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1. The association of education with body mass index and waist circumference in the EPIC-PANACEA study

Author

Amalia Mattiello, Marianne Uhre Jakobsen, Noémie Travier, Dora Romaguera, Rosario Tumino, Jakob Linseisen, Kim Overvad, Giovanna Masala, Rudolf Kaaks, Aurelio Barricarte, Petra H.M. Peeters, Sabina Rinaldi, Silke Hermann, Petra G. Van Boeckel, Jytte Halkjær, Miren Dorronsoro, Bethany Van Guelpen, Esther Molina, Ingegerd Johansson, Francesca L. Crowe, Anne M. May, Paolo Vineis, Anton E. Kunst, Nadia Slimani, Claudia Agnoli, Signe Borgquist, Philippos Orfanos, H. Bas Bueno-de-Mesquita, Traci Mouw, Antonia Trichopoulou, Françoise Clavel-Chapelon, Elio Riboli, Teresa Norat, Manuela M. Bergmann, Kay-Tee Khaw, Tonje Braaten, Androniki Naska, Laudina Rodríguez, Sabine Rohrmann, Hervé Besson, Guy Fagherazzi, Annika Steffen, Anne Tjønneland, María José Tormo, Jonas Manjer, Nicholas J. Wareham, Division of Cancer Epidemiology, German Cancer Research Center - Deutsches Krebsforschungszentrum [Heidelberg] (DKFZ), Social and Preventive Medicine Institute, Universität Zürich [Zürich] = University of Zurich (UZH), Institute of Epidemiology, Helmholtz Centre Munich, Julius Centre for Health Sciences and Primary Care, University Medical Center [Utrecht], National Institute for Public Health and the Environment [Bilthoven] (RIVM), Academic Medical Center - Academisch Medisch Centrum [Amsterdam] (AMC), University of Amsterdam [Amsterdam] (UvA), Medical Research Council, Institute of Metabolic Science-Epidemiology Unit, Department of Epidemiology & Public Health, Imperial College London, Unit of Nutrition, Environment and Cancer, Catalan Institute of Oncology-Environment and Cancer, Epidemiology Service, Murcia Health Council, Preventive Medicine and Public Health Unit, Murcia Medical School, CIBER Epidemiología y Salud Pública (CIBERESP), CIBER de Epidemiología y Salud Pública (CIBERESP), Andalusian School of Public Health [Granada], Public Health Department of Gipuzkoa, Public Health Institute of Navarra, Public Health and Participation Directorate, Health and Health Care Services Council, Cancer Epidemiology Unit, University of Oxford, Department of Public Health and Primary Care, University of Cambridge [UK] (CAM), Department of Cardiology, Aarhus University Hospital, Department of Clinical Epidemiology, Danish Cancer Society, Institute of Cancer Epidemiology, Nutritional Epidemiology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Department of Clinical and Experimental Medicine, University of Naples Federico II = Università degli studi di Napoli Federico II, Cancer Registry and Histopathology Unit, Department of Oncology-Civile - M.P.Arezzo Hospital, Molecular and Nutritional Epidemiology Unit, Cancer Research and Prevention Institute (ISPO), ISI Foundation Institute for Scientific Interchange, Environmental Epidemiology, Department of Hygiene and Epidemiology, University of Athens Medical School [Athens], Hellenic Health Foundation, Deutsches Institut für Ernährungsforschung Potsdam-Rehbrücke (DifE), Leibniz Association, Department of Medical Biosciences and Pathology, Umeå University, Department of Odontology, Department of Oncology, Lund University Hospital, Department of Surgery, Malmö University Hospital, Institute of Community Medicine, University of Tromsø (UiT), Nutrition, hormones et cancer: épidémiologie et prévention (E3N), Epidémiologie, sciences sociales, santé publique (IFR 69), Université Paris 1 Panthéon-Sorbonne (UP1)-Université Paris-Sud - Paris 11 (UP11)-École des hautes études en sciences sociales (EHESS)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Paris 1 Panthéon-Sorbonne (UP1)-Université Paris-Sud - Paris 11 (UP11)-École des hautes études en sciences sociales (EHESS)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Paris-Sud - Paris 11 (UP11)-Institut Gustave Roussy (IGR)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre International de Recherche contre le Cancer - International Agency for Research on Cancer (CIRC - IARC), Organisation Mondiale de la Santé / World Health Organization Office (OMS / WHO), The work was further financially supported by the European Commission: Public Health and Consumer Protection Directorate 1993-2004, Research Directorate-General 2005-.', Ligue contre le Cancer, Societé 3M, Mutuelle Générale de l'Education Nationale, Institut National de la Santé et de la Recherche Médicale (INSERM) (France), German Cancer Aid, German Cancer Research Center, Federal Ministry of Education and Research (Germany), Danish Cancer Society (Denmark), Health Research Fund (FIS) of the Spanish Ministry of Health, The participating regional governments and institutions (Spain), Cancer Research UK, Medical Research Council, Stroke Association, British Heart Foundation, Department of Health, Food Standards Agency, the Wellcome Trust (United Kingdom), Greek Ministry of Health and Social Solidarity, Hellenic Health Foundation and Stavros Niarchos Foundation (Greece), Italian Association for Research on Cancer, National Research Council (Italy), Dutch Ministry of Public Health, Welfare and Sports, Dutch Ministry of Health, Dutch Prevention Funds, LK Research Funds, Dutch ZON (Zorg Onderzoek Nederland), World Cancer Research Fund (WCRF) (the Netherlands), Swedish Cancer Society, Swedish Scientific Council, Regional Government of Skane (Sweden), Norwegian Cancer Society (Norway)., BMC, Ed., University of Zurich, Rohrmann, S, University of Oxford [Oxford], Università degli studi di Napoli Federico II, [Hermann,S, Rohrmann,S, Linseisen,J, Kaaks,R] German Canc Res Ctr, Div Canc Epidemiol, D-6900 Heidelberg, Germany. [Linseisen,J] Helmholtz Ctr Munich, Inst Epidemiol, Neuherberg, Germany. [May,AM., Besson,H, Peeters,PH.M.] Univ Med Ctr Utrecht, Julius Ctr Hlth Sci & Primary Care, Utrecht, Netherlands. [May,AM., van Boeckel,PG.A., Bueno-de-Mesquita,H.B] Natl Inst Publ Hlth & Environm RIVM, Bilthoven, Netherlands. [Kunst,A] Univ Amsterdam, Acad Med Ctr, Amsterdam, Netherlands. [Besson,H, Wareham,NJ.] MRC, Inst Metab Sci, Epidemiol Unit, Cambridge, England. [Romaguera,D, Mouw,T, Norat,T, Riboli,E] Univ London Imperial Coll Sci Technol & Med, Dept Epidemiol & Publ Hlth, London, England. [Travier,N] IDIBELL, Catalan Inst Oncol, Unit Nutr Environm & Canc, Barcelona, Spain. [Tormo,MJ] Murcia Hlth Council, Epidemiol Serv, Murcia, Spain. [Tormo,MJ] Murcia Med Sch, Prevent Med & Publ Hlth Unit, Murcia, Spain. [Molina,E] Andalusian Sch Publ Hlth, Granada, Spain. [Dorronsoro,M] Publ Hlth Dept Gipuzkoa, San Sebastian, Spain. [Barricarte,A] Publ Hlth Inst Navarra, Pamplona, Spain. [Rodriguez,L] Hlth & Hlth Care Serv Council, Publ Hlth & Participat Directorate, Asturias, Spain. [Crowe,FL.] Univ Oxford, Canc Epidemiol Unit, Oxford, England. [Khaw,K-T] Univ Cambridge, Dept Publ Hlth & Primary Care, Cambridge, England. [Overvad,K] Aarhus Univ Hosp, Aalborg Hosp, Dept Cardiol, Aalborg, Denmark. [Overvad,K, Jakobsen,MU] Aarhus Univ Hosp, Dept Clin Epidemiol, Aalborg, Denmark. [Tjonneland,A, Halkjaer,J] Danish Canc Soc, Inst Canc Epidemiol, Copenhagen, Denmark. [Agnoli,C] Fdn IRCCS Ist Nazl Tumori, Nutr Epidemiol Unit, Milan, Italy. [Mattiello,A] Univ Naples Federico 2, Dept Clin & Expt Med, Naples, Italy. [Tumino,R] Civile MP Arezzo Hosp, Dept Oncol, Canc Registry & Histopathol Unit, Ragusa, Italy. [Masala,G] Canc Res & Prevent Inst ISPO, Mol & Nutr Epidemiol Unit, Florence, Italy. [Vineis,P] ISI Fdn, Turin, Italy. [Naska,A, Orfanos,P, Trichopoulou,A] Univ Athens, Sch Med, Dept Hyg & Epidemiol, Athens, Greece. [Bergmann,MM., Steffen,A] German Inst Human Nutr Potsdam Rehbrucke, Nuthetal, Germany. [Van Guelpen,B] Umea Univ, Dept Med Biosci, Umea, Sweden. [Johansson,I] Umea Univ, Dept Odontol, Umea, Sweden. [Borgquist,S] Univ Lund Hosp, Dept Oncol, Lund, Sweden. [Manjer,J] Malmo Univ Hosp, Dept Surg, Malmo, Sweden. [Braaten,T] Univ Tromso, Inst Community Med, Tromso, Norway. [Fagherazzi,G, Clavel-Chapelon,F] Paris S Univ, Inst Gustave Roussy, Villejuif, France. [Fagherazzi,G, Clavel-Chapelon,F] INSERM, ERI20, Villejuif, France. [Besson,H, Rinaldi,S, Slimani,N] Int Agcy Res Canc, Lyon, France. [Rohrmann,S] Univ Zurich, Inst Social & Prevent Med, Zurich, Switzerland, European Commission: Grant no DG Sanco, project number: 2005328. The work was further financially supported by the European Commission: Public Health and Consumer Protection Directorate 1993-2004, Khaw, Kay-Tee [0000-0002-8802-2903], Wareham, Nicholas [0000-0003-1422-2993], Apollo - University of Cambridge Repository, Faculteit der Geneeskunde, APH - Amsterdam Public Health, and Public and occupational health

