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14 results on '"C. Santamaria"'

1. Recirculating Foxp3+ regulatory T cells are restimulated in the thymus under Aire control

Author

Jonathan Charaix, Alexia Borelli, Jérémy C. Santamaria, Lionel Chasson, Matthieu Giraud, Arnauld Sergé, Magali Irla, Centre d'Immunologie de Marseille - Luminy (CIML), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Centre de Recherche en Transplantation et Immunologie - Center for Research in Transplantation and Translational Immunology (U1064 Inserm - CR2TI), Institut National de la Santé et de la Recherche Médicale (INSERM)-Nantes Université - UFR de Médecine et des Techniques Médicales (Nantes Univ - UFR MEDECINE), Nantes Université - pôle Santé, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ)-Nantes Université - pôle Santé, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ), Adhésion et Inflammation (LAI), Aix Marseille Université (AMU)-Assistance Publique - Hôpitaux de Marseille (APHM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), ANR-19-CE18-0021,RANKLthym,Évaluer le potentiel de RANK ligand pour rétablir des fonctions thymiques efficaces après greffe de moelle osseuse et vieillissement(2019), and ANR-10-INBS-0009,France-Génomique,Organisation et montée en puissance d'une Infrastructure Nationale de Génomique(2010)

Subjects
Pharmacology, Cellular and Molecular Neuroscience, [SDV]Life Sciences [q-bio], Autoimmune regulator, Molecular Medicine, Medullary thymic epithelial cells, Autoimmunity, Cell Biology, Foxp3+ regulatory T cells, Molecular Biology, Thymus
Abstract

International audience; Thymically-derived Foxp3+ regulatory T cells (Treg) critically control immunological tolerance. These cells are generated in the medulla through high affinity interactions with medullary thymic epithelial cells (mTEC) expressing the Autoimmune regulator (Aire). Recent advances have revealed that thymic Treg contain not only developing but also recirculating cells from the periphery. Although Aire is implicated in the generation of Foxp3+ Treg, its role in the biology of recirculating Treg remains elusive. Here, we show that Aire regulates the suppressive signature of recirculating Treg independently of the remodeling of the medullary 3D organization throughout life where Treg reside. Accordingly, the adoptive transfer of peripheral Foxp3+ Treg in AireKO recipients led to an impaired suppressive signature upon their entry into the thymus. Furthermore, recirculating Treg from AireKO mice failed to attenuate the severity of multiorgan autoimmunity, demonstrating that their suppressive function is altered. Using bone marrow chimeras, we reveal that mTEC-specific expression of Aire controls the suppressive signature of recirculating Treg. Finally, mature mTEC lacking Aire were inefficient in stimulating peripheral Treg both in polyclonal and antigen-specific co-culture assays. Overall, this study demonstrates that Aire confers to mTEC the ability to restimulate recirculating Treg, unravelling a novel function for this master regulator in Treg biology.

Published
2022

2. Thymocytes trigger self-antigen-controlling pathways in immature medullary thymic epithelial stages

Author

Noella Lopes, Nicolas Boucherit, Jérémy C Santamaria, Nathan Provin, Jonathan Charaix, Pierre Ferrier, Matthieu Giraud, Magali Irla, Centre d'Immunologie de Marseille - Luminy (CIML), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Centre de Recherche en Transplantation et Immunologie - Center for Research in Transplantation and Translational Immunology (U1064 Inserm - CR2TI), Institut National de la Santé et de la Recherche Médicale (INSERM)-Nantes Université - UFR de Médecine et des Techniques Médicales (Nantes Univ - UFR MEDECINE), Nantes Université - pôle Santé, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ)-Nantes Université - pôle Santé, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ), ANR-19-CE18-0021,RANKLthym,Évaluer le potentiel de RANK ligand pour rétablir des fonctions thymiques efficaces après greffe de moelle osseuse et vieillissement(2019), and DUMENIL, Anita

Subjects
CD4-Positive T-Lymphocytes, Male, [SDV]Life Sciences [q-bio], T cells, Mice, Transgenic, Nerve Tissue Proteins, Thymus Gland, Autoantigens, Epithelium, General Biochemistry, Genetics and Molecular Biology, Histones, immunology, Mice, thymus, Animals, mouse, Mice, Knockout, medullary thymic epithelial cells, Thymocytes, tolerance, General Immunology and Microbiology, Gene Expression Profiling, General Neuroscience, Epithelial Cells, cellular crosstalk, General Medicine, DNA-Binding Proteins, Mice, Inbred C57BL, [SDV] Life Sciences [q-bio], Gene Expression Regulation, inflammation, Female, Signal Transduction
Abstract

