Search

Your search keyword '"C Tilikete"' showing total 9 results
Start Over Author "C Tilikete" Publisher hal ccsd
9 results on '"C Tilikete"'

1. Outcomes of coronavirus disease 2019 in patients with neuromyelitis optica and associated disorders

Author

Nicolas Collongues, Damien Biotti, C. Papeix, Abir Wahab, Dalia Dimitri Boulos, Elisabeth Maillart, Julie Pique, Guillaume Mathey, Pierre Labauge, Mickael Zedet, Jérôme De Seze, Sinéad Zeidan, Céline Louapre, Romain Marignier, Ayman Tourbah, Zoé Lepine, L. Kremer, C. Tilikete, Pierre Branger, Centre de Référence des Maladies Inflammatoires Rares du Cerveau et de la Moelle (MIRCEM), Centre d'investigation clinique Neurosciences [CHU Pitié Salpêtrière] (CIC Neurosciences), CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Institut du Cerveau = Paris Brain Institute (ICM), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Pôle neurosciences [Hôpital de Purpan - Toulouse], CHU Toulouse [Toulouse], Service de neurologie [Mondor], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Henri Mondor-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Département de neurologie [Montpellier], Université Montpellier 1 (UM1)-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Hôpital Gui de Chauliac [Montpellier]-Université de Montpellier (UM), Université de Montpellier (UM), Centre de recherche en neurosciences de Lyon - Lyon Neuroscience Research Center (CRNL), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet [Saint-Étienne] (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Hospices Civils de Lyon (HCL), Hôpital neurologique et neurochirurgical Pierre Wertheimer [CHU - HCL], Hôpital Raymond Poincaré [AP-HP], Université de Versailles Saint-Quentin-en-Yvelines - UFR Sciences de la santé Simone Veil (UVSQ Santé), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Service de neurologie [CHRU Nancy], Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), Adaptation, mesure et évaluation en santé. Approches interdisciplinaires (APEMAC), Université de Lorraine (UL), Service de neurologie [Le Kremlin Bicêtre], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Bicêtre, Service de Neurologie [CHU Caen], Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-CHU Caen, Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Tumorothèque de Caen Basse-Normandie (TCBN), Service de Neurologie [Strasbourg], CHU Strasbourg-Hopital Civil, CIC Strasbourg (Centre d’Investigation Clinique Plurithématique (CIC - P) ), Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Nouvel Hôpital Civil de Strasbourg-Hôpital de Hautepierre [Strasbourg], Institut du Cerveau et de la Moëlle Epinière = Brain and Spine Institute (ICM), Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Centre de recherche en neurosciences de Lyon (CRNL), and Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Strasbourg (UNISTRA)-Hôpital de Hautepierre [Strasbourg]-Nouvel Hôpital Civil de Strasbourg

Subjects
Adult, Pediatrics, medicine.medical_specialty, immunosuppressant, NMOSD, Population, Clinical Neurology, Azathioprine, Disease, MOGAD, Young Adult, 03 medical and health sciences, 0302 clinical medicine, medicine, Humans, 030212 general & internal medicine, education, Retrospective Studies, Aquaporin 4, education.field_of_study, Neuromyelitis optica, SARS-CoV-2, business.industry, Neuromyelitis Optica, COVID-19, medicine.disease, Comorbidity, 3. Good health, Neurology, Cohort, Female, Rituximab, [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], Neurology (clinical), business, 030217 neurology & neurosurgery, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology, medicine.drug, Cohort study
Abstract

International audience; Background: Outcomes of coronavirus disease 2019 (COVID-19) in patients with neuromyelitis optica spectrum disorders (NMOSD) or myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD), often treated with immunosuppressive therapies, are still unknown.Methods: We conducted a multicenter, retrospective, observational cohort study among all French expert centers for neuromyelitis optica and related disorders. Patients with NMOSD or MOGAD included in the study received a confirmed or highly suspected diagnosis of COVID-19 between 1 March 2020 and 30 June 2020. Main outcome was COVID-19 severity score assessed on a seven-point ordinal scale ranging from 1 (not hospitalized with no limitations on activities) to 7 (death).Results: Fifteen cases (mean [SD] age: 39.3 [14.3] years, 11 female) were included. Five patients (33.3%) were hospitalized, all receiving rituximab. A 24-year-old patient with positive aquaporine-4 antibody, with obesity as comorbidity, needed mechanical ventilation. Outpatients were receiving anti-CD20 (5), mycophenolate mofetil (3) or azathioprine (3). They were younger (mean [SD] age: 37.0 [13.4] years), with a longer disease duration (mean [SD]: 8.3 [6.3] years) and had a lower expanded disability severity score (EDSS) score (median [range] EDSS: 2.5 [0-4]) relative to patients requiring hospitalization (mean [SD] age: 44.0 [16.4] years, mean [SD] disease duration: 5.8 [5.5] years, median [range] EDSS: 4 [0-6.5]).Conclusions: COVID-19 outcome was overall favorable in this cohort. Larger international studies are needed to identify risk factors of severe COVID-19; however, we recommend personal protective measures to reduce risk of SARS-CoV-2 infection in this immunocompromised population.