Subjects
Male, Epidemiology, Body Mass Index, VDP::Medical disciplines: 700::Health sciences: 800::Nutrition: 811, 0302 clinical medicine, Prospective Studies, Public, Environmental & Occupational Health, MESH: Middle Aged, 3. Good health, MESH: Health Status Disparities, MESH: Waist Circumference, Socioeconomic status, Waist circumference, Public Health, Waist Circumference, Cohort study, VDP::Medisinske Fag: 700::Helsefag: 800::Medisinsk/odontologisk etikk, atferdsfag, historie: 805, Waist, Pes corporal, Education, MESH: Body Mass Index, VDP::Medisinske Fag: 700::Helsefag: 800::Ernæring: 811, 03 medical and health sciences, MESH: Sex Factors, cohort study, Humans, Aged, Science & Technology, MESH: Humans, Prevention, Public Health, Environmental and Occupational Health, lcsh:RA1-1270, MESH: Adult, Body weight, medicine.disease, Obesity, Health Care::Environment and Public Health::Public Health::Epidemiologic Measurements::Biometry::Anthropometry::Body Mass Index [Medical Subject Headings], Health Care::Environment and Public Health::Public Health::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Cohort Studies::Prospective Studies [Medical Subject Headings], ENERGY-INTAKE, OXFORD PARTICIPANTS, PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH, SCI, Educació, MESH: Educational Status, Body mass index, MESH: Female, Demography, Gerontology, Overweight, SOCIOECONOMIC-STATUS, 030212 general & internal medicine, 2. Zero hunger, MESH: Aged, education, Bmi, Cohort Study, Epic, Socioeconomic Status, lcsh:Public aspects of medicine, Public Health, Global Health, Social Medicine and Epidemiology, Middle Aged, Circumference, CANCER, PREVALENCE, European Prospective Investigation into Cancer and Nutrition, Europe, OBESITY, Educational Status, Female, medicine.symptom, Life Sciences & Biomedicine, Research Article, Adult, VDP::Medical disciplines: 700::Health sciences: 800::Medical/dental ethics, behavioural sciences, history: 805, 030209 endocrinology & metabolism, 610 Medicine & health, socioeconomic status, BMI, Sex Factors, Eating disorders and obesity, Phenomena and Processes::Physiological Phenomena::Body Constitution::Body Weights and Measures::Body Size::Waist Circumference [Medical Subject Headings], medicine, ddc:610, Nutrition, OVERWEIGHT, business.industry, Health Care::Environment and Public Health::Public Health::Epidemiologic Measurements::Demography::Health Status::Health Status Disparities [Medical Subject Headings], Health Status Disparities, ADULTS, 10060 Epidemiology, Biostatistics and Prevention Institute (EBPI), 2739 Public Health, Environmental and Occupational Health, MESH: Prospective Studies, MESH: Male, PHYSICAL-ACTIVITY, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, WEIGHT STATUS, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, MESH: Europe, EPIC, business
Abstract

Background To examine the association of education with body mass index (BMI) and waist circumference (WC) in the European Prospective Investigation into Cancer and Nutrition (EPIC). Method This study included 141,230 male and 336,637 female EPIC-participants, who were recruited between 1992 and 2000. Education, which was assessed by questionnaire, was classified into four categories; BMI and WC, measured by trained personnel in most participating centers, were modeled as continuous dependent variables. Associations were estimated using multilevel mixed effects linear regression models. Results Compared with the lowest education level, BMI and WC were significantly lower for all three higher education categories, which was consistent for all countries. Women with university degree had a 2.1 kg/m2 lower BMI compared with women with lowest education level. For men, a statistically significant, but less pronounced difference was observed (1.3 kg/m2). The association between WC and education level was also of greater magnitude for women: compared with the lowest education level, average WC of women was lower by 5.2 cm for women in the highest category. For men the difference was 2.9 cm. Conclusion In this European cohort, there is an inverse association between higher BMI as well as higher WC and lower education level. Public Health Programs that aim to reduce overweight and obesity should primarily focus on the lower educated population.

Published
2011
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2. Structural and functional characterization of the Curli adaptor protein CsgF

Author

Laura Köpping, Johannes Spehr, Madhu Nagaraj, Tobias Schubeis, Mumdooh Ahmed, Christiane Ritter, Janika Viereck, Biological Solid-State NMR Methods - Méthodes de RMN à l'état solide en biologie, Institut des Sciences Analytiques (ISA), Institut de Chimie du CNRS (INC)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS), Helmholtz Centre for Infection Research (HZI), Cellex Patient Treatment GmbH, Hannover Medical School, Integriertes Forsch & Behandlungszentrum Transpla, IMTTS, Dept Internal Med, Div Infect Dis - Univ Michigan, University of Michigan [Ann Arbor], University of Michigan System-University of Michigan System, Aarhus Univ - Interdisciplinary Nanosci Ctr iNANO, Leibniz Universität Hannover [Hannover] (LUH), and We thank Carolin Schaper for excellent technical advice and assistance. The pMC5 and pNH4 plasmids were kindly provided by Matthew Chapman (University of Michigan). This work was supported by the Helmholtz-Association 'Impuls und Vernetzungsfonds' (CR), by the DFG grant RI 2210/1-1 (MA), and the HZI graduate school (TS).

