1. Facile Synthesis of Hydrazine Derivatives of 5H-Pyrrolo[3,4-b]pyrazine and 1H-Pyrrolo[3,4-b]quinoxaline
- Author
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Angelina V. Biitseva, Andrei A. Tolmachev, Olga V. Hordiyenko, Igor V. Rudenko, Axelle Arrault, Irina A. Zamkova, Oleksandr V. Denisenko, Taras Shevchenko National University of Kyiv, Laboratoire de Chimie Physique Macromoléculaire (LCPM), and Institut de Chimie du CNRS (INC)-Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS)
- Subjects
heterocycles ,cyclization ,Pyrazine ,010405 organic chemistry ,[CHIM.ORGA]Chemical Sciences/Organic chemistry ,Organic Chemistry ,Carbohydrazide ,010402 general chemistry ,01 natural sciences ,Medicinal chemistry ,Catalysis ,0104 chemical sciences ,chemistry.chemical_compound ,Quinoxaline ,[CHIM.POLY]Chemical Sciences/Polymers ,chemistry ,chemoselectivity ,nitriles ,hydrazones ,Chemoselectivity ,Semicarbazone ,Hydrazine derivatives - Abstract
International audience; A convenient and efficient route for the chemoselective synthesis of carbohydrazide, arenesulfonylhydrazide, and thiosemicarbazone derivatives of 5H-pyrrolo[3,4-b]pyrazine and 1H-pyrrolo[3,4-b]quinoxaline from the corresponding dinitriles and substituted hydrazines was elaborated. The synthesis of starting pyrazine-2,3-dicarbonitrile was sufficiently improved by using concentrated HCl as a catalyst.
- Published
- 2013