Author: "Arnaud, Laurent" / Publisher: hal ccsd - Searchworks@Jio Institute Digital Library Search Results

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64 results on '"Arnaud, Laurent"'

1. Transaction fees optimization in the Ethereum blockchain

Author: Arnaud Laurent, Luce Brotcorne, Bernard Fortz, Integrated Optimization with Complex Structure (INOCS), Inria Lille - Nord Europe, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-Université libre de Bruxelles (ULB)-Centre de Recherche en Informatique, Signal et Automatique de Lille - UMR 9189 (CRIStAL), Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS), Département d'Informatique [Bruxelles] (ULB), Faculté des Sciences [Bruxelles] (ULB), Université libre de Bruxelles (ULB)-Université libre de Bruxelles (ULB), and Institut National de Recherche en Informatique et en Automatique (Inria)
Subjects: Optimization, Ethereum, Blockchain, General Engineering, Gasprice, General Earth and Planetary Sciences, [INFO.INFO-RO]Computer Science [cs]/Operations Research [cs.RO], Monte-Carlo, Ether, ComputingMilieux_MISCELLANEOUS, Pricing, General Environmental Science
Abstract: International audience; In blockchains, transaction fees are fixed by the users. The probability for a transaction to be processed quickly increases with the fee level. In this paper, we study the transaction fee optimization problem in the Ethereum blockchain. This problem consists of determining the minimum price a user should pay so that its transaction is processed with a given probability in a given amount of time. To reach this goal, we define a new solution method based on a Monte Carlo approach to predict the probability that a transaction will be mined within a given time limit. Numerical results on real data highlight the quality of the results.
Published: 2022

2. New cloud computing resources pricing strategies

Author: Brotcorne, Luce, Fortz, Bernard, Arnaud, Laurent, Integrated Optimization with Complex Structure (INOCS), Inria Lille - Nord Europe, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-Université libre de Bruxelles (ULB)-Centre de Recherche en Informatique, Signal et Automatique de Lille - UMR 9189 (CRIStAL), and Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS)
Subjects: [INFO.INFO-RO]Computer Science [cs]/Operations Research [cs.RO]
Abstract: International audience
Published: 2022

3. Comprehensive biomarkers analysis to explain resistances to PD1-L1 ICIs: The precision immuno-oncology for advanced non-small cell lung cancer (PIONeeR) trial

Author: Greillier, Laurent, Monville, Florence, Leca, Vanina, Vely, Frédéric, Garcia, Stephane, Ciccolini, Joseph, Sabatier, Florence, Ferrani, Gilbert, Boudai, Nawel, Ghezali, Lamia, Landri, Marcellin, Marin, Clémence, Hamimed, Mourad, Arnaud, Laurent, Karlsen, Melanie, Atsou, Kevin, Bokobza, Sivan, Fleury, Pauline, Boyer, Arnaud, Audigier-Valette, Clarisse, Martinez, Stéphanie, Pegliasco, Hervé, Ray, Patrice, Falchero, Lionel, Serre, Antoine, Cloarec, Nicolas, Lebas, Louisiane, Hominal, Stephane, Barre, Patricia, Zahi, Sarah, Frikha, Ahmed, Bory, Pierre, Ray, Maryannick Le, Laborde, Lilian, Martin, Virginie, Malkoun, Richard, Roumieux, Marie, Mazieres, Julien, Perol, Maurice, Vivier, Eric, Benzekry, Sébastien, Fieschi, Jacques, Barlesi, Fabrice, Service d'oncologie multidisciplinaire innovations thérapeutiques [Hôpital Nord - APHM], Assistance Publique - Hôpitaux de Marseille (APHM)- Hôpital Nord [CHU - APHM], Veracyte SAS, Aix Marseille Université (AMU), Assistance Publique - Hôpitaux de Marseille (APHM), Méthodes computationnelles pour la prise en charge thérapeutique en oncologie : Optimisation des stratégies par modélisation mécaniste et statistique (COMPO), Inria Sophia Antipolis - Méditerranée (CRISAM), Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-Centre de Recherche en Cancérologie de Marseille (CRCM), Aix Marseille Université (AMU)-Institut Paoli-Calmettes, Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU)-Institut Paoli-Calmettes, Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Innate Pharma, Hôpital Saint-Joseph [Marseille], Centre Hospitalier Intercommunal Toulon-La Seyne sur Mer - Hôpital Sainte-Musse, Centre Hospitalier d'Aix en Provence [Aix-en-Provence] (CHIAP ), Hôpital Européen [Fondation Ambroise Paré - Marseille], Centre Hospitalier Universitaire de Nîmes (CHU Nîmes), Hôpital Nord-Ouest de Villefranche-sur-Saône, Institut de Cancérologie du GARD ICG - CHU Nîmes (Instit Cancéro - GARD), Centre Hospitalier Henri Duffaut (Avignon), Centre Hospitalier du Val d'Ariège, Centre Hospitalier Annecy-Genevois [Saint-Julien-en-Genevois], Centre hospitalier Jean Rougier, Centre hospitalier de Montauban (CH Montauban), Polyclinique Maymard, Centre Hospitalier de Bastia, Partenaires INRAE, Institut Paoli-Calmettes, Fédération nationale des Centres de lutte contre le Cancer (FNCLCC), Hôpitaux de Toulouse, Centre Léon Bérard [Lyon], Institut Gustave Roussy (IGR), and Université Paris-Saclay
Subjects: [SDV.CAN]Life Sciences [q-bio]/Cancer, [SDV.IMM.IMM]Life Sciences [q-bio]/Immunology/Immunotherapy
Abstract: International audience; Abstract Background: Resistance to PD1/L1 immune checkpoint inhibitors (ICIs) in advanced NSCLC patients is observed in about 80% of individuals with no robust predictive biomarker yet. The PIONeeR trial (NCT03493581) aims to predict such resistances through a comprehensive multiparametric biomarkers analysis. Methodology: Among the >300 advanced NSCLC patients (pts) recruited in PIONeeR, we focused on the first 137 ≥2nd line ECOG PS0-1 pts treated with single-agent nivolumab, pembrolizumab or atezolizumab. Tumor tissue was collected at baseline and pts were re-biopsied at 6 weeks, and blood-sampled every cycle throughout the 24 weeks post C1D1. Response to PD1/L1 ICIs was assessed by RECIST 1.1 every 6 weeks. Immune contexture was characterized in tumor & blood of each pt through FACS for circulating immune cell subtypes quantification and endothelial activation, blood soluble factors dosage, dual- & multiplex IHC/digital pathology to quantify immune cells infiltrating the tumor, WES for TMB & ICI plasma dosage, leading to 331 measured biomarkers in addition to routine clinical parameters. Multivariable (MV) logistic regression was used to examine the association of each biomarker (controlled by sex, age, smoking status, histological type & PDL1+ Tumor Cells) with the risk of Early Progression (EP), i.e. within 3.5 months of treatment. Multivariable Cox regression analysis was conducted for association with PFS and OS. Results: Overall, the 137 pts were mainly male (64%), smokers (92%) and 1% PDL1+ TC in 36% of the cases, and 21% of pts were still on treatment at data cut-off. Archived samples were available for 80% of pts at inclusion and re-biopsy was available in 52.9% of these cases. The median follow up was 19.8 months, 22.5% of pts did not progress at data cut-off while 62% presented EP. Tumor Cytotoxic T-cells density, especially PD1+ were lower in EP (MV OR=0.45, p=0.022); conversely, higher proportions of circulating cytotoxic T-cells and activated T-cells (HLA-DR+) were observed in EP (MV OR=3.8, p65% inter-pt variability was observed in plasma exposures for all ICIs, with 8-10% of pts displaying trough levels below the target engagement threshold. Data will be presented through unsupervised clustering algorithms & multi-modal supervised learning methods. Changes after 6 weeks of treatment will be analyzed to further investigate drugs mechanisms of action. Conclusion: The PIONeeR trial provides with the 1st comprehensive biomarkers’ analysis to establish predictive models of resistance in advanced NSCLC pts treated with PD1/L1 ICIs and highlights how tumor and circulating biomarkers are complementary.
Published: 2022

4. FCGR2A-HH Gene Variants Encoding the Fc Gamma Receptor for the C-Reactive Protein Are Associated with Enhanced Monocyte CD32 Expression and Cardiovascular Events' Recurrence after Primary Acute Coronary Syndrome Accepted for publication in Biomedecines 19/02/22

Author: Paul, Pascale, Picard, Christophe, Lyonnet, Luc, Resseguier, Noémie, Hubert, Lucas, Arnaud, Laurent, Cristofaro, Julie, Laine, Marc, Paganelli, Franck, Dignat-George, Françoise, Frère, Corinne, Sabatier, Florence, Guieu, Regis, Bonello, Laurent, Paul, Pascale, Centre d'Immunologie de Marseille - Luminy (CIML), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Vascular research center of Marseille (VRCM), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre recherche en CardioVasculaire et Nutrition = Center for CardioVascular and Nutrition research (C2VN), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Etablissement Français du Sang Provence-Alpes Côte-d'Azur et Corse (EFS), Assistance Publique - Hôpitaux de Marseille (APHM), Aix Marseille Université (AMU), and Hôpital Nord [CHU - APHM]
Subjects: [SDV] Life Sciences [q-bio], Fc-gamma receptor polymorphism, acute heart failure, circulating monocytes, [SDV]Life Sciences [q-bio], cardiovascular inflammation, CD32, MACE, C-reactive protein
Abstract: International audience; Fcγ receptors (FcγRs) interact with the C-reactive protein (CRP) and mediate activation of inflammation-related pathogenic mechanisms affecting cardiovascular health. Our study evaluated whether FcγRIIA and FcγRIIIA profiles are associated with the recurrence of adverse cardiovascular events during the first year after a primary acute coronary syndrome (ACS). The primary endpoint was the recurrence of cardiovascular events (RCE), identified as a composite outcome comprising acute heart failure (AHF) and major adverse cardiovascular events (MACE). We obtained blood samples of 145 ACS patients to measure hsCRP circulating levels, to identify FcγRIIA-131RH rs1801274 and FcγRIIIA-158FV rs396991 polymorphisms, to analyze circulating monocytes and NK cell subsets expressing CD16 and CD32, and to detect serum-mediated FCGR2A-HH activation by luciferase reporter assays. The hsCRP, CD32-expression, and Fc-R mediated activation levels were similar in all patients regardless of their MACE risk. In contrast, the hsCRP levels and the proportion of CD14+ circulating monocytes expressing the CD32 receptor for CRP were significantly higher in the patients who developed AHF. The FCGR2A rs1801274 HH genotype was significantly more common in patients who developed RCE and MACE than in RCE-free patients and associated with an enhanced percentage of circulating CD32+CD14+ monocytes. The FCGR2A-HH genotype was identified as an independent predictor of subsequent RCE (OR, 2.7; p = 0.048; CI, 1.01–7.44) by multivariate analysis. These findings bring preliminary evidence that host FCGR2A genetic variants can influence monocyte CD32 receptor expression and may contribute to the fine-tuning of CD32-driven chronic activating signals that affect the risk of developing RCEs following primary ACS events.
Published: 2022

5. Radar altimeter waveform simulations in Antarctica with the Snow Microwave Radiative Transfer Model (SMRT)

Author: Larue, Fanny, Picard, Ghislain, Aublanc, Jérémie, Arnaud, Laurent, Robledano-Perez, Alvaro, Le Meur, Emmanuel, Favier, Vincent, Jourdain, Bruno, Savarino, Joel, Thibaut, Pierre, Institut des Géosciences de l’Environnement (IGE), Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP ), Université Grenoble Alpes (UGA), Collecte Localisation Satellites (CLS), and ANR-16-CE01-0011,EAIIST,Projet International d'exploration de la calotte polaire de l'Antarctique de l'Est(2016)
Subjects: [SDU.OCEAN]Sciences of the Universe [physics]/Ocean, Atmosphere, remote sensing, waveform, Antarctic ice sheet, field measurements, modeling, SMRT, radar altimetry
Abstract: International audience; Radar altimeters are important tools to monitor the volume of the ice sheets. The penetration of radar waves in the snowpack is a major source of uncertainty to retrieve surface elevation. To correct this effect, a better understanding of the sensitivity of the radar waveforms to snow properties is needed. Here, we present an extension of the Snow Model Radiative Transfer (SMRT) to compute radar waveforms and conduct a series of simulations on the Antarctic ice sheet. SMRT is driven by snow and surface roughness properties measured over a large latitudinal range during two field campaigns on the Antarctic Plateau. These measurements show that the snowpack is rougher, denser, less stratified, warmer, and has smaller snow grains near the coast than on the central Plateau. These simulations are compared to satellite observations in the Ka, Ku, and S bands. SMRT reproduces the observed waveforms well. For all sites and all sensors, the main contribution comes from the surface echo. The echo from snow grains (volume scattering) represents up to 40% of the amplitude of the total waveform power in the Ka band, and less at the lower frequencies. The highest amplitude is observed on the central Plateau due to the combination
Published: 2021