Published
2020
Full Text
View/download PDF

2. Silence ! On tourne (les vertiges en pratique)

Author

C. Tilikete, Hôpital neurologique et neurochirurgical Pierre Wertheimer [CHU - HCL], Hospices Civils de Lyon (HCL), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon, Integrative, Multisensory, Perception, Action and Cognition Team [Bron] (IMPACT), Centre de recherche en neurosciences de Lyon (CRNL), Université de Lyon-Université de Lyon-Université Jean Monnet [Saint-Étienne] (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), and Université de Lyon-Université de Lyon-Université Jean Monnet [Saint-Étienne] (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)

Subjects
03 medical and health sciences, 0302 clinical medicine, [SDV]Life Sciences [q-bio], 030212 general & internal medicine, Neurology (clinical), 030217 neurology & neurosurgery
Abstract

Resume Le vertige est un symptome tres frequent revelant le plus souvent une pathologie « benigne » comme une neuronite vestibulaire, une maladie de Meniere, une migraine vestibulaire, un vertige paroxystique positionnel benin ou un processus fonctionnel. Mais il peut reveler une pathologie neurologique grave, le plus souvent vasculaire. Outre la definition du vertige, l’entretien avec le patient permet de le classer dans un cadre nosologique assez precis en fonction de la duree, de la recurrence et du mode de declenchement : le vertige durable (> 24 h), les vertiges spontanes recurrents, les vertiges paroxystiques positionnels, les vertiges brefs et tres frequents, l’instabilite posturale. L’examen clinique est essentiel notamment la recherche et la description d’un nystagmus, les manœuvres du Head Impulse Test, du Head Shaking Test, de Dix et Hallpike et la recherche d’une skew deviation.

Published
2020
Full Text
View/download PDF

3. A Spatial Decision Eye-Tracking Task in Patients with Prodromal and Mild Alzheimer’s Disease

Author

Léa Declerck, Brice Laurens, Maité Formaglio, Mathieu Ceccaldi, Vincent Planche, Lejla Koric, C. Tilikete, Magali Seassau, Stéphanie Cubizolle, Sandrine Dupouy, Françcois Tison, Alain Vighetto, Université de Bordeaux (UB), Physiopathologie du système nerveux central - Institut François Magendie, Université Bordeaux Segalen - Bordeaux 2-IFR8-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut des Maladies Neurodégénératives [Bordeaux] (IMN), Université de Bordeaux (UB)-Centre National de la Recherche Scientifique (CNRS), Service de Neurologie [Lyon], CHU Lyon, Service de neurologie et de neuropsychologie, Université de la Méditerranée - Aix-Marseille 2-Assistance Publique - Hôpitaux de Marseille (APHM)- Hôpital de la Timone [CHU - APHM] (TIMONE), Imagerie MOléculaire pour applications THéranostiques personnalisées (IMOTHEP), Institut FRESNEL (FRESNEL), Aix Marseille Université (AMU)-École Centrale de Marseille (ECM)-Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU)-École Centrale de Marseille (ECM)-Centre National de la Recherche Scientifique (CNRS)- Hôpital de la Timone [CHU - APHM] (TIMONE), Institut du Cerveau et de la Moëlle Epinière = Brain and Spine Institute (ICM), Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [APHP]-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Unité de Neuro-Ophtalmologie [Bron], Hôpital neurologique et neurochirurgical Pierre Wertheimer [CHU - HCL], Hospices Civils de Lyon (HCL)-Hospices Civils de Lyon (HCL)-Hôpital Pierre Wertheimer - HCL [Bron], Hospices Civils de Lyon (HCL), Centre National de la Recherche Scientifique (CNRS)-École Centrale de Marseille (ECM)-Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS)-École Centrale de Marseille (ECM)-Aix Marseille Université (AMU)- Hôpital de la Timone [CHU - APHM] (TIMONE), Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Institut du Cerveau = Paris Brain Institute (ICM), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], and Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)

