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20 results on '"ANR: 15-IDEX-0001,UCA JEDI,Idex UCA JEDI(2015)"'

1. Studying dynamics without explicit dynamics: a structure-based study of the export mechanism by AcrB

Author: Simsir, Méliné, Broutin, Isabelle, Mus-Veteau, Isabelle, Cazals, Frédéric, Algorithms, Biology, Structure (ABS), Inria Sophia Antipolis - Méditerranée (CRISAM), Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria), Laboratoire de cristallographie et RMN biologiques (LCRB - UMR 8015), Université Paris Descartes - Paris 5 (UPD5)-Centre National de la Recherche Scientifique (CNRS), Physiologie cellulaire et moléculaire des systèmes intégrés (PCMSI), Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015 - 2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015 - 2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS), ANR: 15-IDEX-0001,UCA JEDI,Idex UCA JEDI(2015), Cibles Thérapeutiques et conception de médicaments (CiTCoM - UMR 8038), Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Institut de pharmacologie moléculaire et cellulaire (IPMC), Centre National de la Recherche Scientifique (CNRS)-Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA), ANR-15-IDEX-0001,UCA JEDI,Idex UCA JEDI(2015), ANR-19-P3IA-0002,3IA@cote d'azur,3IA Côte d'Azur(2019), Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Université Nice Sophia Antipolis (1965 - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA), Cazals, Frederic, Idex UCA JEDI - - UCA JEDI2015 - ANR-15-IDEX-0001 - IDEX - VALID, and 3IA Côte d'Azur - - 3IA@cote d'azur2019 - ANR-19-P3IA-0002 - P3IA - VALID
Subjects: interfaces, allostery, molecular distances, transporters, conformational changes, [INFO.INFO-BI]Computer Science [cs]/Bioinformatics [q-bio.QM], [INFO.INFO-BI] Computer Science [cs]/Bioinformatics [q-bio.QM], clustering
Abstract: RND family proteins are transmembrane proteins identified as large spectrum drug transporters. A prototypical case in this superfamily, responsible for antibiotic resistance in selected gram negative bacteria, is AcrB. AcrB forms a trimer, which uses the proton motive force to efflux drugs, implementing a functional rotation mechanism. Unfortunately, the size of the system (1049 amino-acid per monomer and membrane) has prevented a systematic dynamical exploration, so that the mild understanding of this coupled transport jeopardizes our ability to counter it. To further our understanding, we present a novel strategy based on two key ingredients which are to study dynamics by exploiting information embodied in the numerous crystal structures of AcrB obtained to date, and to systematically consider subdomains, their dynamics, and their interactions. Along the way, we identify the subdomains responsible for dynamic events, refine the states (A,B,E) of the functional rotation mechanism, and analyze the evolution of intra-monomer and inter-monomer interfaces along the functional cycle. Our analysis paves the way to targeted simulations exploiting the most relevant degrees of freedom at certain steps, and also to a targeting of specific interfaces to block the drug efflux. More generally, our work shows that complex dynamics can be unveiled from static snapshots, and our strategy may be used on a variety of molecular machines of large size.
Published: 2020

2. Postprandial hyperglycemia stimulates neuroglial plasticity in hypothalamic POMC neurons after a balanced meal

Author: Tony Heurtaux, Julien Castel, Danae Nuzzaci, Alexia Mathou, Emmanuelle Nédélec, Virginie Tolle, Ewout Foppen, Etienne Audinat, Aleth Lemoine, Selma Ben Fradj, Luc Pénicaud, Céline Cansell, Alexandre Benani, Raphael G. P. Denis, Fabienne Liénard, Amélie Laderrière, Xavier Fioramonti, Jean-Louis Nahon, Dominique Grouselle, Carole Rovère, Centre des Sciences du Goût et de l'Alimentation [Dijon] (CSGA), Université de Bourgogne (UB)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Institut de pharmacologie moléculaire et cellulaire (IPMC), Centre National de la Recherche Scientifique (CNRS)-Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA), Unité de Biologie Fonctionnelle et Adaptative (BFA (UMR_8251 / U1133)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Institut de psychiatrie et neurosciences de Paris (IPNP - U1266 Inserm), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP), Luxembourg Center of Neuropathology, Nutrition et Neurobiologie intégrée (NutriNeuro), Université de Bordeaux (UB)-Institut Polytechnique de Bordeaux-Ecole nationale supérieure de chimie, biologie et physique-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Institut de Génomique Fonctionnelle (IGF), Université de Montpellier (UM)-Université Montpellier 1 (UM1)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Montpellier 2 - Sciences et Techniques (UM2)-Centre National de la Recherche Scientifique (CNRS), STROMALab, Centre National de la Recherche Scientifique (CNRS)-Ecole Nationale Vétérinaire de Toulouse (ENVT), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Etablissement Français du Sang-Institut National de la Santé et de la Recherche Médicale (INSERM), ANR-15-IDEX-0003,BFC,ISITE ' BFC(2015), ANR-13-JSV1-0003,NCAM2,Contrôle nerveux de la prise alimentaire et du métabolisme par une molécule neurale d'adhésion cellulaire(2013), Université de Bourgogne (UB)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut Agro Dijon, Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro), Université Nice Sophia Antipolis (1965 - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), University of Luxembourg [Luxembourg], Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Ecole Nationale Vétérinaire de Toulouse (ENVT), Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Etablissement Français du Sang-Centre National de la Recherche Scientifique (CNRS), DESAILLY, Marion, ISITE ' BFC - - BFC2015 - ANR-15-IDEX-0003 - IDEX - VALID, Jeunes Chercheuses et Jeunes Chercheurs - Contrôle nerveux de la prise alimentaire et du métabolisme par une molécule neurale d'adhésion cellulaire - - NCAM22013 - ANR-13-JSV1-0003 - JC - VALID, Université Bourgogne Franche-Comté [COMUE] (UBFC), Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015 - 2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015 - 2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS), Unité de Biologie Fonctionnelle et Adaptative [Depuis 2020] (BFA (UMR_8251 / U1133)), Institut de psychiatrie et neurosciences (U894 / UMS 1266), Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université Montpellier 1 (UM1)-Université Montpellier 2 - Sciences et Techniques (UM2)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), ANR: 15-IDEX-0001,UCA JEDI,Idex UCA JEDI(2015), and Laboratory for Endocrinology
Subjects: 0301 basic medicine, Blood Glucose, Food intake, obesity, Pro-Opiomelanocortin, food intake, [SDV]Life Sciences [q-bio], satiety, Energy homeostasis, Multidisciplinaire, généralités & autres [F99] [Sciences du vivant], 0302 clinical medicine, rat, hypothalamus, Meals, lcsh:QH301-705.5, 2. Zero hunger, Neurons, Meal, Neuronal Plasticity, [SDV.MHEP] Life Sciences [q-bio]/Human health and pathology, digestive, oral, and skin physiology, Postprandial Period, Postprandial, plasticite synaptique, Hypothalamus, Melanocortin, Neuroglia, hormones, hormone substitutes, and hormone antagonists, endocrine system, melanocortin system, Mice, Transgenic, Multidisciplinary, general & others [F99] [Life sciences], Biology, Plasticity, General Biochemistry, Genetics and Molecular Biology, 03 medical and health sciences, pro-opiomelanocortin neurons, Animals, energy homeostasis, astrocytes, Feeding Behavior, Electrophysiological Phenomena, Mice, Inbred C57BL, [SDV.AEN] Life Sciences [q-bio]/Food and Nutrition, 030104 developmental biology, lcsh:Biology (General), nervous system, Hyperglycemia, plasticity, Synaptic plasticity, Synapses, Neuroscience, [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition, 030217 neurology & neurosurgery, apport alimentaire, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract: Summary: Mechanistic studies in rodents evidenced synaptic remodeling in neuronal circuits that control food intake. However, the physiological relevance of this process is not well defined. Here, we show that the firing activity of anorexigenic POMC neurons located in the hypothalamus is increased after a standard meal. Postprandial hyperactivity of POMC neurons relies on synaptic plasticity that engages pre-synaptic mechanisms, which does not involve structural remodeling of synapses but retraction of glial coverage. These functional and morphological neuroglial changes are triggered by postprandial hyperglycemia. Chemogenetically induced glial retraction on POMC neurons is sufficient to increase POMC activity and modify meal patterns. These findings indicate that synaptic plasticity within the melanocortin system happens at the timescale of meals and likely contributes to short-term control of food intake. Interestingly, these effects are lost with a high-fat meal, suggesting that neuroglial plasticity of POMC neurons is involved in the satietogenic properties of foods. : State-dependent plasticity in neuronal circuits controlling hunger is well established. Nuzzaci et al. show that this process is recapitulated after a meal. Postprandial hyperglycemia induces glial retraction around hypothalamic POMC neurons, which increases the activity of these anorectic neurons. This macronutrient-dependent plasticity provides a neurobiological basis for satiety. Keywords: hypothalamus, plasticity, energy homeostasis, obesity, melanocortin system, pro-opiomelanocortin neurons, astrocytes, food intake, satiety
Published: 2020

3. Élargir les compétences des juristes

Author: Teller, Marina, Groupe de Recherche en Droit, Economie et Gestion (GREDEG), Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015 - 2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015 - 2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS), SMDE, ANR: 15-IDEX-0001,UCA JEDI,Idex UCA JEDI(2015), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA), IDEX uca jedi, Thierry Marteu, Irina Parachkevova et Jean-Baptiste Racine, ANR-19-P3IA-0002,3IA@cote d'azur,3IA Côte d'Azur(2019), and ANR-15-IDEX-0001,UCA JEDI,Idex UCA JEDI(2015)
Subjects: [SPI]Engineering Sciences [physics], [SHS.DROIT]Humanities and Social Sciences/Law, [INFO]Computer Science [cs], ComputingMilieux_MISCELLANEOUS
Abstract: International audience
Published: 2020