Subjects
0301 basic medicine, Protein Folding, Amyloid, Biophysics, [SDV.BC]Life Sciences [q-bio]/Cellular Biology, Intrinsically disordered proteins, Biochemistry, law.invention, 03 medical and health sciences, Protein Domains, Structural Biology, law, Genetics, Escherichia coli, [CHIM]Chemical Sciences, [SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology, Molecular Biology, Nuclear Magnetic Resonance, Biomolecular, solution NMR, Curli, detergent micelles, biology, paramagnetic relaxation enhancement, Chemistry, Escherichia coli Proteins, Biofilm, Signal transducing adaptor protein, functional amyloid, Cell Biology, biology.organism_classification, Enterobacteriaceae, Recombinant Proteins, Transport protein, 030104 developmental biology, Recombinant DNA, intrinsically disordered proteins, Bacterial outer membrane
Abstract

International audience; Curli are functional amyloids that form a major part of the biofilm produced by many enterobacteriaceae. A multiprotein system around the outer membrane protein CsgG is in charge of the export and controlled propagation of the main Curli subunits, CsgA and CsgB. CsgF is essential for the linkage of the main amyloid-forming proteins to the cell surface. Here, we present a profound biochemical and biophysical characterization of recombinant CsgF, highlighted by a solution NMR structure of CsgF in the presence of dihexanoylphosphocholine micelles. Interestingly, CsgF contains large unstructured domains and does not show a globular fold. The data presented shed new light on the molecular mechanism of Curli amyloid surface attachment.

Published
2018
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3. Moving in the Anthropocene: Global reductions in terrestrial mammalian movements

Author

Wiebke Ullmann, Mark Hebblewhite, Aidin Niamir, Ilya R. Fischhoff, David W. Wattles, Emília Patrícia Medici, Katrin Böhning-Gaese, Francesca Cagnacci, Jacob R. Goheen, Martin Rimmler, Sarah C. Davidson, Luca Pedrotti, Simon Chamaillé-Jammes, Justin M. Calabrese, Christen H. Fleming, Niels Martin Schmidt, Abdullahi H. Ali, Matthew J. Kauffman, Laura R. Bidner, Rogério Cunha de Paula, Bart Kranstauber, John W. Wilson, John M. Fryxell, Navinder J. Singh, Hattie L. A. Bartlam-Brooks, Marlee A. Tucker, Benedikt Gehr, Roland Kays, Peter Leimgruber, Lynne A. Isbell, Nir Sapir, Ran Nathan, Martin Wikelski, Daniel I. Rubenstein, Todd E. Dennis, A. Catherine Markham, Marco Heurich, Alessandra Bertassoni, Stephen Blake, Stephen DeStefano, Ugo Mellone, Susanne A. Fritz, Iain Douglas-Hamilton, Eliezer Gurarie, William F. Fagan, Adam Kane, Tracey L. Rogers, Atle Mysterud, Dean E. Beyer, Björn Reineking, Tal Avgar, Christopher C. Wilmers, Dejid Nandintsetseg, Constança Camilo-Alves, João P. Silva, Duncan M. Kimuyu, Evelyn H. Merrill, George Wittemyer, Robert B. O'Hara, Sonia Saïd, Jenny Mattisson, Nina Attias, Ulrich Voigt, Wolfgang Fiedler, Peter M. Kappeler, Kamran Safi, Julian Fennessy, Kirk A. Olson, Florian Jeltsch, Nicolas Morellet, Christopher S. Rosenberry, Andrew M. Allen, Scott D. LaPoint, Agnieszka Sergiel, Guilherme Miranda de Mourão, Christina Fischer, Bruce D. Patterson, Luiz Gustavo R. Oliveira-Santos, Tomasz Zwijacz-Kozica, Samuel L. Díaz-Muñoz, Thomas Mueller, Thomas A. Morrison, Nuria Selva, Olav Strand, André Chiaradia, P J Nico de Bruyn, A. J. Mark Hewison, Buuveibaatar Bayarbaatar, Enkhtuvshin Shiilegdamba, Petra Kaczensky, René Janssen, John Odden, Claudia Fichtel, Edward Hurme, Hall Sawyer, Chloe Bracis, Bram Van Moorter, Niels Blaum, Christian Hof, Siva R. Sundaresan, Erling Johan Solberg, Susan C. Alberts, John D. C. Linnell, Adam T. Ford, Orr Spiegel, Ronaldo Gonçalves Morato, Christer Moe Rolandsen, Danielle D. Brown, Filip Zięba, Jerrold L. Belant, Pascual López-López, Jake Wall, Flávia Koch, Floris M. van Beest, Duane R. Diefenbach, Senckenberg Biodiversity and Climate Research Centre [Germany], Senckenberg – Leibniz Institution for Biodiversity and Earth System Research - Senckenberg Gesellschaft für Naturforschung, Leibniz Association-Leibniz Association, Institut of Zoology - Dept V - Univ. Mainz, Johannes Gutenberg - Universität Mainz (JGU), Department of Biology [USA], University of Maryland [College Park], University of Maryland System-University of Maryland System, Department of Integrative Biology [Canada], University of Guelph, Departments of Biology and Evolutionary Anthropology [Duke Univ., USA], Duke University, Institut de biologie de l'ENS Paris (UMR 8197/1024) (IBENS), Département de Biologie - ENS Paris, École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Fondazione Edmund Mach - Edmund Mach Foundation [Italie] (FEM), Smithsonian Conservation Biology Institute, Centre d'Études Biologiques de Chizé - UMR 7372 (CEBC), Université de La Rochelle (ULR)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Research Department, Phillip Island Nature Parks, Courant Research Centre Geobiology, Georg-August-University [Göttingen], University of Maryland System, Department of Ecosystem and Conservation Science, Wildlife Biology Program, University of Montana, Nationalparkverwaltung Bayerischer Wald, Unité de recherche Comportement et Ecologie de la Faune Sauvage (CEFS), Institut National de la Recherche Agronomique (INRA), Department of Anthropology and Animal Behaviour Graduate Group, University of California [Davis] (UC Davis), University of California-University of California, Inst. Biochem. & Biol., University of Potsdam, Res. Inst. Wildlife Ecol., University of Veterinary Medicine [Vienna] (Vetmeduni), School of Biology and Environmental Science and Earth Institute [Ireland], University College Dublin [Dublin] (UCD), North Carolina Museum of Natural Sciences, Department of Migration and Immuno-ecology, Max Planck Institute for Ornithology, Max-Planck-Gesellschaft-Max-Planck-Gesellschaft, Cavanilles Institute of Biodiversity and Evolutionary Biology, Terrestrial Vertebrates Group, University of Valencia, Grupo de Investigación Zoología de Vertebrados, CIBIO, Universidad de Alicante, Section of Ecology, Behavior and Evolution, University of California [San Diego] (UC San Diego), Centre for Ecological and Evolutionary Synthesis (CEES), Department of Biosciences [Oslo], Faculty of Mathematics and Natural Sciences [Oslo], University of Oslo (UiO)-University of Oslo (UiO)-Faculty of Mathematics and Natural Sciences [Oslo], University of Oslo (UiO)-University of Oslo (UiO), The Hebrew University of Jerusalem (HUJ), Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA), CNERA Cervidés Sanglier (ONCFS), Office National de la Chasse et de la Faune Sauvage, Institute of Evolution and Department of Evolutionary and Environmental Biology, University of Haifa [Haifa], Department of Bioscience, Aarhus University [Aarhus]-Arctic Research Centre, Adam Mickiewicz University in Poznań (UAM), Department of Wildlife, Fish and Environmental Studies, Swedish University of Agricultural Sciences (SLU), School of Zoology, Faculty of Life Sciences [Israel], Tel Aviv University [Tel Aviv], Senckenberg Biodiversity and Climate Research Centre (SBiK-F), Goethe-Universität Frankfurt am Main-Senckenberg – Leibniz Institution for Biodiversity and Earth System Research - Senckenberg Gesellschaft für Naturforschung, Robert Bosch Foundation, Senckenberg Gesell Naturforsch, Goethe Univ, Univ Maryland, Univ Guelph, Norwegian Inst Nat Res, Duke Univ, Hirola Conservat Programme, Swedish Univ Agr Sci, Radboud Univ Nijmegen, Universidade Federal de Mato Grosso do Sul (UFMS), Univ Alberta, Univ London, Wildlife Conservat Soc, Mississippi State Univ, Universidade Estadual Paulista (Unesp), Michigan Dept Nat Resources, Univ Calif Davis, Aarhus Univ, Max Planck Inst Ornithol, Univ Potsdam, Middle Tennessee State Univ, Univ Pretoria, Fdn Edmund Mach, Harvard Univ, Natl Zool Pk, Univ Evora, Univ Montpellier, Phillip Isl Nat Parks, Monash Univ, Ohio State Univ, Fiji Natl Univ, Univ Massachusetts, Penn State Univ, Univ Oxford, Giraffe Conservat Fdn, German Primate Ctr, Tech Univ Munich, Cary Inst Ecosyst Studies, Univ British Columbia, Univ Zurich, Univ Wyoming, Univ Washington, Univ Montana, Bavarian Forest Natl Pk, Albert Ludwigs Univ Freiburg, Univ Toulouse, Bionet Natr Onderzoek, Univ Vet Med Vienna, Univ Coll Cork, North Carolina Museum Nat Sci, North Carolina State Univ, Karatina Univ, Univ Lethbridge, Columbia Univ, Univ Valencia, SUNY Stony Brook, TSG, IPE Inst Pesquisas Ecol Inst Ecol Res, Univ Alicante, Empresa Brasileira de Pesquisa Agropecuária (EMBRAPA), Chico Mendes Inst Conservat Biodivers, Univ Glasgow, NYU, Univ Oslo, Hebrew Univ Jerusalem, Norwegian Univ Sci & Technol NTNU, Field Museum Nat Hist, Consorzio Parco Nazl Stelvio, Univ Grenoble Alpes, Univ Bayreuth, Natl Park Schwarzwald, Univ New South Wales, Penn Game Commiss, Princeton Univ, Univ Konstanz, Off Natl Chasse & Faune Sauvage, Univ Haifa, Western Ecosyst Technol Inc, Polish Acad Sci, Univ Porto, Univ Lisbon, Jackson Hole Conservat, Univ Vet Med Hannover, Univ Calif Santa Cruz, Colorado State Univ, Tatra Natl Pk, Senckenberg Gesellschaft für Naturforschung, École normale supérieure - Paris (ENS Paris)-École normale supérieure - Paris (ENS Paris)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Centre d'études biologiques de Chizé (CEBC), Centre National de la Recherche Scientifique (CNRS), Georg-August-Universität Göttingen, Laboratoire de Comportement et d'Ecologie de la Faune Sauvage, INRA, 31326 Castanet-Tolosan cedex, France, Goethe-Universität Frankfurt am Main-Senckenberg Gesellschaft für Naturforschung, Institut de biologie de l'ENS Paris (IBENS), Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Département de Biologie - ENS Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Institut National de la Santé et de la Recherche Médicale (INSERM)-Département de Biologie - ENS Paris, and École normale supérieure - Paris (ENS Paris)-École normale supérieure - Paris (ENS Paris)-Centre National de la Recherche Scientifique (CNRS)