Subjects
0301 basic medicine, Male, medicine.medical_specialty, Eye Movements, Prodromal Symptoms, Disease, Audiology, behavioral disciplines and activities, 03 medical and health sciences, 0302 clinical medicine, Visual memory, Alzheimer Disease, medicine, Saccades, Humans, Clinical significance, Cognitive Dysfunction, Effects of sleep deprivation on cognitive performance, ComputingMilieux_MISCELLANEOUS, Aged, business.industry, General Neuroscience, Neuropsychology, Cognition, General Medicine, Anticipation, Psychiatry and Mental health, Clinical Psychology, 030104 developmental biology, Case-Control Studies, Disease Progression, Eye tracking, Female, Geriatrics and Gerontology, business, 030217 neurology & neurosurgery, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology, Spatial Navigation
Abstract

BACKGROUND/OBJECTIVE Performances on spatial decision eye-tracking tasks are known to be impaired in patients with moderate Alzheimer's disease (AD), but the clinical relevance of this deficit during earlier stages of AD remains unclear. METHODS This study recruited patients with amnestic mild cognitive impairment (aMCI, prodromal AD), patients with mild AD, and age-matched controls from three French memory clinics. Participants' ability to make spatial judgments and decisions was assessed with an eye-tracking system, and cognitive performance on conventional neuropsychological tests was evaluated. RESULTS We enrolled 26 controls, 25 aMCI patients (median Mini-Mental State Exam [MMSE] 26), and 23 mild-AD patients (median MMSE 23). Patients with mild AD had higher error rates on the spatial decision task than aMCI patients and controls (32.4% versus 23.5%; p

Published
2019
Full Text
View/download PDF

4. Effects of structural and functional cerebellar lesions on sensorimotor adaptation of saccades

Author

Romeo Salemme, Muriel Panouillères, Denis Pélisson, Nadia Alahyane, Bertrand Gaymard, Christian Urquizar, Norbert Nighoghossian, C. Tilikete, Centre de recherche en neurosciences de Lyon (CRNL), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet [Saint-Étienne] (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Université de Lyon, Vision Action Cognition (VAC (URP_7326)), Université de Paris (UP), Hospices Civils de Lyon (HCL), Service de Neurophysiologie [CHU Pitié-Salpêtrière], CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Vassard, Marine, Centre de recherche en neurosciences de Lyon - Lyon Neuroscience Research Center (CRNL), Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), and Université Paris Cité (UPCité)

Subjects
Male, Cerebellum, Neurology, c. tilikete, adaptation, Functional Laterality, 69000 lyon, 0302 clinical medicine, MESH: Adaptation, D. Pélisson University lyon 1, Panouillères, Neurologic Examination, Medulla Oblongata, General Neuroscience, 05 social sciences, Middle Aged, Adaptation, Physiological, MESH: Wallenberg, Stroke, medicine.anatomical_structure, Data Interpretation, Statistical, [SCCO.PSYC] Cognitive science/Psychology, Saccade, [SCCO.PSYC]Cognitive science/Psychology, MESH: Saccades, Female, medicine.symptom, Psychology, Adult, Wallenberg, medicine.medical_specialty, Impact team, c. Urquizar, Adaptation (eye), France M. Panouillères (*) INsERM U1028, 050105 experimental psychology, lyon Neuroscience Research center, Lesion, 03 medical and health sciences, Cerebellar Diseases, cNRs UMR5292, France M. Panouillères, N. Nighoghossian, medicine, Humans, Spinocerebellar Ataxias, 0501 psychology and cognitive sciences, Lateral Medullary Syndrome, Medulla, D. Pélisson INsERM U1028, R. salemme, [SCCO.NEUR]Cognitive science/Neuroscience, [SCCO.NEUR] Cognitive science/Neuroscience, Eye movement, saccades, Saccadic masking, MESH: Cerebellum, nervous system, lyon cerebellum, Neuroscience, Photic Stimulation, Psychomotor Performance, 030217 neurology & neurosurgery
Abstract