4. Une illustration des risques technologiques par le jeu des biais algorithmiques

Author: Teller, Marina, Groupe de Recherche en Droit, Economie et Gestion (GREDEG), Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015 - 2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015 - 2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS), SMDE, ANR: 15-IDEX-0001,UCA JEDI,Idex UCA JEDI(2015), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA), Thierry Marteu, Irina Parachkevova et Jean-Baptiste Racine, ANR-15-IDEX-0001,UCA JEDI,Idex UCA JEDI(2015), and ANR-19-P3IA-0002,3IA@cote d'azur,3IA Côte d'Azur(2019)
Subjects: [SPI]Engineering Sciences [physics], [SHS.DROIT]Humanities and Social Sciences/Law, [INFO]Computer Science [cs], ComputingMilieux_MISCELLANEOUS
Abstract: International audience
Published: 2020

5. Episodes of particle ejection from the surface of the active asteroid (101955) Bennu

Author: Christine Hartzell, Guy Libourel, Bashar Rizk, Jian-Yang Li, Daniel J. Scheeres, David Vokrouhlický, C. Drouet d'Aubigny, Derek S. Nelson, Y. Takahashi, Robert A. Jacobson, Michael C. Moreau, Harold C. Connolly, Eric M. Sahr, William F. Bottke, J. A. Seabrook, J. Y. Pelgrift, Leilah K. McCarthy, J. M. Leonard, Ben Rozitis, Kris J. Becker, S. Selznick, J. de León, Josh Emery, Humberto Campins, Javier Licandro, Carl Hergenrother, Erica Jawin, Marina Brozovic, M. Al Asad, A. B. Davis, Florian Thuillet, Jamie Molaro, Pasquale Tricarico, E. J. Lessac-Chenen, Peter G. Antreasian, Jason P. Dworkin, C. K. Maleszewski, Davide Farnocchia, Carina Bennett, Jay W. McMahon, C. Manzoni, C. W. V. Wolner, Steven R. Chesley, P. Michel, Peter Jenniskens, Andrew J. Liounis, J. N. Kidd, Ronald-Louis Ballouz, Dathon Golish, Michael Daly, Daniella DellaGiustina, Daniel P. Glavin, H. L. Roper, William M. Owen, Coralie D. Adam, Brent J. Bos, B. May, Dante S. Lauretta, Laboratoire Kastler Brossel (LKB (Lhomond)), Université Pierre et Marie Curie - Paris 6 (UPMC)-Fédération de recherche du Département de physique de l'Ecole Normale Supérieure - ENS Paris (FRDPENS), Centre National de la Recherche Scientifique (CNRS)-École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS), Dept. of Physics, University of Central Florida [Orlando] (UCF), IHU-LIRYC, Université Bordeaux Segalen - Bordeaux 2-CHU Bordeaux [Bordeaux], Universidad Autonoma de Nuevo Leon [Mexique] (UANL), NASA Goddard Space Flight Center (GSFC), Laboratoire de physique de l'état condensé (LPEC), Centre National de la Recherche Scientifique (CNRS)-Le Mans Université (UM), Dipartimento di Matematica, University of Pisa - Università di Pisa, Université de Washington Seattle, University of Michigan Medical School [Ann Arbor], University of Michigan [Ann Arbor], University of Michigan System-University of Michigan System, Joseph Louis LAGRANGE (LAGRANGE), Université Côte d'Azur (UCA)-Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Observatoire de la Côte d'Azur, COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), Instituto de Astrofisica de Canarias (IAC), Lunar and Planetary Laboratory [Tucson] (LPL), University of Arizona, The Open University [Milton Keynes] (OU), Institute of Astronomy, Charles University [Prague] (CU), ANR-15-IDEX-0001,UCA JEDI,Idex UCA JEDI(2015), Fédération de recherche du Département de physique de l'Ecole Normale Supérieure - ENS Paris (FRDPENS), École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS), University of Central Florida [Orlando], CHU Bordeaux [Bordeaux]-Université Bordeaux Segalen - Bordeaux 2, Le Mans Université (UM)-Centre National de la Recherche Scientifique (CNRS), Centre de Recherches Pétrographiques et Géochimiques (CRPG), Institut national des sciences de l'Univers (INSU - CNRS)-Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS), Politecnico di Milano [Milan] (POLIMI), Service d'hépato-gastro-entérologie [Hôpital Saint-Louis], Groupe Hospitalier Saint Louis - Lariboisière - Fernand Widal [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Laboratoire Avancé de Spectroscopie pour les Intéractions la Réactivité et l'Environnement - UMR 8516 (LASIRe), Ecole Nationale Supérieure de Chimie de Lille (ENSCL)-Université de Lille-Centre National de la Recherche Scientifique (CNRS), Charles University [Prague], and ANR: 15-IDEX-0001,UCA JEDI,Idex UCA JEDI(2015)
Subjects: Solar System, 010504 meteorology & atmospheric sciences, Origin of water on Earth, Population, [SDU.ASTR.EP]Sciences of the Universe [physics]/Astrophysics [astro-ph]/Earth and Planetary Astrophysics [astro-ph.EP], Astrophysics, 01 natural sciences, 0103 physical sciences, education, 010303 astronomy & astrophysics, ComputingMilieux_MISCELLANEOUS, 0105 earth and related environmental sciences, education.field_of_study, Multidisciplinary, Meteoroid, Spacecraft, [SDU.ASTR]Sciences of the Universe [physics]/Astrophysics [astro-ph], business.industry, 13. Climate action, Asteroid, [SDU]Sciences of the Universe [physics], Solar time, Physics::Space Physics, Astrophysics::Earth and Planetary Astrophysics, business, Orbit determination, Geology
Abstract: INTRODUCTION Active asteroids are small bodies in the Solar System that show ongoing mass loss, such as the ejection of dust, which may be caused by large impacts, volatile release, or rotational acceleration. Studying them informs our understanding of the evolution and destruction of asteroids and the origin of volatile materials such as water on Earth. The OSIRIS-REx (Origins, Spectral Interpretation, Resource Identification, and Security–Regolith Explorer) spacecraft has rendezvoused with the near-Earth asteroid (101955) Bennu. The selection of Bennu as the OSIRIS-REx target was partially based on its spectral similarity to some active asteroids. Observations designed to detect mass loss at Bennu were conducted from Earth and during the spacecraft’s approach, but no signs of asteroid activity were found. However, when the spacecraft entered orbit in January 2019, we serendipitously observed particles in the vicinity of Bennu that had apparently been ejected from its surface. RATIONALE We analyzed the properties and behavior of particles ejected from Bennu to determine the possible mechanisms of ejection and provide understanding of the broader population of active asteroids. Images obtained by the spacecraft indicate multiple discrete ejection events with a range of energies and resultant particle trajectories. We characterized three large ejection events that respectively occurred on 6 January, 19 January, and 11 February 2019. Tracking of individual particles across multiple images by means of optical navigation techniques provided the initial conditions for orbit determination modeling. By combining these approaches, we estimated the locations and times of ejection events and determined initial velocity vectors of particles. We estimated the particle sizes and the minimum energies of the ejection events using a particle albedo and density consistent with observations of Bennu. RESULTS Particles with diameters from 3 m s–1. Estimated energies ranged from 270 mJ for the 6 January event to 8 mJ for the 11 February event. The three events arose from widely separated sites, which do not show any obvious geological distinction from the rest of Bennu’s surface. However, these events all occurred in the late afternoon, between about 15:00 and 18:00 local solar time. In addition to discrete ejection events, we detected a persistent background of particles in the Bennu environment. Some of these background particles have been observed to persist on temporary orbits that last several days—in one case, with a semimajor axis >1 km. The orbital characteristics of these gravitationally bound objects make it possible to determine the ratio of their cross-sectional area to their mass. Combined with their photometric phase functions, this information constrains the parameter space of the particles’ diameters, densities, and albedos. CONCLUSION Plausible mechanisms for the large ejection events include thermal fracturing, volatile release through dehydration of phyllosilicates, and meteoroid impacts. The late-afternoon timing of the events is consistent with any of these mechanisms. Bennu’s boulder geology indicates that thermal fracturing, perhaps enhanced by volatile release, could occur on the asteroid surface. Smaller events, especially those that occur on the night side of Bennu, could be attributable to reimpacting particles. Our observations classify Bennu as an active asteroid. Active asteroids are commonly identified by major mass loss events observable with telescopes, on scales much greater than we observed at Bennu. Our findings indicate that there is a continuum of mass loss event magnitudes among active asteroids.
Published: 2019

