1. Gradients of connectivity distance in the cerebral cortex of the macaque monkey
- Author
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Gary S. Linn, Marcel Falkiewicz, Blazej M. Baczkowski, Ting Xu, Arnaud Falchier, Daniel S. Margulies, Sabine Oligschläger, Max Planck Institute for Human Cognitive and Brain Sciences [Leipzig] (IMPNSC), Max-Planck-Gesellschaft, Universität Leipzig [Leipzig], Child Mind Institute, Nathan S. Kline Institute for Psychiatric Research (NKI), New York State Office of Mental Health, Institut du Cerveau et de la Moëlle Epinière = Brain and Spine Institute (ICM), Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), CHU Pitié-Salpêtrière [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Gestionnaire, Hal Sorbonne Université, Institut du Cerveau = Paris Brain Institute (ICM), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), and Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)
- Subjects
Cortical topography ,Histology ,Macaque ,050105 experimental psychology ,03 medical and health sciences ,0302 clinical medicine ,Similarity (network science) ,biology.animal ,Cortex (anatomy) ,Neural Pathways ,medicine ,Animals ,0501 psychology and cognitive sciences ,Primate ,[SDV.NEU] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] ,030304 developmental biology ,Cerebral Cortex ,0303 health sciences ,Brain Mapping ,Connectivity ,biology ,General Neuroscience ,Functional connectivity ,05 social sciences ,Organizing principles ,Macaca mulatta ,Magnetic Resonance Imaging ,medicine.anatomical_structure ,Cerebral cortex ,Primate phylogeny ,Original Article ,[SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] ,Anatomy ,Nerve Net ,Neuroscience ,030217 neurology & neurosurgery - Abstract
Cortical connectivity conforms to a series of organizing principles that are common across species. Spatial proximity, similar cortical type, and similar connectional profile all constitute factors for determining the connectivity between cortical regions. We previously demonstrated another principle of connectivity that is closely related to the spatial layout of the cerebral cortex. Using functional connectivity from resting-state fMRI in the human cortex, we found that the further a region is located from primary cortex, the more distant are its functional connections with the other areas of the cortex. However, it remains unknown whether this relationship between cortical layout and connectivity extends to other primate species. Here, we investigated this relationship using both resting-state functional connectivity as well as gold-standard tract-tracing connectivity in the macaque monkey cortex. For both measures of connectivity, we found a gradient of connectivity distance extending between primary and frontoparietal regions. In the human cortex, the further a region is located from primary areas, the stronger its connections to distant portions of the cortex, with connectivity distance highest in frontal and parietal regions. The similarity between the human and macaque findings provides evidence for a phylogenetically conserved relationship between the spatial layout of cortical areas and connectivity. Electronic supplementary material The online version of this article (10.1007/s00429-018-1811-1) contains supplementary material, which is available to authorized users.
- Published
- 2019