Subjects
0106 biological sciences, Nutrient cycle, Animal Ecology and Physiology, Ecology (disciplines), Zoology and botany: 480 [VDP], Population, GPS telemetry, 010603 evolutionary biology, 01 natural sciences, Movement ecology, Footprint, Anthropocene, Settore BIO/07 - ECOLOGIA, ddc:570, Animals, Humans, Human Activities, vertebrats fòssils, Ecosystem, 14. Life underwater, education, Zoologiske og botaniske fag: 480 [VDP], ComputingMilieux_MISCELLANEOUS, Mammals, 2. Zero hunger, education.field_of_study, Multidisciplinary, Ecology, 010604 marine biology & hydrobiology, 15. Life on land, 13. Climate action, Geographic Information Systems, Trait, Animal Migration, Terrestrial ecosystem, [SDE.BE]Environmental Sciences/Biodiversity and Ecology
Abstract

Made available in DSpace on 2018-11-26T17:44:52Z (GMT). No. of bitstreams: 0 Previous issue date: 2018-01-26 Robert Bosch Foundation Animal movement is fundamental for ecosystem functioning and species survival, yet the effects of the anthropogenic footprint on animal movements have not been estimated across species. Using a unique GPS-tracking database of 803 individuals across 57 species, we found that movements of mammals in areas with a comparatively high human footprint were on average one-half to one-third the extent of their movements in areas with a low human footprint. We attribute this reduction to behavioral changes of individual animals and to the exclusion of species with long-range movements from areas with higher human impact. Global loss of vagility alters a key ecological trait of animals that affects not only population persistence but also ecosystem processes such as predator-prey interactions, nutrient cycling, and disease transmission. Senckenberg Gesell Naturforsch, Senckenberg Biodivers & Climate Res Ctr, D-60325 Frankfurt, Main, Germany Goethe Univ, Dept Biol Sci, D-60438 Frankfurt, Main, Germany Univ Maryland, Dept Biol, College Pk, MD 20742 USA Univ Maryland, SESYNC, Annapolis, MD 21401 USA Univ Guelph, Dept Integrat Biol, Guelph, ON N1G 2W1, Canada Norwegian Inst Nat Res, POB 5685 Torgard, NO-7485 Trondheim, Norway Duke Univ, Dept Biol, Durham, NC 27708 USA Duke Univ, Dept Evolut Anthropol, Durham, NC 27708 USA Hirola Conservat Programme, Garissa, Kenya Swedish Univ Agr Sci, Dept Wildlife Fish & Environm Studies, S-90183 Umea, Sweden Radboud Univ Nijmegen, Dept Anim Ecol & Physiol, Inst Water & Wetland Res, NL-6500 GL Nijmegen, Netherlands Univ Fed Mato Grosso do Sul, Ecol & Conservat Grad Program, Campo Grande, MS, Brazil Univ Alberta, Dept Biol Sci, Edmonton, AB, Canada Univ London, Royal Vet Coll, Struct & Motion Lab, London NW1 0TU, England Wildlife Conservat Soc, Mongolia Program, Ulaanbaatar, Mongol Peo Rep Mississippi State Univ, Forest & Wildlife Res Ctr, Carnivore Ecol Lab, Box 9690, Mississippi State, MS USA Sao Paulo State Univ, Anim Biol Postgra Program, BR-15054000 Sao Jose Do Rio Preto, SP, Brazil Michigan Dept Nat Resources, 1990 US 41 South, Marquette, MI 49855 USA Univ Calif Davis, Dept Anthropol, Davis, CA 95616 USA Aarhus Univ, Dept Biosci, DK-4000 Roskilde, Denmark Max Planck Inst Ornithol, Vogelwarte Radolfzell, D-78315 Radolfzell am Bodensee, Germany Wildlife Conservat Soc, Bronx, NY 10460 USA Univ Potsdam, Plant Ecol & Nat Conservat, D-14476 Potsdam, Germany Middle Tennessee State Univ, Dept Biol, Murfreesboro, TN 37132 USA Univ Pretoria, Dept Zool & Entomol, Mammal Res Inst, ZA-0028 Gauteng, South Africa Fdn Edmund Mach, Res & Innovat Ctr, Dept Biodivers & Mol Ecol, I-38010 San Michele All Adige, TN, Italy Harvard Univ, Dept Organism & Evolutionary Biol, Cambridge, MA 02138 USA Natl Zool Pk, Smithsonian Conservat Biol Inst, Front Royal, VA USA Univ Evora, Depat Fitotecn, P-7002554 Evora, Portugal Univ Evora, ICAAM, Inst Mediterranean Agr & Environm Sci, Evora, Portugal Univ Montpellier, Univ Paul Valery Montpellier, CNRS,EPHE, Ctr Ecol Fonctionnelle & Evolut,UMR 5175, F-34293 Montpellier 5, France Phillip Isl Nat Parks, Cowes, Vic, Australia Monash Univ, Sch Biol Sci, Melbourne, Vic, Australia Ohio State Univ, Dept Civil Environm & Geodet Engn, Columbus, OH 43210 USA Fiji Natl Univ, Dept Biol, POB 5529, Natabua, Lautoka, Fiji Univ Massachusetts, US Geol Survey, Massachusetts Cooperat Fish & Wildlife Res Unit, Amherst, MA 01003 USA Penn State Univ, US Geol Survey, Penn Cooperat Fish & Wildlife Res Unit, University Pk, PA 16802 USA Univ Oxford, Dept Zool, Oxford OX1 3PS, England Giraffe Conservat Fdn, POB 86099, Eros, Namibia German Primate Ctr, Behav Ecol & Sociobiol Unit, D-37077 Gottingen, Germany Tech Univ Munich, Dept Ecol & Ecosyst Management, Restorat Ecol, D-85354 Freising Weihenstephan, Germany Cary Inst Ecosyst Studies, Millbrook, NY 12545 USA Univ British Columbia, Irving K Barber Sch Arts & Sci, Unit 2, Biol, Okanagan Campus, Kelowna, BC V1V 1V7, Canada Univ Zurich, Dept Evolutionary Biol & Environm Studies, CH-8057 Zurich, Switzerland Univ Wyoming, Dept Zool & Physiol, Laramie, WY 82071 USA Univ Washington, Sch Environm & Forest Sci, Seattle, WA 98195 USA Univ Montana, Coll Forestry & Conservat, Dept Ecosyst & Conservat Sci, Wildlife Biol Program, Missoula, MT 59812 USA Bavarian Forest Natl Pk, Dept Conservat & Res, D-94481 Grafenau, Germany Albert Ludwigs Univ Freiburg, Wildlife Ecol & Management, D-79106 Freiburg, Germany Univ Toulouse, INRA, CEFS, Castanet Tolosan, France Univ Calif Davis, Anim Behav Grad Grp, Davis, CA 95616 USA Bionet Natr Onderzoek, NL-6171 EL Stein, Netherlands Univ Vet Med Vienna, Res Inst Wildlife Ecol, A-1160 Vienna, Austria Univ Coll Cork, Sch Biol Earth & Environm Sci, Cork, Ireland Univ Wyoming, US Geol Survey, Dept Zool & Physiol, Wyoming Cooperat Fish & Wildlife Res Unit, Laramie, WY USA North Carolina Museum Nat Sci, Raleigh, NC 27601 USA North Carolina State Univ, Dept Forestry & Environm Resources, Raleigh, NC 27695 USA Karatina Univ, Dept Nat Resource Management, POB 195710101, Karatina, Kenya Univ Lethbridge, Dept Psychol, Lethbridge, AB T1K 3M4, Canada Columbia Univ, Lamont Doherty Earth Observ, Palisades, NY 10964 USA Univ Valencia, Terr Vertebrates Grp, Cavanilles Inst Biodivers & Evolutionary Biol, E-46980 Valencia, Spain SUNY Stony Brook, Dept Anthropol, Stony Brook, NY 11794 USA TSG, SSC, IUCN, Rua Licuala 622,Damha 1,Campo Grande, BR-79046150 Mato Grosso Sul, Brazil IPE Inst Pesquisas Ecol Inst Ecol Res, Caixa Postal 47, BR-12960000 Sao Paulo, Brazil Univ Alicante, Dept Ciencias Ambient & Recursos Natur, Vertebrates Zool Res Grp, Alicante, Spain Embrapa Pantanal, BR-79320900 Corumba, MS, Brazil Chico Mendes Inst Conservat Biodivers, Natl Res Ctr Carnivores Conservat, BR-12952011 Atiba, SP, Brazil Univ Glasgow, Inst Biodivers Anim Hlth & Comparat Med, Glasgow, Lanark, Scotland NYU, Dept Biol, Ctr Genom & Syst Biol, New York, NY 10003 USA Univ Calif Davis, Dept Microbiol & Mol Genet, Davis, CA 95616 USA Univ Oslo, Dept Biosci, Ctr Ecol & Evolutionary Synth, NO-0316 Oslo, Norway Hebrew Univ Jerusalem, Alexander Silberman Inst Life Sci, Dept Ecol Evolut & Behav, Movement Ecol Lab, IL-91904 Jerusalem, Israel Norwegian Inst Nat Res, NO-0349 Oslo, Norway Norwegian Univ Sci & Technol NTNU, Dept Math Sci & Ctr Biodivers Dynam, N-7491 Trondheim, Norway Univ Fed Mato Grosso do Sul, Dept Ecol, BR-79070900 Campo Grande, MS, Brazil Field Museum Nat Hist, Integrat Res Ctr, Chicago, IL 60605 USA Consorzio Parco Nazl Stelvio, Bormio, Sondrio, Italy Univ Grenoble Alpes, Irstea, UR LESSEM, BP 76, F-38402 St Martin Dheres, France Univ Bayreuth, BayCEER, D-95447 Bayreuth, Germany Natl Park Schwarzwald, D-77889 Seebach, Germany Univ New South Wales, Evolut & Ecol Res Ctr, Sydney, NSW 2052, Australia Univ New South Wales, Sch Biol Earth & Environm Sci, Sydney, NSW 2052, Australia Penn Game Commiss, Harrisburg, PA 17110 USA Princeton Univ, Dept Ecol & Evolutionary Biol, Princeton, NJ 08544 USA Univ Konstanz, Dept Biol, D-78467 Constance, Germany Off Natl Chasse & Faune Sauvage, Studies & Expertise DRE, F-01330 Birieux, France Univ Haifa, Dept Evolutionary & Environm Biol, IL-3498838 Haifa, Israel Western Ecosyst Technol Inc, Laramie, WY 82070 USA Aarhus Univ, Arctic Res Ctr, DK-8000 Aarhus C, Denmark Polish Acad Sci, Inst Nat Conservat, PL-31120 Krakow, Poland Univ Porto, CIBIO InBIO Associate Lab, P-4485661 Vairao, Portugal Univ Lisbon, Inst Super Agron, InBIO Associate Lab, Ctr Appl Ecol Prof Baeta Neves, P-1349017 Lisbon, Portugal Univ Lisbon, Fac Ciencias, Ctr Ecol Evolut & Environm Changes, P-1749016 Lisbon, Portugal Univ Calif Davis, Dept Environm Sci & Policy, Davis, CA 95616 USA Jackson Hole Conservat, Jackson, WY 83001 USA Univ Vet Med Hannover, Inst Terr & Aquat Wildlife Res, D-30173 Hannover, Germany Univ Calif Santa Cruz, Environm Studies Dept, Ctr Integrated Spatial Res, Santa Cruz, CA 95060 USA Univ Pretoria, Dept Zool & Entomol, ZA-0028 Hatfield, South Africa Colorado State Univ, Dept Fish Wildlife & Conservat Biol, Ft Collins, CO 80523 USA Tatra Natl Pk, PL-34500 Zakopane, Poland Sao Paulo State Univ, Anim Biol Postgra Program, BR-15054000 Sao Jose Do Rio Preto, SP, Brazil