6. Influence of Grain Boundary Structural Evolution on Pressure Solution Creep Rates

Author: van den Ende, M. P.A., Niemeijer, A. R., Spiers, C. J., Experimental rock deformation, Géoazur (GEOAZUR 7329), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de la Côte d'Azur, COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud]), High Pressure and Temperature Laboratory, Faculty of Geosciences [Utrecht], Utrecht University [Utrecht]-Utrecht University [Utrecht], ANR-15-IDEX-0001,UCA JEDI,Idex UCA JEDI(2015), European Project: 335915,EC:FP7:ERC,ERC-2013-StG,SEISMIC(2013), Experimental rock deformation, Université Côte d'Azur (UCA)-Université Côte d'Azur (UCA)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud]), and ANR: 15-IDEX-0001,UCA JEDI,Idex UCA JEDI(2015)
Subjects: bepress|Physical Sciences and Mathematics, 010504 meteorology & atmospheric sciences, Constitutive equation, Compaction, bepress|Physical Sciences and Mathematics|Earth Sciences, [SDU.STU]Sciences of the Universe [physics]/Earth Sciences, Soil science, EarthArXiv|Physical Sciences and Mathematics|Earth Sciences, pressure solution, Granular material, 01 natural sciences, Physics::Geophysics, Geochemistry and Petrology, Earth and Planetary Sciences (miscellaneous), Grain boundary diffusion coefficient, compaction, 0105 earth and related environmental sciences, EarthArXiv|Physical Sciences and Mathematics|Earth Sciences|Geology, bepress|Physical Sciences and Mathematics|Earth Sciences|Geology, EarthArXiv|Physical Sciences and Mathematics, Geophysics, Deformation mechanism, Creep, Space and Planetary Science, grain boundary structure, Grain boundary, Pressure solution, Geology
Abstract: International audience; Intergranular pressure solution is a well‐known rock deformation mechanism in wet regions of the upper crust and has been widely studied, especially in the framework of compaction of granular materials, such as reservoir sandstones and fault rocks. Several analytical models exist that describe compaction creep by stress‐induced mass transport, and the parameters involved are relatively well constrained by laboratory experiments. While these models are capable of predicting compaction behavior observed at relatively high porosities, they often overestimate compaction rates at porosities below 20% by up to several orders of magnitude. This suggests that the microphysical processes operating at low porosities are different and are not captured well by existing models. The implication is that available models cannot be extrapolated to describe compaction of sediments and fault rocks to the low porosities often reached under natural conditions. To address this problem, we propose a new, thermodynamic model that describes the decline of pressure solution rates within individual grain contacts as a result of time‐averaged growth of asperities or islands and associated constriction of the grain boundary diffusion path (here termed grain boundary evolution). The resulting constitutive equations for single grain‐grain contacts are then combined and solved semianalytically. The compaction rates predicted by the model are compared with those measured in high‐strain compaction experiments on wet granular halite. A significant reduction in compaction rate is predicted when grain boundary evolution is considered, which compares favorably with the experimental compaction data.
Published: 2019

7. Evaluating Smartphone Accuracy for LTE Power Measurement

Author: BOUSSAD, Yanis, Mahfoudi, Mohamed Naoufal, Legout, Arnaud, Lizzi, Leonardo, Ferrero, Fabien, Dabbous, Walid, Design, Implementation and Analysis of Networking Architectures (DIANA), Inria Sophia Antipolis - Méditerranée (CRISAM), Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria), Laboratoire d'Electronique, Antennes et Télécommunications (LEAT), Centre National de la Recherche Scientifique (CNRS)-Université Nice Sophia Antipolis (... - 2019) (UNS), Université Côte d'Azur (UCA)-Université Côte d'Azur (UCA), UCA, Inria, UCA, LEAT, and ANR: 15-IDEX-0001,UCA JEDI,Idex UCA JEDI(2015)
Subjects: LTE, wireless power measurement, [INFO.INFO-MC]Computer Science [cs]/Mobile Computing, [INFO.INFO-NI]Computer Science [cs]/Networking and Internet Architecture [cs.NI], [INFO.INFO-PF]Computer Science [cs]/Performance [cs.PF], IMU, smartphone, calibration
Abstract: Smartphones are today relatively cheap devices that embed a large variety of sensors such as magnetometers or orientation sensors, but also the hardware to connect to most wireless communication technologies such as Wi-Fi, Bluetooth, or cellular networks. For this reason, companies, such as OpenSignal or Tutela use smartphones to make crowd-based measurements of the received power from the cellular infrastructure to help operators manage their infrastructure. However, to the best of our knowledge, the accuracy of such measurements has never been rigorously assessed. The goal of this paper is to assess how accurate are measurements of received power from a 4G (LTE) antenna when performed from a Commercial Off-The-Shelf~(COTS) smartphone in different environments. We first evaluate the granularity and limitations of the Android API that returns the received power. We explore how reliable are the measurements from a mono-polarized antenna in a fully controlled environment. We show that the orientation of the smartphone, the position of the source, and the distance to the source has a significant impact on the accuracy of the measurements. We introduce several calibration techniques based on radiation matrices manipulations and machine learning to calibrate the measurements, that is, to improve the accuracy to less than 5 dBm RMSE compared to a professional equipment. Finally, we explore how reliable are measurements in an outdoor environment, in the context of a multi-polarized antenna.
Published: 2019

8. Éthique et IA : un préambule pour un autre droit

Author: Teller, Marina, Groupe de Recherche en Droit, Economie et Gestion (GREDEG), Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA), SMDE, ANR-15-IDEX-0001,UCA JEDI,Idex UCA JEDI(2015), ANR-19-P3IA-0002,3IA@cote d'azur,3IA Côte d'Azur(2019), COMUE Université Côte d'Azur (2015 - 2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015 - 2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS), and ANR: 15-IDEX-0001,UCA JEDI,Idex UCA JEDI(2015)
Subjects: regtech, [SHS.DROIT]Humanities and Social Sciences/Law, IA, finance, banque, éthique, ComputingMilieux_MISCELLANEOUS
Abstract: International audience
Published: 2019

9. The geomorphology, color, and thermal properties of Ryugu: Implications for parent-body processes

Author: Axel Hagermann, Yuri Shimaki, Makoto Yoshikawa, Masateru Ishiguro, Osamu Mori, Takehiko Arai, Masahiro Hayakawa, Takahiro Hiroi, Robert Gaskell, Manabu Yamada, Kei Shirai, N. Takaki, Takanao Saiki, Moe Matsuoka, Yuto Takei, Hirotaka Sawada, Naru Hirata, Fuyuto Terui, Yoshiaki Ishihara, Yoshiyuki Tsuda, Seiichi Tazawa, Hiroaki Kamiyoshihara, Ryodo Hemmi, Deborah L. Domingue, Rina Noguchi, Shinsuke Abe, Nicole Schmitz, Masanao Abe, Ralf Jaumann, Satoru Nakazawa, L. Le Corre, Kazuyoshi Asari, Takanobu Shimada, Shogo Tachibana, Yusuke Oki, M. Ozaki, R. Yamada, Katharina A. Otto, Hiroshi Araki, Faith Vilas, S. Oshigami, Toshimichi Otsubo, Patrick Michel, C. Sugimoto, K. Ogawa, Hideaki Kikuchi, Sei-ichiro Watanabe, Hiroki Senshu, Florian Thuillet, Yutaka Suzuki, T. Fukuhara, Sunao Hasegawa, K. Yamamoto, Ronald-Louis Ballouz, Satoshi Tanaka, Naoya Sakatani, Hirohide Demura, Paul A. Abell, Yuya Mimasu, T. G. Müller, Yoshiko Ogawa, Hideaki Miyamoto, Goro Komatsu, Shota Kikuchi, Carolyn M. Ernst, Fumi Yoshida, Olivier S. Barnouin, Eric Palmer, Rie Honda, Tomoki Nakamura, Yasuhiro Yokota, Yuki Takao, Tomohiko Sekiguchi, Kosuke Yoshioka, Shingo Kameda, Satoshi Hosoda, Eri Tatsumi, Kenji Nagata, Hajime Yano, Takahiro Iwata, Stefan Schröder, Yukio Yamamoto, Makoto Taguchi, Tatsuhiro Michikami, Kent Yoshikawa, J. Kimura, H. Suzuki, Seiji Sugita, Noriyuki Namiki, Yuichiro Cho, Go Ono, C. Honda, Hikaru Yabuta, Tomokatsu Morota, Ryudo Tsukizaki, A. Higuchi, Masatoshi Hirabayashi, Masato Okada, T. Takahashi, M. Shizugami, Chikako Hirose, Kazutaka Nishiyama, Takahide Mizuno, Hirotomo Noda, M. A. Barucci, Sho Sasaki, Masaki Fujimoto, Atsushi Fujii, Seiitsu Tsuruta, Tatsuaki Okada, Stefania Soldini, H. Ikeda, Tomohiro Yamaguchi, Michael E. Zolensky, Toru Kouyama, Koji Matsumoto, Naoko Ogawa, Yuichi Iijima, Hiroshi Takeuchi, Institute of Ecology, Tallinn University-Tallinn University, Institute of Space and Astronautical Science (ISAS), Department of Physics, Tokyo, Waseda University, Institute for Research on Earth Evolution [Yokosuka] (IFREE), Japan Agency for Marine-Earth Science and Technology (JAMSTEC), Institute of Observational Research for Global Change, Department of Applied Physics, The University of Tokyo, University of Electro-Communications [Tokyo] (UEC), Seoul National University [Seoul] (SNU), Tsukuba Space Center (TKSC), Japan Aerospace Exploration Agency [Tokyo] (JAXA), National Institute of Polar Research [Tokyo] (NiPR), Brown University, Service d'hépato-gastro-entérologie [Hôpital Saint-Louis], Groupe Hospitalier Saint Louis - Lariboisière - Fernand Widal [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Assistance publique - Hôpitaux de Paris (AP-HP) (APHP), Max-Planck-Institut für Quantenoptik (MPQ), Max-Planck-Gesellschaft, College of Industrial Technology, Nihon University, The Open University [Milton Keynes] (OU), Hiroshima University, Electronic Navigation Research Institute (ENRI), Ministry of Land, Infrastructure, Transport and Tourism, Dept Anim & Dairy Sci, University of Gerogia, National Institute of Agro-Environmental Sciences (NIAES), Mitsubishi Research Institute, Inc., Department of Natural History Sciences, Hokkaido University, Planetary Science Institute [Tucson] (PSI), Sol Agro et hydrosystème Spatialisation (SAS), Institut National de la Recherche Agronomique (INRA)-AGROCAMPUS OUEST, Max-Planck-Institut für Sonnensystemforschung (MPS), Laboratoire d'études spatiales et d'instrumentation en astrophysique (LESIA), Centre National de la Recherche Scientifique (CNRS)-Université Paris Diderot - Paris 7 (UPD7)-Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC), GEOMA, Université de Vigo, Universidate de Vigo, Plasma Research Center, University of Tsukuba, IHP Microelctronics, Advanced Materials Institute and Department of Chemistry, Fukuoka University, Department of Applied Mathematics and Physics, Graduate school of Mathematics, Kyoto-Kyoyo University, Department of Environmental and Materials Engineering, Nagoya Institute, Graduate School of Science and Engineering, Tokyo Metropolitan University [Tokyo], Institute of Environmental Systems (SUIKO), Kyushu University [Fukuoka], Graduate School of Science and Technology, Keio University, Rikkyo University [Tokyo], Dept. of Electronics Engineering, University of Electro-Communication, Institute for Sustainable Humanosphere (RISH), Kyoto University [Kyoto], Graduate School of Pharmaceutical Sciences, Tohoku, Tohoku University [Sendai], SolarTerrestrial Environment Laboratory, Nagoya University, Department of Geology and Geophysics, Ministry of Land, Infrastructure, Transport and Tourism (MLIT), Hokkaido University [Sapporo, Japan], DLR Institute of Planetary Research, German Aerospace Center (DLR), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Universidade de Vigo, Department of Advanced Technology and Development, BML, Matoba, Japan Aerospace Exploration Agency [Sagamihara] (JAXA), Department of Physics, University of California [Irvine] (UCI), University of California-University of California, Biomécanique et génie biomédical (BIM), Centre National de la Recherche Scientifique (CNRS), University of Alaska [Fairbanks] (UAF), Information Science Laboratory, Department of Electronics and Electrical Engineering, Faculty of Science and Technology, Keio University, Department of Earth and Planetary Sciences [Kobe], Kobe University, ANR: 15-IDEX-0001,UCA JEDI,Idex UCA JEDI(2015), The University of Tokyo (UTokyo), Joseph Louis LAGRANGE (LAGRANGE), Université Côte d'Azur (UCA)-Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Observatoire de la Côte d'Azur, COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'études spatiales et d'instrumentation en astrophysique (LESIA (UMR_8109)), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), and ANR-15-IDEX-0001,UCA JEDI,Idex UCA JEDI(2015)
Subjects: Asteroiden und Kometen, Physics, Multidisciplinary, 010504 meteorology & atmospheric sciences, [SDU.ASTR]Sciences of the Universe [physics]/Astrophysics [astro-ph], Stereochemistry, [SDU.ASTR.EP]Sciences of the Universe [physics]/Astrophysics [astro-ph]/Earth and Planetary Astrophysics [astro-ph.EP], 01 natural sciences, Article, Planetengeologie, [SDU]Sciences of the Universe [physics], 0103 physical sciences, Ryugu, [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph], 010303 astronomy & astrophysics, ComputingMilieux_MISCELLANEOUS, 0105 earth and related environmental sciences
Abstract: 著者人数: 120名(所属. 宇宙航空研究開発機構宇宙科学研究所 (JAXA)(ISAS): 澤田, 弘崇; 横田, 康弘; 坂谷, 尚哉; 岡田, 達明; 田中, 智; 飯島, 祐一; 早川, 雅彦; 松岡, 萌; R.-L. Ballouz; 嶌生, 有理; 水野, 貴秀; 石原, 吉明; 長谷川, 直; 藤本, 正樹; 吉川, 真; 山本, 幸生; 白井, 慶; R. Noguchi; 尾川, 順子; 照井, 冬人; 菊地, 翔太; 山口, 智宏; 竹内, 央, 三桝, 裕也; 高橋, 忠輝; 竹井, 洋; 藤井, 淳; 中澤, 暁; 細田, 聡史; 森, 治; 嶋田, 貴信; Soldini, Stefania; 岩田, 隆浩; 安部, 正真; 矢野, 創; 月崎, 竜童; 尾崎, 正伸; 西山, 和孝; 佐伯, 孝尚; 渡邊, 誠一郎; 津田, 雄一), Accepted: 2019-03-12, 資料番号: SA1180387000
Published: 2019