Interactions of developing T cells with Aire+ medullary thymic epithelial cells expressing high levels of MHCII molecules (mTEChi) are critical for the induction of central tolerance in the thymus. In turn, thymocytes regulate the cellularity of Aire+ mTEChi. However, it remains unknown whether thymocytes control the precursors of Aire+ mTEChi that are contained in mTEClo cells or other mTEClo subsets that have recently been delineated by single-cell transcriptomic analyses. Here, using three distinct transgenic mouse models, in which antigen presentation between mTECs and CD4+ thymocytes is perturbed, we show by high-throughput RNA-seq that self-reactive CD4+ thymocytes induce key transcriptional regulators in mTEClo and control the composition of mTEClo subsets, including Aire+ mTEChi precursors, post-Aire and tuft-like mTECs. Furthermore, these interactions upregulate the expression of tissue-restricted self-antigens, cytokines, chemokines, and adhesion molecules important for T-cell development. This gene activation program induced in mTEClo is combined with a global increase of the active H3K4me3 histone mark. Finally, we demonstrate that these self-reactive interactions between CD4+ thymocytes and mTECs critically prevent multiorgan autoimmunity. Our genome-wide study thus reveals that self-reactive CD4+ thymocytes control multiple unsuspected facets from immature stages of mTECs, which determines their heterogeneity.

Published
2022

3. Impact of shell structure on the fusion of neutron-rich mid-mass nuclei

Author

H. O. Soler, Kyle Brown, Varinderjit Singh, M. Sorensen, Rekam Giri, Romualdo deSouza, Andy Hannaman, C. Santamaria, J. Lubian, Zachary Tobin, J. Vadas, James Johnstone, Alan McIntosh, A. Abbott, B. V. Carlson, A. Chbihi, Dieter Ackermann, Catherine Balhoff, Sherry Yennello, Sylvie Hudan, Michael Famiano, Quentin Hourdille, Aditya Wakhle, Grand Accélérateur National d'Ions Lourds (GANIL), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Université de Caen Normandie (UNICAEN), Normandie Université (NU), and Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)

Subjects
Physics, Fusion, [PHYS.NUCL]Physics [physics]/Nuclear Theory [nucl-th], 010308 nuclear & particles physics, Projectile, Nuclear Theory, Oxygen target, Shell (structure), 01 natural sciences, Ion, Cross section (physics), 0103 physical sciences, Neutron, Atomic physics, 010306 general physics, Nuclear Experiment, Excitation
Abstract

International audience; The influence of shell effects on fusion of mid-mass nuclei is explored using isotopic chains of K and Ar ions on an oxygen target. Comparison of the reduced excitation functions reveals that the fusion cross section for the open neutron-shell projectile nuclei K41 and K45 is systematically larger than for the closed neutron-shell projectiles K39 and K47. The São Paulo fusion model using matter densities from systematics fails to describe the measured excitation functions. Use of more realistic densities from a Dirac-Hartree-Bogoliubov (DHB) approach performs significantly better though it still overpredicts the closed-shell nuclei.

Published
2021

4. Robust intrathymic development of regulatory T cells in young NOD mice is rapidly restrained by recirculating cells

Author

Ariel Galindo‐Albarrán, Olivier Joffre, Joost P. M. van Meerwijk, Ellen A. Robey, Paola Romagnoli, Jeremy C. Santamaria, Julie Darrigues, Centre de Physiopathologie Toulouse Purpan (CPTP), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Station d'écologie théorique et expérimentale (SETE), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Observatoire Midi-Pyrénées (OMP), Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD), University of California [Berkeley], and University of California

Subjects
0301 basic medicine, Male, thymic niche, Immunology, Population, Regulatory T-Lymphocytes, chemical and pharmacologic phenomena, Thymus Gland, Biology, T-Lymphocytes, Regulatory, regulatory T cells, 03 medical and health sciences, Mice, 0302 clinical medicine, Mice, Inbred NOD, thymus, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, Immune Tolerance, inbred mouse strains, Immunology and Allergy, Animals, education, NOD mice, education.field_of_study, tolerance, hemic and immune systems, 030104 developmental biology, Diabetes Mellitus, Type 1, 030215 immunology
Abstract

International audience; Regulatory T lymphocytes (Treg) play a vital role in the protection of the organism against autoimmune pathology. It is therefore paradoxical that comparatively large numbers of Treg were found in the thymus of type I diabetes-prone NOD mice. The Treg population in the thymus is composed of newly developing cells and cells that had recirculated from the periphery back to the thymus. We here demonstrate that exceptionally large numbers of Treg develop in the thymus of young, but not adult, NOD mice. Once emigrated from the thymus, an unusually large proportion of these Treg is activated in the periphery, which causes a particularly abundant accumulation of recirculating Treg in the thymus. These cells then rapidly inhibit de novo development of Treg. The proportions of developing Treg thus reach levels similar to or lower than those found in most other, type 1 diabetes-resistant, inbred mouse strains. Thus, in adult NOD mice the particularly large Treg-niche is actually composed of mostly recirculating cells and only few newly developing Treg.