6. Combined Temperature and Radiation Effects on the Gain of Er- and Er–Yb-Doped Fiber Amplifiers

Author: Aziz Boukenter, C. Ranger, Luciano Mescia, Emmanuel Marin, Julien Mekki, Arnaud Laurent, Youcef Ouerdane, Marine Aubry, Adriana Morana, Sylvain Girard, Thierry Robin, Laboratoire Hubert Curien [Saint Etienne] (LHC), Institut d'Optique Graduate School (IOGS)-Université Jean Monnet [Saint-Étienne] (UJM)-Centre National de la Recherche Scientifique (CNRS), iXBlue Photonics, Centre National d'Études Spatiales [Toulouse] (CNES), and Politecnico di Bari
Subjects: Ytterbium, Nuclear and High Energy Physics, EYDFA, Optical fiber, Materials science, Erbium-doped fiber amplifiers, chemistry.chemical_element, Radiation effects, Radiation, 01 natural sciences, law.invention, Erbium, Degradation, EDFA, [SPI]Engineering Sciences [physics], law, Optical fiber amplifiers, 0103 physical sciences, X-rays, Optical fiber devices, Optical fibers, Fiber, Irradiation, Electrical and Electronic Engineering, ComputingMilieux_MISCELLANEOUS, Optical amplifier, 010308 nuclear & particles physics, business.industry, Amplifier, Nuclear Energy and Engineering, chemistry, Optical fiber testing, Optoelectronics, business
Abstract: We investigated the coupled radiation and temperature effect on the gain degradation of erbium-doped fiber amplifier (EDFA) and erbium–ytterbium-doped fiber amplifier (EYDFA). The irradiation temperatures range from −40 °C to 120 °C. Steady-state $X$ -ray (40 keV, 300 krad (SiO2), ~27 rad/s) experiments provide evidence for a minor coupled radiation and temperature effect on the gains of both reference and radiation-tolerant EDFA and EYDFA. This is an important result as it validates the reliance on room-temperature testing in establishing the suitability of fiber amplifiers for space applications. Furthermore, we also investigated the radiation-induced attenuation (RIA) kinetics during and after the various rare-earth-doped fiber irradiations to improve our knowledge of the basic radiation-effects mechanisms and their dependence on the temperature during irradiation. It appears that these effects also depend on the presence of cerium, a codopant that is incorporated to passivate the Al- or P-related defects and then to enhance the amplifier radiation tolerance.
Published: 2021

7. Prevalence of antineutrophil cytoplasmic antibody (ANCA)‐associated vasculitis and spatial association with quarries in a French Northeast region

Author: Giorgiutti, Stéphane, Dieudonné, Yannick, Hinschberger, Olivier, Nespola, Benoît, Campagne, Julien, Rakotoarivelo, Hanta Nirina, Hannedouch, Thierry, Moulin, Bruno, Blaison, Gilles, Weber, Jean-Christophe, Dalmas, Marie‐Caroline, De Blay De Gaix, Frederic, Lipsker, Dan, Chantrel, François, Gottenberg, Jacques Eric, Dimitrov, Yves, Imhoff, Olivier, Gavand, Pierre‐Edouard, Andres, Emmanuel, Debry, Christian, Hansmann, Yves, Klein, Alexandre, Lohmann, Caroline, Mathiaux, François, Guffroy, Aurélien, Poindron, Vincent, Martin, Thierry, Korganow, Anne-sophie, Arnaud, Laurent, Immunopathologie et chimie thérapeutique (ICT), Institut de biologie moléculaire et cellulaire (IBMC), Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS), Archives Henri-Poincaré - Philosophie et Recherches sur les Sciences et les Technologies (AHP-PReST), Université de Strasbourg (UNISTRA)-Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'Histoire des Sciences et de Philosophie - Archives Henri Poincaré (LHSP), Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS), Mitochondrie, stress oxydant et protection musculaire (MSP), Université de Strasbourg (UNISTRA), Biomatériaux et Bioingénierie (BB), Université de Strasbourg (UNISTRA)-Matériaux et nanosciences d'Alsace (FMNGE), Institut de Chimie du CNRS (INC)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM), Virulence bactérienne précoce : fonctions cellulaires et contrôle de l'infection aiguë et subaiguë, Immuno-Rhumatologie Moléculaire, and Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Strasbourg (UNISTRA)
Subjects: [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract: Objective: Silica is one of the strongest environmental substances linked with autoimmunity. The aim of this study was to assess the prevalence of granulomatosis with polyangiitis (GPA), microscopic polyangiitis (MPA) and renal limited vasculitis (RLV) in a French northeast region, and their geospatial association with quarries. Methods: Potential ANCA-Associated Vasculitis (AAV) cases were identified using three sources: hospital records, immunology laboratories and the National Health Insurance System. Patients who resided in Alsace on January 1, 2016 and fulfilled ACR AAV criteria or Chapel Hill Consensus Conference 2012 definition were included. Incomplete case ascertainment was corrected using capture-recapture analysis. The spatial association between the number of cases and quarries in each administrative entity was assessed using geographical weighted regression (GWR). Results: From 910 potential AAV cases, we identified 185 patients meeting inclusion criteria: 120 GPA, 35 MPA, 30 RLV. The number of cases missed by any source was 6.4 (95%CI 3.6-11.5). Accordingly, the 2016 estimated prevalence in Alsace was 65.5 cases per million inhabitants (95%CI 47.3-93.0) for GPA, 19.1 (95%CI 11.3-34.3) for MPA, and 16.8 (95%CI 8.7-35.2) for RLV. The risk of AAV was significantly increased in communes with quarries (OR: 2.51 [95%CI: 1.66-3.80]) and GWR revealed a significant spatial association between quarries and GPA cases (p = 0.039), and, regarding ANCA serotype, between quarries and both PR3-AAV (p = 0.04) and MPO-AAV (p = 0.03)." Conclusion: In a region with a high density of quarries, the spatial association of AAV with quarries supports the role of silica as a specific environmental factor.
Published: 2021

8. Pattern mining‐based pruning strategies in stochastic local searches for scheduling problems

Author: Vincent Clerc, Damien Lamy, Arnaud Laurent, Benjamin Dalmas, Integrated Optimization with Complex Structure (INOCS), Inria Lille - Nord Europe, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-Université libre de Bruxelles (ULB)-Centre de Recherche en Informatique, Signal et Automatique de Lille - UMR 9189 (CRIStAL), Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS), École des Mines de Saint-Étienne (Mines Saint-Étienne MSE), Institut Mines-Télécom [Paris] (IMT), Institut Henri Fayol (FAYOL-ENSMSE), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT), Laboratoire d'Informatique, de Modélisation et d'Optimisation des Systèmes (LIMOS), Ecole Nationale Supérieure des Mines de St Etienne (ENSM ST-ETIENNE)-Centre National de la Recherche Scientifique (CNRS)-Université Clermont Auvergne (UCA)-Institut national polytechnique Clermont Auvergne (INP Clermont Auvergne), Université Clermont Auvergne (UCA)-Université Clermont Auvergne (UCA), FAYOL-ENSMSE - Département Génie mathématique et industriel, Centre Ingénierie et Santé (CIS-ENSMSE), Université libre de Bruxelles (ULB)-Inria Lille - Nord Europe, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-Centre de Recherche en Informatique, Signal et Automatique de Lille - UMR 9189 (CRIStAL), Université de Lille-Centrale Lille-Centre National de la Recherche Scientifique (CNRS)-Université de Lille-Centrale Lille-Centre National de la Recherche Scientifique (CNRS), Ecole Nationale Supérieure des Mines de St Etienne-Centre National de la Recherche Scientifique (CNRS)-Université Clermont Auvergne (UCA)-Institut national polytechnique Clermont Auvergne (INP Clermont Auvergne), Institut National de Recherche en Informatique et en Automatique (Inria), Département Génie mathématique et industriel (FAYOL-ENSMSE), Ecole Nationale Supérieure des Mines de St Etienne-Institut Henri Fayol, École des Mines, Centre Ingénierie Santé, Saint-Étienne (CIS - MINES), and Institut Henri Fayol-Ecole Nationale Supérieure des Mines de St Etienne
Subjects: Mathematical optimization, Speedup, Computer science, Job shop, Strategy and Management, 0211 other engineering and technologies, Scheduling (production processes), 02 engineering and technology, Management Science and Operations Research, Scheduling Problem, Machine Learning, Local optimum, Knowledge extraction, [INFO.INFO-LG]Computer Science [cs]/Machine Learning [cs.LG], Management of Technology and Innovation, 0202 electrical engineering, electronic engineering, information engineering, Local search (optimization), Resource Constrained Project Scheduling Problem, Pruning (decision trees), Business and International Management, 021103 operations research, Job shop scheduling, business.industry, Job-shop, [INFO.INFO-RO]Computer Science [cs]/Operations Research [cs.RO], Pattern Mining, [INFO.INFO-MO]Computer Science [cs]/Modeling and Simulation, Stochastic Local Search, Computer Science Applications, job‐shop, 020201 artificial intelligence & image processing, business
Abstract: International audience; Scheduling problems are a subclass of combinatorial problems consisting of a set of tasks/activities/jobs to be processed by a set of resources usually to minimize a time criterion. Some optimization methods used to solve these problems are hybridized with knowledge discovery techniques to extract information during the optimization process and enhance it. However, most of these hybrid techniques are custom‐designed and lack generalization. In this paper, a module for knowledge extraction in Stochastic Local Searches is designed, aiming to be problem independent and plugged into optimization methods that relies on multiple Stochastic Local Search replications. The objective is to prune parts of the search space for which the exploration is likely to lead to poor solutions. This is performed through the extraction of high‐quality patterns occurring in locally optimal solutions. Benchmarked on two well‐known scheduling problems, the Job‐shop Problem and the Resource Constrained Project Scheduling Problem, the results show both a speed up in the convergence and the reaching of better local optima solutions.
Published: 2021

9. Article type: Research letter

Author: Aitmehdi, Raphael, Arnaud, Laurent, Francès, Camille, Senet, Patricia, Monfort, Jean-Benoît, de Risi-Pugliese, Tullia, Barbaud, Annick, Cohen-Aubart, Fleur, Haroche, Julien, Pha, Micheline, Hie, Miguel, Le Guern, Véronique, Costedoat-Chalumeau, Nathalie, Mékinian, Arsène, Fain, Olivier, Mathian, Alexis, Amoura, Zahir, CHU Tenon [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Institut des Géosciences de l’Environnement (IGE), Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP ), Université Grenoble Alpes (UGA), CHU Pitié-Salpêtrière [AP-HP], CHU Saint-Antoine [AP-HP], Service de dermatologie et allergologie [CHU Tenon], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Université Grenoble Alpes (UGA)-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Institut de Recherche pour le Développement (IRD)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP ), Service de médecine interne [CHU Pitié-Salpétrière], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU), Institut E3M [CHU Pitié-Salpêtrière], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Centre National de Référence du Lupus Systémique, Syndrome des Anticorps Anti-phospholipides et Maladies Auto-immunes Systémiques Rares [CHU Pitié Salpêtrière], Service de Médecine Interne 2, maladies auto-immunes et systémiques [CHU Pitié-Salpêtrière], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Institut E3M [CHU Pitié-Salpêtrière], Service de Médecine Interne [CHU Saint-Antoine], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Pitié-Salpêtrière [AP-HP], and Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut E3M [CHU Pitié-Salpêtrière]
Subjects: ComputingMilieux_MISCELLANEOUS, [SDV.MHEP.DERM]Life Sciences [q-bio]/Human health and pathology/Dermatology
Abstract: International audience
Published: 2021

10. Coupled Temperature and Radiation Effects on Erbium and Erbium- Ytterbium Doped Fiber Amplifiers

Author: Aubry, Marine, Girard, Sylvain, campanella, cosimo, Marin, Emmanuel, Ouerdane, Y., Boukenter, Aziz, Mescia, Luciano, Morana, Adriana, Mekki, Julien, Arnaud, Laurent, Robin, Thierry, Laboratoire Hubert Curien [Saint Etienne] (LHC), Institut d'Optique Graduate School (IOGS)-Université Jean Monnet [Saint-Étienne] (UJM)-Centre National de la Recherche Scientifique (CNRS), Politecnico di Bari, Centre National d'Études Spatiales [Toulouse] (CNES), and iXBlue Photonics
Subjects: [PHYS]Physics [physics], ComputingMilieux_MISCELLANEOUS
Abstract: International audience
Published: 2020

11. Recent Advances on Radiation-Hardened Optical Fiber Technologies

Author: Adriana Morana, Arnaud Laurent, Alexandre Barnini, Aziz Boukenter, Laurent Lablonde, Gilles Melin, Youcef Ouerdane, Emmanuel Marin, Thierry Robin, Benoit Cadier, Sylvain Girard, Laboratoire Hubert Curien [Saint Etienne] (LHC), Institut d'Optique Graduate School (IOGS)-Université Jean Monnet [Saint-Étienne] (UJM)-Centre National de la Recherche Scientifique (CNRS), and iXBlue Photonics
Subjects: Optical amplifier, [PHYS]Physics [physics], Optical fiber, Materials science, business.industry, 02 engineering and technology, Radiation, Communications system, Laser, 01 natural sciences, law.invention, 010309 optics, 020210 optoelectronics & photonics, law, 0103 physical sciences, 0202 electrical engineering, electronic engineering, information engineering, Key (cryptography), Optoelectronics, Point (geometry), business, ComputingMilieux_MISCELLANEOUS, Free-space optical communication
Abstract: Silica-based optical fibers possess key advantages for integration in radiation-rich environments as parts of communication systems, laser sources, optical amplifiers, diagnostics and point or distributed sensors. We reviewed how the understanding of the basic mechanisms of radiation effects can be exploited to optimize their tolerance to the most challenging environments.
Published: 2020