10. UBTD1 is a mechano‐regulator controlling cancer aggressiveness

Author: Damien Ambrosetti, Amel Mettouchi, Frédéric Bost, Christophe Lamaze, Maeva Gesson, Stéphanie Torrino, Jay P. Uhler, Emmanuel Lemichez, Lisa Kaminski, Stephan Clavel, Kathiane Laurent, Jean-François Michiels, Sabrina Pisano, François-René Roustan, Thomas Bertero, Maeva Dufies, Cedric Gaggioli, Centre méditerranéen de médecine moléculaire (C3M), Université Nice Sophia Antipolis (1965 - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Côte d'Azur (UCA), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA), Centre National de la Recherche Scientifique (CNRS), Institut de Recherche sur le Cancer et le Vieillissement (IRCAN), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA), Hôpital Pasteur [Nice] (CHU), University of Gothenburg (GU), Toxines bactériennes - Bacterial Toxins, Institut Pasteur [Paris] (IP)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Chimie biologique des membranes et ciblage thérapeutique (CBMCT - UMR 3666 / U1143), Université Paris Descartes - Paris 5 (UPD5)-Institut Curie [Paris]-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), This work has been supported by the French government, through the UCA‐JEDI Investments in the Future project managed by the National Research Agency (ANR) with the reference number ANR‐15‐IDEX‐01. S.T. is a recipient of a post‐doctoral fellowship from 'La Fondation de France'. L.K. is a recipient of a doctoral fellowship from the French ministry of research. F.B. is a CNRS researcher., We thank the GIS‐IBISA multi‐sites platform 'Microscopie Imagerie Côte d'Azur' (MICA), and particularly the imaging site of C3M and IRCAN (PICMI), which are supported by the 'Conseil General 06' and 'Conseil Départemental 06'. The PICMI AFM was supported by the Association pour la Recherche sur le Cancer (ARC) and by the 'Conseil General 06 de la Région Provence Alpes‐Côte'., ANR-15-IDEX-0001,UCA JEDI,Idex UCA JEDI(2015), Université Nice Sophia Antipolis (... - 2019) (UNS), Institut Pasteur [Paris]-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Dynamique et mécanique membranaires de la signalisation intracellulaire, Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Paris sciences et lettres (PSL), Université Côte d'Azur (UCA)-Université Côte d'Azur (UCA)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université Côte d'Azur (UCA), Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Nice Sophia Antipolis (... - 2019) (UNS), Université Côte d'Azur (UCA)-Université Côte d'Azur (UCA), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Paris Sciences et Lettres (PSL), and ANR: 15-IDEX-0001,UCA JEDI,Idex UCA JEDI(2015)
Subjects: RHOA, Cell, Regulator, Cell Cycle Proteins, [SDV.BC.BC]Life Sciences [q-bio]/Cellular Biology/Subcellular Processes [q-bio.SC], Mechanotransduction, Cellular, Biochemistry, 0302 clinical medicine, Ubiquitin, Neoplasms, matrix stiffness, ROCK2, Insulin-Like Growth Factor I, beta Catenin, 0303 health sciences, biology, Chemistry, Articles, Prognosis, 3. Good health, Cell biology, Ubiquitin ligase, Gene Expression Regulation, Neoplastic, medicine.anatomical_structure, Disease Progression, Disease Susceptibility, YAP, Protein Binding, Signal Transduction, [SDV.CAN]Life Sciences [q-bio]/Cancer, Protein Serine-Threonine Kinases, Models, Biological, UBTD1, 03 medical and health sciences, Cell Adhesion, Genetics, medicine, Humans, Hippo Signaling Pathway, Ubiquitins, Molecular Biology, 030304 developmental biology, Cancer, [SDV.BBM.BM]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Molecular biology, β‐TrCP, beta-Transducin Repeat-Containing Proteins, medicine.disease, Cancer cell, biology.protein, rhoA GTP-Binding Protein, Protein Processing, Post-Translational, 030217 neurology & neurosurgery, Transcription Factors
Abstract: International audience; Ubiquitin domain-containing protein 1 (UBTD1) is highly evolutionary conserved and has been described to interact with E2 enzymes of the ubiquitin-proteasome system. However, its biological role and the functional significance of this interaction remain largely unknown. Here, we demonstrate that depletion of UBTD1 drastically affects the mechanical properties of epithelial cancer cells via RhoA activation and strongly promotes their aggressiveness. On a stiff matrix, UBTD1 expression is regulated by cell-cell contacts, and the protein is associated with β-catenin at cell junctions. Yes-associated protein (YAP) is a major cell mechano-transducer, and we show that UBTD1 is associated with components of the YAP degradation complex. Interestingly, UBTD1 promotes the interaction of YAP with its E3 ubiquitin ligase β-TrCP Consequently, in cancer cells, UBTD1 depletion decreases YAP ubiquitylation and triggers robust ROCK2-dependent YAP activation and downstream signaling. Data from lung and prostate cancer patients further corroborate the in cellulo results, confirming that low levels of UBTD1 are associated with poor patient survival, suggesting that biological functions of UBTD1 could be beneficial in limiting cancer progression.
Published: 2019