International audience; The cerebellum is critically involved in the adaptation mechanisms that maintain the accuracy of goaldirected acts such as saccadic eye movements. Two categories of saccades, each relying on different adaptation mechanisms, are defined: reactive (externally triggered) saccades and voluntary (internally triggered) saccades. The contribution of the medio-posterior part of the cerebellum to reactive saccades adaptation has been clearly demonstrated, but the evidence that other parts of the cerebellum are also involved is limited. Moreover, the cerebellar substrates ofvoluntary saccades adaptation have only been marginally investigated. Here, we addressed these two questions by investigating the adaptive capabilities of patients with cerebellar or pre-cerebellar stroke. We recruited three groups of patients presenting focal lesions located, respectively in the supero-anterior cerebellum, the infero-posterior cerebellum and the lateral medulla (leading to a Wallenberg syndrome including motor dysfunctions similar to those resulting from lesion of the medio-posterior cerebellum). Adaptations of reactive saccades and of voluntary saccades were tested during separate sessions in all patients and in a group of healthy participants. The functional lesion ofthe medio-posterior cerebellum in Wallenberg syndrome strongly impaired the adaptation of both reactive and voluntary saccades. In contrast, patients with lesion in the supero-anterior part of the cerebellum presented a specific adaptation deficit of voluntary saccades. Finally, patientswith an infero-posterior cerebellar lesion showed mild adaptation deficits. We conclude that the medio-posterior cerebellum is critical for the adaptation of both saccade categories, whereas the supero-anterior cerebellum is specifically involved in the adaptation of voluntary saccades.

Published
2013
Full Text
View/download PDF

5. Pedunculopontine nucleus stimulation induces monocular oscillopsia

Author

Peggy Gerardin, Muriel Ferraye, Bettina Debû, Pierre Pollak, Stephan Chabardes, Eric Seigneuret, Jean-Francois LeBas, Alim-Louis Benabid, Valérie Fraix, C. Tilikete, Grenoble Institut des Neurosciences (GIN), Université Joseph Fourier - Grenoble 1 (UJF)-Institut National de la Santé et de la Recherche Médicale (INSERM), Espace et action, Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Hospices Civils de Lyon (HCL)-Institut National de la Santé et de la Recherche Médicale (INSERM), Fondation de France Michael J Fox Foundation, and Savasta, Marc

Subjects
Eye Movements, genetic structures, [SDV.MHEP.CHI] Life Sciences [q-bio]/Human health and pathology/Surgery, MESH: Antiparkinson Agents, [SDV.MHEP.PSM] Life Sciences [q-bio]/Human health and pathology/Psychiatrics and mental health, Stimulation, Antiparkinson Agents, Levodopa, Pedunculopontine Tegmental Nucleus/*physiology, Vision, Monocular/*physiology, 0302 clinical medicine, Gait (human), MESH: Eye Movements, Mesencephalon, Pedunculopontine Tegmental Nucleus, Parkinson Disease/*complications/*drug therapy, Pedunculopontine nucleus, MESH: Aged, MESH: Levodopa, 0303 health sciences, Mesencephalon/*physiology, MESH: Electric Stimulation, Parkinson Disease, Electrodes, Implanted, Levodopa/*therapeutic use, Psychiatry and Mental health, [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], medicine.symptom, Psychology, [SDV.MHEP.CHI]Life Sciences [q-bio]/Human health and pathology/Surgery, MESH: Pedunculopontine Tegmental Nucleus, Midbrain, 03 medical and health sciences, Oscillopsia, Vision, Monocular, medicine, Oculomotor Nerve Diseases, Humans, MESH: Gait Disorders, Neurologic, [SDV.NEU] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], MESH: Oculomotor Nerve Diseases, Gait Disorders, Neurologic, 030304 developmental biology, Aged, Monocular, MESH: Humans, MESH: Vision, Monocular, Oculomotor Nerve Diseases/*etiology/*physiopathology, Eye movement, Eye Movements/*physiology, MESH: Mesencephalon, Electric Stimulation, Electric Stimulation/adverse effects, ddc:616.8, Gait Disorders, Neurologic/*drug therapy/*etiology, [SDV.MHEP.PSM]Life Sciences [q-bio]/Human health and pathology/Psychiatrics and mental health, Surgery, MESH: Electrodes, Implanted, Neurology (clinical), Neuroscience, Antiparkinson Agents/*therapeutic use, 030217 neurology & neurosurgery, MESH: Parkinson Disease
Abstract

International audience; Two patients with Parkinson's disease with pedunculopontine nucleus (PPN) stimulation for gait impairments reported "trembling vision" during the setting of the electrical parameters, although there was no clinically observable abnormal eye movement. Oculomotor recordings revealed frequency locked voltage dependent vertical or oblique movements of the eye ipsilateral to the active contact, suggesting current spreading to the mesencephalic oculomotor fibres. These results emphasise the difficulty of stimulating this mesencephalic region.