12. Coupled radiation and temperature effects on Erbium-doped fiber amplifiers

Author: Luciano Mescia, Sylvain Girard, Thierry Robin, Adriana Morana, Aziz Boukenter, Marine Aubry, Julien Mekki, Arnaud Laurent, Youcef Ouerdane, Emmanuel Marin, Laboratoire Hubert Curien [Saint Etienne] (LHC), Institut d'Optique Graduate School (IOGS)-Université Jean Monnet [Saint-Étienne] (UJM)-Centre National de la Recherche Scientifique (CNRS), Centre National d'Études Spatiales [Toulouse] (CNES), Politecnico di Bari, and iXBlue Photonics
Subjects: Materials science, Optical fiber, Optical communication, Radiation, optical communications, 01 natural sciences, doped fibers, law.invention, Erbium doped fiber amplifier, EDFA, law, 0103 physical sciences, Irradiation, radiation effects, temperature effects, space environment, ComputingMilieux_MISCELLANEOUS, Optical amplifier, [PHYS]Physics [physics], 010308 nuclear & particles physics, business.industry, Ranging, Optoelectronics, business, Free-space optical communication
Abstract: Combined radiation and temperature effects on the performances of three different Erbium-doped fiber amplifiers (EDFAs) have been evaluated for free-space optical communications. Each EDFA has been tested during and after an exposure to 40 keV X-rays up to a cumulated dose of 3 kGy (SiO2) (300 krad) and at a dose rate of ~0.27 Gy (SiO2)/s. Tests have been done at different temperatures of irradiation ranging from -40°C to 120°C showing that this parameter does not significantly affect the EDFA radiation response, comforting the pertinence of room temperature tests for system vulnerability evaluation.
Published: 2020

13. Immunogram to decipher PD1/L1 ICI resistance: a proof of concept in advanced Non-small cell lung cancer patients of the PIONeeR Project

Author: Monville, Florence, Vely, Frederic, Ciccolini, Joseph, Sabatier, Florence, Garcia, Stephane, Leca, Vanina, Fabre, Marion, Piperoglou, Christelle, Outters, Pernelle, Arnaud, Laurent, Vanhille, Laurent, Lauge, Caroline, Martirosyan, Anna, Collignon, Aurelie, Roumieux, Marie, Mazieres, Julien, Perol, Maurice, Dignat-George, Francoise, Eric Vivier, Barlesi, Fabrice, Fieschi, Jacques, Institut Paoli-Calmettes, Fédération nationale des Centres de lutte contre le Cancer (FNCLCC), Aix Marseille Université (AMU), Centre recherche en CardioVasculaire et Nutrition = Center for CardioVascular and Nutrition research (C2VN), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Assistance Publique - Hôpitaux de Marseille (APHM), Département cancer environnement (Centre Léon Bérard - Lyon), Centre Léon Bérard [Lyon], Hôpital de la Conception [CHU - APHM] (LA CONCEPTION), and French National Research Agency (ANR)
Subjects: [SDV]Life Sciences [q-bio], ComputingMilieux_MISCELLANEOUS
Abstract: International audience
Published: 2019

14. Bin Packing Problem with priorities and incompatibilities using PSO: application in a health care community

Author: Arnaud Laurent, Nathalie Klement, Laboratoire d'Informatique, de Modélisation et d'Optimisation des Systèmes (LIMOS), Ecole Nationale Supérieure des Mines de St Etienne-Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-Centre National de la Recherche Scientifique (CNRS), Laboratoire d’Ingénierie des Systèmes Physiques et Numériques (LISPEN), Arts et Métiers Sciences et Technologies, HESAM Université (HESAM)-HESAM Université (HESAM), Ecole Nationale Supérieure des Mines de St Etienne (ENSM ST-ETIENNE)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-Centre National de la Recherche Scientifique (CNRS), and HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)
Subjects: 0209 industrial biotechnology, Mathematical optimization, Computer science, business.industry, Group (mathematics), Bin packing problem, 020208 electrical & electronic engineering, Particle swarm optimization, 02 engineering and technology, Extension (predicate logic), Modélisation et simulation [Informatique], [INFO.INFO-MO]Computer Science [cs]/Modeling and Simulation, 020901 industrial engineering & automation, Work (electrical), Control and Systems Engineering, Health care, 0202 electrical engineering, electronic engineering, information engineering, business
Abstract: International audience; The present work deals with the Hospital Group of Territory problem. The objective of the cooperation between these health institutions is to provide a better treatment other. To do so, these entities pool their means together. Our goal is to propose efficient methods to assign the different operations to the periods and resources, considering resources compatibilities anddue dates. We consider this problem as an extension of the classical Bin Packing Problem. We propose a Particle Swarm Optimization to solve this problem using a hybridization proposed by Klement et al. (2017). The results show the interest of the proposed PSO for this kind of problem.
Published: 2019

15. Radiation Effects on WDM and DWDM Architectures of Preamplifier and Boost-Amplifier

Author: Cosimo Campanella, Benoit Cadier, Julien Mekki, Mathieu Boutillier, Ayoub Ladaci, Arnaud Laurent, Thierry Robin, Emmanuel Marin, Sylvain Girard, Youcef Ouerdane, Marine Aubry, Adriana Morana, Aziz Boukenter, Jeoffray Vidalot, Luciano Mescia, Laboratoire Hubert Curien (LHC), Institut d'Optique Graduate School (IOGS)-Université Jean Monnet - Saint-Étienne (UJM)-Centre National de la Recherche Scientifique (CNRS), Dipartimento di Elettrotecnica ed Elettronica [Bari] (DEE), Politecnico di Bari, iXBlue Photonics, Centre National d'Études Spatiales [Toulouse] (CNES), DAM Île-de-France (DAM/DIF), Direction des Applications Militaires (DAM), and Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)
Subjects: Nuclear and High Energy Physics, Materials science, Optical fiber, optical fibers, Preamplifier, chemistry.chemical_element, 01 natural sciences, law.invention, Erbium, [SPI]Engineering Sciences [physics], law, Wavelength-division multiplexing, 0103 physical sciences, X-rays, Fiber, Electrical and Electronic Engineering, Optical amplifier, 010308 nuclear & particles physics, business.industry, Amplifier, Attenuation, Er-doped fiber preamplifier (EDFA), Amplifiers, erbium, radiation effects, Nuclear Energy and Engineering, chemistry, Optoelectronics, business
Abstract: We investigated the X-ray [40 keV, 700 Gy(SiO2), ~80 mGy/s] radiation effects on the performances (gain) of Er-doped fiber preamplifier (EDFA) and Er/Yb codoped fiber boost amplifier (EYDFA). Various EDFA and EYDFA architectures have been designed to operate either in wavelength division multiplexing (WDM) or dense WDM (DWDM) schemes. We compare the performances of amplifiers based on conventional or radiation-hardened (RH) versions of the active Er-doped or Er/Yb-codoped fibers. Our results show that for all amplifier architectures, the various channels undergo similar gain degradation levels and kinetics, as expected from the measured spectral dependence of the radiation-induced attenuation of the phosphosilicate (ErYb-doped) and aluminosilicate (Er-doped) glass matrixes of these fibers. This degradation remains very limited for the amplifiers based on RH fibers, with a gain decrease of less than 0.3 mdB.Gy−1 for the EDFA (~30 dB initial gain) and less than 0.8 mdB.Gy−1 for the EYDFA (~18 dB initial gain) in the DWDM architecture.
Published: 2019

16. Realization and Numerical Simulation of a High Power and High Efficiency Holmium Doped Fiber Laser at 2.1 μm

Author: Pierre Bourdon, Thierry Robin, Arnaud Laurent, Benoit Cadier, Julien Le Gouët, François Gustave, DOTA, ONERA, Université Paris Saclay (COmUE) [Palaiseau], ONERA-Université Paris Saclay (COmUE), and iXFiber SAS
Subjects: [PHYS]Physics [physics], Work (thermodynamics), Materials science, Computer simulation, FIBER LASER, HAUTE PUISSANCE, business.industry, HOLMIUM, Doping, EYESAFE, chemistry.chemical_element, Physics::Optics, 7. Clean energy, Power (physics), SECURITE OCULAIRE, [SPI]Engineering Sciences [physics], HIGH POWER, chemistry, Fiber laser, Optoelectronics, LASER A FIBRE, Holmium, Absorption (electromagnetic radiation), business, Realization (systems)
Abstract: International audience; Holmium fiber lasers pumped in-band with Tm fiber lasers appear as interesting solutions when looking for high power in a single spatial mode and high electro-optic efficiency, in a spectral domain that guarantees eye-safe emission and low absorption by the atmosphere. We will present the progress of our work on a high efficiency holmium (Ho) fiber laser, detailing the numeric model, experimental realization and results.
Published: 2019

17. Spotlight on anifrolumab and its potential for the treatment of moderate-to-severe systemic lupus erythematosus: evidence to date

Author: Felten, Renaud, Scher, Florence, Sagez, Flora, chasset, françois, Arnaud, Laurent, Gestionnaire, Hal Sorbonne Université, Service de rhumatologie [Strasbourg], CHU Strasbourg-Hôpital de Hautepierre [Strasbourg], Immunopathologie et chimie thérapeutique (ICT), Institut de biologie moléculaire et cellulaire (IBMC), Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS), CHU Strasbourg, Sorbonne Université (SU), Service de dermatologie et allergologie [CHU Tenon], CHU Tenon [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Immuno-Rhumatologie Moléculaire, Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM), Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), and Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-CHU Tenon [APHP]-Sorbonne Université (SU)
Subjects: [SDV.MHEP.RSOA] Life Sciences [q-bio]/Human health and pathology/Rhumatology and musculoskeletal system, Drug Design, Development and Therapy, interferon-alpha, Review, [SDV.IMM.IMM]Life Sciences [q-bio]/Immunology/Immunotherapy, [SDV.MHEP.DERM] Life Sciences [q-bio]/Human health and pathology/Dermatology, Antibodies, Monoclonal, Humanized, interferon type I, systemic lupus erythematosus, [SDV.MHEP.RSOA]Life Sciences [q-bio]/Human health and pathology/Rhumatology and musculoskeletal system, Animals, Humans, Lupus Erythematosus, Systemic, anifrolumab, receptors interferon, [SDV.IMM.IMM] Life Sciences [q-bio]/Immunology/Immunotherapy, [SDV.MHEP.DERM]Life Sciences [q-bio]/Human health and pathology/Dermatology
Abstract: Renaud Felten,1–3 Florence Scher,4 Flora Sagez,1,2 François Chasset,5 Laurent Arnaud1,2,61Rheumatology Department, University Hospital of Strasbourg, Université de Strasbourg, Strasbourg, F-67000, France; 2National Reference Centre for Rare Systemic and Autoimmune Diseases East South-West (RESO), Strasbourg, France; 3Immunology Laboratory, “Immunopathologie et Chimie Thérapeutique”, Institut de Biologie Moléculaire et Cellulaire (IBMC), CNRS UPR3572, Strasbourg, F-67000, France; 4Pharmacy-Sterilisation Department, University Hospital of Strasbourg, University of Strasbourg, Strasbourg, France; 5Faculty of Medicine at Sorbonne University, AP-HP, Dermatology and Allergology Department, Tenon Hospital, Sorbonne University, Paris, F-75020, France; 6Immuno-Rheumatology Laboratory, “Laboratoire d‘ImmunoRhumatologie Moléculaire”, INSERM UMR_S1109, Strasbourg, F-67000, FranceAbstract: Previous reports have described the appearance of systemic lupus erythematosus (SLE) cases following interferon-α (IFN-α) therapy, IFN-regulated gene expression is significantly increased in SLE, and an association between SLE and gene variants belonging to IFN downstream pathways has been shown. Based on this, targeting of IFN and of their signaling pathways has appeared to be interesting developments within the field of SLE therapy. Different specific type I IFN antagonists have been studied in clinical trials and some of those have already reached Phase III. A potential approach would be to target IFN receptors rather than IFN themselves. Anifrolumab (previously MEDI-546) is a fully human monoclonal antibody (Ab) that binds to subunit 1 of the type I IFN receptor (IFNAR1), blocking the action of different type I IFNs (IFN-α, IFN-β and IFN-ω). This drug has been assessed in 11 clinical studies: 9 in SLE, 1 in systemic sclerosis and 1 in rheumatoid arthritis. In SLE, clinical development reached Phase I for 1 study and Phases II and III for 5 and 3 trials, respectively. The Phase IIb, randomized control trial (RCT), double-blind, placebo-controlled study of adults with moderate-to-severe SLE (MUSE trial) showed positive results on the composite primary endpoint SRI-4. Greater efficacy was seen in patients with high baseline IFN gene signature compared with those with low baseline IFN gene signature. Anifrolumab also demonstrated promising results on cutaneous and arthritic manifestations, especially among patients with a high IFN gene signature. The pivotal Treatment of Uncontrolled Lupus via the Interferon IFN Pathway (TULIP 1 and 2 studies are now completed. In August 2018, the promoter announced that the TULIP 1 Phase III trial did not reach its primary endpoint. The release of the completed but not yet published Phase II studies and of the TULIP pivotal trials results will further inform us on the actual therapeutic potential of anifrolumab.Keywords: systemic lupus erythematosus, interferon type I, interferon-alpha, anifrolumab, receptors interferon
Published: 2019

