHU Nîmes), Virulence bactérienne et maladies infectieuses (VBMI), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), and MOLLE, Virginie
- Subjects
Staphylococcus aureus ,medicine.drug_class ,Health, Toxicology and Mutagenesis ,Antibiotics ,Virulence ,Review ,Anti-toxin strategies ,Skin infection ,Toxicology ,medicine.disease_cause ,Microbiology ,Sepsis ,03 medical and health sciences ,Antibiotic resistance ,medicine ,Pathogenicity ,Toxins ,Pathogen ,030304 developmental biology ,0303 health sciences ,030306 microbiology ,Toxin ,business.industry ,medicine.disease ,[SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology ,3. Good health ,[SDV.TOX] Life Sciences [q-bio]/Toxicology ,[SDV.TOX]Life Sciences [q-bio]/Toxicology ,Medicine ,[SDV.MP.BAC] Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology ,business - Abstract
Staphylococcus aureus is a clinically important pathogen that causes a wide range of human infections, from minor skin infections to severe tissue infection and sepsis. S. aureus has a high level of antibiotic resistance and is a common cause of infections in hospitals and the community. The rising prevalence of community-acquired methicillin-resistant S. aureus (CA-MRSA), combined with the important severity of S. aureus infections in general, has resulted in the frequent use of anti-staphylococcal antibiotics, leading to increasing resistance rates. Antibiotic-resistant S. aureus continues to be a major health concern, necessitating the development of novel therapeutic strategies. S. aureus uses a wide range of virulence factors, such as toxins, to develop an infection in the host. Recently, anti-virulence treatments that directly or indirectly neutralize S. aureus toxins have showed promise. In this review, we provide an update on toxin pathogenic characteristics, as well as anti-toxin therapeutical strategies.
- Published
- 2021