Published
2020

5. Spectroscopy of $^{16}$B from quasi-free ($p,pn$) reaction with $^{17}$B

Author

T. Kobayashi, Yosuke Kondo, J. Yasuda, Alessandra Corsi, D. Calvet, T. Isobe, Y. Kanaya, H. Sato, K. Hasegawa, Atsumi Saito, C. Santamaria, Tsuyoshi Miyazaki, Toshiyuki Sumikama, Satoshi Sakaguchi, Y. Shindo, T. Ozaki, M. Shikata, G. Authelet, J. M. Gheller, J. Tsubota, M. Tabata, S. Kawakami, Noritsugu Nakatsuka, D. Kim, T. Motobayashi, Motoki Kobayashi, Shoko Koyama, K. Yoneda, Z. Korkulu, H. Baba, Y. Nishio, T. Uesaka, A. Ohkura, Juzo Zenihiro, V. Lapoux, Masaki Sasano, J.-Y. Roussé, Y. Kiyokawa, A. Giganon, Yasuhiro Togano, A. Gillibert, Yuya Kubota, A. Obertelli, S. Reichert, Takashi Nakamura, Ji Feng, N. A. Orr, Y. L. Sun, S. Ota, J. Gibelin, C. Caesar, M. Sako, V. Panin, Yohei Shimizu, Zaihong Yang, L. Stuhl, F. M. Marqués, Yukie Maeda, Nagao Kobayashi, Stefanos Paschalis, F. Flavigny, A. Delbart, Masanori Dozono, E. C. Pollacco, Hideaki Otsu, Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Institut de Physique Nucléaire d'Orsay (IPNO), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11), Laboratoire de physique corpusculaire de Caen (LPCC), Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-École Nationale Supérieure d'Ingénieurs de Caen (ENSICAEN), Normandie Université (NU)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), École Nationale Supérieure d'Ingénieurs de Caen (ENSICAEN), Normandie Université (NU), Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), and Normandie Université (NU)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)

Subjects
Physics, Paper, History, 010308 nuclear & particles physics, [PHYS.NEXP]Physics [physics]/Nuclear Experiment [nucl-ex], 01 natural sciences, Molecular physics, 3. Good health, Computer Science Applications, Education, ddc, TheoryofComputation_ANALYSISOFALGORITHMSANDPROBLEMCOMPLEXITY, 0103 physical sciences, Halo, 010306 general physics, Spectroscopy
Abstract

Spectroscopy of 16B plays an essential role in understanding the halo structure in 17B, but very limited knowledge has so far been obtained. We have carried out a kinematically complete measurement on the spectroscopy of 16B by using quasi-free (p,pn) reaction on 17B. The level scheme of 16B up to 5 MeV was made clear for the first time.

Published
2020

6. $^{78}$Ni revealed as a doubly magic stronghold against nuclear deformation

Author

Frédéric Nowacki, L. Olivier, K. Yoneda, Tsuyoshi Miyazaki, H. Wang, I. Stefan, J. Simonis, Zhengyu Xu, C. Santamaria, Javier Fernandez Menendez, Ertan Şahin, D. Calvet, Kazuyuki Ogata, R. Lozeva, C. Louchart, Takaharu Otsuka, Satoshi Takeuchi, Alexandre Obertelli, Yusuke Tsunoda, J.-Y. Roussé, Tadaaki Isobe, F. Giacoppo, F. Château, A. Gottardo, E. C. Pollacco, Jenny Lee, T. Sumikama, K. Matsui, Zs. Vajta, David Steppenbeck, Sophie Péru, S. Nishimura, Zena Patel, Frank Browne, C. M. Shand, Tohru Motobayashi, Shinsuke Ota, S. Momiyama, Hiroyoshi Sakurai, K. Hadynska-Klek, H. Otsu, Alfredo Poves, A. Gillibert, Daisuke Suzuki, Hidetada Baba, A. Delbart, S. Franchoo, Yuki Kubota, V. Lapoux, V. Werner, Pär-Anders Söderström, M. Matsushita, Shunpei Koyama, M. Lettmann, Jason D. Holt, Z. Korkulu, A. Corsi, Alan Peyaud, Achim Schwenk, Yoshiaki Shiga, R. Taniuchi, Jin Wu, L. X. Chung, S. R. Stroberg, M. Niikura, Tomohiro Uesaka, Zs. Dombrádi, Pieter Doornenbal, C. Péron, G. Authelet, J. M. Gheller, Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Institut Pluridisciplinaire Hubert Curien (IPHC), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), Direction des Applications Militaires (DAM), Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Institut de Physique Nucléaire d'Orsay (IPNO), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11), Centre de Sciences Nucléaires et de Sciences de la Matière (CSNSM), Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), and Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)

Subjects
Proton, Nuclear Theory, media_common.quotation_subject, Astrophysics::High Energy Astrophysical Phenomena, Strong interaction, FOS: Physical sciences, 01 natural sciences, Asymmetry, Nuclear Theory (nucl-th), Magic number (programming), 0103 physical sciences, Effective field theory, Physics::Atomic and Molecular Clusters, Neutron, Nuclear Experiment (nucl-ex), 010306 general physics, Nuclear Experiment, media_common, Physics, [PHYS]Physics [physics], Multidisciplinary, 010308 nuclear & particles physics, Magic (programming), Atomic nucleus, Atomic physics
Abstract