Published
2018
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4. Evolution of atomic structure during nanoparticle formation

Author

Gavin Vaughan, Christoffer Tyrsted, Nina Lock, Hermann Emerich, Kirsten M. Ø. Jensen, Mogens Christensen, Espen Drath Bøjesen, Simon J. L. Billinge, Bo B. Iversen, Center for Materials Crystallography [Aarhus] (CMC), Department of Chemistry [Aarhus], Aarhus University [Aarhus]-Aarhus University [Aarhus], Aarhus Univ, iNANO, DK-8000 Aarhus, Denmark, Univ Gottingen, Fac Chem, D-37077 Gottingen, Germany, Columbia University [New York], European Synchrotron Radiation Facility (ESRF), Brookhaven National Laboratory [Upton, NY] (BNL), U.S. Department of Energy [Washington] (DOE)-UT-Battelle, LLC-Stony Brook University [SUNY] (SBU), and State University of New York (SUNY)-State University of New York (SUNY)

Subjects
total scattering, Nucleation, Nanoparticle, Ionic bonding, Nanotechnology, 02 engineering and technology, EXAFS, PDF, in situ, nanoparticle, 010402 general chemistry, 01 natural sciences, Biochemistry, [CHIM]Chemical Sciences, General Materials Science, Cubic zirconia, lcsh:Science, Yttria-stabilized zirconia, Chemistry, Final product, Rational design, General Chemistry, 021001 nanoscience & nanotechnology, Condensed Matter Physics, Research Papers, 0104 chemical sciences, Amorphous solid, Chemical physics, lcsh:Q, sense organs, 0210 nano-technology
Abstract

The complete structural transformation of ionic species in the precursor solution, over an amorphous solid and finally into crystalline nanoparticles, is elucidated by in situ investigations under supercritical solvothermal conditions., Understanding the mechanism of nanoparticle formation during synthesis is a key prerequisite for the rational design and engineering of desirable materials properties, yet remains elusive due to the difficulty of studying structures at the nanoscale under real conditions. Here, the first comprehensive structural description of the formation of a nanoparticle, yttria-stabilized zirconia (YSZ), all the way from its ionic constituents in solution to the final crystal, is presented. The transformation is a complicated multi-step sequence of atomic reorganizations as the material follows the reaction pathway towards the equilibrium product. Prior to nanoparticle nucleation, reagents reorganize into polymeric species whose structure is incompatible with the final product. Instead of direct nucleation of clusters into the final product lattice, a highly disordered intermediate precipitate forms with a local bonding environment similar to the product yet lacking the correct topology. During maturation, bond reforming occurs by nucleation and growth of distinct domains within the amorphous intermediary. The present study moves beyond kinetic modeling by providing detailed real-time structural insight, and it is demonstrated that YSZ nanoparticle formation and growth is a more complex chemical process than accounted for in conventional models. This level of mechanistic understanding of the nanoparticle formation is the first step towards more rational control over nanoparticle synthesis through control of both solution precursors and reaction intermediaries.

Published
2014
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5. Genome-wide association meta-analysis of human longevity identifies a novel locus conferring survival beyond 90 years of age