18. Osseous sarcoidosis: a multicenter case-control study

Author: Ben Hassine, Imen, Rein, Christopher, Comarmond, Cloé, Glanowski, Camille, Saidenberg-Kermanac’h, Nathalie, Meunier, Benoit, Schleinitz, Nicolas, Chanson, Noémie, Sacre, Karim, Scherlinger, Marc, Richez, Christophe, Hirschi, Sandrine, Groh, Matthieu, Devilliers, Hervé, Bielefeld, Philip, Saadoun, David, Chapelon-Abric, Catherine, Arnaud, Laurent, Cacoub, Patrice, Immunologie - Immunopathologie - Immunothérapie (I3), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Service de médecine interne et d'immunologie clinique [CHU Pitié-Salpêtrière], Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-CHU Pitié-Salpêtrière [APHP], Departement Hospitalo- Universitaire - Inflammation, Immunopathologie, Biothérapie [Paris] (DHU - I2B), CHU Pitié-Salpêtrière [APHP]-Sorbonne Université (SU), Hôpital d'Instruction des Armées Legouest, Service de Santé des Armées, Service de rhumatologie, inflammation-immunopathologie- biothérapie [CHU Saint-Antoine] (DHU i2B ), Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-CHU Saint-Antoine [APHP], Hôpital d'Instruction des Armées Begin, Physiopathologie, Cibles et Thérapies de la Polyarthrite Rhumatoïde, Université Paris 13 (UP13)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université Sorbonne Paris Cité (USPC), Aix-Marseille Université - Faculté de médecine (AMU MED), Aix Marseille Université (AMU), Hôpital de la Timone [CHU - APHM] (TIMONE), CIC - CHU Bichat, Institut National de la Santé et de la Recherche Médicale (INSERM), CHU Bordeaux [Bordeaux], CHU Strasbourg, Hôpital Foch [Suresnes], Service de médecine interne et maladies systémiques (SOC 2) [CHU de Dijon], Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon), Service de rhumatologie [Strasbourg], CHU Strasbourg-Hôpital de Hautepierre [Strasbourg], Immuno-Rhumatologie Moléculaire, Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM), Immunologie - Immunopathologie - Immunothérapie [CHU Pitié Salpêtrière] (I3), CHU Charles Foix [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), CHU Trousseau [APHP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-CHU Saint-Antoine [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Service de rhumatologie [CHU Saint-Antoine], CHU Saint-Antoine [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Service de Département de médecine interne et immunologie clinique [CHU Pitié-Salpêtrière] (DMIIC), Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Sorbonne Université (SU)-CHU Pitié-Salpêtrière [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-CHU Saint-Antoine [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-CHU Trousseau [APHP], and Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU)
Subjects: musculoskeletal diseases, Sarcoidosis, [SDV.MHEP.RSOA]Life Sciences [q-bio]/Human health and pathology/Rhumatology and musculoskeletal system, Bone involvement, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, musculoskeletal system, Osseous manifestations
Abstract: International audience; Objective: To describe the clinical presentation, distribution of lesions, treatment, and outcomes of osseous sarcoidosis.Methods: A French retrospective multicenter study of patients with biopsy-proven sarcoidosis analyzed patients with 1) a biopsy-proven granuloma without caseous necrosis, and either 2) osseous clinical manifestations, or 3) abnormal osseous imaging. Sarcoidosis patients with osseous involvement (cases) were compared with 264 age- and sex-matched sarcoidosis patients with no osseous manifestations (controls).Results: In the osseous sarcoidosis group (n = 88), forty-two (48%) patients had osseous-related symptoms involving the axial (69%) and/or appendicular (58%) skeleton. On imaging, the most commonly affected bones were in the spine (52%), pelvis (42%), hands (22%) and femur (19%). Compared with controls, cases had higher rates of mediastinal (93% vs. 47%) and extra-thoracic lymph node involvement (66% vs. 21%), pulmonary (90% vs. 65%) and cutaneous involvement (44% vs. 23%) (all P < 0.0001), and hypercalcemia (8.5% vs. 2%, P = 0.014). Spleen/liver and gastrointestinal involvement were less frequent in the osseous sarcoidosis group (29% vs. 45%, and 1% vs. 17%, respectively, P < 0.0001). Response rates to with glucocorticoids alone, glucocorticoids plus methotrexate or glucocorticoids plus hydroxychloroquine were 23/44 (52%), 9/13 (69%) and 4/6 (67%), respectively.Conclusion: In patients with osseous sarcoidosis the spine and pelvis were the most commonly affected bones. Compared with controls, cases with osseous sarcoidosis have higher rates of thoracic and extra-thoracic lymph node involvement, pulmonary and cutaneous involvement, and hypercalcemia. Most patients with osseous sarcoidosis had a good response to glucocorticoids in combination with methotrexate or hydroxychloroquine.
Published: 2019

19. Risk of thromboembolic events in patients treated with thalidomide for cutaneous lupus erythematosus: A multicenter retrospective study

Author: Cesbron, Elise, Bessis, Didier, Jachiet, Marie, Lipsker, Dan, Cordel, Nadège, Bouaziz, Jean-David, Bagot, Martine, Arnaud, Laurent, Barbaud, Annick, Francès, Camille, chasset, françois, Étude des Maladies Systémiques en Dermatologie, EMSED, Service de dermatologie et allergologie [CHU Tenon], CHU Tenon [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Sorbonne Université (SU), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Pathogénèse et contrôle des infections chroniques (PCCI), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-Centre Hospitalier Universitaire de Montpellier (CHU Montpellier ), Service de Dermatologie [AP-HP Hôpital Saint-Louis], Hopital Saint-Louis [AP-HP] (AP-HP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Université Paris Diderot - Paris 7 (UPD7), CHU Strasbourg, Université de Strasbourg (UNISTRA), CHU Pointe-à-Pitre/Abymes [Guadeloupe], Université des Antilles (Pôle Guadeloupe), Université des Antilles (UA), Physiopathologie, Autoimmunité, maladies Neuromusculaires et THErapies Régénératrices (PANTHER), Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service de rhumatologie [Strasbourg], CHU Strasbourg-Hôpital de Hautepierre [Strasbourg], Immuno-Rhumatologie Moléculaire, and Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM)
Subjects: Adult, Male, medicine.medical_specialty, Dermatology, Risk Assessment, Severity of Illness Index, Drug Administration Schedule, Cohort Studies, Hospitals, University, 030207 dermatology & venereal diseases, 03 medical and health sciences, 0302 clinical medicine, Age Distribution, Thromboembolism, Severity of illness, Lupus Erythematosus, Cutaneous, Medicine, Humans, Sex Distribution, Survival rate, ComputingMilieux_MISCELLANEOUS, Aged, Retrospective Studies, 030203 arthritis & rheumatology, Lupus erythematosus, Dose-Response Relationship, Drug, business.industry, Incidence (epidemiology), Incidence, Retrospective cohort study, Middle Aged, medicine.disease, 3. Good health, Thalidomide, Survival Rate, Female, France, business, Risk assessment, Immunosuppressive Agents, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology, Cohort study, medicine.drug, Follow-Up Studies
Abstract: International audience
Published: 2018

20. All-Polarization-Maintaining One- and Two-Stage Holmium-doped Fiber Amplifiers at 2051 nm

Author: Robert E. Tench, Arnaud Laurent, Benoit Cadier, Thierry Robin, Jean-Marc Delavaux, Clément Romano, Télécommunications Optiques (GTO), Laboratoire Traitement et Communication de l'Information (LTCI), Institut Mines-Télécom [Paris] (IMT)-Télécom Paris-Institut Mines-Télécom [Paris] (IMT)-Télécom Paris, Département Communications & Electronique (COMELEC), Télécom ParisTech, and HAL, TelecomParis
Subjects: Materials science, [SPI.OPTI] Engineering Sciences [physics]/Optics / Photonic, business.industry, Slope efficiency, chemistry.chemical_element, 02 engineering and technology, 021001 nanoscience & nanotechnology, Polarization (waves), 01 natural sciences, Multiplexer, 010309 optics, Erbium doped fiber amplifier, Thulium, chemistry, 0103 physical sciences, Fiber amplifier, [SPI.OPTI]Engineering Sciences [physics]/Optics / Photonic, Optical noise, Optoelectronics, Optical fiber lasers, 0210 nano-technology, business, Holmium, ComputingMilieux_MISCELLANEOUS
Abstract: We report the performance of one- and two-stage single clad polarization-maintaining (PM) Ho-doped fiber amplifiers (HDFAs) at λ s = 2051 nm, pumped at λ p ≈ 1950 nm. We show that the Ho-doped fiber has a slope efficiency η = 70 %, and demonstrate an output power P out of 3.5 W and a gain G = 43 dB.
Published: 2018

21. X-rays, γ-rays, electrons and protons radiation-induced changes on the lifetimes of Er 3+ and Yb 3+ ions in silica-based optical fibers

Author: Ayoub Ladaci, Sylvain Girard, Diego Di Francesca, Adriana Morana, Mathieu Boutillier, Aziz Boukenter, Youcef Ouerdane, Arnaud Laurent, Benoit Cadier, Luciano Mescia, Thierry Robin, Laboratoire Hubert Curien [Saint Etienne] (LHC), Institut d'Optique Graduate School (IOGS)-Université Jean Monnet [Saint-Étienne] (UJM)-Centre National de la Recherche Scientifique (CNRS), iXBlue Photonics, Politecnico di Bari, and Centre National d’Études Spatiales [Paris] (CNES)
Subjects: Ytterbium, spectroscopy, Fiber amplifier, Optical fiber, Materials science, Biophysics, Analytical chemistry, chemistry.chemical_element, 02 engineering and technology, Radiation, Biochemistry, law.invention, Ion, Erbium, [SPI]Engineering Sciences [physics], 020210 optoelectronics & photonics, law, 0202 electrical engineering, electronic engineering, information engineering, Fiber, Irradiation, Radiation induced attenuation, General Chemistry, 021001 nanoscience & nanotechnology, Condensed Matter Physics, Atomic and Molecular Physics, and Optics, chemistry, 13. Climate action, Rare Earth, Fiber amplifier, Rare Earth, Radiation induced attenuation, spectroscopy, 0210 nano-technology, Luminescence
Abstract: International audience; The evolution of Ytterbium 2F5/2 and Erbium 4I13/2 energy level lifetimes versus doses of various radiation types (40 keV X-rays, 480 MeV protons, 1.2 MeV γ-rays and 6 MeV electrons) were investigated on samples of silica-based Rare-Earth Doped optical Fibers (REDFs). For each studied sample (Er-doped and Er/Yb-doped), a strong dependence of the lifetime value on the irradiation dose (for equivalent doses ranging from 10 Gy(SiO2) to 10 MGy(SiO2)) is observed regardless of the radiation nature. For both fiber types and luminescent ions, complex dose dependences are observed: a limited decrease of the lifetime at the lower doses, whereas a large reduction is reported at doses exceeding 100 kGy(SiO2). The results highlighted the vulnerability of REDF based systems, such as optical amplifiers and sources, for space and nuclear applications. In such harsh environments, Radiation Induced Attenuation (RIA) is also a key issue. The positive effect of Ce co-doping on both the RIA and the lifetimes is reported even at the highest dose of 10 MGy(SiO2). The basic mechanisms involved during the interaction between radiation and fiber material were also investigated through low temperature spectroscopic measurements that revealed the fundamental role of radiation-induced point defects.
Published: 2018