Nuclear magic numbers, which emerge from the strong nuclear force based on quantum chromodynamics, correspond to fully occupied energy shells of protons, or neutrons inside atomic nuclei. Doubly magic nuclei, with magic numbers for both protons and neutrons, are spherical and extremely rare across the nuclear landscape. While the sequence of magic numbers is well established for stable nuclei, evidence reveals modifications for nuclei with a large proton-to-neutron asymmetry. Here, we provide the first spectroscopic study of the doubly magic nucleus $^{78}$Ni, fourteen neutrons beyond the last stable nickel isotope. We provide direct evidence for its doubly magic nature, which is also predicted by ab initio calculations based on chiral effective field theory interactions and the quasi-particle random-phase approximation. However, our results also provide the first indication of the breakdown of the neutron magic number 50 and proton magic number 28 beyond this stronghold, caused by a competing deformed structure. State-of-the-art phenomenological shell-model calculations reproduce this shape coexistence, predicting further a rapid transition from spherical to deformed ground states with $^{78}$Ni as turning point.

Published
2019

7. Spectroscopic Study in Neutron-Rich Mn Isotopes Around the $N=40$ 'Island of Inversion'

Author

X. D. Tang, C. Péron, G. Authelet, Y. H. Lam, Shunji Nishimura, J. M. Gheller, V. Lapoux, Megumi Niikura, Tomohiro Uesaka, Masaki Sasano, D. Calvet, De-fu Hou, A. Gillibert, K. Matsui, G. L. Stefan, C. M. Shand, F. Browne, H. Baba, Toshiyuki Sumikama, P. M. Walker, M. Lettmann, Feng-Shou Zhang, F. Giacoppo, K. Yoneda, C. Santamaria, Zs. Vajta, David Steppenbeck, L. Olivier, E. C. Pollacco, C. Louchart, Jinguang Wu, Hideaki Otsu, S. M. Lenzi, Yoshiaki Shiga, Bing Ding, M. D. Sun, T. Miyazaki, Satoru Momiyama, A. Obertelli, Shuichi Ota, T. H. Huang, F. Nowacki, Hiroyoshi Sakurai, B. D. Linh, T. Motobayashi, Jenny Lee, P. A. Söderström, H. Lu, R. Lozeva, X.Y. Liu, Zena Patel, K. Hadynska-Klek, E. Sahin, Zhenci Xu, Z. Korkulu, Zs. Dombradi, Yuya Kubota, X. H. Zhou, T. Isobe, P. Doornenbal, Zi Hong Liu, V. Werner, F. Château, Satoshi Takeuchi, W.Q. Zhang, S. Franchoo, H. Wang, Y. H. Zhang, J.-Y. Roussé, L. X. Chung, H. S. Xu, Daisuke Suzuki, Alan Peyaud, A. Corsi, A. Delbart, Ryo Taniuchi, Shoko Koyama, A. Gottardo, Masafumi Matsushita, Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Institut Pluridisciplinaire Hubert Curien (IPHC), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), Institut de Physique Nucléaire d'Orsay (IPNO), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11), Centre de Sciences Nucléaires et de Sciences de la Matière (CSNSM), Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), and Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)

Subjects
Materials science, 21.10.-k, Isotope, [PHYS.NUCL]Physics [physics]/Nuclear Theory [nucl-th], Island of inversion, structure evolution, Mineralogy, 23.20.Lv, [PHYS.NEXP]Physics [physics]/Nuclear Experiment [nucl-ex], island of inversion, Quansi-rotational band, 7. Clean energy, In-beam γ-ray spectroscopy, 21.60.Cs, Neutron, 21.10.Re
Abstract

International audience; Excited states in Mn isotopes with mass number A from 63 to 67 were studied via in-beam γ–ray spectroscopy following knockout reactions from 67,68Fe. In odd-A isotopes 63,65,67Mn, similar level schemes, consisting of the 11/2-, 9/2-, 7/2-, and 5/2-g.s. level sequence, connected by I →I -1 transitions, were established, the first time for 65,67Mn. Experimental results of odd-A Mn isotopes are compared with large-scale shell-model calculations in the model space that includes the vg9/2 and vd5/2 orbitals with the state-of-the-art LNPS effective interaction. The constructed level schemes in odd-odd isotopes 64,66Mn show rotational-like properties. Spin and parity of the excited states, as well as the πf7/2 ⊗ vg9/2 configuration of the bands are tentatively assigned based on the level systematics in the odd-odd isotopes. These new data extends the knowledge of the excited states in Mn isotopes. Discussion in terms of the systematics helps to deepen our understanding of the N = 40 “island of inversion”.