11. Seismic and landslides hazards in the high stakes area of the Nice Côte d'Azur airport

Author: Courboulex, F., Sébastien Migeon, Anthony Sladen, Christophe Larroque, Maëlle Kelner, Anne Deschamps, Yann Hello, Courboulex, Françoise, Idex UCA JEDI - - UCA JEDI2015 - ANR-15-IDEX-0001 - IDEX - VALID, Suivi temporel de déformation et évaluation des aléas gravitaires associés à des pressions de fluide (pente niçoise). - - MODAL2017 - ANR-17-CE01-0017 - AAPG2017 - VALID, Géoazur (GEOAZUR 7329), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de la Côte d'Azur, Université Côte d'Azur (UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud]), Sorbonne Université (SU), Université de Reims Champagne-Ardenne (URCA), ANR-15-IDEX-0001,UCA JEDI,Idex UCA JEDI(2015), ANR-17-CE01-0017,MODAL,Suivi temporel de déformation et évaluation des aléas gravitaires associés à des pressions de fluide (pente niçoise).(2017), Université Côte d'Azur (UCA)-Université Côte d'Azur (UCA)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud]), ANR: 15-IDEX-0001,UCA JEDI,Idex UCA JEDI(2015), Institut national des sciences de l'Univers (INSU - CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud])-Centre National de la Recherche Scientifique (CNRS)-Observatoire de la Côte d'Azur, Université Côte d'Azur (UCA)-Université Côte d'Azur (UCA), and COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud])
Subjects: [SHS.SOCIO]Humanities and Social Sciences/Sociology, [SDU.STU.GP]Sciences of the Universe [physics]/Earth Sciences/Geophysics [physics.geo-ph], [SHS.SOCIO] Humanities and Social Sciences/Sociology, [SPI] Engineering Sciences [physics], offshore landslides, [SHS.GEO] Humanities and Social Sciences/Geography, Landslides-prone areas, Site effects, [SDU.STU]Sciences of the Universe [physics]/Earth Sciences, [SHS.GEO]Humanities and Social Sciences/Geography, [SDE.ES]Environmental Sciences/Environmental and Society, Seismic hazards, [SPI]Engineering Sciences [physics], [SDU.STU] Sciences of the Universe [physics]/Earth Sciences, [SDU.STU.GP] Sciences of the Universe [physics]/Earth Sciences/Geophysics [physics.geo-ph], [SDE.ES] Environmental Sciences/Environmental and Society
Abstract: International audience; A smart city must be equipped with efficient and interconnected transportation. Unfortunately, economic or operational reasons for creating an infrastructure sometimes compete with imperatives of natural hazards. The case of Nice Cote d'Azur airport is an interesting example. As air traffic increased, the airport has been progressively extended. The largest extension occurred between 1975 and 1979 when a large amount of backfill material has been accumulated on the continental shelf to reclaim land and create new tracks. In October 1979, a submarine landslide destroyed part of a seawall under construction and killed 10 people. This landslide was associated with a tsunami wave that swept the coast from Menton to Antibes: the damage was significant but much less than if it had occurred in summer during the tourist season. This disaster stopped all projects in the area for 40 years. However, recently, development projects have again been mentioned (information relayed by the press) with, in particular, the idea of a new port near the airport, able to accommodate ferries.For several years now, scientists have been working on the area to qualify natural hazard. Their results show that the airport tracks are subsiding [1] and that the surrounding offshore area is subject to recurrent small landslides [2], while geotechnical studies point to its unstable nature [3]. Recently, a seismological sensor installed under the sea during two years has recorded small local earthquakes. Our analysis of the signals revels a strong amplification effect of seismic waves related with the presence of a thick layer of sediments. Likewise, a future larger earthquake would also be amplified in this area, accentuating the potential for a significant submarine landslide. A domino effect is therefore to be feared: an earthquake, a landslide, a tsunami and maybe the only major local airport unable to operate properly in a time of crisis.A smart city should be a safe and resilient city that takes into account the contributions of all its stakeholders, including scientists. How scientific results can be taken into account into public decisions is still an open question.[1] Cavalié O., Sladen A., & Kelner M. (2015) Natural Hazards and Earth System Sciences [2] Kelner M., Migeon S. et al. (2016) Marine Geology [3] Dan G., Sultan et al. (2007) Marine Geology.
Published: 2019

12. Neurymenolide A, a Novel Mitotic Spindle Poison from the New Caledonian Rhodophyta Phacelocarpus neurymenioides

Author: Xavier Fant, Jeannette Chloë Bulinski, Omid Feizbakhsh, Stéphane Bach, Sandrine Ruchaud, Mohamed Mehiri, Sofia-Eléna Motuhi, Claire Delehouzé, Arnaud Cousseau, Béatrice Foll-Josselin, Claude Payri, Blandine Baratte, Ecologie marine tropicale des océans Pacifique et Indien (ENTROPIE [Nouvelle-Calédonie]), Institut de Recherche pour le Développement (IRD [Nouvelle-Calédonie])-Ifremer - Nouvelle-Calédonie, Institut Français de Recherche pour l'Exploitation de la Mer (IFREMER)-Institut Français de Recherche pour l'Exploitation de la Mer (IFREMER)-Université de la Nouvelle-Calédonie (UNC), Phophorylation de protéines et Pathologies Humaines (P3H), Station biologique de Roscoff [Roscoff] (SBR), Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS), Institut de Chimie de Nice (ICN), Université Nice Sophia Antipolis (1965 - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA), Laboratoire de Biologie Intégrative des Modèles Marins (LBI2M), Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Station biologique de Roscoff (SBR), Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS), Plate-forme de criblage d'inhibiteurs de protéines kinases=Kinase Inhibitor Specialized Screening facility (KISSf), Fédération de recherche de Roscoff (FR2424), Station biologique de Roscoff (SBR), Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Station biologique de Roscoff (SBR), Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Columbia University [New York], Laboratoire d'Excellence CORAIL (LabEX CORAIL), Institut de Recherche pour le Développement (IRD)-Université des Antilles et de la Guyane (UAG)-École des hautes études en sciences sociales (EHESS)-École Pratique des Hautes Études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut Français de Recherche pour l'Exploitation de la Mer (IFREMER)-Université de La Réunion (UR)-Université de la Polynésie Française (UPF)-Université de la Nouvelle-Calédonie (UNC)-Institut d'écologie et environnement-Université des Antilles (UA), Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Systématique, adaptation, évolution (SAE), Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS), Université des Antilles (UA)-Institut d'écologie et environnement-Université de la Nouvelle Calédonie (UNC)-Université de la Polynésie Française (UPF)-Université de La Réunion (UR)-Institut Français de Recherche pour l'Exploitation de la Mer (IFREMER)-École pratique des hautes études (EPHE)-École des hautes études en sciences sociales (EHESS)-Université des Antilles et de la Guyane (UAG)-Institut de Recherche pour le Développement (IRD), Wellcome Trust Centre for Cell Biology, University of Edinburgh, Ecologie marine tropicale dans les Océans Pacifique et Indien (ENTROPIE [Réunion]), Centre National de la Recherche Scientifique (CNRS)-Université de La Réunion (UR)-Institut de Recherche pour le Développement (IRD), Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015 - 2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015 - 2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS), ANR: 15-IDEX-0001,UCA JEDI,Idex UCA JEDI(2015), European Project: 654008,H2020,H2020-INFRADEV-1-2014-1,EMBRIC(2015), Université des Antilles (UA)-Institut d'écologie et environnement-Université de la Nouvelle-Calédonie (UNC)-Université de la Polynésie Française (UPF)-Université de La Réunion (UR)-Institut Français de Recherche pour l'Exploitation de la Mer (IFREMER)-École pratique des hautes études (EPHE), and Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-École des hautes études en sciences sociales (EHESS)-Université des Antilles et de la Guyane (UAG)-Institut de Recherche pour le Développement (IRD)
Subjects: Cell division, [SDV]Life Sciences [q-bio], Pharmaceutical Science, [CHIM.THER]Chemical Sciences/Medicinal Chemistry, 01 natural sciences, Flow cytometry, necrosis, 03 medical and health sciences, New Caledonia, [CHIM.ANAL]Chemical Sciences/Analytical chemistry, Drug Discovery, Fluorescence microscope, medicine, [CHIM]Chemical Sciences, Prometaphase, mitotic spindle poison, lcsh:QH301-705.5, Pharmacology, Toxicology and Pharmaceutics (miscellaneous), Mitotic catastrophe, Phacelocarpus neurymenioides, mitotic catastrophe, ComputingMilieux_MISCELLANEOUS, neurymenolide A, 030304 developmental biology, Antibacterial agent, 0303 health sciences, medicine.diagnostic_test, 010405 organic chemistry, Chemistry, apoptosis, [SDV.SP]Life Sciences [q-bio]/Pharmaceutical sciences, 3. Good health, 0104 chemical sciences, Spindle apparatus, lcsh:Biology (General), Biochemistry, Apoptosis, Rhodophyta
Abstract: The marine &alpha, pyrone macrolide neurymenolide A was previously isolated from the Fijian red macroalga, Neurymenia fraxinifolia, and characterized as an antibacterial agent against antibiotic-resistant strains that also exhibited moderate cytotoxicity in vitro against cancer cell lines. This compound was also shown to exhibit allelopathic effects on Scleractinian corals. However, to date no mechanism of action has been described in the literature. The present study showed, for the first time, the isolation of neurymenolide A from the New Caledonian Rhodophyta, Phacelocarpus neurymenioides. We confirmed the compound&rsquo, s moderate cytotoxicity in vitro against several human cell lines, including solid and hematological malignancies. Furthermore, we combined fluorescence microscopy and flow cytometry to demonstrate that treatment of U-2 OS osteosarcoma human cells with neurymenolide A could block cell division in prometaphase by inhibiting the correct formation of the mitotic spindle, which induced a mitotic catastrophe that led to necrosis and apoptosis. Absolute configuration of the stereogenic center C-17 of neurymenolide A was deduced by comparison of the experimental and theoretical circular dichroism spectra. Since the total synthesis of this compound has already been described, our findings open new avenues in cancer treatment for this class of marine molecules, including a new source for the natural product.
Published: 2019