22. Modèles mathématiques à base de flots pour le RCPSP multi-site

Author: Arnaud Laurent, Laurent Deroussi, Nathalie Grangeon, Sylvie Norre, Laboratoire d'Informatique, de Modélisation et d'optimisation des Systèmes (LIMOS), SIGMA Clermont (SIGMA Clermont)-Université d'Auvergne - Clermont-Ferrand I (UdA)-Ecole Nationale Supérieure des Mines de St Etienne-Centre National de la Recherche Scientifique (CNRS)-Université Blaise Pascal - Clermont-Ferrand 2 (UBP), Université Blaise Pascal - Clermont-Ferrand 2 (UBP)-Université d'Auvergne - Clermont-Ferrand I (UdA)-SIGMA Clermont (SIGMA Clermont)-Ecole Nationale Supérieure des Mines de St Etienne (ENSM ST-ETIENNE)-Centre National de la Recherche Scientifique (CNRS), and Grangeon, Nathalie
Subjects: [INFO.INFO-RO] Computer Science [cs]/Operations Research [cs.RO], [INFO]Computer Science [cs], [INFO.INFO-RO]Computer Science [cs]/Operations Research [cs.RO], [INFO] Computer Science [cs]
Abstract: International audience; Le Resource-Constrained Project Scheduling Problem (RCPSP) a pour but d'ordonnancer un ensemble de tâches nécessitant des ressources pour s'exécuter. Ces tâches peuvent être liées par des contraintes de précédence. L'extension du RCPSP multi-site ajoute au problème un contexte multi-site avec le choix du lieu d'exécution pour les tâches. Chaque couple de sites est séparé par un temps de déplacement. Une tâche a obligatoirement besoin d'un site pour être exécutée. Une ressource est soit mobile, soit fixe. Les ressources mobiles peuvent se déplacer d'un site à l'autre. Les ressources fixes sont affectées à un site de référence. Les ressources mobiles sont sujettes à des temps de déplacement dans le cas où elles doivent exécuter successivement deux tâches sur deux sites différents. Ce temps s'applique aussi s'il existe une contrainte de précédence entre deux tâches qui ne sont pas réalisées sur le même site. L'objectif est d'affecter les tâches sur les sites, de les ordonnancer et de déterminer quelles ressources doivent les exécuter. Nous avons rencontré ce problème en étudiant la mutualisation des ressources dans les groupements hospitaliers de territoire. Ce problème peut trouver des applications dans un contexte industriel (emplois du temps ou gestion de projet multi-site).
Published: 2018

23. Factors Associated with Specific Quality of Life Evolution in SLE Patients: A French Prospective Longitudinal Multicenter Study

Author: Devilliers, Hervé, Corneloup, Marie, Maurier, François, Wahl, Denis, Muller, Géraldine, Aumaître, Olivier, Seve, Pascal, Blaison, Gilles, Pennaforte, Jean-Loup, Martin, Thierry, Magy, Nadine, Berthier, Sabine, Arnaud, Laurent, Bourredjem, Abderrahmane, Amoura, Zahir, Service de Médecine Interne (SOC 1 et SOC 2) [CHU de Dijon], Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon), CHU Dijon, Centre d'Investigation Clinique 1432 (Dijon) - Epidemiologie Clinique/Essais Cliniques (CIC-EC), Université de Bourgogne (UB)-Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service de médecine interne [HPMetz], Hôpitaux Privés de Metz (HPMetz), Défaillance Cardiovasculaire Aiguë et Chronique (DCAC), Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL), Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), Hôpital Européen Georges Pompidou [APHP] (HEGP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO), Service de médecine interne [CHU Pitié-Salpétrière], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU), Service de Médecine Interne [Hôpital Croix Rousse, CHU Lyon], CHU Lyon-Hôpital de la Croix-Rousse [CHU - HCL], Hospices Civils de Lyon (HCL)-Hospices Civils de Lyon (HCL), Service de Médecine Interne - Hôpital général de Colmar, Département de Médecine Interne, Immunologie clinique et maladies infectieuses [CHU Reims], Université de Reims Champagne-Ardenne (URCA)-Centre Hospitalier Universitaire de Reims (CHU Reims), CHU Strasbourg, Département de Médecine Interne et Immunologie Clinique (DMIIC - STRASBOURG), Institut de biologie moléculaire et cellulaire (IBMC), Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), Service de médecine interne (Med Int - BESANCON), Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon), Service de médecine interne et immunologie clinique (SOC 1) [CHU de Dijon], Karolinska Institutet, Department of Rheumatology, Karolinska University Hospital [Stockholm], Sorbonne Université (SU), and université de Bourgogne, LNC
Subjects: [SDV.MHEP.RSOA] Life Sciences [q-bio]/Human health and pathology/Rhumatology and musculoskeletal system, [SDV.MHEP.RSOA]Life Sciences [q-bio]/Human health and pathology/Rhumatology and musculoskeletal system
Abstract: IF 7.879; International audience
Published: 2018

24. Radiation hardened high-power Er 3+ /Yb 3+ -codoped fiber amplifiers for free-space optical communications

Author: Adriana Morana, Aziz Boukenter, Carine Ranger, Youcef Ouerdane, Baidy Sane, Benoit Cadier, Arnaud Laurent, Emmanuel Marin, Ayoub Ladaci, Thierry Robin, Sylvain Girard, Mathieu Boutillier, Luciano Mescia, David Kermen, Laboratoire Hubert Curien [Saint Etienne] (LHC), Institut d'Optique Graduate School (IOGS)-Université Jean Monnet [Saint-Étienne] (UJM)-Centre National de la Recherche Scientifique (CNRS), Politecnico di Bari, iXBlue Photonics, and Centre National d’Études Spatiales [Paris] (CNES)
Subjects: Rare earth-doped materials, Free-space optical communication, Materials science, Optical communication, chemistry.chemical_element, 02 engineering and technology, Radiation, 01 natural sciences, Signal, 010309 optics, Erbium, [SPI]Engineering Sciences [physics], Optics, 0103 physical sciences, Irradiation, Optical amplifier, Fiber devices and optical amplifiers, Fiber optics sensors, business.industry, 021001 nanoscience & nanotechnology, Atomic and Molecular Physics, and Optics, chemistry, Transceiver, 0210 nano-technology, business
Abstract: International audience; The radiation responses of different high-power erbium/ytterbium-codoped fiber amplifiers (HP-EYDFA) have been investigated up to 100 krad (SiO2) dose levels. These devices are able to deliver 20 W of signal output power at 1565 nm by pumping at 915 nm (43 W) radiation tolerant (Er/Yb) or radiation hardened (ErYbCe) active few mode fibers; these performances are needed for free-space communications between low-orbit satellites and ground transceivers. X-ray irradiation results show that, thanks to a positive influence of the photo- and thermal-bleaching phenomena associated with such high-power operating conditions, the gain degradation levels of HP-EYDFA based on radiation hardened fibers remain below 6% after 100 krad at an accelerated dose rate of 3.4 rad/s.
Published: 2018

25. Numerical experiments on vapor diffusion in polar snow and firn and its impact on isotopes using the multi-layer energy balance model Crocus in SURFEX v8.0

Author: Touzeau, Alexandra, Landais, Amaëlle, Morin, Samuel, Arnaud, Laurent, Picard, Ghislain, Laboratoire des Sciences du Climat et de l'Environnement [Gif-sur-Yvette] (LSCE), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Glaces et Continents, Climats et Isotopes Stables (GLACCIOS), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Météo-France Direction Interrégionale Sud-Est (DIRSE), Météo-France, Institut des Géosciences de l’Environnement (IGE), Institut de Recherche pour le Développement (IRD)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Météo France, Université Grenoble Alpes (UGA)-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Institut de Recherche pour le Développement (IRD)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP ), and Université Grenoble Alpes (UGA)
Subjects: lcsh:Geology, [SDU.OCEAN]Sciences of the Universe [physics]/Ocean, Atmosphere, lcsh:QE1-996.5, [SDU.ENVI]Sciences of the Universe [physics]/Continental interfaces, environment, human activities
Abstract: To evaluate the impact of vapor diffusion on isotopic composition variations in snow pits and then in ice cores, we introduced water isotopes in the detailed snowpack model Crocus. At each step and for each snow layer, (1) the initial isotopic composition of vapor is taken at equilibrium with the solid phase, (2) a kinetic fractionation is applied during transport, and (3) vapor is condensed or snow is sublimated to compensate for deviation to vapor pressure at saturation.We study the different effects of temperature gradient, compaction, wind compaction, and precipitation on the final vertical isotopic profiles. We also run complete simulations of vapor diffusion along isotopic gradients and of vapor diffusion driven by temperature gradients at GRIP, Greenland and at Dome C, Antarctica over periods of 1 or 10 years. The vapor diffusion tends to smooth the original seasonal signal, with an attenuation of 7 to 12 % of the original signal over 10 years at GRIP. This is smaller than the observed attenuation in ice cores, indicating that the model attenuation due to diffusion is underestimated or that other processes, such as ventilation, influence attenuation. At Dome C, the attenuation is stronger (18 %), probably because of the lower accumulation and stronger δ18O gradients.
Published: 2018

26. Long-term efficacy and safety of antitumour necrosis factor alpha treatment in rhupus: an open-label study of 15 patients

Author: Danion, François, Sparsa, Laëtitia, Arnaud, Laurent, Alsaleh, Ghada, Lefebvre, François, Gies, Vincent, Martin, Thierry, Lukas, Cédric, Durckel, Jean, Ardizzone, Marc, Javier, Rose-Marie, Kleinmann, Jean-François, Moreau, Paul, Blaison, Gilles, Goetz, Joëlle, Chatelus, Emmanuel, Gottenberg, Jacques-Eric, Sibilia, Jean, Sordet, Christelle, Kleinmann, François, Service de rhumatologie [Strasbourg], CHU Strasbourg-Hôpital de Hautepierre [Strasbourg], Département de Rhumatologie, Hôpitaux Universitaires de Strasbourg, Centre Hospitalier de Mulhouse (Service de Rhumatologie), Centre Hospitalier Emile Muller [Mulhouse] (CH E.Muller Mulhouse), Groupe Hospitalier de Territoire Haute Alsace (GHTHA)-Groupe Hospitalier de Territoire Haute Alsace (GHTHA), Fédération de Médecine Translationnelle de Strasbourg (FMTS), Université de Strasbourg (UNISTRA), Immuno-Rhumatologie Moléculaire, Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM), Les Hôpitaux Universitaires de Strasbourg (HUS), Département de Santé Publique [Hôpitaux Universitaires de Strasbourg] (HUS), Immunopathologie et chimie thérapeutique (ICT), Institut de biologie moléculaire et cellulaire (IBMC), Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS), Département de Médecine Interne et Immunologie Clinique (DMIIC - STRASBOURG), CHU Strasbourg, Département de Rhumatologie[Montpellier], Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Hôpital Lapeyronie, Les Hôptaux universitaires de Strasbourg (HUS), Hôpital pasteur [Colmar], Central Laboratory of Immunology, Rhumatologie, Lissalde, Claire, Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Strasbourg (UNISTRA), Centre National de la Recherche Scientifique (CNRS)-Institut de biologie moléculaire et cellulaire (IBMC), and Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS)
Subjects: rheumatoid arthritis, medicine.medical_specialty, Necrosis, [SDV.IMM] Life Sciences [q-bio]/Immunology, Immunology, Alpha (ethology), Arthritis, anti-tnf, Sciences du Vivant [q-bio]/Médecine humaine et pathologie, Gastroenterology, Etanercept, 03 medical and health sciences, 0302 clinical medicine, Rheumatology, Open label study, systemic lupus erythematosus, Prednisone, Internal medicine, medicine, Adalimumab, Immunology and Allergy, Connective Tissue Diseases, skin and connective tissue diseases, 030203 arthritis & rheumatology, [SDV.MHEP.RSOA] Life Sciences [q-bio]/Human health and pathology/Rhumatology and musculoskeletal system, treatment, business.industry, medicine.disease, das28, [SDV.MHEP.RSOA]Life Sciences [q-bio]/Human health and pathology/Rhumatology and musculoskeletal system, Rheumatoid arthritis, [SDV.IMM]Life Sciences [q-bio]/Immunology, medicine.symptom, business, 030215 immunology, medicine.drug
Abstract: Background The efficacy of antitumour necrosis factor alpha (anti-TNF-α) treatment is well recognised in rheumatoid arthritis (RA) but remains controversial in systemic lupus erythematosus (SLE). Therefore, the role of anti-TNF-α treatment in ‘Rhupus’, a disease sharing features of RA and SLE, is still debated. Objective To evaluate the efficacy and tolerance of anti-TNF-α in patients with rhupus. Methods Fifteen patients with rhupus with Disease Activity Score 28 (DAS 28) >3.2 despite conventional disease-modifying anti-rheumatic drugs were included in an open-label study. Patients were monitored at months (M) 3, 6, 12, 24 and 60 with SLE Disease Activity Index (SLEDAI) and DAS 28. Statistical analyses were performed using Bayesian methods and Prob >97.5% was considered significant. Results Twelve patients were treated with etanercept for a median duration of 62.5 (range: 6–112) months and three patients by adalimumab during 36.0 (range: 4–52) months. At baseline, median DAS 28 and SLEDAI were 5.94 (4.83–8.09) and 6 (4–8), respectively. DAS 28 and SLEDAI decreased significantly after 3 months, respectively, to 3.70 (1.80–6.42) and 4 (0–6) (Prob >99.9%, for both). These changes persisted at M6, M12, M24 and M60 (Prob >99.9%, for all). Median prednisone dose decreased significantly from 15 (5–35) mg/day to 5 (0–20) mg/day after 6 months and over the follow-up (Prob >99.9%, for all). Tolerance was acceptable, with a severe infection rate of 3.0 per 100 patient-years. Conclusion This pilot study suggests that anti-TNF-α is effective in patients with rhupus with refractive arthritis and has an acceptable safety profile. journal article 2017 2017 12 29 imported
Published: 2017