Author

Doris Lechner, Miriam Capri, Stefan Böhringer, Stefan Schreiber, Gonneke Willemsen, Paolo Garagnani, Irene Maeve Rea, Andres Metspalu, Palmi V. Jonsson, Thomas B. L. Kirkwood, Lene Christiansen, Fernando Rivadeneira, Giuseppina Rose, J. Wouter Jukema, Serena Dato, Owen A. Ross, Almut Nebel, Cornelia M. van Duijn, Gary Saunders, Bernard Jeune, David J. Stott, Jeanine J. Houwing-Duistermaat, A. Murphy, Anton J. M. de Craen, Friederike Flachsbart, Karen Andersen-Ranberg, Albert Hofman, Ian Ford, Ellen A. Nohr, Giuseppe Passarino, Krista Fischer, Elisa Cevenini, Carmen Martin-Ruiz, Jutta Gampe, Iris Postmus, Christopher P. Nelson, Stefano Salvioli, Alberto Montesanto, Mark Lathrop, Marianne Nygaard, Marie E. Breen, Jennifer Harrow, Hae-Won Uh, Erik B. van den Akker, Thorkild I. A. Sørensen, André G. Uitterlinden, Alexander Viktorin, Bastiaan T. Heijmans, Susan E. McNerlan, Quinta Helmer, Naveed Sattar, Claudio Franceschi, Eco J. C. de Geus, E. Mihailov, Jouke-Jan Hottenga, Qihua Tan, Kari Stefansson, Yoichiro Kamatani, Paolina Crocco, Henning Tiemeier, Stella Trompet, Patrik K. E. Magnusson, Marian Beekman, Riin Tamm, Amke Caliebe, Maris Alver, Femke-Anouska Heinsen, Pilar Galan, Daníel F. Guðbjartsson, Joris Deelen, Linda Broer, Ruud van der Breggen, Kristin L. Ayers, Anna M. Bennet, Dorret I. Boomsma, P. Eline Slagboom, Kaare Christensen, Diana van Heemst, Joanna Collerton, Karen Davies, Rudi G. J. Westendorp, Hélène Blanché, Lavinia Paternoster, Nilesh J. Samani, Hreinn Stefansson, Simon P. Mooijaart, Heather J. Cordell, Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Netherlands Consortium for Healthy Aging [Leiden, Netherlands] (NCHA), LeidenUniversity Medical Centre, Department of Epidemiology, The Netherlands Cancer Institute, Institute of Genetic Medicine, Newcastle University [Newcastle], National Institute of Public Health, University of Southern Denmark (SDU), Department of Clinical Genetics, Odense University Hospital, Fondation Jean Dausset - Centre d’Étude du Polymorphisme Humain, Department of Medical Epidemiology and Biostatistics (MEB), Karolinska Institutet [Stockholm], University of Tartu, Institute of Molecular and Cell Biology, Department of Gerontology and Geriatrics, Leiden University Medical Center (LUMC), deCODE genetics [Reykjavik], Christian-Albrechts University of Kiel, University of Calabria, Delft University of Technology (TU Delft), Department of Cardiovascular Sciences, Université Catholique de Louvain = Catholic University of Louvain (UCL), University Hospitals Leicester, Genome Campus, The Wellcome Trust Sanger Institute [Cambridge], School of Medicine, Dentistry and Biomedical Sciences [Belfast], Queen's University [Belfast] (QUB), University of Iowa [Iowa City], DIMES: Department of Experimental, Diagnostic and Specialty Medicine, Bologna University Hospital, Institute for Ageing and Health, University of Glasgow, Max Planck Institute for Demographic Research (MPIDR), Max-Planck-Gesellschaft, Vrije universiteit = Free university of Amsterdam [Amsterdam] (VU), EMGO Institute for Health and Care Research, VU University Amsterdam Medical Center, Landspitali National University Hospital of Iceland, University of Iceland, McGill University = Université McGill [Montréal, Canada], Genome Quebec Innovation Centre, Institut de Génomique, Belfast Health and Social Care Trust, Estonian Biocentre, Partenaires INRAE, Aarhus University [Aarhus], School of Social and Community Medicine, Erasmus University Rotterdam, Mayo Clinic, BHF Glasgow Cardiovascular Research Centre, University Medical Center Schleswig-Holstein, Institute of Cardiovascular and Medical Sciences, Sophia Children's Hospital, Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS (U1153 / UMR_A_1125 / UMR_S_1153)), Université Paris Diderot - Paris 7 (UPD7)-Université Sorbonne Paris Cité (USPC)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Recherche Agronomique (INRA), Augustinus Foundation, Avera Institute for Human Genetics (AIHG), AXA Research Fund, Belfast City Hospital Trust Fund, Biobanking and Biomolecular Resources Research Infrastructure (BBMRI -NL) [184.021.007], Biotechnology and Biological Sciences Research Council (BBSRC), Bristol-Myers Squibb, Center for Inherited Disease Research (CIDR), Centre for Medical Systems Biology (CMSB), CERA Foundation, Commissariat a L'Energie Atomique (CEA)-Centre National de Genotypage (CNG), Danish Agency for Science, Technology and Innovation (DASTI)/The Danish Council for Independent Research (DCIR) [11-107308], Danish National Research Foundation (DNRF), Department of Health and Social Services (Northern Ireland), DFG-Cluster of Excellence 'Inflammation at Interfaces', Dunhill Medical Trust [R124/0509], Egmont Foundation, Estonian Science Foundation [7859], Estonian Government [SF0180142s08], European Research Council (ERC) [230374], European Science Foundation (ESF) [EU/QLRT-2001-01254], European Union [FP5-QLK6-CY-2001-00128, FP6-LIFESCIHEALTH-36894, FP6-LSH M-CT-2004-503270, FP7-HEALTH-2007-B-223004, FP7-HEALTH-F4-2007-201413, FP7-HEALTH-F4-2008-202047, FP7-HEALTH-2009-single-stage-242244, FP7-HEALTH-2010-two-stage-259679], Fondation Caisse d'Epargne Rhone-Alpes Lyon CERAL, Genetic Association Information Network (GAIN) of the Foundation for the US National Institutes of Health (NIMH) [MH081802], GenomEUtwin [EU/QLRT-2001-01254, QLG2-CT-2002-01254], Guy's & St Thomas' NHS Foundation Trust, Health Foundation, Heart and Lung foundation [20070481], Innovation-Oriented Research Program on Genomics (SenterNovem) [IGE05007], Institut National de la Recherche Agronomique (INRA), Institut National de la Sante et de la Recherche Medicale (INSERM), King's College London, Medical Research Council (MRC) [G0500997, G0601333], Ministere de l'Enseignement superieur et de la Recherche (MESR), National Institutes of Health (NIH)/National Institute of Aging (NIA) [P01AG08761, R01D0042157-01A, U01DK066134], National Institute for Health Research (NIHR) Newcastle Biomedical Research Centre, NBIC BioAssist [NWO-NBIC/BioAssist/RK/2008.024], Netherlands Consortium for Healthy Ageing (NCHA) [050-060-810], Netherlands Genomics Initiative (NGI), Netherlands Heart Foundation (NHF) [2001 D 032], Netherlands Organization for Scientific Research (NWO, MagW/ZonMW) [904-61-090, 904-61-193, 480-04-004, 400-05-717, Spinozapremie 56-464-14192, 175.010.2005.011, 911-03-012, 985-10-002, Addiction-31160008, Middelg-root-911-09-032], Netspar - Living longer for a good health, NHS North of Tyne (Newcastle Primary Care