13. The strategic environment effect in beauty contest games

Author: Yukio Koriyama, Angela Sutan, Marc Willinger, Nobuyuki Hanaki, Groupe de Recherche en Droit, Economie et Gestion (GREDEG), Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA), Département d'Économie de l'École Polytechnique (X-DEP-ECO), École polytechnique (X), Burgundy School of Business (BSB) - Ecole Supérieure de Commerce de Dijon Bourgogne (ESC) (BSB), Centre d'Economie de l'Environnement - Montpellier - FRE2010 (CEE-M), Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro), Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut National de la Recherche Agronomique (INRA)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM), CODIREM, ANR-15-ORAR-0004,BEAM,Analyses comportementales et exp?rimentales en macro-finance(2015), ANR-11-LABX-0047,ECODEC,Réguler l'économie au service de la société(2011), ANR-15-IDEX-0001,UCA JEDI,Idex UCA JEDI(2015), Université Côte d'Azur (UCA)-Université Côte d'Azur (UCA)-Centre National de la Recherche Scientifique (CNRS), Institut National de la Recherche Agronomique (INRA)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro), ANR: BEAM,ANR-15-ORAR-0004, ANR: 11-LABX-0047,ECODEC,Réguler l'économie au service de la société(2011), ANR: 15-IDEX-0001,UCA JEDI,Idex UCA JEDI(2015), and Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro)-Institut National de la Recherche Agronomique (INRA)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)
Subjects: Economics and Econometrics, strategic complementarity, Microeconomics, symbols.namesake, Environment effect, 0502 economics and business, Economics, strategic substitutability, iterative reasoning, JEL: C - Mathematical and Quantitative Methods/C.C9 - Design of Experiments/C.C9.C91 - Laboratory, Individual Behavior, 050207 economics, Robustness (economics), 050205 econometrics, Strategic complements, Welfare economics, 05 social sciences, Nominal rigidity, Rational agent, [SHS.ECO]Humanities and Social Sciences/Economics and Finance, Cognitive Hierarchy Theory, Beauty contest, Nash equilibrium, symbols, JEL: C - Mathematical and Quantitative Methods/C.C7 - Game Theory and Bargaining Theory/C.C7.C72 - Noncooperative Games, Finance, beauty contest games
Abstract: Recent experimental studies have shown that observed outcomes deviate significantly morefrom the Nash equilibrium when actions are strategic complements than when they are strategic substitutes. This "strategic environment effect" offers promising insights into the aggregate consequences of interactions among heterogeneous boundedly rational agents, but its macroeconomic implications have been questioned because the underlying experiments involve a small number of agents. We studied beauty contest games with a unique interior Nash equilibrium to determine the critical group size for triggering the strategic environment effect, and we use both theory and experiments to shed light on its effectiveness. Based on cognitive hierarchy and level-K models, we show theoretically that the effect is operative for interactions among three or more agents. Our experimental results show a statistically significant strategic environment effect for groups of five or more agents, establishing its robustness against the increase in the population size. Our results bolster other experimental ndings on the strategic environment effects that are relevant for macroeconomic issues such as price fluctuations and nominal rigidity.
Published: 2018

14. Rab4b Deficiency in T Cells Promotes Adipose Treg/Th17 Imbalance, Adipose Tissue Dysfunction, and Insulin Resistance

Author: Gilleron, Jérôme, Bouget, Gwennaelle, Ivanov, Stoyan, Meziat, Cindy, Ceppo, Franck, Vergoni, Bastien, Djedaini, Mansour, Soprani, Antoine, Dumas, Karine, Jacquel, Arnaud, Yvan-Charvet, Laurent, Venteclef, Nicolas, Tanti, Jean-François, Cormont, Mireille, Centre méditérannéen de médecine moléculaire (C3M), Université Nice Sophia Antipolis (... - 2019) (UNS), Université Côte d'Azur (UCA)-Université Côte d'Azur (UCA)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre méditerranéen de médecine moléculaire (C3M), Washington University school of medicine, Institut de signalisation, biologie du développement et cancer (ISBDC), Université Côte d'Azur (UCA)-Université Côte d'Azur (UCA)-Centre National de la Recherche Scientifique (CNRS), Métabolisme et physiologie rénale (CRC - UMR_S 1138), Centre de Recherche des Cordeliers (CRC (UMR_S_1138 / U1138)), École pratique des hautes études (EPHE)-Université Paris Diderot - Paris 7 (UPD7)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-École pratique des hautes études (EPHE)-Université Paris Diderot - Paris 7 (UPD7)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA)-Institut National de la Santé et de la Recherche Médicale (INSERM), École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), Sorbonne Université - Faculté de Médecine (SU FM), Sorbonne Université (SU), ANR-15-IDEX-0001,UCA JEDI,Idex UCA JEDI(2015), ANR-11-LABX-0028,SIGNALIFE,Réseau d'Innovation sur les Voies de Signalisation en Sciences de la Vie(2011), COMUE Université Côte d'Azur (2015 - 2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015 - 2019) (COMUE UCA)-Institut National de la Santé et de la Recherche Médicale (INSERM), COMUE Université Côte d'Azur (2015 - 2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015 - 2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS), ANR: 15-IDEX-0001,UCA JEDI,Idex UCA JEDI(2015), and ANR: 11-LABX-0028,SIGNALIFE,Réseau d'Innovation sur les Voies de Signalisation en Sciences de la Vie(2011)
Subjects: Aging, ectopic lipids, CD3 Complex, immunometabolism, T-Lymphocytes, Regulatory, Glucose Intolerance, Adipocytes, Animals, Humans, endocytosis, Obesity, RNA, Messenger, lcsh:QH301-705.5, ComputingMilieux_MISCELLANEOUS, Inflammation, Mice, Knockout, rab4 GTP-Binding Proteins, Fatty Acids, Cell Polarity, [SDV.MHEP.EM]Life Sciences [q-bio]/Human health and pathology/Endocrinology and metabolism, Lipid Metabolism, adipose tissue, lcsh:Biology (General), small GTPase, Th17 Cells, [SDV.IMM]Life Sciences [q-bio]/Immunology, Insulin Resistance
Abstract: Summary: Obesity modifies T cell populations in adipose tissue, thereby contributing to adipose tissue inflammation and insulin resistance. Here, we show that Rab4b, a small GTPase governing endocytic trafficking, is pivotal in T cells for the development of these pathological events. Rab4b expression is decreased in adipose T cells from mice and patients with obesity. The specific depletion of Rab4b in T cells causes adipocyte hypertrophy and insulin resistance in chow-fed mice and worsens insulin resistance in obese mice. This phenotype is driven by an increase in adipose Th17 and a decrease in adipose Treg due to a cell-autonomous skew of differentiation toward Th17. The Th17/Treg imbalance initiates adipose tissue inflammation and reduces adipogenesis, leading to lipid deposition in liver and muscles. Therefore, we propose that the obesity-induced loss of Rab4b in adipose T cells may contribute to maladaptive white adipose tissue remodeling and insulin resistance by altering adipose T cell fate. : Gilleron et al. show that Rab4b expression is decreased in adipose T cells during obesity in mice and humans. They reveal that Rab4b in T cells is critical for the control of adipose tissue remodeling and insulin sensitivity by regulating the adipose Th17/Treg balance. Keywords: immunometabolism, small GTPase, endocytosis, adipose tissue, ectopic lipids
Published: 2018

15. A survey of the literature on human capital-intensive firms

Author: Cézanne, Cécile, Krafft, Jackie, Saglietto, Laurence, Université Côte d'Azur (UCA), Groupe de Recherche en Droit, Economie et Gestion (GREDEG), Université Nice Sophia Antipolis (... - 2019) (UNS), Université Côte d'Azur (UCA)-Université Côte d'Azur (UCA)-Centre National de la Recherche Scientifique (CNRS), GFI, ANR: 15-IDEX-0001,UCA JEDI,Idex UCA JEDI(2015), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA), and ANR-15-IDEX-0001,UCA JEDI,Idex UCA JEDI(2015)
Subjects: Knowledge, Bibliometric analysis, Firms, Human capital, [SHS.GESTION]Humanities and Social Sciences/Business administration, Critical appraisal, Survey, [SHS.ECO]Humanities and Social Sciences/Economics and Finance, ComputingMilieux_MISCELLANEOUS
Abstract: International audience; The aim of this paper is to provide an exhaustive survey of the academic research dedicated to the study of human capital‐intensive firms (HCIFs). We use a bibliometric analysis based on the three widely used databases (Econlit, Science Direct and Wiley) over the period 1992–2015. We are adapting a methodology developed in previous works to our specific object of study, and we generate a bottom‐up clustering on keywords, titles and abstracts. Our examination of the data sheds a light on five main clusters of works that respectively focus on (1) critical human resource management, (2) intellectual capital assessment, (3) funding risk and innovation (4) high‐skilled employees supporting economic development and (5) internal and external valuable social networks. In a critical appraisal of our results, we stress that the bibliometric analysis remains silent on how the different clusters are linked with each other. Based on our own appreciation of the HCIFs literature, we propose a further step in the identification of a central question linking up these clusters: a transversal review of the five clusters reveals that HCIFs appear as a network of specialized agents whose complementary human resources are decisive for the value‐creation process.
Published: 2018