27. A new extension of the RCPSP in a multi-site context: Mathematical model and metaheuristics

Author: Nathalie Grangeon, Sylvie Norre, Laurent Deroussi, Arnaud Laurent, Laboratoire d'Informatique, de Modélisation et d'Optimisation des Systèmes (LIMOS), Ecole Nationale Supérieure des Mines de St Etienne (ENSM ST-ETIENNE)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'Informatique, de Modélisation et d'optimisation des Systèmes (LIMOS), Université Blaise Pascal - Clermont-Ferrand 2 (UBP)-Université d'Auvergne - Clermont-Ferrand I (UdA)-SIGMA Clermont (SIGMA Clermont)-Ecole Nationale Supérieure des Mines de St Etienne (ENSM ST-ETIENNE)-Centre National de la Recherche Scientifique (CNRS), Ecole Nationale Supérieure des Mines de St Etienne-Centre National de la Recherche Scientifique (CNRS)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020]), and SIGMA Clermont (SIGMA Clermont)-Université d'Auvergne - Clermont-Ferrand I (UdA)-Ecole Nationale Supérieure des Mines de St Etienne-Centre National de la Recherche Scientifique (CNRS)-Université Blaise Pascal - Clermont-Ferrand 2 (UBP)
Subjects: Mathematical optimization, General Computer Science, Linear programming, Iterated local search, Computer science, Resource pooling, Pooling, 0211 other engineering and technologies, Metaheuristic, 02 engineering and technology, Scheduling (computing), 0202 electrical engineering, electronic engineering, information engineering, Local search (optimization), Transportation time, Multi-Site, 021103 operations research, RCPSP, business.industry, Scheduling, General Engineering, Multi site, [INFO.INFO-RO]Computer Science [cs]/Operations Research [cs.RO], Simulated annealing, 020201 artificial intelligence & image processing, business
Abstract: International audience; This article proposes an extension of the Resource Constrained Project Scheduling Problem: the multi-site RCPSP with resource pooling between several sites. This extension considers new constraints for the RCPSP like transportation times and choice of the site where tasks are performed. A linear program of this problem is given. Four approximate methods are described: Local Search, Simulated Annealing and Iterated Local Search with two different acceptance criteria: Simulated Annealing type acceptance criterion and Better Walk acceptance criterion. We compare the results obtained with each method. The best results are obtained with Simulated Annealing and Iterated Local Search metaheuristics.
Published: 2017

28. Modèle mathématique et métaheuristiques pour un problème de mutualisation de ressources en contexte hospitalier

Author: Sylvie Norre, Nathalie Grangeon, Arnaud Laurent, Laurent Deroussi, Laboratoire d'Informatique, de Modélisation et d'optimisation des Systèmes (LIMOS), SIGMA Clermont (SIGMA Clermont)-Université d'Auvergne - Clermont-Ferrand I (UdA)-Ecole Nationale Supérieure des Mines de St Etienne-Centre National de la Recherche Scientifique (CNRS)-Université Blaise Pascal - Clermont-Ferrand 2 (UBP), Grangeon, Nathalie, and Université Blaise Pascal - Clermont-Ferrand 2 (UBP)-Université d'Auvergne - Clermont-Ferrand I (UdA)-SIGMA Clermont (SIGMA Clermont)-Ecole Nationale Supérieure des Mines de St Etienne (ENSM ST-ETIENNE)-Centre National de la Recherche Scientifique (CNRS)
Subjects: [INFO.INFO-RO] Computer Science [cs]/Operations Research [cs.RO], Control and Systems Engineering, [INFO.INFO-RO]Computer Science [cs]/Operations Research [cs.RO], Electrical and Electronic Engineering, Industrial and Manufacturing Engineering, ComputingMilieux_MISCELLANEOUS, Computer Science Applications
Abstract: International audience
Published: 2016

29. Radiation-resistant rare-earth-doped optical fiber and method of radiation-hardening a rare-earth-doped optical fiber

Author: Cadier, Benoît, Arnaud, Laurent, Robin, Thierry, Girard, Sylvain, Marcandella, Claude, IxFiber SAS (IxFiber), industriel, Laboratoire Hubert Curien (LHC), Institut d'Optique Graduate School (IOGS)-Université Jean Monnet - Saint-Étienne (UJM)-Centre National de la Recherche Scientifique (CNRS), DAM Île-de-France (DAM/DIF), Direction des Applications Militaires (DAM), and Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)
Subjects: [SPI]Engineering Sciences [physics]
Published: 2015

30. MATHEMATICAL FORMULATION AND APPROXIMATE METHODS FOR AN EXTENSION OF THE RCPSP : THE MULTI-SITE RCPSP

Author: Arnaud Laurent, Nathalie Grangeon, Laurent Deroussi, Sylvie Norre, Laboratoire d'Informatique, de Modélisation et d'Optimisation des Systèmes (LIMOS), Ecole Nationale Supérieure des Mines de St Etienne-Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-Centre National de la Recherche Scientifique (CNRS), Grangeon, Nathalie, and Ecole Nationale Supérieure des Mines de St Etienne (ENSM ST-ETIENNE)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-Centre National de la Recherche Scientifique (CNRS)
Subjects: RCPSP, [INFO.INFO-RO] Computer Science [cs]/Operations Research [cs.RO], Scheduling, Resource pooling, Metaheuristic, Transportation time, [INFO.INFO-RO]Computer Science [cs]/Operations Research [cs.RO], Multi-Site
Abstract: International audience; This article proposes an extension of the Resource Constrained Project Scheduling Problem: the Multi-Site RCPSP with resource pooling between several sites. This extension considers new constraints for the RCPSP like transportation times and choice of the site where tasks are performed. A linear program of this problem is given. Four approximate methods are described: local search, simulated annealing and Iterated Local Searches with two different acceptance criteria: Simulated Annealing type acceptance criterion and Better Walk acceptance criterion. We compare the results obtained with each method. Simulated Annealing and Iterated Local Searches give good results.
Published: 2015

31. Proton irradiation response of Hole-Assisted Carbon Coated Erbium-Doped Fiber Amplifiers

Author: Claude Marcandella, P. Paillet, Mathieu Boutillier, Marc Gaillardin, Melanie Raine, Aziz Boukenter, Diego Di Francesca, Sylvain Girard, Ayoub Ladaci, Arnaud Laurent, Benoit Cadier, Emmanuel Pinsard, Olivier Duhamel, Thierry Robin, Youcef Ouerdane, Laboratoire Hubert Curien [Saint Etienne] (LHC), Université Jean Monnet [Saint-Étienne] (UJM)-Centre National de la Recherche Scientifique (CNRS)-Institut d'Optique Graduate School (IOGS), IxFiber SAS (IxFiber), industriel, DAM Île-de-France (DAM/DIF), Direction des Applications Militaires (DAM), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Centre National d'Études Spatiales [Toulouse] (CNES), Laboratoire Hubert Curien (LHC), and Institut d'Optique Graduate School (IOGS)-Université Jean Monnet - Saint-Étienne (UJM)-Centre National de la Recherche Scientifique (CNRS)
Subjects: Nuclear and High Energy Physics, Materials science, Optical fiber, 02 engineering and technology, Radiation, 7. Clean energy, 01 natural sciences, Fluence, law.invention, [SPI]Engineering Sciences [physics], 020210 optoelectronics & photonics, Optics, law, 0103 physical sciences, 0202 electrical engineering, electronic engineering, information engineering, Fiber, Irradiation, Electrical and Electronic Engineering, Optical amplifier, 010308 nuclear & particles physics, business.industry, Doping, Core (optical fiber), Nuclear Energy and Engineering, Optoelectronics, business
Abstract: International audience; We investigated the behavior of a new class of erbium-doped fiber amplifier (EDFA) when exposed to 63 MeV protons. The EDFA is designed with a radiation hardened hole-assisted carbon coated (HACC) Er3 + -doped optical fiber. The particular structure of this HACC fiber allows to permanently incorporate an optimal amount of D2 or H2 gases into its core, reducing its radiation sensitivity without degrading the EDFA performances. Irradiations up to a fluence of 7.5 ×1011 p/cm2 confirm the excellent tolerance of this HACC-EDFA component. It exhibits a limited decrease of ~ 0.6 dB of its ~ 27 dB gain for this fluence corresponding to an ionization dose of 100 krad(Si). Such a device can then survive to the radiative environments associated with both today's space missions and future more challenging applications.
Published: 2014

32. Radiation-hard erbium optical fiber and fiber amplifier for both low- and high-dose space missions

Author: Emmanuel Pinsard, Mathieu Boutillier, Youcef Ouerdane, Sylvain Girard, Aziz Boukenter, Thierry Robin, Benoit Cadier, Arnaud Laurent, Claude Marcandella, Laboratoire Hubert Curien (LHC), Institut d'Optique Graduate School (IOGS)-Université Jean Monnet - Saint-Étienne (UJM)-Centre National de la Recherche Scientifique (CNRS), IxFiber SAS (IxFiber), industriel, Centre National d'Études Spatiales [Toulouse] (CNES), Département de Conception et Réalisation des Experimentations, CEA-DIF (DCRE CEA), Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Laboratoire Hubert Curien [Saint Etienne] (LHC), and Institut d'Optique Graduate School (IOGS)-Université Jean Monnet [Saint-Étienne] (UJM)-Centre National de la Recherche Scientifique (CNRS)
Subjects: Optical fiber, Materials science, chemistry.chemical_element, 02 engineering and technology, Radiation, 7. Clean energy, 01 natural sciences, Space exploration, law.invention, 010309 optics, Erbium, 020210 optoelectronics & photonics, Optics, Fiber optics amplifiers and oscillators, law, 0103 physical sciences, 0202 electrical engineering, electronic engineering, information engineering, Fiber, Optical amplifier, [PHYS.PHYS.PHYS-OPTICS]Physics [physics]/Physics [physics]/Optics [physics.optics], business.industry, Amplifier, (060.2320) Fiber optics amplifiers and oscillators, (350.5610) Radiation, (120.6085) Space instrumentation, (060.2410) Fibers, erbium, Atomic and Molecular Physics, and Optics, Core (optical fiber), erbium, Fibers, Space instrumentation, chemistry, Optoelectronics, business
Abstract: International audience; We present a new structure for erbium-doped optical fibers [hole-assisted carbon-coated, (HACC)] that, combined with an appropriate choice of codopants in the core, strongly enhances their radiation tolerance. We built an erbium doped fiber amplifier based on this HACC fiber and characterize its degradation under γ-ray doses up to 315 krad(SiO2) in the ON mode. The 31 dB amplifier is practically radiation insensitive, with a gain change of merely −2.2 × 10−3 dB∕krad. These performances authorize the use of HACC doped fibers and amplifiers for various applications in environments associated with today's missions (of doses up to 50 krad) and even for future space missions associated with higher dose constraints.
Published: 2014

33. RCPSP multi-sites - Application à une CHT

Author: Arnaud Laurent, Laurent Deroussi, Nathalie Grangeon, Sylvie Norre, Laboratoire d'Informatique, de Modélisation et d'optimisation des Systèmes (LIMOS), Université Blaise Pascal - Clermont-Ferrand 2 (UBP)-Université d'Auvergne - Clermont-Ferrand I (UdA)-SIGMA Clermont (SIGMA Clermont)-Ecole Nationale Supérieure des Mines de St Etienne (ENSM ST-ETIENNE)-Centre National de la Recherche Scientifique (CNRS), Société française de recherche opérationnelle et d'aide à la décision, Courbin-Coulaud, Martine, and SIGMA Clermont (SIGMA Clermont)-Université d'Auvergne - Clermont-Ferrand I (UdA)-Ecole Nationale Supérieure des Mines de St Etienne-Centre National de la Recherche Scientifique (CNRS)-Université Blaise Pascal - Clermont-Ferrand 2 (UBP)
Subjects: [INFO.INFO-RO] Computer Science [cs]/Operations Research [cs.RO], heuristiques rcpsp PLNE multisites CHT, Méta, [INFO.INFO-RO]Computer Science [cs]/Operations Research [cs.RO]
Abstract: International audience; Une Communauté Hospitalière de Territoire (CHT) est une association de plusieurs hôpitaux publics distants (sites) qui mettent en commun leurs ressources humaines et matérielles afin d'améliorer l'offre de soin locale. La mutualisation des ressources amène ces structures à se doter d'outils d'aide à la décision spécifiques pour la planification des activités de soins. Le problème est le suivant : les patients doivent recevoir un ou plusieurs examens (radio, scanner, IRM, ...). L'objectif est de les ordonnancer sur les sites de manière à optimiser un certain nombre de critères (coût, temps d'attente, ...). Ce problème peut être identifié comme une extension du RCPSP que nous nommons RCPSP multi-sites. La principale originalité réside dans l'aspect multi-sites du problème. Certaines ressources sont fixes, le lieu d'exécution des tâches va donc dépendre des ressources utilisées. Un temps d'attente entre deux activités reliées par une contrainte de précédence réalisées sur deux sites différents modélise le déplacement d'un patient. Quant à un déplacement de ressources, il est modélisé par un temps d'attente entre deux activités réalisées successivement par une même ressource sur deux sites distincts. Des contraintes spécifiques sont également ajoutées au modèle de base du RCPSP telles que les incompatibilités entre ressources, et entre les ressources et les tâches. Une modélisation mathématique linéaire du problème est réalisée. Ce modèle est résolu à l'aide du logiciel CPLEX pour des instances de petite taille. Afin de traiter des instances de taille réelle, des méta-heuristiques à individus sont proposées. Les premiers résultats sont encourageants
Published: 2014