Published
2018

8. Structure of Beryllium Isotopes Beyond the Neutron Dripline

Author

V. Panin, Tsuyoshi Miyazaki, K. Yoneda, T. Isobe, S. Reichert, T. Uesaka, K. Hasegawa, Y. Shindo, Nagao Kobayashi, Stefanos Paschalis, F. Flavigny, J. Gibelin, C. Caesar, T. Ozaki, D. Kim, J.-Y. Roussé, Yuya Kubota, Yasuhiro Togano, F. M. Marqués, Yohei Shimizu, Takashi Nakamura, Zaihong Yang, Ji Feng, M. Sako, G. Authelet, J. M. Gheller, T. Kobayashi, E. C. Pollacco, Hideaki Otsu, Masanori Dozono, Yukie Maeda, Atsumi Saito, V. Lapoux, L. Stuhl, D. Calvet, M. Shikata, Toshiyuki Sumikama, Satoshi Sakaguchi, Noritsugu Nakatsuka, Juzo Zenihiro, A. Corsi, A. Delbart, Masaki Sasano, A. Ohkura, J. Yasuda, Motoki Kobayashi, Shoko Koyama, Z. Korkulu, Y. Kanaya, H. Sato, Yosuke Kondo, A. Gillibert, Y. Kiyokawa, A. Obertelli, Y. Nishio, A. Giganon, M. Tabata, T. Motobayashi, S. Kawakami, H. Baba, B. Monteagudo, J. Tsubota, C. Santamaria, N. A. Orr, S. Ota, Laboratoire de physique corpusculaire de Caen (LPCC), Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-École Nationale Supérieure d'Ingénieurs de Caen (ENSICAEN), Normandie Université (NU)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Institut de Physique Nucléaire d'Orsay (IPNO), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11), Normandie Université (NU)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), and Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)

Subjects
Physics, [PHYS.NUCL]Physics [physics]/Nuclear Theory [nucl-th], 010308 nuclear & particles physics, Astrophysics::High Energy Astrophysical Phenomena, Nuclear Theory, Nuclear structure, Structure (category theory), 01 natural sciences, 7. Clean energy, Nuclear physics, medicine.anatomical_structure, 0103 physical sciences, medicine, Spontaneous emission, Neutron, 010306 general physics, Isotopes of beryllium, Nuclear Experiment, Nucleus, Beam (structure)
Abstract

International audience; Dineutron decay is a forefront topic in nuclear structure that still lacks a firm experimental claim. The spontaneous emission of a dineutron should be favored in nuclei that are unbound with respect to two-neutron emission but bound with respect to single-neutron emission. A very interesting candidate can be found by adding two neutrons to the most neutron-rich Beryllium isotope,$^{14}$Be, a well-known 2n-halo nucleus. The intriguing nature of the phenomenon has motivated recent theoretical calculations and a new experimental campaign at RIKEN RIBF. In this work, the decay properties of$^{16}$Be and the structure of$^{15}$Be have been probed via the proton-knockout reaction from a$^{17}$B beam.

Published
2018

9. Tracking with the MINOS Time Projection Chamber

Author

Masaki Sasano, A. Giganon, C. S. Lee, D. Calvet, C. Santamaria, A. Gillibert, T. Motobayashi, Yuya Kubota, E. Takada, H. N. Liu, F. Château, E. C. Pollacco, Yosuke Kondo, P. Doornenbal, Hideaki Otsu, V. Lapoux, A. Obertelli, M. Kurata-Nishimura, D. Leboeuf, L. Audirac, Juzo Zenihiro, Hidetada Baba, Masafumi Matsushita, G. Prono, Shuichi Ota, Alan Peyaud, A. Corsi, C. Lahonde-Hamdoun, Megumi Niikura, Tomohiro Uesaka, A. Delbart, Hiroshi Tokieda, Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), and Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay

Subjects
Nuclear and High Energy Physics, Vertex (computer graphics), Physics::Instrumentation and Detectors, vertex detector, Tracking software, Tracking (particle physics), 7. Clean energy, 01 natural sciences, programming, Nuclear physics, benchmark, 0103 physical sciences, [PHYS.PHYS.PHYS-INS-DET]Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det], 010306 general physics, Spectroscopy, numerical calculations, Instrumentation, spatial resolution, Physics, MINOS, Time projection chamber, 010308 nuclear & particles physics, Scattering, track data analysis, time projection chamber, Full width at half maximum, Hough transform, efficiency, Spectroscopy of exotic nuclei, Physics::Accelerator Physics, Nucleon, performance
Abstract

We report on the performance of the MINOS Time Projection Chamber developed as a vertex tracker to study exotic nuclei produced from hydrogen-induced knockout via in-beam γ -ray and invariant-mass spectroscopy . In-beam measurements with 4 He and 20Ne beams at 200 and 350 MeV/nucleon, respectively, were performed at the HIMAC facility. The tracking algorithm for protons after quasi-free scattering is described. Realistic simulations and physics experiments are compared and show a good agreement. The vertex position resolution reaches 5 mm FWHM, mostly from re-scattering with the target and the Aluminum reaction chamber. The overall efficiency of vertex reconstruction is also benchmarked with the first experimental campaign data performed at the RIBF, confirming an overall efficiency better than 90% for physics experiments.