16. Detection of Brain Strokes Using Microwave Tomography

Author: Claire Mialiaccio, Ibtissam El Kanfoud, Christian Pichot, Pierre-Henri Tournier, Vanna Lisa Coli, Laure Blanc-Féraud, Victorita Dolean, Università degli Studi di Modena e Reggio Emilia (UNIMORE), Algorithms and parallel tools for integrated numerical simulations (ALPINES), Institut National des Sciences Mathématiques et de leurs Interactions (INSMI)-Inria de Paris, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-Laboratoire Jacques-Louis Lions (LJLL (UMR_7598)), Université Paris Diderot - Paris 7 (UPD7)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Diderot - Paris 7 (UPD7)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'Electronique, Antennes et Télécommunications (LEAT), Centre National de la Recherche Scientifique (CNRS)-Université Nice Sophia Antipolis (... - 2019) (UNS), Université Côte d'Azur (UCA)-Université Côte d'Azur (UCA), Morphologie et Images (MORPHEME), Inria Sophia Antipolis - Méditerranée (CRISAM), Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-Institut de Biologie Valrose (IBV), Université Nice Sophia Antipolis (... - 2019) (UNS), Université Côte d'Azur (UCA)-Université Côte d'Azur (UCA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Nice Sophia Antipolis (... - 2019) (UNS), Université Côte d'Azur (UCA)-Université Côte d'Azur (UCA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Signal, Images et Systèmes (Laboratoire I3S - SIS), Laboratoire d'Informatique, Signaux, et Systèmes de Sophia Antipolis (I3S), Université Côte d'Azur (UCA)-Université Côte d'Azur (UCA)-Centre National de la Recherche Scientifique (CNRS)-Université Nice Sophia Antipolis (... - 2019) (UNS), Université Côte d'Azur (UCA)-Université Côte d'Azur (UCA)-Centre National de la Recherche Scientifique (CNRS)-Laboratoire d'Informatique, Signaux, et Systèmes de Sophia Antipolis (I3S), Université Côte d'Azur (UCA)-Université Côte d'Azur (UCA)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS), ANR-13-MONU-0012,MEDIMAX,Résolution des Equations de Maxwell pour un système d'Imagerie Médicale complet(2013), ANR: 15-IDEX-0001,UCA JEDI,Idex UCA JEDI(2015), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA)-Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA)-Signal, Images et Systèmes (Laboratoire I3S - SIS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA)-Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA)-Laboratoire d'Informatique, Signaux, et Systèmes de Sophia Antipolis (I3S), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA)-Centre National de la Recherche Scientifique (CNRS), ANR-15-IDEX-0001,UCA JEDI,Idex UCA JEDI(2015), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Côte d'Azur (UCA)-Centre National de la Recherche Scientifique (CNRS)-Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Côte d'Azur (UCA)-Centre National de la Recherche Scientifique (CNRS)-Signal, Images et Systèmes (Laboratoire I3S - SIS), Università degli Studi di Modena e Reggio Emilia = University of Modena and Reggio Emilia (UNIMORE), Université Nice Sophia Antipolis (1965 - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA)-Université Nice Sophia Antipolis (1965 - 2019) (UNS), and COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA)-Université Nice Sophia Antipolis (1965 - 2019) (UNS)
Subjects: QA75, Cerebral infarction, business.industry, Computer science, 020206 networking & telecommunications, Domain decomposition methods, Pattern recognition, 010103 numerical & computational mathematics, 02 engineering and technology, Inverse problem, medicine.disease, 01 natural sciences, 3. Good health, [SPI.ELEC]Engineering Sciences [physics]/Electromagnetism, Microwave imaging, 0202 electrical engineering, electronic engineering, information engineering, medicine, cardiovascular diseases, Tomography, Artificial intelligence, 0101 mathematics, business, Massively parallel, Microwave tomography
Abstract: International audience; Brain stroke is a major cause of disability and death worldwide. There are two types of stroke, ischemic or cerebral infarction (85% of cases) and hemorrhagic (15%). The diagnosis must be made quickly (within 3 to 4 hours after the onset of symptoms) to determine the nature of the stroke and proceed to treatment. Recent works have shown the modification of the complex permittivity according to the nature of stroke [1] in the microwave domain. We are interested here in the detection of brain strokes using microwave tomography. We present results obtained by electromagnetic simulations coupled to a realistic noise model of measurements. The forward problem is based on a massively parallel computing using domain decomposition method, and an inverse problem based on L-BFGS algorithm with a regularization based on total variation (TV).
Published: 2018

17. Observational and reinforcement pattern-learning: An exploratory study

Author: Paul Pezanis-Christou, Alan Kirman, Nobuyuki Hanaki, Groupe de Recherche en Droit, Economie et Gestion (GREDEG), Université Nice Sophia Antipolis (... - 2019) (UNS), Université Côte d'Azur (UCA)-Université Côte d'Azur (UCA)-Centre National de la Recherche Scientifique (CNRS), National Centre of Scientific Research (CAMS-CERMESCNRS- EHESS), Paris, France, Bureau d'Économie Théorique et Appliquée (BETA), Institut National de la Recherche Agronomique (INRA)-Université de Strasbourg (UNISTRA)-Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS), University of Adelaide, Australian Research Council (DP140102949), CODIREM, ANR-11-FRJA-0002,BECOA,Fondations comportementales et cognitives de la modélisation mutli-agents(2011), ANR: BEAM,ANR-15-ORAR-0004, ANR-11-IDEX-0001-02/11-LABX-0061,OTMed,Objectif Terre : Bassin Méditerranéen(2011), ANR: 15-IDEX-0001,UCA JEDI,Idex UCA JEDI(2015), Université Nice Sophia Antipolis (1965 - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA), Centre National de la Recherche Scientifique (CNRS), Université Côte d'Azur (UCA), École des hautes études en sciences sociales (EHESS), Centre d'Analyse et de Mathématique sociales (CAMS), École des hautes études en sciences sociales (EHESS)-Centre National de la Recherche Scientifique (CNRS), Aix Marseille Université (AMU), ANR-15-ORAR-0004,BEAM,Analyses comportementales et exp?rimentales en macro-finance(2015), ANR-11-IDEX-0001,Amidex,INITIATIVE D'EXCELLENCE AIX MARSEILLE UNIVERSITE(2011), ANR-15-IDEX-0001,UCA JEDI,Idex UCA JEDI(2015), and Université de Lorraine (UL)-Université de Strasbourg (UNISTRA)-Institut National de la Recherche Agronomique (INRA)-Centre National de la Recherche Scientifique (CNRS)
Subjects: Economics and Econometrics, Computer Science::Computer Science and Game Theory, reinforcement learning, Exploratory research, JEL: D - Microeconomics/D.D8 - Information, Knowledge, and Uncertainty/D.D8.D83 - Search • Learning • Information and Knowledge • Communication • Belief • Unawareness, Machine learning, computer.software_genre, Multi-armed bandit, payoff patterns, 0502 economics and business, Observational learning, Reinforcement learning, 050207 economics, Reinforcement, Baseline (configuration management), multi-armed bandit, 050205 econometrics, business.industry, 05 social sciences, Stochastic game, JEL: D - Microeconomics/D.D8 - Information, Knowledge, and Uncertainty/D.D8.D81 - Criteria for Decision-Making under Risk and Uncertainty, [SHS.ECO]Humanities and Social Sciences/Economics and Finance, observational learning, Observational study, Artificial intelligence, business, Psychology, computer, Finance
Abstract: International audience; Understanding how individuals learn in an unknown environment is an important problem in economics. We model and examine experimentally behavior in a very simple multi-armed bandit framework in which participants do not know the inter-temporal payoff structure. We propose a baseline reinforcement learning model that allows for pattern-recognition and change in the strategy space. We also analyse three augmented versions that accommodate observational learning from the actions and/or payoffs of another player. The models successfully reproduce the distributional properties of observed discovery times and total payoffs. Our study further shows that when one of the pair discovers the hidden pattern, observing another's actions and/or payoffs improves discovery time compared to the baseline case.
Published: 2018

18. Numerical and Empirical Simulation of Linear Elastic Seismic Response of a Building: The Case of Nice Prefecture

Author: Laetitia Foundotos, Anne Deschamps, Etienne Bertrand, Françoise Courboulex, Guillermo Wenceslao Fernández Lorenzo, Maria Paola Santisi d'Avila, E. Diego Mercerat, Laboratoire Jean Alexandre Dieudonné (LJAD), Université Nice Sophia Antipolis (1965 - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA), Géoazur (GEOAZUR 6526), Institut de Recherche pour le Développement (IRD)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Université Nice Sophia Antipolis (1965 - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de la Côte d'Azur, COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA)-Université Côte d'Azur (UCA)-Centre National de la Recherche Scientifique (CNRS), Centre d'Etudes et d'Expertise sur les Risques, l'Environnement, la Mobilité et l'Aménagement - Equipe-projet MOUVGS (Cerema Equipe-projet MOUVGS), Centre d'Etudes et d'Expertise sur les Risques, l'Environnement, la Mobilité et l'Aménagement (Cerema), CEA, ANR-15-IDEX-0001,UCA JEDI,Idex UCA JEDI(2015), Laboratoire Jean Alexandre Dieudonné (JAD), Université Côte d'Azur (UCA)-Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS), Institut de Recherche pour le Développement (IRD)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Université Nice Sophia Antipolis (... - 2019) (UNS), Géoazur (GEOAZUR 7329), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de la Côte d'Azur, COMUE Université Côte d'Azur (2015 - 2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015 - 2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud])-Université Côte d'Azur (UCA), Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015 - 2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015 - 2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS), CEA Cadarache, Commissariat à l'énergie atomique et aux énergies alternatives (CEA), and ANR: 15-IDEX-0001,UCA JEDI,Idex UCA JEDI(2015)
Subjects: Engineering, 010504 meteorology & atmospheric sciences, business.industry, [SDU.STU.GP]Sciences of the Universe [physics]/Earth Sciences/Geophysics [physics.geo-ph], Linear elasticity, [SDU.STU]Sciences of the Universe [physics]/Earth Sciences, Structural engineering, 010502 geochemistry & geophysics, Geotechnical Engineering and Engineering Geology, Reinforced concrete, 01 natural sciences, Physics::Geophysics, [SPI.GCIV]Engineering Sciences [physics]/Civil Engineering, Geophysics, [SPI.GCIV.DV]Engineering Sciences [physics]/Civil Engineering/Dynamique, vibrations, business, ComputingMilieux_MISCELLANEOUS, 0105 earth and related environmental sciences
Abstract: International audience; The structural motion of a tall reinforced concrete (RC) building on alluvial soil in Nice (France) is continuously recorded using accelerometers. The structural behavior of the building is studied using operational modal analysis (OMA) to identify its dynamic properties, a finite element (FE) model to reproduce the building response, and empirical Green's functions (EGFs) to generate the structural response to ground motions stronger than those registered in the analyzed seismic area. These different approaches are applied for the analysis of seismic response of the instrumented building and results are consistent. The FE model is calibrated by comparing natural frequencies and mode shapes with those obtained using OMA. Numerically-simulated time histories are qualitatively and quantitatively compared with recordings showing good agreement. Based on regional earthquakes, linear seismic response of the building is simulated for a stronger scenario earthquake using EGF. This approach allows for structural deformation analysis of existing buildings without the need of structural plans and mechanical parameter calibration in the case where the seismic response is within linear elastic regime.
Published: 2018