34. Radiation-hardened Erbium-doped optical fibers and amplifiers for future high-dose space missions

Author: Thierry Robin, Claude Marcandella, Aziz Boukenter, Emmanuel Pinsard, Sylvain Girard, Y. Ouerdane, B. Cadier, Mathieu Boutillier, Arnaud Laurent, Laboratoire Hubert Curien [Saint Etienne] (LHC), Institut d'Optique Graduate School (IOGS)-Université Jean Monnet [Saint-Étienne] (UJM)-Centre National de la Recherche Scientifique (CNRS), IxFiber SAS (IxFiber), industriel, Centre National d'Études Spatiales [Toulouse] (CNES), DAM Île-de-France (DAM/DIF), Direction des Applications Militaires (DAM), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Laboratoire Hubert Curien (LHC), and Institut d'Optique Graduate School (IOGS)-Université Jean Monnet - Saint-Étienne (UJM)-Centre National de la Recherche Scientifique (CNRS)
Subjects: Optical amplifier, Materials science, Optical fiber, 010308 nuclear & particles physics, business.industry, Amplifier, chemistry.chemical_element, 02 engineering and technology, Radiation, 01 natural sciences, law.invention, Erbium, 020210 optoelectronics & photonics, Optics, chemistry, law, 0103 physical sciences, 0202 electrical engineering, electronic engineering, information engineering, [SPI.OPTI]Engineering Sciences [physics]/Optics / Photonic, Optoelectronics, Fiber, Irradiation, business, Radiation resistance
Abstract: We present a new class of Erbium-doped optical fibers: the Hole-Assisted Carbon-Coated, HACC fibers. Optical fibers with this particular structure have been made by iXFiber on the basis of an appropriate choice of codopants in their core and claddings. By using an additional pre-treatment with deuterium (D2) loading authorized by the HACC structure, we highlight the efficiency of such components and demonstrated that this new type of fiber presents a strongly enhanced radiation resistance compared to the other types of erbium-doped optical fibers studied in litterature. We also built an Erbium-doped Fiber Amplifier (EDFA) with one of these HACC fibers and compared its radiation response to the one of the same fiber composition but without the HACC structure and D2 loading. We tested the performances of this EDFA under Υ-rays and characterize its gain degradation up to doses of 315 krad. Before irradiation, the amplifier presents a gain of about 31 dB that is comparable to the optical performances of amplifiers based on HACC fibers without the D2 pre-treatment and the HACC structure. During irradiation, our results demonstrate that the tested amplifier is nearly unaffected by radiations. Its gain slowly decreases with the dose at a slope rate of about -2.2×10-3 dB/krad. This strong radiation resistance (enhancement of a factor of ×10 compared to the previous or conventional radiation tolerant EDFA) will authorize the use of HACC doped fibers and amplifiers for various applications in space for missions associated both with low or large irradiation doses.
Published: 2014

35. Acoustical Properties of Hemp Concretes (Book Chapter)

Author: Glé, Philippe, Gourdon, Emmanuel, Arnaud, Laurent, École Nationale des Travaux Publics de l'État (ENTPE), École Nationale des Travaux Publics de l'État (ENTPE)-Ministère de l'Ecologie, du Développement Durable, des Transports et du Logement, Laboratoire de Tribologie et Dynamique des Systèmes (LTDS), École Centrale de Lyon (ECL), and Université de Lyon-Université de Lyon-École Nationale des Travaux Publics de l'État (ENTPE)-Ecole Nationale d'Ingénieurs de Saint Etienne-Centre National de la Recherche Scientifique (CNRS)
Subjects: [SPI.ACOU]Engineering Sciences [physics]/Acoustics [physics.class-ph], ComputingMilieux_MISCELLANEOUS
Abstract: International audience
Published: 2013

36. Micro-spectromètre a ondes évanescentes

Author: Arnaud, Laurent, Hadjar, Yassine, Renault, Mickaël, Bruyant, Aurélien, Blaize, Sylvain, VU VAN, Jean-Baptiste, Laboratoire de Nanotechnologie et d'Instrumentation Optique (LNIO), Institut Charles Delaunay (ICD), and Université de Technologie de Troyes (UTT)-Centre National de la Recherche Scientifique (CNRS)-Université de Technologie de Troyes (UTT)-Centre National de la Recherche Scientifique (CNRS)
Subjects: [SPI.OPTI] Engineering Sciences [physics]/Optics / Photonic, [SPI.OPTI]Engineering Sciences [physics]/Optics / Photonic
Abstract: L'invention concerne un microspectromètre par ondes évanescentes comprenant : un dioptre plan (D) séparant deux milieux transparents, un capteur optique (30) comprenant un réseau de pixels, et disposé dans le deuxième milieu transparent (M2), et un dispositif d'interférences ((10, F1); (11, F1_1, F1_2)) disposé tel qu'une partie au moins dudit dispositif d'interférences soit au contact d'ondes évanescentes générées à la surface du dioptre. Il est essentiellement caractérisé en ce qu'il comprend aussi : une mémoire stockant une cartographie (40) comprenant un ensemble de grilles de données (41, 42, 43) comprenant la réponse optique dudit capteur (30) pour un ensemble de longueurs d'onde quasi monochromatiques d'une source lumineuse de calibration, et un calculateur (50) configuré pour déterminer le spectre ( ψ) d'une source lumineuse test configurée pour générer des ondes évanescentes à la surface dudit dioptre (D), en fonction de ladite cartographie (40) et de la réponse optique dudit capteur (30).
Published: 2013

37. On the modelling of the acoustical properties of hemp concrete

Author: GLÉ, Philippe, Horoshenkov, Kirill, Gourdon, Emmanuel, Arnaud, Laurent, Département génie civil et batiment (DGCB), ENTP, Société Française d'Acoustique, and System, HAL
Subjects: [SPI.ACOU]Engineering Sciences [physics]/Acoustics [physics.class-ph], [SPI.ACOU] Engineering Sciences [physics]/Acoustics [physics.class-ph], multiple porosity, hemp particles, particle size distribution
Abstract: International audience; Hemp concrete is an attractive alternative to traditional materials used in building construction. It has a very low environmental impact and it is characterized by high thermal insulation and sound absorption properties. The shape of hemp aggregates is parallelepiped and individual particles in a hemp mix can be organized in a plurality of ways. As a result, modeling of such material is quite complicated. This paper is focused on the fundamental understanding of the relations between the particle shape and size distribution and the acoustical properties of the resultant material mix. The sound absorption and the transmission loss of various hemp aggregates is characterized using laboratory experiments and three theoretical models. These models are used to relate the particle size distribution to the pore size distribution. It is shown that the pore size distribution is a main characteristic which controls the observed acoustical behavior.
Published: 2012

38. Radiation hardening techniques for Er/Yb doped optical fibers and amplifiers for space application

Author: Sylvain Girard, Aziz Boukenter, Thierry Robin, Arnaud Laurent, Youcef Ouerdane, Marilena Vivona, Emmanuel Pinsard, Claude Marcandella, Benoit Cadier, DAM Île-de-France (DAM/DIF), Direction des Applications Militaires (DAM), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Laboratoire Hubert Curien [Saint Etienne] (LHC), Institut d'Optique Graduate School (IOGS)-Université Jean Monnet [Saint-Étienne] (UJM)-Centre National de la Recherche Scientifique (CNRS), Dipartimento di Scienze Fisiche ed Astronomiche, Università di Palermo (DIPARTIMENTO DI SCIENZE FISICHE ED ASTRONOMICHE, UNIVERSITà DI PALERMO), Dipartimento di Scienze Università di Palermo, IxFiber SAS (IxFiber), industriel, Laboratoire Hubert Curien (LHC), Institut d'Optique Graduate School (IOGS)-Université Jean Monnet - Saint-Étienne (UJM)-Centre National de la Recherche Scientifique (CNRS), Università degli studi di Palermo - University of Palermo, and Université Jean Monnet [Saint-Étienne] (UJM)-Centre National de la Recherche Scientifique (CNRS)-Institut d'Optique Graduate School (IOGS)
Subjects: Ytterbium, Optical fiber, Materials science, chemistry.chemical_element, 02 engineering and technology, 01 natural sciences, law.invention, 010309 optics, Erbium, Optics, law, 0103 physical sciences, Fiber, Plastic optical fiber, Radiation hardening, Optical amplifier, [PHYS.PHYS.PHYS-OPTICS]Physics [physics]/Physics [physics]/Optics [physics.optics], business.industry, Amplifier, 021001 nanoscience & nanotechnology, Atomic and Molecular Physics, and Optics, chemistry, Optoelectronics, 060.2320) Fiber optics amplifiers and oscillators, (350.5610) Radiation, (160.2220) Defect-center materials, (060.2330) Fiber optics communications, 0210 nano-technology, business
Abstract: International audience; We investigated the efficiencies of two different approaches to increase the radiation hardness of optical amplifiers through development of improved rare-earth (RE) doped optical fibers. We demonstrated the efficiency of codoping with Cerium the core of Erbium/Ytterbium doped optical fibers to improve their radiation tolerance. We compared the g-rays induced degradation of two amplifiers with comparable pre-irradiation characteristics (~19 dB gain for an input power of ~10 dBm): first one is made with the standard core composition whereas the second one is Ce codoped. The radiation tolerance of the Ce-codoped fiber based amplifier is strongly enhanced. Its output gain decrease is limited to ~1.5 dB after a dose of ~900 Gy, independently of the pump power used, which authorizes the use of such fiber-based systems for challenging space missions associated with high total doses. We also showed that the responses of the two amplifiers with or without Ce-codoping can be further improved by another technique: the pre-loading of these fibers with hydrogen. In this case, the gain degradation is limited to 0.4 dB for the amplifier designed with the standard composition fiber whereas 0.2 dB are reported for the one made with Ce-codoped fiber after a cumulated dose of ~900 Gy. The mechanisms explaining the positive influences of these two treatments are discussed.
Published: 2012

39. Nanowire coupled to a waveguide for the characterization of the guided light

Author: Arnaud, Laurent, Apuzzo, Aniello, Salas-Montiel, Rafael, Renault, Mickaël, Hadjar, Yassine, Bruyant, Aurélien, Lerondel, Gilles, Blaize, Sylvain, Laboratoire de Nanotechnologie et d'Instrumentation Optique (LNIO), Institut Charles Delaunay (ICD), Université de Technologie de Troyes (UTT)-Centre National de la Recherche Scientifique (CNRS)-Université de Technologie de Troyes (UTT)-Centre National de la Recherche Scientifique (CNRS), Université de Rennes (UR), Université de Rennes (UNIV-RENNES), and VU VAN, Jean-Baptiste
Subjects: [SPI.OPTI] Engineering Sciences [physics]/Optics / Photonic, [SPI.OPTI]Engineering Sciences [physics]/Optics / Photonic, ComputingMilieux_MISCELLANEOUS
Abstract: International audience
Published: 2012

40. Gold nanowire coupled with waveguide for integrated sensing and spectroscopy

Author: Arnaud, Laurent, Bruyant, Aurélien, Renault, Mikael, Hadjar, Yassine, Lerondel, Gilles, Blaize, Sylvain, Laboratoire de Nanotechnologie et d'Instrumentation Optique (LNIO), Institut Charles Delaunay (ICD), Université de Technologie de Troyes (UTT)-Centre National de la Recherche Scientifique (CNRS)-Université de Technologie de Troyes (UTT)-Centre National de la Recherche Scientifique (CNRS), and VU VAN, Jean-Baptiste
Subjects: [SPI.OPTI] Engineering Sciences [physics]/Optics / Photonic, [SPI.OPTI]Engineering Sciences [physics]/Optics / Photonic, ComputingMilieux_MISCELLANEOUS
Abstract: International audience
Published: 2011

41. Des matières premières au béton de chanvre : optimisation des propriétés thermiques et mécaniques

Author: GOURLAY, Etienne, Arnaud, Laurent, Association Française de Mécanique, and Service irevues, irevues
Subjects: [PHYS.MECA]Physics [physics]/Mechanics [physics], [PHYS.MECA] Physics [physics]/Mechanics [physics]
Abstract: Colloque avec actes et comité de lecture. Internationale.; International audience; Le béton de chanvre est un matériau composite utilisé dans le domaine de la construction obtenu en mélangeant des particules de chanvre (la chènevotte) à un liant. Ce béton se caractérise par une porosité très importante (plus de 80% en volume) avec plusieurs tailles caractéristiques de pores. Le choix des matières premières permet de piloter la porosité du matériau et d'ainsi concevoir des formulations types optimisées en termes de propriétés thermiques et mécaniques pour la fabrication de bétons de chanvre répondant à des exigences précises.
Published: 2011