Published
2018

10. Inelastic scattering of neutron-rich Ni and Zn isotopes off a proton target

Author

R. Lozeva, M. Lettmann, J.-Y. Roussé, Tadaaki Isobe, Pieter Doornenbal, F. Nowacki, Zena Patel, Satoshi Takeuchi, H. Otsu, K. Matsui, M. L. Cortés, K. Yoneda, C. Santamaria, S. Franchoo, Tohru Motobayashi, Hidetada Baba, E. Sahin, Hiroyoshi Sakurai, Shuichi Ota, C. Péron, S. Nishimura, G. Authelet, F. Giacoppo, Shunpei Koyama, E. C. Pollacco, Alan Peyaud, Jin Wu, L. X. Chung, H. Wang, F. Château, F. Browne, Ryo Taniuchi, J. M. Gheller, Marc Dupuis, T. Sumikama, V. Lapoux, D. Calvet, Zs. Vajta, David Steppenbeck, A. Gillibert, A. Obertelli, Daisuke Suzuki, A. Gottardo, P. A. Söderström, Jenny Lee, S. M. Lenzi, Yoshiaki Shiga, A. Corsi, Kathrin Wimmer, K. Hadynska-Klek, Yuya Kubota, Megumi Niikura, Sophie Péru, Tomohiro Uesaka, I. Stefan, Zs. Dombrádi, C. M. Shand, Norbert Pietralla, A. Delbart, V. Werner, Z. Korkulu, Zhengyu Xu, T. Miyazaki, M. Matsushita, L. Olivier, C. Louchart, Masaki Sasano, Satoru Momiyama, Direction des Applications Militaires (DAM), Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Institut Pluridisciplinaire Hubert Curien (IPHC), Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Institut de Physique Nucléaire d'Orsay (IPNO), Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Centre de Sciences Nucléaires et de Sciences de la Matière (CSNSM), Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), and Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11)

Subjects
Physics, Nuclear and High Energy Physics, Proton, 010308 nuclear & particles physics, Scattering, Hadron, Nuclear Theory, Inelastic scattering, [PHYS.NEXP]Physics [physics]/Nuclear Experiment [nucl-ex], 01 natural sciences, 7. Clean energy, Nuclear physics, 0103 physical sciences, Isotopes of zinc, Gamma spectroscopy, Neutron, 010306 general physics, Nucleon, Nuclear Experiment
Abstract

International audience; Proton inelastic scattering of Ni72,74 and Zn76,80 ions at energies around 235 MeV/nucleon was performed at the Radioactive Isotope Beam Factory and studied using γ-ray spectroscopy. Angular integrated cross sections for direct inelastic scattering to the 21+ and 41+ states were measured. The Jeukenne-Lejeune-Mahaux folding model, extended beyond 200 MeV, was used together with neutron and proton densities stemming from quasiparticle random-phase approximation (QRPA) calculations to interpret the experimental cross sections and to infer neutron to proton matrix element ratios. In addition, coupled-channels calculations with a phenomenological potential were used to determine deformation lengths. For the Ni isotopes, correlations favor neutron excitations, thus conserving the Z=28 gap. A dominance of proton excitation, on the other hand, is observed in the Zn isotopes, pointing to the conservation of the N=50 gap approaching Ni78. These results are in agreement with QRPA and large-scale shell-model calculations.

Published
2018

11. Application of the Generic Electronics for Time Projection Chamber (GET) readout system for heavy Radioactive isotope collision experiments

Author

S. Tangwancharoen, Hiroyoshi Sakurai, G. Cerizza, J.W. Lee, T. Murakami, C. Santamaria, Daisuke Suzuki, Noritsugu Nakatsuka, M. B. Tsang, M. Kaneko, E. C. Pollacco, J. Barney, M. Kurata-Nishimura, G. Jhang, J. Estee, W. G. Lynch, T. Isobe, Hidetada Baba, P. Baron, W. Powell, Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), and Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay

Subjects
Nuclear and High Energy Physics, Physics::Instrumentation and Detectors, Radioactive isotope, 01 natural sciences, 7. Clean energy, Optics, Pion, Data acquisition, Sampling (signal processing), 0103 physical sciences, Electronics, [PHYS.PHYS.PHYS-INS-DET]Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det], 010306 general physics, Nuclear Experiment, Instrumentation, Physics, Time projection chamber, Heavy ion collision, 010308 nuclear & particles physics, business.industry, Dynamic range, Readout electronics, Beamline, business, Beam (structure)
Abstract

We have implemented the Generic Electronics for Time Projection Chamber (GET) in a SAMURAI Pion Reconstruction and Ion-Tracker (S π RIT) readout system for heavy radioactive ion collision experiments at RIKEN-RIBF. The S π RIT experiment is designed for heavy ion collision experiments with radioactive ion beams, where a Time Projection Chamber (TPC) with 12096 pixelized readout pads is employed as the main device. Since the TPC is located on the beam line, the readout electronics must handle small signals from pions as well as very large signals from beam or large fragment particles. Operation of the GET electronics during experiment functioned well using 270 time-bucket readout with 25 MHz sampling at an event Data acquisition (DAQ) rate of 60 Hz. Using the slope information of acquired signals it is possible to extend the dynamic range of dE/dx information compared to using the peak height information. However, huge signals arising from energetic δ -rays produced by un-interacted projectiles induce dead channels, which can be recovered after 70 μ s on average.