Trust), Pharmacy Foundation, Regione Autonoma della Sardegna, Rutgers University Cell and DNA Repository [NIMH U24 MH068457-06], Swedish Research Council [M-2005-1112], Tampere University Hospital and Academy of Finland, Danish Interdisciplinary Research Council, Health Foundation (Helsefonden), Ministry for Higher Education, National Program for Research Infrastructure [09-063256], March of Dimes Birth Defects Foundation, Swedish Foundation for Strategic Research (SSF), Unilever Discover Colworth, Universite Paris 13, University of Tartu [SP1GVAR-ENG], Velux Foundation, VU University's Institute for Health and Care Research (EMGO+) and Neuroscience Campus Amsterdam (NCA), Wellcome Trust [084762, 085475, 087436], IDEAL [FP7-HEALTH-2010-two-stage-259679], Research and Education into Ageing-0153, European Regional Development Fund, Deelen J, Beekman M, Uh HW, Broer L, Ayers KL, Tan Q, Kamatani Y, Bennet AM, Tamm R, Trompet S, Guðbjartsson DF, Flachsbart F, Rose G, Viktorin A, Fischer K, Nygaard M, Cordell HJ, Crocco P, van den Akker EB, Böhringer S, Helmer Q, Nelson CP, Saunders GI, Alver M, Andersen-Ranberg K, Breen ME, van der Breggen R, Caliebe A, Capri M, Cevenini E, Collerton JC, Dato S, Davies K, Ford I, Gampe J, Garagnani P, de Geus EJ, Harrow J, van Heemst D, Heijmans BT, Heinsen FA, Hottenga JJ, Hofman A, Jeune B, Jonsson PV, Lathrop M, Lechner D, Martin-Ruiz C, McNerlan SE, Mihailov E, Montesanto A, Mooijaart SP, Murphy A, Nohr EA, Paternoster L, Postmus I, Rivadeneira F, Ross OA, Salvioli S, Sattar N, Schreiber S, Stefánsson H, Stott DJ, Tiemeier H, Uitterlinden AG, Westendorp RG, Willemsen G, Samani NJ, Galan P, Sørensen TI, Boomsma DI, Jukema JW, Rea IM, Passarino G, de Craen AJ, Christensen K, Nebel A, Stefánsson K, Metspalu A, Magnusson P, Blanché H, Christiansen L, Kirkwood TB, van Duijn CM, Franceschi C, Houwing-Duistermaat JJ, Slagboom PE., Leiden Univ, Dept Mol Epidemiol, NL-2300 RC Leiden, Netherlands [ 2 ] Leiden Univ, Netherlands Consortium Healthy Ageing, NL-2300 RC Leiden, Netherlands [ 3 ] Leiden Univ, Dept Med Stat & Bioinformat, NL-2300 RC Leiden, Netherlands [ 4 ] Leiden Univ, Dept Cardiol, NL-2300 RC Leiden, Netherlands [ 5 ] Leiden Univ, Dept Gerontol & Geriatr, NL-2300 RC Leiden, Netherlands [ 6 ] Erasmus MC, Dept Epidemiol, NL-3000 CA Rotterdam, Netherlands [ 7 ] Erasmus MC, Dept Internal Med, NL-3000 CA Rotterdam, Netherlands [ 8 ] Newcastle Univ, Int Ctr Life, Inst Med Genet, Newcastle Upon Tyne NE1 3BZ, Tyne & Wear, England [ 9 ] Univ So Denmark, Inst Publ Hlth, DK-5000 Odense C, Denmark [ 10 ] Univ So Denmark, Inst Clin Res, Dept Gynecol & Obstet, DK-5000 Odense C, Denmark [ 11 ] Odense Univ Hosp, Dept Clin Genet, DK-5000 Odense C, Denmark [ 12 ] Odense Univ Hosp, Clin Biochem & Pharmacol, DK-5000 Odense C, Denmark [ 13 ] Fdn Jean Dausset CEPH, F-75010 Paris, France [ 14 ] Karolinska Inst, Dept Med Epidemiol & Biostat, SE-17177 Stockholm, Sweden [ 15 ] Univ Tartu, Estonian Genome Ctr, Tartu 51010, Estonia [ 16 ] Univ Tartu, Inst Mol & Cell Biol, EE-51010 Tartu, Estonia [ 17 ] deCODE Genet, Populat Gen, IS-101 Reykjavik, Iceland [ 18 ] Univ Kiel, Inst Clin Mol Biol, D-24105 Kiel, Germany [ 19 ] Univ Kiel, Inst Med Informat & Stat, D-24105 Kiel, Germany [ 20 ] Univ Calabria, Dept Biol Ecol & Earth Sci, I-87036 Arcavacata Di Rende, Italy [ 21 ] Delft Univ Technol, Delft Bioinformat Lab, NL-2600 GA Delft, Netherlands [ 22 ] Univ Leicester, Dept Cardiovasc Sci, Leicester LE3 9QP, Leics, England [ 23 ] Glenfield Hosp, Cardiovasc Biomed Res Unit, Natl Inst Hlth Res, Leicester LE3 9QP, Leics, England [ 24 ] Wellcome Trust Sanger Inst, Wellcome Trust Genome Campus, Cambridge CB10 1SA, England [ 25 ] Queens Univ Belfast, Sch Med Dent & Biomed Sci, Belfast BT9 7BL, Antrim, North Ireland [ 26 ] Univ Iowa, Dept Psychiat, Iowa City, IA 52242 USA [ 27 ] Univ Bologna, Dept Expt Diagnost & Specialty Med, I-40126 Bologna, Italy [ 28 ] Univ Bologna, Interdepartmental Ctr L Galvani, I-40126 Bologna, Italy [ 29 ] Newcastle Univ, Inst Ageing & Hlth, Newcastle Upon Tyne NE4 5PL, Tyne & Wear, England [ 30 ] Univ Glasgow, Robertson Ctr Biostat, Glasgow G12 8QQ, Lanark, Scotland [ 31 ] Univ Glasgow, Inst Cardiovasc & Med Sci, Glasgow G12 8QQ, Lanark, Scotland [ 32 ] Max Planck Inst Demograf Forsch, Lab Stat Demog, D-18057 Rostock, Germany [ 33 ] Vrije Univ Amsterdam, Dept Biol Psychol, NL-1081 BT Amsterdam, Netherlands [ 34 ] Vrije Univ Amsterdam Med Ctr, EMGO Inst Hlth & Care Res, NL-1081 BT Amsterdam, Netherlands [ 35 ] Landspitali Univ Hosp, IS-101 Reykjavik, Iceland [ 36 ] Univ Iceland, Fac Med, IS-101 Reykjavik, Iceland [ 37 ] CEA, Inst Genom, F-91057 Evry, France [ 38 ] McGill Univ, Montreal, PQ H3G 1A4, Canada [ 39 ] Genome Quebec Innovat Ctr, Montreal, PQ H3G 1A4, Canada [ 40 ] Belfast Hlth & Social Care Trust, Cytogenet Lab, Belfast BT8 8BH, Antrim, North Ireland [ 41 ] Estonian Bioctr, EE-51010 Tartu, Estonia [ 42 ] Aarhus Univ, Dept Publ Hlth, Epidemiol Sect, DK-8000 Aarhus C, Denmark [ 43 ] Univ Bristol, Sch Social & Community Med, MRC Ctr Causal Anal Translat Epidemiol, Bristol BS8 2BN, Avon, England [ 44 ] Mayo Clin, Dept Neurosci, Jacksonville, FL 32224 USA [ 45 ] Univ Glasgow, Fac Med, BHF Glasgow Cardiovasc Res Ctr, Glasgow G12 8TA, Lanark, Scotland [ 46 ] Univ Kiel, PopGen Biobank, D-24105 Kiel, Germany [ 47 ] Univ Hosp Schleswig Holstein, D-24105 Kiel, Germany [ 48 ] Sophia Childrens Univ Hosp, Erasmus Med Ctr, Dept Child & Adolescent Psychiat, NL-3000 CA Rotterdam, Netherlands [ 49 ] Univ Paris 04, UREN, U557, INSERM, F-93017 Bobigny, France [ 50 ] U1125 Inra, F-93017 Bobigny, France [ 51 ] Cnam, F-93017 Bobigny, France [ 52 ] Univ Paris 13, CRNH IdF, F-93017 Bobigny, France [ 53 ] Univ Copenhagen, Fac Hlth & Med Sci, Sect Metab Genet, Novo Nordisk Fdn Ctr, DK-2200 Copenhagen N, Denmark [ 54 ] Inst Prevent Med, DK-2000 Copenhagen, Denmark [ 55 ] Frederiksberg Univ Hosp, DK-2000 Copenhagen, Denmark [ 56 ] Interuniv Cardiol Inst Netherlands, NL-3501 DG Utrecht, Netherlands [ 57 ] Bellaria Hosp, IRCCS Inst Neurol Sci, I-40139 Bologna, Italy [ 58 ] CNR, ISOF, I-40129 Bologna, Italy, Epidemiology, Surgery, Internal Medicine, Child and Adolescent Psychiatry / Psychology, ProdInra, Migration, Vrije Universiteit Amsterdam [Amsterdam] (VU), Institut National de la Recherche Agronomique (INRA)-Université Paris Diderot - Paris 7 (UPD7)-Université Paris Descartes - Paris 5 (UPD5)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM), VU University Amsterdam, Biological Psychology, and EMGO+ - Lifestyle, Overweight and Diabetes