Published
2009
Full Text
View/download PDF

6. Retention of habituation of vestibulo-ocular reflex and sensation of rotation in humans

Author

C. Tilikete, J. H. Courjon, Gilles Clément, Centre de recherche cerveau et cognition (CERCO), Institut des sciences du cerveau de Toulouse. (ISCT), Université Toulouse - Jean Jaurès (UT2J)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-CHU Toulouse [Toulouse]-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Toulouse - Jean Jaurès (UT2J)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-CHU Toulouse [Toulouse]-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS), Espace et action, Université Claude Bernard Lyon 1 (UCBL), and Université de Lyon-Université de Lyon-Hospices Civils de Lyon (HCL)-Institut National de la Santé et de la Recherche Médicale (INSERM)

Subjects
Adult, Male, medicine.medical_specialty, Rotation, genetic structures, Nystagmus, Audiology, 050105 experimental psychology, Developmental psychology, 03 medical and health sciences, 0302 clinical medicine, Nystagmus, Physiologic, Recovery, Sensation, medicine, Humans, 0501 psychology and cognitive sciences, Gravity Sensing, Habituation, Habituation, Psychophysiologic, Balance (ability), Vestibular system, Vestibulo-ocular reflex, General Neuroscience, 05 social sciences, Caloric theory, Reflex, Vestibulo-Ocular, Middle Aged, Sensation of rotation, Reflex, Female, [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], Vestibule, Labyrinth, sense organs, Vestibulo–ocular reflex, medicine.symptom, Psychology, 030217 neurology & neurosurgery
Abstract

International audience; In humans, habituation of vestibulo-ocular reflex (VOR) by repeated caloric or rotational stimulation has been well documented. However, less attention has been directed to the effect of habituation on the sensation of self-rotation and little is known about the retention duration of vestibular habituation. To investigate these characteristics, subjects were exposed to ten sessions of angular velocity steps in yaw, with a chair rotating either alternatively in both CW and CCW directions (bidirectional protocol) or always in the same direction (unidirectional protocol), i.e., CW or CCW. The retention of habituation of VOR and sensation of rotation induced by both protocols was studied for a period up to 8 months following the end of the habituation protocols. There was a progressive decline in the VOR peak slow phase velocity and time constant throughout the sessions during both protocols. These parameters then followed an exponential recovery with a time constant of about 1 month. The duration of the sensation of rotation also habituated during repeated angular velocity steps, but it was shorter for both directions of stimulation, including after the unidirectional protocol. Sinusoidal VOR gain was not affected by vestibular habituation to velocity steps, but sinusoidal VOR phase showed an increase in phase lead at 0.02 and 0.04 Hz, which also returned to baseline values within about 1 month. We conclude that vestibular habituation is a long-lasting phenomenon. These results may be helpful for designing and scheduling the protocols for drug studies using crossover design, rehabilitation of balance disorder patients, and for the application of intermittent artificial gravity during space missions.

Published
2008
Full Text
View/download PDF

7. Subthalamic stimulation improves orienting gaze movements in Parkinson's disease

Author

Alain Vighetto, Alim-Louis Benabid, Denis Pélisson, Jean-Hubert Courjon, Paul Krack, Pierre Pollak, Paul Sauleau, C. Tilikete, Service de neurophysiologie, Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES), Neurosciences précliniques, Université Joseph Fourier - Grenoble 1 (UJF)-Institut National de la Santé et de la Recherche Médicale (INSERM), Espace et action, Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Hospices Civils de Lyon (HCL)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service de neuro-ophtalmologie, Hospices Civils de Lyon (HCL), Collaboration, Université de Rennes (UR), and Savasta, Marc