Published
2018

12. Signatures of triaxiality in low-spin spectra of $^{86}$Ge

Author

I. Stefan, Alessandra Corsi, C. M. Shand, L. Olivier, M. Dewald, Satoru Momiyama, Megumi Niikura, Norbert Pietralla, Tomohiro Uesaka, A. Gillibert, Jian Liu, R. J. Caroll, Bing Ding, Victor Vaquero, A. Gottardo, S. Nagamine, F. Browne, Tomás R. Rodríguez, A. Delbart, D. Calvet, Zs. Podolyák, Ryo Taniuchi, A. Blazhev, C. R. Nobs, T. Arici, T. Saito, C. Lizarazo, G. Authelet, Zena Patel, M. L. Cortés, J.-Y. Roussé, C. R. Nita, Zhenci Xu, J. M. Gheller, David Steppenbeck, A. Jungclaus, M. Lettmann, A. Giganon, A. Obertelli, F. Château, Pieter Doornenbal, Alison Bruce, Kamila Sieja, Toshiaki Ando, M. Górska, Si-Ge Chen, N. Paul, Noritsugu Nakatsuka, M. Rudigier, P. A. Söderström, Zi Hong Liu, V. Werner, C. Santamaria, L. X. Chung, Hiroyoshi Sakurai, T. Motobayashi, K. Moschner, Hidetada Baba, Kathrin Wimmer, B. D. Linh, Jenny Lee, V. Lapoux, S. Franchoo, F. Flavigny, Département de Physique Nucléaire (ex SPhN) (DPHN), Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Institut Pluridisciplinaire Hubert Curien (IPHC), Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), Institut de Physique Nucléaire d'Orsay (IPNO), Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Federal Ministry of Education and Research (Germany), SCOAP, European Commission, Ministerio de Economía y Competitividad (España), Vietnam Academy of Science and Technology, Science and Technology Facilities Council (UK), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11), Département de Physique Nucléaire (ex SPhN) ( DPHN ), Institut de Recherches sur les lois Fondamentales de l'Univers ( IRFU ), Commissariat à l'énergie atomique et aux énergies alternatives ( CEA ) -Université Paris-Saclay-Commissariat à l'énergie atomique et aux énergies alternatives ( CEA ) -Université Paris-Saclay, Institut Pluridisciplinaire Hubert Curien ( IPHC ), Centre National de la Recherche Scientifique ( CNRS ) -Université de Strasbourg ( UNISTRA ), Institut de Physique Nucléaire d'Orsay ( IPNO ), Université Paris-Sud - Paris 11 ( UP11 ) -Institut National de Physique Nucléaire et de Physique des Particules du CNRS ( IN2P3 ) -Centre National de la Recherche Scientifique ( CNRS ), and Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)

Subjects
Physics, History, Time projection chamber, Spectrometer, 010308 nuclear & particles physics, Fission, State (functional analysis), [PHYS.NEXP]Physics [physics]/Nuclear Experiment [nucl-ex], 01 natural sciences, Spectral line, Computer Science Applications, Education, Nuclear physics, MINOS, 0103 physical sciences, [ PHYS.NEXP ] Physics [physics]/Nuclear Experiment [nucl-ex], 010306 general physics, Spectroscopy, Spin (physics)
Abstract

7 pags., 4 figs. -- XXII International School on Nuclear Physics, Neutron Physics and Applications. -- Open Access funded by Creative Commons Atribution Licence 3.0, Low-spin states of neutron-rich Ge-84,Ge-86,Ge-88 were measured by in-flight gamma-ray spectroscopy at 270 MeV/u at the RIKEN-RIBF facility. The exotic beams have been produced by primary U-238 in-flight fission reactions and impinged on the MINOS device. MINOS combines a 10-cm long LH2 target with a Time Projection Chamber (TPC) to reconstruct the reaction vertices. The reactions were selected by the BigRIPS and the ZeroDegree spectrometers for the incoming and outgoing channels, respectively. Emitted gamma radiation was detected by the NaI-array DALI2. De-excitations from the 6(1)(+), 4(1,2)(+), and 2(1,2)(+) states of Ge-84,Ge- 86 and 4(1)(+) and 26 states of Ge-88 were observed. The data are compared to state-of-the-art shell model and beyond-mean-field calculations. Furthermore, a candidate for a 3(1)(+) state of Ge-86 was identified. This state plays a key role in the discussion of ground-state triaxiality of Ge-86, along with other features of the low-energy level scheme., We acknowledge support from the German BMBF Grant Nos. 05P12RDFN1, 05P12RDFN8 and 05P15PKFNA, the ERC Grant No. MINOS258567, the Spanish Ministerio de Economıa y Competitividad under contracts FPA2014-57196-C5-4-P and FIS−2014−53434, the Vietnam Ministry of Science and Technology, as well as from the Science and Technology Facilities Council (STFC). We further thank GSI for providing computing facilities