Subjects
Male, Netherlands Twin Register (NTR), Disease/genetics, Lífslíkur, Longevity/genetics, [SDV.MHEP.PHY] Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO], Genetic Linkage, Genome-wide association study, 0302 clinical medicine, Prospective Studies, Genetics (clinical), Genetics, Aged, 80 and over, 0303 health sciences, education.field_of_study, [SDV.MHEP] Life Sciences [q-bio]/Human health and pathology, Association Studies Articles, Age Factors, Chromosome Mapping, Genetic Loci/physiology, General Medicine, 3. Good health, Europe, Phenotype, Cardiovascular Diseases, Hypertension, Chromosomes, Human, Pair 5, Female, Human Longevity, genetics, meta-analysis, Aging/genetics, Cardiology and Cardiovascular Medicine, HUMAN AGING, Longevity, European Continental Ancestry Group, Population, HUMAN GENETICS, Single-nucleotide polymorphism, Locus (genetics), Biology, FAMILIAL LONGEVITY, White People, 03 medical and health sciences, Gene mapping, SDG 3 - Good Health and Well-being, Cardiovascular Diseases/genetics, [SDV.MHEP.PHY]Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO], Humans, Allele, education, Molecular Biology, Aged, 030304 developmental biology, Genetic association, Öldrun, Genome, Human, Arfgengi, Minor allele frequency, Ageing, Genetic Loci, Chromosomes, Human, Pair 19, Hypertension/genetics, 030217 neurology & neurosurgery, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology, Genome-Wide Association Study
Abstract

To access publisher's full text version of this article, please click on the hyperlink in Additional Links field or click on the hyperlink at the top of the page marked Files. This article is open access. The genetic contribution to the variation in human lifespan is ∼ 25%. Despite the large number of identified disease-susceptibility loci, it is not known which loci influence population mortality. We performed a genome-wide association meta-analysis of 7729 long-lived individuals of European descent (≥ 85 years) and 16 121 younger controls (

Published
2014
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