Subjects
Male, Parkinson's disease, genetic structures, MESH: Head Movements, Stimulation, MESH: Movement, 0302 clinical medicine, Fixation, Ocular, MESH: Aged, 0303 health sciences, MESH: Middle Aged, Electric Stimulation Therapy/*methods, Body movement, Parkinson Disease, Middle Aged, MESH: Case-Control Studies, Sensory Systems, Subthalamic nucleus, MESH: Photic Stimulation, Neurology, Head Movements, Female, Movement/physiology/*radiation effects, Psychology, Adult, medicine.medical_specialty, Subthalamus/*physiology/radiation effects, Movement, Parkinson Disease/*therapy, MESH: Orientation, MESH: Electric Stimulation Therapy, Electric Stimulation Therapy, MESH: Psychophysics, 03 medical and health sciences, Physical medicine and rehabilitation, Physiology (medical), Orientation, MESH: Analysis of Variance, medicine, Psychophysics, Humans, 030304 developmental biology, Aged, MESH: Fixation, Ocular, Analysis of Variance, MESH: Humans, Superior colliculus, Eye movement, MESH: Adult, medicine.disease, Gaze, MESH: Male, ddc:616.8, MESH: Subthalamus, Case-Control Studies, Subthalamus, Fixation (visual), Head Movements/physiology/radiation effects, Orientation/physiology/*radiation effects, Neurology (clinical), Neuroscience, MESH: Female, 030217 neurology & neurosurgery, Photic Stimulation, MESH: Parkinson Disease
Abstract

International audience; OBJECTIVE: To determine the effect of subthalamic stimulation on visually triggered eye and head movements in patients with Parkinson's disease (PD). METHODS: We compared the gain and latency of visually triggered eye and head movements in 12 patients bilaterally implanted into the subthalamic nucleus (STN) for severe PD and six age-matched control subjects. Visually triggered movements of eye (head restrained), and of eye and head (head unrestrained) were recorded in the absence of dopaminergic medication. Bilateral stimulation was turned OFF and then turned ON with voltage and contact used in chronic setting. The latency was determined from the beginning of initial horizontal eye movements relative to the target onset, and the gain was defined as the ratio of the amplitude of the initial movement to the amplitude of the target movement. RESULTS: Without stimulation, the initiation of the head movement was significantly delayed in patients and the gain of head movement was reduced. Our patients also presented significantly prolonged latencies and hypometry of visually triggered saccades in the head-fixed condition and of gaze in head-free condition. Bilateral STN stimulation with therapeutic parameters improved performance of orienting gaze, eye and head movements towards the controls' level CONCLUSIONS: These results demonstrate that visually triggered saccades and orienting eye-head movements are impaired in the advanced stage of PD. In addition, subthalamic stimulation enhances amplitude and shortens latency of these movements. SIGNIFICANCE: These results are likely explained by alteration of the information processed by the superior colliculus (SC), a pivotal visuomotor structure involved in both voluntary and reflexive saccades. Improvement of movements with stimulation of the STN may be related to its positive input either on the STN-Substantia Nigra-SC pathway or on the parietal cortex-SC pathway.

Published
2008
Full Text
View/download PDF

8. Contraversive eye deviation during stimulation of the subthalamic region

Author

Paul Sauleau, Paul Krack, Pierre Pollak, C. Tilikete, Alain Vighetto, Denis Pélisson, Alim-Louis Benabid, Issartel, Jean-Paul, Neurosciences précliniques, Université Joseph Fourier - Grenoble 1 (UJF)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service de neurophysiologie, Université de Rennes (UR), Espace et Action, Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-IFR19-Institut National de la Santé et de la Recherche Médicale (INSERM), Université de Rennes 1 (UR1), and Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)

Subjects
Adult, Parkinson's disease, Deep brain stimulation, Electric Stimulation Therapy/*adverse effects, medicine.medical_treatment, Eye disease, Subthalamic Nucleus/*physiopathology, MESH: Electric Stimulation Therapy, Stimulation, Electric Stimulation Therapy, Functional Laterality, MESH: Magnetic Resonance Imaging, Central nervous system disease, 03 medical and health sciences, 0302 clinical medicine, Ocular Motility Disorders, Subthalamic Nucleus, medicine, Humans, MESH: Ocular Motility Disorders, MESH: Functional Laterality, 030304 developmental biology, MESH: Subthalamic Nucleus, 0303 health sciences, MESH: Humans, fungi, Eye movement, Parkinson Disease, Parkinson Disease/pathology/therapy, MESH: Adult, Frontal eye fields, medicine.disease, Magnetic Resonance Imaging, Electrodes, Implanted, Ocular Motility Disorders/*etiology/pathology, Subthalamic nucleus, Neurology, Electrodes, Implanted/adverse effects, Female, MESH: Electrodes, Implanted, Neurology (clinical), Psychology, Neuroscience, MESH: Female, 030217 neurology & neurosurgery, MESH: Parkinson Disease
Abstract