42. Diagramme de rayonnement d'un nanofil métallique en interaction avec un guide d'onde

Author: Arnaud, Laurent, Bruyant, Aurélien, Renault, Mikael, Hadjar, Yassine, Lerondel, Gilles, Royer, Pascal, Blaize, Sylvain, Laboratoire de Nanotechnologie et d'Instrumentation Optique (LNIO), Institut Charles Delaunay (ICD), Université de Technologie de Troyes (UTT)-Centre National de la Recherche Scientifique (CNRS)-Université de Technologie de Troyes (UTT)-Centre National de la Recherche Scientifique (CNRS), and VU VAN, Jean-Baptiste
Subjects: [SPI.OPTI] Engineering Sciences [physics]/Optics / Photonic, [SPI.OPTI]Engineering Sciences [physics]/Optics / Photonic, ComputingMilieux_MISCELLANEOUS
Abstract: International audience
Published: 2011

43. Radiation effects on fiber amplifiers: design of radiation tolerant Yb/Er-based devices

Author: Marilena Vivona, Aziz Boukenter, Claude Marcandella, Arnaud Laurent, Benoit Cadier, Youcef Ouerdane, Thierry Robin, Sylvain Girard, Direction des Applications Militaires (DAM), Commissariat à l'énergie atomique et aux énergies alternatives (CEA), IxFiber SAS (IxFiber), industriel, Laboratoire Hubert Curien (LHC), Institut d'Optique Graduate School (IOGS)-Université Jean Monnet - Saint-Étienne (UJM)-Centre National de la Recherche Scientifique (CNRS), and Università degli studi di Palermo - University of Palermo
Subjects: Ytterbium, [PHYS.PHYS.PHYS-OPTICS]Physics [physics]/Physics [physics]/Optics [physics.optics], Optical fiber, Materials science, optical fibers, business.industry, Amplifier, chemistry.chemical_element, ytterbium, Radiation, law.invention, Core (optical fiber), Erbium, erbium, Optics, chemistry, law, Fiber laser, radiation effects, amplifiers, Fiber, business
Abstract: International audience; Rare-earth doped optical fibers have been shown to be very sensitive to radiations, limiting the integration of fiber-based systems in space missions. In this paper, we present the characterization of two amplifiers based on a set of prototype active Erbium/Ytterbium codoped double clad fibers developed by Ixfiber SAS. One of these fibers has been codoped with cerium inside its core to enhance its radiation tolerance whereas the other is a classical phosphosilicate Er/Yb fiber. The two amplifiers based on these fibers have been exposed to γ-rays at a low dose rate (0.3 rad/s) and to doses up to 90 krad. Previous studies indicated that Er/Yb amplifiers using this type of fiber suffered significant degradation for cumulated dose above 5-10 krad. We observed, on the contrary, that with our radiation hardened fiber, the degradation of the fiber amplifier's output power can be limited to less than 30% after an exposure dose of ~90 krad.
Published: 2011

44. Evolution des paramètres acoustiques des bétons de chanvre sous l'effet du compactage

Author: Glé, Philippe, GOURDON, Emmanuel, Arnaud, Laurent, Service irevues, irevues, and Association Française de Mécanique
Subjects: [PHYS.MECA]Physics [physics]/Mechanics [physics], [PHYS.MECA] Physics [physics]/Mechanics [physics]
Abstract: Colloque avec actes et comité de lecture. Internationale.; International audience; Le béton de chanvre est un béton poreux qui apparaît aujourd'hui comme une alternative très intéressante aux matériaux traditionnellement utilisés dans le bâtiment. Afin de contrôler et d'optimiser son comportement acoustique, il est important de pouvoir prédire les performances de ce matériau en fonction des paramètres qui entrent en jeu lors de sa fabrication. Les travaux qui vont être présentés ont été réalisés afin de déterminer les relations qui existent entre les paramètres des modèles acoustiques et des paramètres intrinsèques aux constituants et au mode de fabrication utilisés.
Published: 2011

45. Model for infrared reflectivity reveals the effect of Ge amount on the interface state and the crystalline quality of the 3C-SiC/Ge/Si heterostructure

Author: Kazan, Michel, Bruyant, Aurélien, Royer, Pascal, Arnaud, Laurent, Couteau, Christophe, Lerondel, Gilles, Department of Physics, American University of Beirut [Beyrouth] (AUB), Laboratoire de Nanotechnologie et d'Instrumentation Optique (LNIO), Institut Charles Delaunay (ICD), and Université de Technologie de Troyes (UTT)-Centre National de la Recherche Scientifique (CNRS)-Université de Technologie de Troyes (UTT)-Centre National de la Recherche Scientifique (CNRS)
Subjects: [SPI.OPTI]Engineering Sciences [physics]/Optics / Photonic, ComputingMilieux_MISCELLANEOUS
Abstract: International audience
Published: 2010

46. Guided Wave in integrated optics with the use of metamaterial

Author: Arnaud, Laurent, Blaize, Sylvain, Bruyant, Aurélien, Vial, Alexandre, Lerondel, Gilles, Institut FRESNEL (FRESNEL), Centre National de la Recherche Scientifique (CNRS)-École Centrale de Marseille (ECM)-Aix Marseille Université (AMU), Laboratoire de Nanotechnologie et d'Instrumentation Optique (LNIO), Institut Charles Delaunay (ICD), Université de Technologie de Troyes (UTT)-Centre National de la Recherche Scientifique (CNRS)-Université de Technologie de Troyes (UTT)-Centre National de la Recherche Scientifique (CNRS), VU VAN, Jean-Baptiste, and Aix Marseille Université (AMU)-École Centrale de Marseille (ECM)-Centre National de la Recherche Scientifique (CNRS)
Subjects: [SPI.OPTI] Engineering Sciences [physics]/Optics / Photonic, [SPI.OPTI]Engineering Sciences [physics]/Optics / Photonic, ComputingMilieux_MISCELLANEOUS
Abstract: International audience
Published: 2010

47. Modélisation acoustique des matériaux du bâtiment à base de particules végétales et présentant plusieurs échelles de porosité

Author: Glé, Philippe, Gourdon, Emmanuel, Arnaud, Laurent, Département génie civil et batiment (ENTPE) (DGCB), École Nationale des Travaux Publics de l'État (ENTPE)-Centre National de la Recherche Scientifique (CNRS), Société Française d'Acoustique - SFA, and Leclere, Quentin
Subjects: [SPI.ACOU]Engineering Sciences [physics]/Acoustics [physics.class-ph], [SPI.ACOU] Engineering Sciences [physics]/Acoustics [physics.class-ph], Porosité multi-echelle, Particules végétales, [PHYS.MECA.ACOU] Physics [physics]/Mechanics [physics]/Acoustics [physics.class-ph], Absorption acoustique, Matériaux du bâtiment, [PHYS.MECA.ACOU]Physics [physics]/Mechanics [physics]/Acoustics [physics.class-ph]
Abstract: National audience; Parallèlement à la croissance des exigences en isolation acoustique, on attend des matériaux utilisés dans le domaine du bâtiment, aussi bien au niveau de la rénovation que de la construction neuve, d'être de plus en plus performants et respectueux de l'environnement. Les matériaux du bâtiment fabriqués à base de particules végétales tels que le béton de chanvre répondent parfaitement à ces nouvelles exigences. De plus, les matériaux à base de particules végétales ont la particularité d'être poreux, sièges de phénomènes de dissipation à la fois thermiques et visco-inertiels. Pour le béton de chanvre, on note même la présence de plusieurs réseaux de pores, à des échelles différentes. Ce dernier présente en effet au sein de ses particules des pores dont le diamètre est de l'ordre d'une dizaine de microns, et, entre les particules et selon le dosage en liant, des pores d'un diamètre de l'ordre de quelques millimètres. Enfin, dans le liant lui-même, il existe également des pores de diamètre de l'ordre du micromètre. Les excellentes propriétés acoustiques de ce matériau ont été constatées expérimentalement, mais à ce jour, on ne sait pas encore modéliser ces dernières. Cette étude vise donc à caractériser les propriétés acoustiques de ces matériaux en prenant en compte les différentes échelles de porosité, pour ensuite être capable d'optimiser leur processus de fabrication, en fonction de leur utilisation. Dans le cadre de cette étude, différentes formulations de bétons de chanvre ont été fabriquées, constituées par les mélanges de plusieurs liants à plusieurs granulométries de particules. Les échantillons confectionnés ont alors été caractérisés par des mesures de porosité, résistivité, module d'incompressibilité, densité dynamique... En parallèle, les constituants de base (les particules de chènevotte ainsi que les liants) ont également été caractérisés. Il est alors montré que l'absorption acoustique de ces matériaux dépend grandement du choix de ses constituants et de sa mise en oeuvre. Les résultats de modélisations en simple et double porosité sont comparés aux mesures effectuées sur les échantillons.
Published: 2010

48. Roughness influence on periodic gratings and application to optical metrology of roughness

Author: Vauselle, Alexandre, Arnaud, Laurent, Georges, Gaelle, Amra, Claude, Deumie, Carole, Maillot, P., Institut FRESNEL (FRESNEL), Centre National de la Recherche Scientifique (CNRS)-École Centrale de Marseille (ECM)-Aix Marseille Université (AMU), STMicroelectronics, Gallais, Laurent, and Aix Marseille Université (AMU)-École Centrale de Marseille (ECM)-Centre National de la Recherche Scientifique (CNRS)
Subjects: [PHYS.PHYS.PHYS-OPTICS] Physics [physics]/Physics [physics]/Optics [physics.optics], [PHYS.PHYS.PHYS-OPTICS]Physics [physics]/Physics [physics]/Optics [physics.optics], ComputingMilieux_MISCELLANEOUS
Abstract: International audience
Published: 2010

49. The five-point bending test applied on wearing courses laid on orthotropic steel decks

Author: Houel, Adrien, Arnaud, Laurent, Centre d'études techniques de l'équipement de Lyon (CETE de Lyon), Avant création Cerema, Département génie civil et batiment (ENTPE) (DGCB), École Nationale des Travaux Publics de l'État (ENTPE)-Centre National de la Recherche Scientifique (CNRS), and Cadic, Ifsttar
Subjects: ESSAI NON DESTRUCTIF, STEEL ORTHOTROPIC PLATE, [SPI.MECA.STRU]Engineering Sciences [physics]/Mechanics [physics.med-ph]/Structural mechanics [physics.class-ph], ESSAI DE FLEXION, [SPI.MECA.STRU] Engineering Sciences [physics]/Mechanics [physics.med-ph]/Structural mechanics [physics.class-ph], FISSURE, BETON A ULTRA HAUTES PERFORMANCES
Abstract: TREMTI, ANTIGUA, GUATEMALA, 11-/11/2009 - 13/11/2009
Published: 2009

50. Damage characterization of asphalt in laboratory by ultrasonic wave propagation

Author: Houel, Adrien, Arnaud, Laurent, Centre d'études techniques de l'équipement de Lyon (CETE de Lyon), Avant création Cerema, Département génie civil et batiment (ENTPE) (DGCB), École Nationale des Travaux Publics de l'État (ENTPE)-Centre National de la Recherche Scientifique (CNRS), and Cadic, Ifsttar
Subjects: [SPI.OTHER]Engineering Sciences [physics]/Other, BETON BITUMINEUX, ESSAI NON DESTRUCTIF, VISCOELASTICITE, [SPI.OTHER] Engineering Sciences [physics]/Other, ENROBE, PROPAGATION DES ONDES, [SPI.MAT] Engineering Sciences [physics]/Materials, FISSURE, [SPI.MAT]Engineering Sciences [physics]/Materials
Abstract: Une méthode non-destructive est utilisée afin de suivre le comportement mécanique des couches d'enrobé bitumineux, méthode couplée à des essais classiques de laboratoire sur ce type de matériaux. Ces essais sont issus de la propagation d'ondes ultrasonores (ondes de compression et de cisaillement). Par analyse inverse, il est possible de calculer et suivre l'évolution de caractéristiques mécaniques comme le module complexe, le module ½dométrique. Cette méthode peut être en effet utilisée pour caractériser les enrobés bitumineux pendant les essais de module complexe. Ce papier compare les résultats de module complexe, à partir des mesures des déformations et à partir des essais non-destructifs. De plus, les ondes ultrasonores permettent de suivre la température interne du matériau et de déterminer son homogénéité à c½ur. Enfin, cette technique permet de suivre à chaque instant l'endommagement du matériau durant un essai de fatigue en mesurant et calculant l'évolution des modules mécaniques. Ces essais non-destructifs sont appliqués à deux dispositifs expérimentaux de laboratoire : l'essai de flexion 5 points et les essais classiques sur éprouvettes cylindriques d'enrobés bitumineux. Les résultats présentés fournissent d'excellentes perspectives dans l'utilisation de cette technique complémentaire aux essais sur enrobés bitumineux.
Published: 2009

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