Published
2017

13. Inelastic scattering of $^{72,74}Ni$ off a proton target

Author

J.-Y. Roussé, Tadaaki Isobe, David Steppenbeck, R. Lozeva, T. Sumikama, Masaki Sasano, Zs. Dombradi, A. Gillibert, Satoshi Takeuchi, Zhengyu Xu, K. Hadynska-Klek, S. Franchoo, E. C. Pollacco, F. Château, E. Sahin, T. Miyazaki, Satoru Momiyama, Jenny Lee, Zena Patel, C. Santamaria, Hidetada Baba, Daisuke Suzuki, D. Calvet, C. Péron, Z. Korkulu, Yuya Kubota, G. Authelet, Alessandra Corsi, H. Wang, C. M. Shand, J. M. Gheller, M. Matsushita, Pieter Doornenbal, S. Nishimura, M. Lettmann, A. Gottardo, F. Giacoppo, K. Matsui, V. Werner, K. Yoneda, Zs. Vajta, P. A. Söderström, C. Louchart, Shuichi Ota, A. Delbart, R. Taniuchi, M. L. Cortés, Megumi Niikura, Tomohiro Uesaka, F. Browne, Jin Wu, L. X. Chung, L. Olivier, Hideaki Otsu, I. Stefan, Tohru Motobayashi, V. Lapoux, A. Obertelli, Yoshiaki Shiga, Hiroyoshi Sakurai, Shoko Koyama, Norbert Pietralla, Alan Peyaud, Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Institut de Physique Nucléaire d'Orsay (IPNO), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11), Institut Pluridisciplinaire Hubert Curien (IPHC), Université de Strasbourg (UNISTRA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA), Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), and Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)

Subjects
History, Proton, Spectrometer, Isotope, 010308 nuclear & particles physics, Fission, Gamma ray, chemistry.chemical_element, Inelastic scattering, [PHYS.NEXP]Physics [physics]/Nuclear Experiment [nucl-ex], 01 natural sciences, 7. Clean energy, Computer Science Applications, Education, Ion, Nuclear physics, chemistry, 0103 physical sciences, Beryllium, Atomic physics, 010306 general physics, Nuclear Experiment
Abstract

International audience; Inelastic scattering of (72,74)Ni off a proton target was performed at RIBF, RIKEN, Japan. The isotopes were produced by the fission of (238)U on a thick Beryllium target and were then selected and identified on an event-by-event basis using the BigRIPS separator. Selected isotopes were focused onto the liquid hydrogen target of the MINOS device and gamma rays from the reactions were measured with the DALI2 array. The energy of the ions in the middle of the target was 213 MeV/u. Outgoing particles were identified using the ZeroDegree spectrometer. Here, we report on the current status of the data analysis and preliminary results for the proton inelastic scattering cross sections for both isotopes.

Published
2015

14. MINOS: A vertex tracker coupled to a thick liquid-hydrogen target for in-beam spectroscopy of exotic nuclei

Author

Hidetada Baba, C. Péron, G. Authelet, C. Lahonde-Hamdoun, J. M. Gheller, L. Audirac, Tomohiro Uesaka, D. Leboeuf, D. Calvet, Alan Peyaud, A. Mohamed, B. Bruyneel, J.-Y. Roussé, A. Giganon, C. Santamaria, A. Corsi, Alexandre Obertelli, F. Château, D. Loiseau, A. Delbart, E. C. Pollacco, Hideaki Otsu, S. Anvar, P. Doornenbal, J. Ph. Mols, G. Prono, Département de Physique Nucléaire (ex SPhN) (DPHN), Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, RIKEN Nishina Center for Accelerator-Based Science [Wako] (RIKEN RNC), RIKEN - Institute of Physical and Chemical Research [Japon] (RIKEN), and Département d'Electronique, des Détecteurs et d'Informatique pour la Physique (ex SEDI) (DEDIP)

Subjects
Physics, Nuclear and High Energy Physics, Time projection chamber, Luminosity (scattering theory), 010308 nuclear & particles physics, Physics::Instrumentation and Detectors, [PHYS.NEXP]Physics [physics]/Nuclear Experiment [nucl-ex], 01 natural sciences, 7. Clean energy, Particle detector, Nuclear physics, MINOS, 0103 physical sciences, Nuclear fusion, Gamma spectroscopy, Atomic physics, 010306 general physics, Nucleon, Spectroscopy
Abstract

International audience; MINOS is a new apparatus dedicated to in-beam nuclear structure experiments with lowintensityexotic beams in inverse kinematics at intermediate energies above 150MeV/nucleon. The deviceis composed of a thick liquid-hydrogen target coupled to a compact time projection chamber (TPC) servingas a vertex tracker. Either used for in-beam gamma spectroscopy of bound excited states or invariant-massspectroscopy of unbound states, MINOS aims at improving the luminosity by a very significant factorcompared to standard solid-target material experiments while improving experimental resolutions.

Published
2014

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