International audience; Contraversive eye deviation (CED) is most often observed intraoperatively during subthalamic nucleus implantation for Parkinson's disease and considered to result from wrong electrode positioning. We report on a woman, bilaterally implanted in the subthalamic nucleus for severe Parkinson's disease disclosing long-lasting CED only when the stimulators were activated separately. Clinical examination and eye movements recording in this patient showed that CED occurred when stimulation was applied at the site and at similar intensity used for the best antiparkinsonian effect. These results suggest that the subthalamic area may be involved in orienting movements, either through the subthalamic nucleus itself or the fibers from the Frontal Eye Fields. Interestingly, this report shows that CED may be corrected by bilateral stimulation and that CED may not necessarily implicate electrode repositioning.

Published
2007
Full Text
View/download PDF

9. Saccadic lateropulsion in Wallenberg syndrome: a window to access cerebellar control of saccades?

Author

Ansgar Koene, Denis Pélisson, C. Tilikete, Alain Vighetto, Norbert Nighoghossian, Unité de Neuro-Ophtalmologie [Bron], Hôpital neurologique et neurochirurgical Pierre Wertheimer [CHU - HCL], Hospices Civils de Lyon (HCL)-Hospices Civils de Lyon (HCL)-Hôpital Pierre Wertheimer - HCL [Bron], Centre de recherche en neurosciences de Lyon (CRNL), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet [Saint-Étienne] (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Université de Lyon, Hospices Civils de Lyon (HCL), Espace et Action, Université de Lyon-Université de Lyon-IFR19-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre de recherche en neurosciences de Lyon - Lyon Neuroscience Research Center (CRNL), Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), and Pelisson, Denis

Subjects
Male, Cerebellum, Visual perception, Rotation, [SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology, Videooculography, Functional Laterality, Optics, medicine, Saccadic dysmetria, Humans, Lateral Medullary Syndrome, Aged, Lateral medullary syndrome, Video-oculography, Analysis of Variance, business.industry, General Neuroscience, [SCCO.NEUR]Cognitive science/Neuroscience, [SCCO.NEUR] Cognitive science/Neuroscience, [SDV.NEU.NB] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology, Eye movement, Oculomotor cerebellum, Middle Aged, medicine.disease, Control subjects, Saccadic masking, Eye movements, medicine.anatomical_structure, Medullary lesion, Saccade, Visual Perception, Female, Visual Fields, Psychology, business, Neuroscience, Photic Stimulation
Abstract

International audience; Saccadic lateropulsion is characterized by an undershoot of contralaterally directed saccades, an overshoot of ipsilaterally directed saccades and an ipsilateral deviation of vertical saccades. In Wallenberg syndrome, it is thought to result from altered signals in the olivo-cerebellar pathway to the oculomotor cerebellar network. In the current study we aimed to determine whether saccadic lateropulsion results from a cerebellar impairment of motor related signals or visuo-spatial related signals. We studied the trajectory, the accuracy, the direction and the amplitude of a variety of vertical and oblique saccades produced by Wve patients and nine control subjects. Some results are consistent with previous data suggesting altered motor related signals. Indeed, the horizontal error of contralesional saccades in patients increased with the desired horizontal saccade size. Furthermore, the initial directional error measured during the saccadic acceleration phase was smaller than the global directional error, suggesting that the eye tra-jectory curved progressively. However, some other results suggest that the processes that specify the horizontal spatial goal of the saccades might be impaired in the patients. Indeed, the horizontal error of ipsilesional saccades in patients did not change signiWcantly with the desired horizontal saccade size. In addition, when comparing saccades with similar intended direction, it was found that the directional error was inversely related to the vertical saccade amplitude. Thus we conclude that the cerebellum might be involved both in controlling the motor execution of saccades and in determining the visuo-spatial information about their goal.

Published
2006
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results