19. Control of panic behavior in a non identical network coupled with a geographical model

Author: Cantin, Guillaume, Aziz-Alaoui, M, Verdière, Nathalie, Lanza, Valentina, Charrier, Rodolphe, Bertelle, Cyrille, Provitolo, Damienne, Dubos-Paillard, Edwige, Laboratoire de Mathématiques Appliquées du Havre (LMAH), Université Le Havre Normandie (ULH), Normandie Université (NU)-Normandie Université (NU), Equipe Réseaux d'interactions et Intelligence Collective (RI2C - LITIS), Laboratoire d'Informatique, de Traitement de l'Information et des Systèmes (LITIS), Normandie Université (NU)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Institut national des sciences appliquées Rouen Normandie (INSA Rouen Normandie), Institut National des Sciences Appliquées (INSA)-Normandie Université (NU)-Institut National des Sciences Appliquées (INSA)-Université Le Havre Normandie (ULH), Institut National des Sciences Appliquées (INSA)-Normandie Université (NU)-Institut National des Sciences Appliquées (INSA), Géoazur (GEOAZUR 7329), Université Côte d'Azur (UCA)-Institut national des sciences de l'Univers (INSU - CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud])-Centre National de la Recherche Scientifique (CNRS)-Observatoire de la Côte d'Azur, Université Côte d'Azur (UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA), Géographie-cités (GC (UMR_8504)), Université Paris 1 Panthéon-Sorbonne (UP1)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), ANR-15-IDEX-0001,UCA JEDI,Idex UCA JEDI(2015), Institut national des sciences appliquées Rouen Normandie (INSA Rouen Normandie), Institut National des Sciences Appliquées (INSA)-Normandie Université (NU)-Institut National des Sciences Appliquées (INSA)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Université Le Havre Normandie (ULH), Normandie Université (NU), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de la Côte d'Azur, COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud]), Normandie Université (NU)-Institut National des Sciences Appliquées (INSA)-Normandie Université (NU)-Institut National des Sciences Appliquées (INSA)-Université de Rouen Normandie (UNIROUEN), Institut national des sciences de l'Univers (INSU - CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud])-Centre National de la Recherche Scientifique (CNRS)-Observatoire de la Côte d'Azur, Université Côte d'Azur (UCA)-Université Côte d'Azur (UCA), Université Panthéon-Sorbonne (UP1)-École des hautes études en sciences sociales (EHESS)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris, ANR: 15-IDEX-0001,UCA JEDI,Idex UCA JEDI(2015), Université Côte d'Azur (UCA)-Université Côte d'Azur (UCA)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud]), Université Panthéon-Sorbonne (UP1)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), CANTIN, Guillaume, and Idex UCA JEDI - - UCA JEDI2015 - ANR-15-IDEX-0001 - IDEX - VALID
Subjects: [SHS.GEO] Humanities and Social Sciences/Geography, panic, [MATH] Mathematics [math], PARIS team, [SHS.GEO]Humanities and Social Sciences/Geography, [INFO.INFO-MO]Computer Science [cs]/Modeling and Simulation, coupled network, bifurcation, Control, [INFO]Computer Science [cs], [INFO.INFO-MO] Computer Science [cs]/Modeling and Simulation, [MATH]Mathematics [math], COM, synchronization
Abstract: International audience; In this paper, our aim is to study the control of panic behavior in a non-identical network coupled with a model for human behaviors during catastrophic events, and to establish the link between control and synchronization of the network. We show how to model the domino effect in the case of a succession of disasters and exhibit a Hopf bifurcation. We explore the patterns emerging from basic two-nodes configurations and analyze the effect of the coupling strength on the bifurcations that occur in the subsequent dynamical system. We illustrate our qualitative results by a numerical simulation of a specific catastrophe, prepared with the collaboration of geographers.
Published: 2017

20. The dynamics of knowledge-intensive sectors' knowledge base: Evidence from Biotechnology and Telecommunications

Author: Jackie Krafft, Pier Paolo Saviotti, Francesco Quatraro, Groupe de Recherche en Droit, Economie et Gestion (GREDEG), Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA), Laboratoire d'Economie Appliquée = Grenoble Applied Economics Laboratory (GAEL), Université Pierre Mendès France - Grenoble 2 (UPMF)-Institut National de la Recherche Agronomique (INRA), GFI, European Project: 266959,EC:FP7:SSH,FP7-SSH-2010-2,PICK-ME(2011), Université Côte d'Azur (UCA)-Université Côte d'Azur (UCA)-Centre National de la Recherche Scientifique (CNRS), Grenoble Applied Economics Laboratory (GAEL), COMUE Université Côte d'Azur (2015 - 2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015 - 2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'Economie Appliquée = Grenoble Applied Economics Laboratory [ 2003-2015] (GAEL [2003-2015]), ANR: 15-IDEX-0001,UCA JEDI,Idex UCA JEDI(2015), European Project: 290647,EC:FP7:SSH,FP7-SSH-2011-1,WWWFOREUROPE(2012), Université de Nice Sophia-Antipolis (UNSA), Collegio Carlo Alberto, Université Nice Sophia Antipolis (1965 - 2019) (UNS), and Université Pierre Mendès France - Grenoble 2 (UPMF)-Institut National de la Recherche Agronomique (INRA)-Centre National de la Recherche Scientifique (CNRS)
Subjects: technological classes, Process (engineering), Computer science, patents, JEL: O - Economic Development, Innovation, Technological Change, and Growth/O.O3 - Innovation • Research and Development • Technological Change • Intellectual Property Rights, Knowledge base,knowledge intensive sectors,variety,coherence,cognitive distance,technological classes,patents, Knowledge base, knowledge intensive sectors, Management of Technology and Innovation, Technology life cycle, ComputingMilieux_MISCELLANEOUS, cognitive distance, business.industry, Knowledge economy, Knowledge value chain, [SHS.ECO]Humanities and Social Sciences/Economics and Finance, General Business, Management and Accounting, JEL: L - Industrial Organization/L.L2 - Firm Objectives, Organization, and Behavior, technological classes,coherence,cognitive distance,knowledge base,knowledge intensive sectors,variety,patents, Variety (cybernetics), Biotechnology, coherence, variety, patent, Work (electrical), Telecommunications, business, Coherence (linguistics)
Abstract: International audience; In this paper, we present a methodology to represent and measure knowledge which takes into account knowledge heterogeneity and its sectoral level theoretical and empirical implications in knowledge intensive environments. We draw on work on recombinant knowledge, extending the approach to include the way the dynamics of technological knowledge creation evolves according to a life cycle; testing the existence of concepts such as technological paradigms; mapping the characteristics of the search process in the phases of exploration and exploitation during this technology life cycle and detecting the differences in sectoral evolution that can be explained by the properties of the knowledge base. We use European Patent Office data (1981-2005) to propose some operational metrics for the knowledge base and its evolution in two knowledge intensive sectors: biotechnology and telecommunications. Our empirical results show that there are interesting and meaningful differences across sectors, which are linked to the different phases of the technology life cycles.
Published: 2014

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20 results on '"ANR: 15-IDEX-0001,UCA JEDI,Idex UCA JEDI(2015)"'

1. Studying dynamics without explicit dynamics: a structure-based study of the export mechanism by AcrB

2. Postprandial hyperglycemia stimulates neuroglial plasticity in hypothalamic POMC neurons after a balanced meal

3. Élargir les compétences des juristes

4. Une illustration des risques technologiques par le jeu des biais algorithmiques

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6. Influence of Grain Boundary Structural Evolution on Pressure Solution Creep Rates

7. Evaluating Smartphone Accuracy for LTE Power Measurement

8. Éthique et IA : un préambule pour un autre droit

9. The geomorphology, color, and thermal properties of Ryugu: Implications for parent-body processes

10. UBTD1 is a mechano‐regulator controlling cancer aggressiveness

11. Seismic and landslides hazards in the high stakes area of the Nice Côte d'Azur airport

12. Neurymenolide A, a Novel Mitotic Spindle Poison from the New Caledonian Rhodophyta Phacelocarpus neurymenioides

13. The strategic environment effect in beauty contest games

14. Rab4b Deficiency in T Cells Promotes Adipose Treg/Th17 Imbalance, Adipose Tissue Dysfunction, and Insulin Resistance

15. A survey of the literature on human capital-intensive firms

16. Detection of Brain Strokes Using Microwave Tomography

17. Observational and reinforcement pattern-learning: An exploratory study

18. Numerical and Empirical Simulation of Linear Elastic Seismic Response of a Building: The Case of Nice Prefecture

19. Control of panic behavior in a non identical network coupled with a geographical model

20. The dynamics of knowledge-intensive sectors' knowledge base: Evidence from Biotechnology and Telecommunications

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